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Efficacy of Xanthan-Based Chlorhexidine Gel in Peri-Implant Mucositis Treatment: A Split-Mouth Randomized Clinical Trial
CONCLUSION: The adjunctive use of XanCHX gel did not result in any statistically significant clinical benefit compared to PMPR alone in the treatment of PM up to 6 months, despite the reported clinical positive effects within the first month after treatment. →
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Effectiveness of the Systems Analysis and Improvement Approach to optimise outpatient mental, neurological, and substance-use disorder treatment cascades in Mozambique: a cluster-randomised trial
BACKGROUND: To our knowledge, there are no evidence-based implementation strategies for care cascade optimisation of mental, neurological, and substance use (MNS) disorder treatment in low-income and middle-income countries. This trial evaluated the effectiveness of the Systems Analysis and Improvement Approach for Mental Health (SAIA-MH) implementation strategy to improve MNS disorder care cascade outcomes in Mozambique. →
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Everyone Hates Ads on Social Media. Or Do They?
Everyone hates ads on social media. Or do they? New research suggests that, at least on Facebook, users don’t actually mind the steady stream of ads. It’s a bold claim—not only because it cuts against conventional wisdom, but because conducting robust research on the effects of online advertising is very difficult to do. To land… →
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GRACE score for risk stratification and completeness of revascularization in older patients with myocardial infarction
CONCLUSION: The GRACE score was confirmed to be predictive of adverse outcomes even in older MI patients. Physiology-guided complete revascularization was associated with benefit across the GRACE spectrum, suggesting that the GRACE score alone should not preclude this strategy in older patients with MI. →
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Claude for your personal productivity
The first Claude Code edition we published gave you 30+ use cases across every GTM function. Beyond the core functions, a few fun wild ones were included. Since that edition, we’ve been getting a flood of questions about broad-reaching personal productivity use cases, in addition to GTM ones. So that’s what what this edition is… →
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Cost-Effectiveness of Oral Immunotherapy Treatments vs No Treatment for Peanut Allergy in Children
CONCLUSIONS AND RELEVANCE: This economic evaluation found that for remission, both PPOIT and OIT were cost-effective and good value compared with no treatment, with OIT associated with a larger effect size but no clinically meaningful difference. When QALYs are prioritized, PPOIT offers the best value. Key factors associated with cost-effectiveness were treatment product pricing and… →
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Treatment with inhaled nitric oxide in patients with pulmonary embolism
CONCLUSION: Inhaled NO therapy in complex therapy of PE demonstrated safety and efficacy in relation to clinical, functional and laboratory parameters. →
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Effects of Cipepofol on Cardiac Depolarization and Repolarization in Healthy Subjects: A Single-Center, Randomized, Placebo and Positive-Controlled Thorough QT Study
CONCLUSION: Cipepofol exhibited no clinically relevant effects on the QTc interval or other ECG parameters, and was safe and well tolerated in healthy subjects. →
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Predictive value of OGTT parameters and clinical markers in gestational diabetes mellitus: a prospective randomized controlled trial from a tertiary center in Turkiye
CONCLUSION: The one-step 75 g OGTT increases diagnostic labeling without improving short-term clinical outcomes. Post-load OGTT values-particularly 2-hour glucose levels-provide the most clinically meaningful prognostic information and may support a risk-stratified approach to GDM management rather than expansion of diagnostic thresholds alone. →
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Randomized Controlled Trial of the Meaning-Making Intervention (MMi) in Patients Newly Diagnosed With Advanced Cancer: Full Trial
BACKGROUND: This study aimed to test whether the Meaning-Making intervention (MMi) increases the sense of meaning in life in people newly diagnosed with any type of advanced cancer. →
