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Integrated community-based versus facility-based care for people with HIV, diabetes, and hypertension in sub-Saharan Africa (INTE-COMM): an open-label, multicountry, cluster-randomised trial
BACKGROUND: In sub-Saharan Africa, the burden of diabetes and hypertension is high, alongside a high prevalence of HIV. Whether these conditions can be managed in an integrated way in the community is unknown. We aim to compare integrated community-based care with integrated facility-based care for people with HIV, diabetes, and hypertension in Tanzania and Uganda. →
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Effect of Nociceptors Hypostimulation Versus Nociceptors Hyperstimulation on Electromyography of Cervical Muscles, Myofascial Trigger Points Sensitivity, Pain, and Disability in Patients With Chronic Cervical Pain: A Randomized Double-Blinded Controlled Trial
BACKGROUND AND PURPOSE: Chronic cervical pain is a common disorder and is difficult to manage. Therefore, this study was conducted to investigate the effects of nociceptor hypostimulation versus hyperstimulation on electromyographic (EMG) activity of cervical muscles, myofascial trigger point (MTP) sensitivity, pain intensity, and disability in patients with chronic cervical pain. →
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Impact of Robotic Assisted Treadmill Gait Training on Walking Performance in Children With Spastic Diplegic Cerebral Palsy: A Randomized Controlled Study
BACKGROUND AND PURPOSE: Children diagnosed with diplegic cerebral palsy frequently experience gait difficulties that can significantly affect their independence and quality of life. The development of advanced technologies presents opportunities to enhance their walking abilities and overall functional performance. The purpose of this study was to determine how children with spastic diplegia performed when walking… →
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Efficacy and Safety of Vibegron Add-On Therapy for Persistent Overactive Bladder Symptoms in Benign Prostatic Hyperplasia Patients With α1-Blocker Treatment: A Multi-Center Prospective Randomized Controlled Study (VATON Study)
CONCLUSIONS: Vibegron add-on therapy to an α(1)-blocker may be effective and safe for treating BPH with persistent OAB symptoms. →
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Effect of Prebiotic Supplementation With and Without Physiotherapy on Pain and Pain Sensitivity in People with Knee Osteoarthritis
Background: Emerging evidence links the gut microbiome to chronic pain processing. Inulin, a prebiotic fibre, modulates the gut microbiome, while physiotherapy-supported exercise (PSE) improves pain and function. We evaluated the effects of inulin supplementation with and without PSE on knee osteoarthritis (OA) pain. Methods: In a 2 × 2 factorial RCT, 117 community-dwelling adults with… →
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Effect of a digital training package on clinical outcomes in Malawi’s index case testing programme: a cluster randomised controlled trial
CONCLUSIONS: Enhanced digital training positively impacted meaningful clinical outcomes and could be replicated for expansion to other evidence-based interventions. →
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Effects of Exercise on Cognitive Impairment in Patients Receiving Chemotherapy: A Multicenter Phase III Randomized Controlled Trial
CONCLUSIONS: EXCAP may reduce CRCI and mental fatigue, particularly in patients receiving 2-week cycles of chemotherapy. A healthy inflammatory response, characterized by increases in both proinflammatory and anti-inflammatory cytokines, is associated with less cognitive impairment during chemotherapy. →
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The Growth OS Map: Winning in the Age of Channel Collapse
This edition felt like a particularly important one, given the speed at which channels are evolving. TL;DR The problem: CAC payback has hit 57 months. Traditional channels (SEO, Outbound, Ads) are collapsing under AI noise. The shift: You can no longer rent attention. You must build an Operating System of defensible “Growth Loops” that compound… →
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Can Nocebo Effects Be Reduced via Open- and Closed-Label Counterconditioning?
CONCLUSIONS: These results show that particularly open-label counterconditioning is an effective method to modulate nocebo effects on pressure pain. This provides promise in designing non-deceptive learning-based treatments to reduce nocebo effects in diverse patient groups, including chronic pain disorders. →
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Guided Tissue Regeneration and Subepithelial Connective Tissue Graft in the Treatment of Gingival Recession: A Randomized Clinical Trial
CONCLUSIONS: The findings of this study indicate that both surgical procedures may effectively treat Miller’s class I and II GRs, resulting in satisfactory root coverage. →