Clinical Trials
Category Added in a WPeMatico Campaign
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Anti-Nogo-A NG101 treatment induces changes in spinal cord micro- and macrostructure following spinal cord injury
NG101 is a recombinant antibody that neutralizes the nerve growth inhibitor Nogo-A, promoting neural repair and improving upper extremity motor function in spinal cord injury (SCI). This study evaluated spinal cord MRI biomarkers to detect treatment-related structural changes and enhance patient stratification using data from 106 participants with acute cervical SCI in the phase 2b…
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Comparison of polypropylene versus polyester mesh in lichtenstein inguinal hernia repair with respect to chronic pain and inflammatory changes
CONCLUSION: Polypropylene and polyester meshes demonstrated comparable short-term pain, chronic pain, and recurrence outcomes following Lichtenstein inguinal hernia repair. Polyester mesh was associated with lower early postoperative inflammatory markers and reduced early swelling, although these differences did not translate into significant differences in 3-month pain outcomes. Larger multicentric studies with longer follow-up are required to…
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Experiences and Perceived Influence of the Artificial Intelligence-Based Health Education Accurately Linking System (AI-HEALS) on Health Behaviors Among Patients With Type 2 Diabetes: Qualitative Study
CONCLUSIONS: Patients generally perceived AI-HEALS as a useful source of ongoing education, behavioral prompting, and everyday support for diabetes self-management. The findings suggest that artificial intelligence-enabled education may work not only by increasing knowledge but also by reinforcing awareness, translating guidance into feasible daily action, and supporting psychological adaptation. At the same time, the intervention’s…
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Attenuating trauma- and cocaine-related intrusions by blocking memory reconsolidation with minocycline: protocol for a transdiagnostic randomized controlled trial
Background: Post-traumatic stress disorder (PTSD) and substance use disorders frequently co-occur, with their comorbidity linked to poorer treatment outcomes. Beyond this epidemiological overlap, PTSD and, in particular, cocaine use disorder (CUD) have also been conceptually linked, as maladaptive memory processes are thought to play a central role in both of their etiopathogeneses. PTSD and CUD…
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Effect of electroacupuncture at Yifeng (TE17) and Fengchi (GB20) on prognosis of moderate-to-severe peripheral facial paralysis in the acute stage: a randomized controlled trial
CONCLUSION: Electroacupuncture at Yifeng (TE17) and Fengchi (GB20) can effectively promote the recovery of voluntary movement in the middle and lower facial muscles of patients with moderate-to-severe peripheral facial paralysis in the acute stage, and improve their physical and social functions, demonstrating a high clinical application value.
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Mammographic surveillance in breast cancer patients aged 50 years or older: a synopsis of the Mammo-50 RCT
CONCLUSION: For patients aged ≥ 50 years and 3 years post diagnosis, less-frequent mammograms were non-inferior and cost-effective compared with annual mammograms, with no detriment to patients’ quality of life. Mammo-50 provides evidence to inform guideline development.
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Timing matters in type 2 diabetes: Early high-Fiber nutrition enhances glycemic control and reshapes gut microbiota
Early, intensive dietary intervention may open a therapeutic window for type 2 diabetes (T2D) remission. We conducted a randomized, 2:1 crossover trial in 34 newly diagnosed overweight or obese patients with T2D. Participants were assigned to receive either high-fiber nutritional therapy (HFNT)-a 7-day very-low-calorie, high-fiber diet followed by a 23-day standard diabetes diet-or conventional diabetes…
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User perspectives on the Molbio Truenat platform and tuberculosis assays for decentralised testing in Mozambique and Tanzania
CONCLUSIONS: The Truenat platform and TB assays were perceived as easy to use by health providers, and as acceptable and feasible across stakeholder groups. Its implementation in decentralised settings was considered a preferred alternative to off-site Xpert testing for TB in Mozambique and Tanzania.
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Olaparib combined with abiraterone in HRR-mutated metastatic hormone-sensitive prostate cancer: a single-arm phase II trial
CONCLUSION: In this phase II single-arm study, olaparib plus abiraterone and ADT showed preliminary activity and a manageable safety profile in patients with HRR-mutated mHSPC, but these findings need to be confirmed in larger phase III studies.
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Sintilimab plus cisplatin and nab-paclitaxel induction treatment for locally advanced borderline-resectable oesophageal squamous cell carcinoma: A single-arm, prospective, phase 2 study (NEOCRTEC2001)
CONCLUSIONS: The regimen under investigation did not exhibit the anticipated statistical benefit in enhancing surgical conversion rates for BR-ESCC. Nevertheless, the treatment strategy of induction immunochemotherapy followed by surgery resulted in significant tumour downstaging and a significant pathological complete response rate. Patients who achieved R0 resection exhibited improved survival outcomes.