Clinical Trials
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Effects of the mHealth Supportive Care Program for Family Caregivers of Individuals With Dementia and Diabetes: Pilot Randomized Controlled Trial
CONCLUSIONS: This theoretically grounded mHealth supportive care program effectively reduced burden and improved outcomes for FCGs managing dementia-diabetes comorbidity. The integrated online-offline delivery model shows particular promise for male, younger, manual labor, and lower-income caregivers, suggesting mHealth’s potential to address health equity. These findings provide a feasible model for scalable caregiver support in resource-limited primary…
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Improving cancer clinical trial enrollment and patient understanding using TrialTalk, a structured communication method: a pilot randomized controlled trial
CONCLUSION: Patients who met with TrialTalk-trained oncologists were more likely to sign consent to participate in a clinical trial. The decision-making conversation with the oncologist is a critical moment for patients considering clinical trial participation, and targeting these encounters has the potential to increase overall trial participation rates.
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Positional Release Technique Versus Muscle Energy Technique for Patients With Nonspecific Low Back Pain With Facet Joint Restriction: A Pilot Randomized Comparative Study
CONCLUSION: Based on this pilot RCT, the results indicate that the short-term outcomes of patients with NSLBP who also have facet joint restrictions were more significantly improved through the use of the MET technique in comparison with PRT. Further research is necessary to confirm the potential of the MET technique to reduce pain associated with…
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Six-month open-label clinical study of a novel topical solution for mild distal lateral subungual onychomycosis
Systemic antifungals such as terbinafine and itraconazole are often limited by drug interactions and side effects in the treatment of onychomycosis. We tested a new topical solution to address the clinical need for safer and more effective topical therapies. The solution (containing urea, lactic acid, ethoxydiglycol, decylene glycol, and polyquaternium-7) was applied twice daily for…
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Exploratory Analysis of Liraglutide Effects on Obstructive Sleep Apnea and Health-Related Quality of Life in Individuals With Obesity and COPD: A Secondary Analysis of a Randomised Controlled Trial
Obstructive sleep apnea (OSA) is associated with chronic obstructive pulmonary disease (COPD) and obesity, and all three are linked to reduced health-related quality of life (HRQoL). Coexistence of OSA and COPD increases morbidity and mortality compared to each condition alone. Liraglutide, a glucagon-like peptide 1 receptor agonist, may influence respiratory and HRQoL outcomes. In this…
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The Acute Effect of Methylphenidate Ingestion in a Visuomotor Task at Absolute Power Alpha in Healthy Subjects
Methylphenidate (MPH) is a psychostimulant widely used to enhance attention and executive functions through increased dopaminergic and noradrenergic transmission. Although its effects on cognitive performance are well documented, its acute influence on cortical oscillatory activity, particularly α power, during tasks requiring simultaneous motor and cognitive processing remains poorly understood in healthy adults.To investigate the acute…
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Perfluorohexyloctane eye drops in treating dry eye disease associated with meibomian gland dysfunction: a post hoc analysis by baseline severity
CONCLUSION: Perfluorohexyloctane was well tolerated and improved the signs and symptoms of DED associated with MGD in patients with different baseline disease severity compared to saline control.
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Safety and efficacy of direct versus conventional transfer to angiography suite in patients with severe acute stroke treated with thrombectomy (DIRECT ANGIO) in France: a multicentre, open-label, blinded-endpoint, randomised controlled trial
BACKGROUND: Direct transfer to angiography suite (DTAS) for patients with suspected stroke primarily admitted to an endovascular-capable centre could accelerate in-hospital workflow and improve outcome. We aimed to assess the safety and efficacy of DTAS for patients with acute severe neurological deficit highly suggestive of ischaemic stroke due to a large vessel occlusion (ASND-LVO).
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The effect of motivational interviewing on coping, functioning, and quality of life in patients with bipolar disorder: A randomized controlled study
CONCLUSION: We concluded that motivational interviewing was effective in enhancing stress coping, improving functionality, and increasing quality of life in individuals with bipolar disorder. It is suggested that it is important for psychiatric nurses to be familiar with motivational interviewing techniques, and that this practice should be disseminated in psychiatric clinics.
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A Rectus Sheath Block in Open Hysterectomy
Introduction: Open gynecological surgery results in a large wound and severe postoperative pain, and adequate postoperative analgesia is necessary. Rectus sheath block (RSB) is used to block the sensory nerves of the anterior abdominal wall, thereby contributing to pain relief after lower abdominal surgeries. RSB provides effective perioperative analgesia and is related to lower perioperative…