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Behavioural nudges to reduce low-value care for low back pain in the emergency department (NUDG-ED): a 2 2 factorial, pragmatic cluster randomized trial
BACKGROUND: Low-value care exposes patients to unnecessary risk and wastes scarce health resources. We aimed to determine if patient- or clinician-directed nudges could reduce low-value care for low back pain in the emergency department. →
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How to Reap Compound Benefits From Generative AI
Carolyn Geason-Beissel/MIT SMR | Minneapolis Institute of Art In domain after domain, AI has compressed work that used to be expensive — generating drafts, code, prototypes, and analyses. The marginal cost of a first attempt has dropped sharply. What remains expensive is what happens after the output arrives: evaluating what gets generated. That involves separating… →
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Glenn Jocher of Ultralytics (YOLO) Is Speaking at OSCCA
2.5 billion model inferences every day across robotics, healthcare, manufacturing, and beyond. That’s the scale at which Ultralytics YOLO operates, and at OSCCA on May 4th in Los Angeles, you’ll hear directly from the person who built it. We’re excited to announce that Glenn Jocher, Founder and CEO of Ultralytics, will be delivering an pre-recorded… →
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Longitudinal Patterns of Symptoms in Patients Undergoing Chemotherapy: A Secondary Analysis of a Cluster Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This secondary analysis of a cluster randomized clinical trial of patients with cancer characterized the burden of cancer-related symptoms and described normative experiences for patients receiving chemotherapy for 3 common types of cancer and found that mortality was associated with patients’ evolving health status. These findings may help inform programs to monitor… →
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Assessing Lifestyle Goal Setting in Patients with COPD
CONCLUSION: A majority of patients with COPD were willing to set lifestyle goals, particularly related to PA, but satisfaction with current behaviors and health-related barriers often limited engagement. These findings provide input for the design of future interventions to support sustainable lifestyle change in COPD care. →
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The effect of structured hand massage on hand function and grip strength in rheumatoid arthritis patients: a randomized controlled pilot study
CONCLUSION: Hand massage interventions for patients with RA enhance grip strength, hand function, and overall patient evaluations. No effect on pain or tactile thresholds was observed. Further studies with larger sample sizes and longer follow-up periods are required to corroborate these findings. →
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Impact of 12 weeks of physiotherapy-led integrated care of older people on intrinsic capacity and quality of life among community-dwelling older adults: a randomised controlled trial
CONCLUSIONS: PTICOPE enhanced key IC domains, locomotion, vitality, and cognition, and produced meaningful improvements in QoL. These findings support physiotherapy-led, person-centred care as an effective community strategy for healthy ageing. →
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Telmisartan vs. other antihypertensives on cardiometabolic and vascular outcomes in diabetic hypertension: A randomised trial
Background and objectives Insulin resistance and elevated endothelin-1 (ET-1) levels are key contributors to cardiovascular and renal complications in patients with type 2 diabetes mellitus (T2DM) and hypertension. This study compared the effects of telmisartan with other commonly used antihypertensive agents on insulin sensitivity in terms of homeostatic model assessment for insulin resistance (HOMA-IR) and… →
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Skeletal Muscle and Circulating microRNAs Adaptations to 12-Week HIIT With or Without L-Citrulline in Obese Older Adults
CONCLUSION: HIIT did not impact the expression level of myo-microRNAs and muscle-related microRNAs but induced changes in muscle-nonspecific microRNAs in muscle biopsy and serum. Modulations of microRNAs in muscle (miR-504-5p, -744-5p) and serum (miR-151a-3p, -4433b-5p, -106b-5p) were associated with HIIT’s beneficial effects, suggesting their role in the HIIT effects and their potential as candidate biomarkers… →
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Women’s IschemiA TRial to Reduce Events In Non-ObstRuctive CAD (WARRIOR): a randomised controlled trial
CONCLUSIONS AND RELEVANCE: Among women with suspected ANOCA/INOCA, outcomes were dominated by chest pain and IMT did not improve outcomes, although limited power precludes concluding that it may not be helpful. The findings support the need for more investigation in this population with high burden of angina hospitalisation, health resource consumption and poor quality of… →