CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, community optometrist-led monitoring of quiescent nAMD was noninferior to hospital monitoring for detecting disease activity requiring treatment. These results provide evidence for its use in integrated clinical care models. →

BACKGROUNDLiquid biopsy has emerged as a minimally invasive method for tumor diagnosis, monitoring, and therapeutic guidance. For CNS tumors, cerebrospinal fluid (CSF) provides a reliable and accessible source of tumor-derived cell-free DNA (ctDNA).METHODSThis study evaluates the clinical utility of CSF liquid biopsy in a real-world prospective setting. A total of 148 CSF samples from 120… →

CONCLUSION: Although body temperature increased significantly in the radiant heater environment compared with the incubator environment, this difference did not appear to play a vital role in affecting the physiological parameters of the newborn. →

BACKGROUND: Vaccine misinformation can undermine vaccine confidence, institutional trust, and uptake. Arabic speakers in Australia are disproportionately susceptible to vaccine misinformation and have experienced adverse health outcomes. This randomized controlled trial tested the effectiveness of Cranky Uncle — Vaccine (Arabic), a gamified psychological inoculation intervention, in improving vaccine attitudes, misinformation discernment, and institutional trust among… →

CONCLUSIONS: Ublituximab was associated with significant treatment benefits at Week 96 in treatment-naïve participants and those receiving treatment within three years of symptom onset. →

CONCLUSIONS: Although no significant training benefit was shown, becoming familiar with the sensations associated with hypercapnia under appropriate supervision could be useful to rebreather divers both recreationally and within occupational settings. →

CONCLUSION: The integration of hypnosuggestive interventions and algorithmic coaching within the proposed method is an effective alternative to traditional approaches, ensuring resistance to professional destruction. →

CONCLUSION: Integrating FILMARRAY® into pediatric pneumonia clinical management did not significantly boost initial overall antibiotic modification rates. However, exploratory analysis showed it improved targeted antimicrobial adjustments and facilitated antibiotic de-escalation, suggesting FILMARRAY® may add value to antibiotic stewardship. Subsequent trials could substantiate this theoretical proposition. →

INTRODUCTION: Emerging evidence supports a role for interleukin 6 (IL-6), a pro-inflammatory cytokine, in the pathogenesis of treatment-resistant major depressive disorder (TRD). However, interventional studies targeting IL-6 in this population remain scarce. Tocilizumab is a humanised monoclonal antibody that inhibits IL-6 signalling and is approved for the treatment of autoimmune conditions such as rheumatoid arthritis.… →

CONCLUSION: Combined MEK and autophagy inhibition showed limited tolerability in human PDAC. Divergent efficacy between preclinical and clinical settings likely reflects differences in tumor cell state heterogeneity between models. Integration of diverse, representative preclinical models is critical to guide development of effective therapies in PDAC. →