Nasopharyngeal carcinoma is prevalent in Thailand, with a substantial proportion of cases diagnosed at advanced stages. The standard treatment, concurrent chemoradiotherapy, is associated with considerable adverse effects, which may compromise therapeutic efficacy and diminish patients’ quality of life. While vitamin C has shown potential in reducing chemotherapy-induced toxicities in some cancers, its effects in nasopharyngeal… →

CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of patient-mediated genetic cascade screening supported by a web-based platform, participation in genetic testing and detection of familial hypercholesterolemia was increased compared with usual care. These results suggest that the use of digital communication tools enhanced the reach and effectiveness of genetic screening programs within privacy-regulated health… →

CONCLUSION: CST was associated with short-term improvements in developmental assessment scores and reduced reflex-related responses under standardized clinical conditions. These findings should be interpreted cautiously and considered preliminary. Further research using objective outcome measures and long-term follow-up is required before drawing conclusions regarding clinical effectiveness or preventive applications. →

CONCLUSIONS: At the societal level, the SELFIE intervention exceeded the WTP threshold. Tests for robustness showed higher probabilities of cost-effectiveness from a healthcare perspective, likely reflecting the absence of educational productivity loss costs in the societal perspective, and in youth recruited from specialized mental health services. The innovative field of blended EMIs yields encouraging first… →

Metastatic castration-resistant prostate cancer (mCRPC) after treatment with docetaxel and androgen receptor signaling inhibitors (ARSIs) has limited treatment options. Although enzalutamide has shown activity after abiraterone and docetaxel, robust evidence from randomized phase III trials is lacking. Deutenzalutamide, a novel derivative with slower metabolism and improved pharmacokinetics, may offer enhanced safety and efficacy. This phase… →

Individuals with hearing loss, even when using hearing aids, often perceive pleasant environmental sounds as less pleasant than do those with normal hearing. This bias in emotional response may negatively impact well-being, leading to decreased social participation and increased loneliness. The present study examined whether the Positive Focus intervention-encouraging hearing aid users to focus on… →

CONCLUSIONS: Frailty, as assessed by the CFS, was independently associated with adverse outcomes. Complete revascularization was effective regardless of frailty status and should be considered in all older MI patients with multivessel disease undergoing an invasive strategy. →