Clinical Trials
Category Added in a WPeMatico Campaign
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Efficacy of 8% arginine associated with low-level laser therapy in the treatment of dentin hypersensitivity: randomized double-blind clinical trial
CONCLUSIONS: All evaluated therapies were effective in reducing DH over the 8-week follow-up period, with a progressive reduction in symptoms over time. However, no statistically significant differences were observed between the interventions, and no additive effect was identified for the combined therapy.
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A randomized crossover clinical trial of the Deseyne contact lens for presbyopia with extended depth of focus
CONCLUSIONS: The Deseyne contact lens for presbyopia with extended depth of focus extends the depth of focus of the eye and thus improves intermediate and near visual acuity.
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Intra- and inter-rater reproducibility of the echocardiographic data of the Nigerian UPRIGHT-HTM trial participants
CONCLUSION: The risk-carrying echocardiographic traits were obtained with moderate repeatability in three Nigerian tertiary referral centres. As data quality augments with expertise, these findings call for a Nigerian training programme in echocardiography with certification.
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Psychometric evaluation of the Mastocytosis Symptom Severity Daily Diary (MS2D2) in adults with nonadvanced systemic mastocytosis (NonAdvSM)
CONCLUSIONS: MS2D2 is a reliable, valid, and responsive instrument for assessing symptom severity in NonAdvSM, with evidence supporting its use in clinical trials to evaluate treatment benefit.
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Quantitative ultrasound evaluation of the thoracolumbar fascia after manual and acupuncture therapies: an exploratory mechanistic randomized controlled trial with a sequential within-subject phase
CONCLUSION: Chiropractic and massage, unlike acupuncture, elicited detectable biomechanical changes, while chiropractic also enhanced disability outcomes. HKD detected no microstructural changes.
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Video-Based Training on Physicians’ Proficiency in Invasive Fungal Disease: A Multicentre, Cluster Randomised Controlled Trial
CONCLUSION: Both video and PDF training modules are appealing to physicians. Further, the video training module displayed superior efficacy in improving physicians’ knowledge of IFD.
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Attachment Orientations and Treatment Outcomes in Psychotherapy: Does the Alliance Mediate the Association?
Previous research has demonstrated associations between patients’ attachment orientations and psychotherapy outcomes. Both theoretical and clinical literature suggest that the therapeutic alliance may serve as a mediator in this relationship. The present study investigated whether the therapeutic alliance mediates the connection between adult attachment and treatment outcomes in a clinical sample. One hundred eighteen patients…
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The cost-effectiveness of the stopping elderly accidents, deaths and injuries options randomised quality improvement trial to prevent falls among older adults
CONCLUSION: Within the study cohort, the intervention was highly likely to be cost-effective. However, differences in medically treated falls and total healthcare costs were not statistically significant; therefore, we cannot rule out the possibility that the intervention had no impact.
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Group Therapy for Posttraumatic Stress Disorder Symptoms Among Veterans With Military Sexual Trauma: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This randomized clinical trial showed that both treatments demonstrated efficacy in reducing PTSD symptoms, but the MST-focused treatment compared with the active control demonstrated greater improvements in posttraumatic cognitions. The results support the use of the MST-focused group treatment for PTSD symptoms associated with MST.
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Baseline serum metabolites predict fractures in individuals who were Black and had type 2 diabetes
CONCLUSION: In summary, the metabolic differences identified here highlight the role of altered systemic metabolism and its relationship to fracture risk. Future investigations will determine if the identified metabolites serve as predictors of fracture in patients with T2D who are not Black.