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Take 5: Is Your Price Right?
From the launch of a new car model to the rollout of a pioneering medicine, finding the right price can mean a product’s success or failure. Given years of R&D, the rigors of competitors’ offerings, and the many demands on consumers’ attentions and pocketbooks, this process can be difficult to get right. Here are five… →
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Effects of the mHealth Supportive Care Program for Family Caregivers of Individuals With Dementia and Diabetes: Pilot Randomized Controlled Trial
CONCLUSIONS: This theoretically grounded mHealth supportive care program effectively reduced burden and improved outcomes for FCGs managing dementia-diabetes comorbidity. The integrated online-offline delivery model shows particular promise for male, younger, manual labor, and lower-income caregivers, suggesting mHealth’s potential to address health equity. These findings provide a feasible model for scalable caregiver support in resource-limited primary… →
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Improving cancer clinical trial enrollment and patient understanding using TrialTalk, a structured communication method: a pilot randomized controlled trial
CONCLUSION: Patients who met with TrialTalk-trained oncologists were more likely to sign consent to participate in a clinical trial. The decision-making conversation with the oncologist is a critical moment for patients considering clinical trial participation, and targeting these encounters has the potential to increase overall trial participation rates. →
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Positional Release Technique Versus Muscle Energy Technique for Patients With Nonspecific Low Back Pain With Facet Joint Restriction: A Pilot Randomized Comparative Study
CONCLUSION: Based on this pilot RCT, the results indicate that the short-term outcomes of patients with NSLBP who also have facet joint restrictions were more significantly improved through the use of the MET technique in comparison with PRT. Further research is necessary to confirm the potential of the MET technique to reduce pain associated with… →
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Six-month open-label clinical study of a novel topical solution for mild distal lateral subungual onychomycosis
Systemic antifungals such as terbinafine and itraconazole are often limited by drug interactions and side effects in the treatment of onychomycosis. We tested a new topical solution to address the clinical need for safer and more effective topical therapies. The solution (containing urea, lactic acid, ethoxydiglycol, decylene glycol, and polyquaternium-7) was applied twice daily for… →
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The Acute Effect of Methylphenidate Ingestion in a Visuomotor Task at Absolute Power Alpha in Healthy Subjects
Methylphenidate (MPH) is a psychostimulant widely used to enhance attention and executive functions through increased dopaminergic and noradrenergic transmission. Although its effects on cognitive performance are well documented, its acute influence on cortical oscillatory activity, particularly α power, during tasks requiring simultaneous motor and cognitive processing remains poorly understood in healthy adults.To investigate the acute… →
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Exploratory Analysis of Liraglutide Effects on Obstructive Sleep Apnea and Health-Related Quality of Life in Individuals With Obesity and COPD: A Secondary Analysis of a Randomised Controlled Trial
Obstructive sleep apnea (OSA) is associated with chronic obstructive pulmonary disease (COPD) and obesity, and all three are linked to reduced health-related quality of life (HRQoL). Coexistence of OSA and COPD increases morbidity and mortality compared to each condition alone. Liraglutide, a glucagon-like peptide 1 receptor agonist, may influence respiratory and HRQoL outcomes. In this… →
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Perfluorohexyloctane eye drops in treating dry eye disease associated with meibomian gland dysfunction: a post hoc analysis by baseline severity
CONCLUSION: Perfluorohexyloctane was well tolerated and improved the signs and symptoms of DED associated with MGD in patients with different baseline disease severity compared to saline control. →
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Why Leaders Lose the Room in High-Stakes Meetings
Carolyn Geason-Beissel/MIT SMR | Getty Images Most advice about leadership communication focuses on presentation skills: Be concise, be clear, tell better stories. But the most consequential leadership communication happens in meetings where tough issues are being discussed and real decisions are being made. Even some of the most skilled leaders find themselves in moments where… →