Clinical Trials
Category Added in a WPeMatico Campaign
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Effect of intravenous vitamin C administration on chemotherapy-induced adverse events in patients with nasopharyngeal cancer
Nasopharyngeal carcinoma is prevalent in Thailand, with a substantial proportion of cases diagnosed at advanced stages. The standard treatment, concurrent chemoradiotherapy, is associated with considerable adverse effects, which may compromise therapeutic efficacy and diminish patients’ quality of life. While vitamin C has shown potential in reducing chemotherapy-induced toxicities in some cancers, its effects in nasopharyngeal…
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Web-Based Personalized Machine Learning Recommendations to Enhance Shared Decision-Making in Prostate-Specific Antigen Screening: Randomized Controlled Trial
CONCLUSIONS: Integrating personalized ML recommendations into SDM workflows provides emotional scaffolding for older men, reducing decisional distress and enhancing confidence without undermining autonomy. By addressing geriatric‑specific vulnerabilities through a facilitated digital interface, this ML‑driven approach complements traditional clinical consultations. These findings support the scalable integration of artificial intelligence-assisted decision support to foster patient‑centered care…
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Genetic Cascade Screening for Familial Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of patient-mediated genetic cascade screening supported by a web-based platform, participation in genetic testing and detection of familial hypercholesterolemia was increased compared with usual care. These results suggest that the use of digital communication tools enhanced the reach and effectiveness of genetic screening programs within privacy-regulated health…
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Short-term effects of craniosacral therapy and rhythmic movement training on developmental assessment scores and primitive reflex expression in typically developing children: a randomized controlled trial
CONCLUSION: CST was associated with short-term improvements in developmental assessment scores and reduced reflex-related responses under standardized clinical conditions. These findings should be interpreted cautiously and considered preliminary. Further research using objective outcome measures and long-term follow-up is required before drawing conclusions regarding clinical effectiveness or preventive applications.
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Cost-utility and cost-effectiveness of SELFIE, a transdiagnostic ecological momentary intervention for improving self-esteem in youth aged 12-26 years exposed to childhood adversity: Findings from a multicenter randomized controlled trial
CONCLUSIONS: At the societal level, the SELFIE intervention exceeded the WTP threshold. Tests for robustness showed higher probabilities of cost-effectiveness from a healthcare perspective, likely reflecting the absence of educational productivity loss costs in the societal perspective, and in youth recruited from specialized mental health services. The innovative field of blended EMIs yields encouraging first…
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Emotional Response to Pleasant Sounds Plays a Role in the Effectiveness of the Positive Focus Intervention
Individuals with hearing loss, even when using hearing aids, often perceive pleasant environmental sounds as less pleasant than do those with normal hearing. This bias in emotional response may negatively impact well-being, leading to decreased social participation and increased loneliness. The present study examined whether the Positive Focus intervention-encouraging hearing aid users to focus on…
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Deutenzalutamide, a novel androgen receptor inhibitor, after progression on docetaxel and abiraterone in metastatic castration-resistant prostate cancer: results from the randomized phase III HC-1119-04 trial
Metastatic castration-resistant prostate cancer (mCRPC) after treatment with docetaxel and androgen receptor signaling inhibitors (ARSIs) has limited treatment options. Although enzalutamide has shown activity after abiraterone and docetaxel, robust evidence from randomized phase III trials is lacking. Deutenzalutamide, a novel derivative with slower metabolism and improved pharmacokinetics, may offer enhanced safety and efficacy. This phase…
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Consistent benefit of physiology-guided complete revascularization across the spectrum of frailty in older patients with myocardial infarction: a prespecified analysis of the FIRE trial
CONCLUSIONS: Frailty, as assessed by the CFS, was independently associated with adverse outcomes. Complete revascularization was effective regardless of frailty status and should be considered in all older MI patients with multivessel disease undergoing an invasive strategy.
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Effectiveness of a Parent-Child Interaction Therapy-Based Trauma-Focused Interaction Module for Trauma-Exposed Children: A Pilot Randomized Controlled Trial
CONCLUSION: These findings provide preliminary evidence that TFI-PCIT may be a promising, developmentally sensitive intervention for young traumatized children and their caregivers.
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Parasternal electromyography in participants with mild or moderate chronic obstructive pulmonary disease in primary care: cohort study to assess technical and clinical application
CONCLUSIONS: EMG(para) measurement is feasible in primary care. In this group of COPD patients, lung function was stable across the three time points and EMG(para) was associated with the degree of airflow obstruction. In the resting stable state in mild/moderate disease, there was no association between EMG(para) and participant-reported outcomes. Further work should investigate the…