Clinical Trials
Category Added in a WPeMatico Campaign
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Intensified return to work clinical aftercare for sick-listed employees with diagnosed mental disorders in Germany: effects of a multicentre randomized controlled trial
CONCLUSIONS: On average, RTW-PIA did not significantly improve SRTW or secondary outcomes. Employees without a recognized disability degree, with low social support at work, or with diagnosed recurrent depressive disorders might benefit from RTW-PIA. These hypotheses need to be tested in independent samples. Further research should also focus on the implementation of RTW-PIA.
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Clinical and Inflammatory Benefits of Nebulized Furosemide with Salbutamol-Ipratropium in COPD Exacerbations: A Randomized Controlled Trial
Exacerbations of chronic obstructive pulmonary disease (COPD) are a leading cause of morbidity, mortality, and healthcare burden. While standard bronchodilator therapy alleviates airway obstruction, its efficacy is often limited. This study evaluated nebulized furosemide, which has bronchodilatory and anti-inflammatory effects, as an adjunct to salbutamol-ipratropium in hospitalized COPD patients. Ninety‑two patients with exacerbated COPD were…
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Denecimig (Mim8) prophylaxis over 52 weeks in adolescents and adults with hemophilia A: FRONTIER2 extension study
CONCLUSIONS: Denecimig maintained low ABRs over 52 weeks, was well tolerated, and improved patient-reported outcomes in adolescents and adults with HA with or without inhibitors.
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Does baseline physical function modify the response to a physical activity intervention in adults with arthritis? A secondary analysis of a randomized trial
Responses to physical activity interventions vary among adults with arthritis, and baseline functional limitations may affect increases in walking. To determine whether baseline physical function moderated changes in accelerometer-measured steps/day after a telephone-delivered Walk With Ease (WWE-T) intervention. This secondary analysis included 267 adults from a randomized trial of WWE-T versus wait-list control. Baseline function…
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Wound dehiscence following biportal endoscopic versus microscopic spine surgery for single-level lumbar decompression: a post hoc analysis of two randomized controlled trials
CONCLUSIONS: BESS was associated with significantly lower wound dehiscence rates compared with MSS in patients undergoing single-level lumbar decompression or discectomy. Drainage volume ≥ 100 mL may serve as a clinical indicator for enhanced wound surveillance in MSS patients. These hypothesis-generating findings warrant validation in independent cohorts.
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A secondary analysis of the SODa-BIC randomized clinical trial using multiple hierarchical composite outcomes
CONCLUSION: In this post-hoc analysis of the SODa-BIC trial, the use of hierarchical composite outcomes did not alter the neutral overall interpretation of the original trial. However, this analysis provides additional insight into the relative contribution of individual components of the primary outcome.
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Clinical Characteristics and Factors Associated with One-Year Smoking Cessation Among Smokers with COPD: A Subgroup Analysis of a Multicentre Randomised Trial
CONCLUSION: Immediate referral to a cessation clinic was the factor most strongly associated with one-year abstinence, together with absence of comorbidity and, tentatively, repeated hospitalisation; greater disease severity was associated with quitting only in unadjusted comparisons. These exploratory findings support structured cessation pathways in routine COPD care.
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Emotion-focused therapy in the treatment of prolonged grief disorder: study protocol for a randomized controlled trial
BACKGROUND: Prolonged grief disorder (PGD) impacts various dimensions of the bereaved person’s life, such as psychological, social, and/or health domains. Psychological interventions, particularly those beyond the cognitive-behavioral approach, are essential to address these difficulties. This is especially relevant given that not all interventions are effective for all bereaved individuals, leaving a subset of people without…
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Effectiveness of psychosocial counselling on treatment adherence among patients with a new tuberculosis diagnosis in primary care: a study protocol for a cluster-randomised controlled trial
INTRODUCTION: Newly diagnosed tuberculosis (TB) patients frequently experience psychological distress, stigma, and concerns regarding treatment duration, side effects and social consequences, which may negatively affect adherence. Psychosocial counselling has been proposed as a patient-centred strategy to address these challenges; however, evidence regarding its effectiveness among newly diagnosed TB patients in primary care settings remains limited.…
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The effects of therapeutic play on angiography procedures in children: a randomised controlled trial
CONCLUSIONS: Our study found that therapeutic play programmes can reduce pain, fear and anxiety in children. These findings demonstrate that negative experiences during invasive procedures affect children not only physiologically, but also psychologically and behaviourally. Therapeutic play can therefore be a powerful supportive intervention. Therefore, we recommend integrating therapeutic play into nursing clinical guidelines and…