Clinical Trials
Category Added in a WPeMatico Campaign
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Efficacy and safety of iguratimod in patients with primary Sjogren’s syndrome: a multicentre randomised controlled trial
CONCLUSION: IGU monotherapy demonstrated significant improvements in composite, systemic and serologic outcomes compared with HCQ in active pSS and was well-tolerated. These findings establish IGU as a promising therapeutic option for pSS, particularly in the subset of patients with hyperglobulinaemia.
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Association of race and survival in patients treated with apalutamide: Pooled analysis of two phase 3 trials
CONCLUSIONS: In this study, the authors did not find any evidence of difference in the treatment effect of apalutamide on OS across patients of different races, although interpretation remains limited by poor representation of racial minorities. Among apalutamide-treated patients, there was no association of race with OS.
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Remote ischemic conditioning in necrotizing enterocolitis: an extended phase I safety study
CONCLUSIONS: RIC intervention with 5-min ischemia-reperfusion cycles is safe. RIC is also safe when extended to extremely preterm neonates with confirmed medical or surgical NEC.
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Pooled randomised QUARTET trials assessing effectiveness of a single pill for hypertension
CONCLUSION: This prospective individual participant data pooled analysis provides further evidence that the quadpill strategy is superior to initial monotherapy by virtue of improved BP-lowering, less need for uptitration and being associated with less treatment inertia.
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Eye tracking as a novel approach to cognitive assessment in DOC patients based on evidence from a multicenter clinical trial
The proper assessment of cognitive functioning is the subject of numerous scientific studies. Current behavioral methods essentially preclude this assessment in patients with disorders of consciousness (DOC). However, the development of eye-tracking technology (ETT) and the establishment of contact via this channel have created an opportunity to diagnose the cognitive function (CF) of DOC patients.…
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Effects of music and conversation on pain and anxiety levels during transrectal ultrasound-guided prostate biopsy: a randomized-controlled prospective study
CONCLUSIONS: The study demonstrated that listening to music had no significant effect on pain and anxiety in patients undergoing TRUS-PBx. Conversely, the findings showed that engaging patients in conversation significantly reduced pain and anxiety during the procedure.
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Home-based diabetes self-management education and support through Orem’s self-care model: a randomized controlled trial
The aim of this study was to provide health interventions by integrating the Diabetes Self-Management Education and Support recommended by the American Diabetes Association with Orem’s self-care model to address the challenges in diabetes self-management. This research is a randomized controlled experimental research. Sixty-five diabetic patients (30 controls, 35 experimental) were included in the study.…
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Impact of partial restoration margin level in combination with connective tissue graft on the treatment of single RT1 gingival recessions associated with non-carious cervical lesions: a 1-year randomized parallel-group trial
CONCLUSIONS: PR margins at or 1 mm apical to the CEJ provided similar clinical and esthetic outcomes when combined with CAF + CTG. The CEJ-1 approach improved early patient comfort without compromising root coverage.
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Randomized clinical trial of vaginal microbiota in menopausal genitourinary syndrome using radiofrequency and topical estriol
CONCLUSION: There was improvement in the parameters analyzed regarding the vaginal microbiota in the intervention with FRAXX with a higher proportion of Lactobacillus and a decrease in pH. And there was no superiority of FRAXX in relation to the use of topical estriol.
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Efficacy of Exercise on Severity of Paclitaxel-Induced Peripheral Neuropathy and Improving Quality of Life in Women with Non-metastatic Breast Cancer: Results of an Interim Analysis from an Ongoing Randomized Clinical Trial (ExPIN Trial)
CONCLUSIONS: Exercise intervention during paclitaxel therapy significantly reduced PIPN severity and improved quality of life. Findings are preliminary and warrant further confirmation.