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Evaluating context effects on PHQ-8 somatic item scores among people with a chronic medical condition: a scleroderma patient-centred intervention network randomised experiment
CONCLUSIONS: We did not find evidence that responses to PHQ-8 somatic items were influenced by whether participants were aware they were responding to items about depression. This finding supports the validity of self-reported questionnaires for depression symptom assessment in people with chronic medical conditions. →
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Earlier ICU Transfer after CONCERN Early Warning System Score Escalation Reduced Sepsis-related Mortality: Results from a Multi-site Pragmatic Cluster Randomized Controlled Trial
Early recognition and timely escalation of care are critical for improving sepsis outcomes. This post-hoc analysis of a multi-site clinical trial examined whether the timing of ICU transfer following CONCERN Early Warning System (EWS) score escalation was associated with in-hospital mortality among patients later diagnosed with sepsis. Among 54 patients with CONCERN score changes prior… →
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Safety and efficacy of fordadistrogene movaparvovec in ambulatory participants with Duchenne muscular dystrophy (CIFFREO): a phase 3, double-blind, randomised, placebo-controlled study
BACKGROUND: Gene transfer is a promising therapeutic approach for Duchenne muscular dystrophy as the disease results from mutations in a single gene. Fordadistrogene movaparvovec is an investigational recombinant adeno-associated virus 9 (rAAV9)-based vector encoding a mini-dystrophin transgene protein for Duchenne muscular dystrophy . We aimed to assess the safety and efficacy of fordadistrogene movaparvovec in… →
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Home-based extended rehabilitation for older people with frailty (HERO): a randomised controlled trial
CONCLUSIONS: We do not recommend routine commissioning of extended rehabilitation for older people with frailty after discharge home from hospital or intermediate care, following an acute admission with a medical illness or injury. →
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How to Price Your Product: A Pricing Model Decision Tree
Recently, we published an edition called How to Price Your AI Product, co-written with DealOps, that went through critical considerations for pricing. The demand that we got for more pricing information was overwhelmingly positive. We wrote this edition to answer that call and build out a true pricing model decision tree, along with a full… →
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Single-Entry-Point Thread Implantation Technique Using the Gerbera Pattern for Facial Skin Rejuvenation: A Prospective Intraindividual Controlled Clinical Study
CONCLUSION: The single-entry-point thread implantation technique using the Gerbera pattern significantly reduced pain at needle penetration compared with the conventional multiple-entry-point technique, demonstrating good tolerability in clinical practice. →
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Sex- and Age-Stratified Outcomes of Colonoscopy Versus Faecal Immunochemical Testing: Post-Analysis of the COLONPREV Study
CONCLUSION: Participation and reductions in CRC-related mortality and incidence were consistent across sex and age groups for both FIT- and colonoscopy-based screening strategies. The higher baseline risk observed in men could not be fully mitigated by screening. →
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Cost and cost-effectiveness of ivermectin mass drug administration for malaria control in Kwale county, Kenya: a modelling analysis of a cluster-randomised trial
BACKGROUND: Malaria remains a major health burden in sub-Saharan Africa, where traditional vector control methods are hindered by insecticide resistance and evolving mosquito behaviour causing residual transmission. In the BOHEMIA cluster-randomised trial in Kenya, ivermectin mass drug administration (iMDA), delivered once a month for 3 months with approximately 64% population coverage, was shown to reduce… →
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A Randomized Clinical Trial: The Comparative Therapeutic Efficacy of Tap Water-UVA, Saltwater-UVA, and Conventional Bath PUVA in Palmoplantar Pustulosis
CONCLUSIONS: Immersion in water or saltwater prior to UVA without psoralens may provide a therapeutic effect. →
