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Clinical study of acupuncture at force-sensitive acupoints in treatment of diarrhea-predominant irritable bowel syndrome
CONCLUSIONS: Acupuncture at force-sensitive acupoints has a definite curative effect on IBS-D. This therapy is high in safety and satisfactory in long-term effect. In the aspects of the alleviation of the severity of symptoms and the improvement of the quality of life in the patients with IBS-D, acupuncture at force-sensitive acupoints with high sensitivity is… →
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MRD-driven initial therapy of acalabrutinib and lenalidomide plus rituximab or obinutuzumab for mantle cell lymphoma
This phase 2 study evaluated the efficacy and safety of combining acalabrutinib and lenalidomide with either rituximab (ALR) or obinutuzumab (ALO), with longitudinal minimal residual disease (MRD) monitoring in frontline MCL treatment. The primary objective was molecular complete response (CR) after 12 cycles of induction, defined by Lugano criteria, and undetectable MRD of <10-6 (uMRD6)… →
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Feasibility of ultra-low flow rate coronary CT angiography using photon-counting detector CT: a prospective randomized trial
CONCLUSION: For patients with difficulty establishing venous access routes, ultra-low contrast agent flow rates in PCD-CT maintain objective image quality comparable to that of standard protocols, with acceptable diagnostic performance despite slight reductions. →
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Feasibility Trial of Prolonged versus Single-Dose Challenge in Penicillin Allergy
CONCLUSIONS: Conducting a double-blind, placebo-controlled randomized trial of single-dose versus multidose oral amoxicillin challenge was feasible. A fully powered efficacy trial is needed to assess between-group differences in immune-mediated adverse events. (Funded by Austin Health and others; trial registration: ANZCTR — ACTRN12623001242617, registered on November 30, 2023.). →
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AI Is Not Improving Productivity: Nobel Laureate Daron Acemoglu
In this bonus episode of the Me, Myself, and AI podcast, Nobel Prize-winning economist Daron Acemoglu joins host Sam Ransbotham to challenge some of the most common assumptions about artificial intelligence’s future. Drawing on his book Power and Progress, Daron argues that technology doesn’t have a fixed destiny — and that today’s choices will determine… →
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Evaluation of oncologic safety and clinical effectiveness of immediate autologous fat grafting in breast-conserving surgery: a multicenter, prospective, randomized controlled clinical trial for breast cancer
CONCLUSION: Our results provide clear evidence that IAFG is a safe and effective surgical technique that does not increase the risk of local or distant recurrence in breast cancer patients and yields higher satisfaction with postoperative breast appearance and psychosocial outcomes. →
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Impact of breathing frequency on respiratory oscillometry measurements: a randomised cross-over and observational study of asthma patients
CONCLUSION: Higher breathing frequencies significantly reduce total Rrs . When performing respiratory oscillometry, breathing frequency should be controlled at approximately 15 bpm to reduce risk of misclassification. →
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Cost-utility analysis of the Circle of Security-Parenting programme to reduce perinatal psychopathology in birthing parents in England
CONCLUSIONS: On average, COS-P was associated with higher costs and did not demonstrate improvements in health-related quality of life compared with TAU alone. Given the uncertainty surrounding the estimates, further research is warranted to explore potential longer term economic and clinical impacts of COS-P in perinatal mental health settings. →
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Three Myths Fueling Companies’ Icy Silence on Politics
Brian Stauffer/theispot.com In 1963, as the U.S. civil rights movement reached a new peak, most U.S. companies stayed quiet. That changed after events in Birmingham, Alabama. Images of peaceful demonstrators, including children, being attacked by police dogs and high-powered fire hoses shocked the country. Economic boycotts of segregated businesses in and near Birmingham followed. Under… →
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Podcast: The Global Trends Shaping the Way We Do Business
If your long-term business outlook doesn’t account for geopolitical trends, it might need amending. “We’ve been really lucky in being able to focus on building our businesses and designing our economic strategies mostly without thinking about geopolitics. That’s just not true anymore,” says Nancy Qian, a professor of managerial economics and decision sciences at Kellogg… →