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Therapeutical efficacy of immunobiotics in patients with newly diagnosed rheumatoid arthritis
CONCLUSIONS: Adjunctive probiotic supplementation with specific strains may enhance clinical outcomes, reduce inflammation, and increase remission rates in early RA, supporting probiotics as a safe, accessible adjunctive therapy. →
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The CEO’s Playbook for Difficult Board Directors
Carolyn Geason-Beissel/MIT SMR | Getty Images Ideally, board meetings feature thoughtful and challenging engagement between the board and CEO as they execute a fundamental responsibility: to lead their company toward sustained value creation. However, board and CEO dynamics often fall short of this ideal. Frequently, the human element in the boardroom is the key issue.… →
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Impact of secukinumab with modified nourishing blood and moisturising decoction on superficial fungal infections in patients with psoriasis with blood-dryness pattern
CONCLUSION: In this study, combining secukinumab with a modified nourishing and moisturising TCM regimen yielded superior clinical outcomes, including greater symptom relief, improved quality of life, and a reduced risk of superficial fungal infections compared with biologic monotherapy. →
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A BOPPPS-based micro-lecture teaching intervention for orthopaedic postgraduates in China
BACKGROUND: Orthopaedics is a highly specialized discipline characterized by complex theoretical frameworks and extensive knowledge, posing challenges for postgraduate teaching. With the advancement of educational technology, micro-lectures have been increasingly adopted in medical education. However, their isolated use may be insufficient to sustain student engagement or ensure effective learning. The bridge-in, learning objective, pre-test, participatory… →
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Early essential newborn care for late preterm and term infants delivered by cesarean section: a randomized controlled trial on neonatal hypoglycemia and breastfeeding
CONCLUSION: The EENC improves neonatal glucose regulation and breastfeeding in cesarean-born late preterm and term infants, potentially enhancing neonatal health, maternal-infant bonding, and postpartum transition. →
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Interobserver agreement for the assessment of erosive reflux esophagitis: a post hoc analysis of clinical trial data
Interobserver agreement for the Los Angeles (LA) classification of erosive reflux esophagitis was good in validation studies, but limited agreement data exists from clinical trials (CTs). We conducted a post hoc evaluation of interobserver agreement between CT endoscopists and independent expert adjudicators in a multi-center, randomized controlled trial of a new acid suppression therapy. Trial… →
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Feasibility trial of a transdiagnostic individual lifestyle evaluation and intervention (Lev-i) for health behavior change
CONCLUSION: Findings suggest that Lev-i is a feasible and acceptable intervention for promoting health behaviors among individuals with disabilities. However, further refinements may enhance feasibility for both patients and professionals before conducting a randomized controlled trial. ClinicalTrials.gov (NCT05889936). →
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How to Navigate Rapid Growth
Carolyn Geason-Beissel/MIT SMR | Getty Images In 2019, two Dutch entrepreneurs founded an environmental, social, and governance (ESG) consulting firm with six like-minded friends and former classmates. United by a shared vision to transform their industry, the close-knit team members poured themselves into the venture, working long hours and celebrating every small win. Within a… →