Clinical Trials
Category Added in a WPeMatico Campaign
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Effects of deprescribing antidepressants in nursing home residents with dementia-a cluster randomized controlled trial
CONCLUSIONS: The intervention did not significantly reduce antidepressant use among older nursing home residents with dementia. Further optimization and testing in a larger study are needed.
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The effect of therapeutic artistic activities on anxiety and psychological well-being in adolescents with type 1 diabetes: a randomized controlled study
CONCLUSION: It was concluded that therapeutic art activities were effective in reducing anxiety and improving psychological well-being in adolescents with diabetes. It is recommended that therapeutic art activities be integrated into the care programs for children with diabetes.
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Identification of distinct disease activity trajectories in patients with psoriatic arthritis receiving tofacitinib: a post hoc analysis of two phase 3 studies
CONCLUSIONS: In patients with PsA receiving tofacitinib, five distinct trajectory groups were identified with different baseline characteristics and treatment outcomes, but no clear trends in AEs. The tofacitinib 5 and 10 mg twice daily models showed comparable trajectories and baseline characteristics. In patients with HDA, enthesitis and tender joint count may impact timing and/or magnitude…
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Evaluation of self designed breast molds in enhancing doctor patient communication
To evaluate the value of self-made breast model in preoperative communication between doctors and patients with breast cancer. 200 patients with mammary tumor were randomly divided into control group and model group (100 patients in each group). The control group received traditional preoperative interpretation, and the model group used self-made breast model to assist interpretation.…
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Effectiveness of a WeChat Mini Program-Based Intervention on Promoting Multiple Health Behavior Changes Among Chinese Patients With Cardiovascular Diseases in Home-Based Rehabilitation: Randomized Controlled Trial
CONCLUSIONS: The 10-week Healthy Action Process Approach-based WeChat mini program intervention effectively improved MVPA, FVC, integrated lifestyle indicator, psychosocial resources of behavior change, and health-related outcomes among Chinese patients with CVDs. This intervention provides a valuable addition to rehabilitation strategies aimed at promoting long-term health and activity in cardiac patients following hospital discharge.
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Effects of sake lees intake on fecal uremic toxins, plasma D-alanine, constipation, and gut microbiome in healthy adults: A single-arm clinical trial
CONCLUSION: Sake lees intake may reduce fecal uremic toxins, elevate plasma D-alanine levels, alleviate constipation, and modify the gut microbiome. However, future studies are needed to confirm these effects in patients with CKD.
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Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease
Clinical trials of anti-amyloid-β (Aβ) monoclonal antibodies in Alzheimer disease (AD) infer target engagement from Aβ positron emission tomography (PET) and/or fluid biomarkers such as cerebrospinal fluid (CSF) Aβ42/40. However, these biomarkers measure brain Aβ deposits indirectly and/or incompletely. In contrast, neuropathologic assessments allow direct investigation of treatment effects on brain Aβ deposits-and on potentially…
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A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhibitor, in patients with mild to moderate atopic dermatitis: a proof-of-concept study with Post-hoc biomarker analysis
CONCLUSION: Baseline biomarkers, such as K2C5, ENTP6, and CRK, may serve as predictors of clinical improvement in AD patients treated with Nu0.5, highlighting the potential for personalized treatment strategies. Further research is required to validate these findings in larger patient cohorts.
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The effect of simulation-based breast health education on breast cancer awareness and breast self-examination skills of Afghan refugee women: a randomized controlled trial
CONCLUSIONS: The simulation-based breast health education intervention for Afghan refugee women was found to be a practical and innovative approach to raising breast cancer awareness and providing breast self-examination skills. This intervention may play a significant role in identifying at-risk individuals and raising their awareness. If sustained, this could potentially increase future screening participation and…
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Comparison of Neoadjuvant Chemotherapy With FLOT and Modified DCF Regimens in Nonmetastatic Gastric Adenocarcinoma
CONCLUSION: According to the study, patients with limited local invasion gastric adenocarcinoma who are eligible for surgery may benefit more from the FLOT neoadjuvant regimen than the mDCF regimen. The FLOT regimen proves to be more efficient and has fewer complications.