Clinical Trials
Category Added in a WPeMatico Campaign
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The efficacy of complex decongestive therapy in the treatment of lymphedema associated with endometrial and cervical cancer: evaluation of sensation and balance
CONCLUSIONS: CDT may not fully address sensory deficits in patients with LLL. Balance issues appear to worsen with lymphedema progression regardless of treatment. However, CDT shows promise in improving kinesthesia.
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Caregiver Screening for Relapse Among Children Recently Recovered From Severe Acute Malnutrition: A Randomized Controlled Feasibility Trial
Relapse to acute malnutrition after recovery from severe acute malnutrition (SAM) is common. However, most programmatic resources are devoted to the acute phase of recovery, and fewer interventions are available for children recently discharged from outpatient nutritional programs. We evaluated the feasibility of training caregivers to screen for relapse using mid-upper arm circumference (MUAC) tapes…
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A cluster randomized trial of Visitect CD4 Advanced Disease platform among outpatients with advanced HIV disease in Uganda
CONCLUSIONS: Implementation of Visitect CD4 testing demonstrated more rapid initiation of HIV therapy with equivalent 24-week survival and retention-in-care compared with other point-of-care CD4 strategies at equivalent cost. Despite its poor specificity, the Visitect CD4 platform remains a cost-neutral option compared to standard CD4 modalities.
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Clinical study on heat-sensitive moxibustion for reducing toxicity and enhancing efficacy in adjuvant tumor chemotherapy
CONCLUSIONS: Heat-sensitive moxibustion can reduce the incidence of chemotherapy-induced adverse reactions, alleviate gastrointestinal discomfort and bone marrow suppression, improve chemotherapy efficacy. It is worthy of clinical promotion and application.
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Predictive Model of Acupuncture Adherence in Alzheimer Disease: Secondary Analysis of Randomized Controlled Trials
CONCLUSIONS: This study is the first to develop and validate a predictive model for acupuncture adherence in patients with AD. In clinical research, it can facilitate participant stratification and help identify individuals who may need additional adherence support, thereby reducing bias and enhancing trial quality. In clinical practice, the nomogram enables proactive adherence management by…
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Outcome of pars plana vitrectomy with and without internal limiting membrane peeling in proliferative diabetic retinopathy
CONCLUSION: ILM peeling during diabetic vitrectomy effectively minimizes the risk of postoperative ERM formation and reduces the need for further Anti-VEGF injections for DME. However, it does not confer a significant advantage in terms of visual acuity improvements.
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Impact of Artificial Intelligence for Detection of Precancerous Colonic Lesions in a Fecal Immunochemical Blood Test-Based Organized Screening Program in Italy: A Randomized Control Trial
CONCLUSIONS: In a FIT-based organized CRC screening setting, CADe did not enhance detection of AADR with a modest increase in withdrawal time. NCT04441580.
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Evaluation of Ahmed glaucoma valve versus Ex-PRESS shunt implantation with conbercept therapy in neovascular glaucoma
Neovascular glaucoma (NVG) is a vision-threatening condition commonly associated with uncontrolled intraocular pressure (IOP). Ahmed glaucoma valve (AGV) implantation and Ex-PRESS shunt insertion are 2 frequently applied surgical techniques. This study aimed to compare the short-term and 1-year outcomes of these procedures when combined with intravitreal conbercept therapy. Forty-four patients diagnosed with NVG were randomly…
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Reduction of adult employees’ anxiety disorder in the work environment: Implications for anthropological philosophers and a case of multivariate analysis
CONCLUSION: Based on the findings, we recommend that an intervention program be developed to identify and diagnose distorted or maladaptive financial attitudes and behavior in people suffering from various debt-related mental health disorders.
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Which arthralgia patients benefit most in reduction of subclinical joint inflammation by methotrexate treatment: results from the TREAT EARLIER trial
CONCLUSIONS: CSA patients with subclinical inflammation who responded best to methotrexate during the first year were identified by increased levels of subclinical inflammation at diagnosis, primarily due to multiple sites of tenosynovitis with/without osteitis. These data may contribute to personalised medicine for arthralgia at risk for RA.