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Instructional Emphasis and PHQ-9 and GAD-7 Scores Among Participants With Anxiety or Depression: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of instructional emphasis on PHQ-9 and GAD-7 scores among participants with anxiety or depression, findings suggest that variation in how questionnaire instructions are emphasized can influence PHQ-9 and GAD-7 scores, underscoring the need for standardized administration in clinical, research, and digital settings. →
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Paramedic analgesia comparing ketamine and morphine in trauma. A synopsis of the PACKMaN double-blind RCT
CONCLUSION: Ketamine does not provide superior analgesia than morphine when treating acute severe trauma pain. Ketamine is a suitable alternative that is safe for use by paramedics. →
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Early Detection and Temporal Progression of Hemidiaphragmatic Paralysis After Supraclavicular Brachial Plexus Block with 20 mL vs 30 mL Ropivacaine: A Randomized Controlled Trial
CONCLUSION: HDP can be detected as early as 5 minutes after SCBPB, with incidence plateauing by 20 minutes while CMAP amplitude continues declining. Higher volume (30 mL) nearly doubles HDP risk (RR=1.972). Respiratory monitoring should begin within 5 minutes of block placement. →
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Cardiac Rehabilitation for Cardiovascular Risk Modification in Patients With Rheumatoid Arthritis and Hypertension: A Randomized Controlled Trial
CONCLUSION: In selected patients with clinically stable rheumatoid arthritis and coexisting hypertension who were receiving stable pharmacologic therapy and were able to participate in supervised exercise, a structured cardiac rehabilitation program was associated with improvements in estimated cardiovascular risk profiles, ambulatory systolic blood pressure, and cardiorespiratory fitness without worsening disease activity. These findings support further… →
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Subgingival air polishing (glycine powder) versus minocycline hydrochloride: efficacy in residual periodontal pockets following endoscope-assisted scaling and root planing
CONCLUSIONS: Combining E-SRP with glycine air polishing or local minocycline improved periodontal conditions, suppressed early biofilm and inflammation, and promoted healing of deep residual pockets. Both treatments produced equivalent outcomes at all follow-up time points, with stage-specific therapeutic effects observed among patients at different periodontal stages. The 4-week early adjunct approach is practicable in clinical… →
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A clinical study on fall risk assessment and preventive nursing in older adults with non-Hodgkin’s lymphoma undergoing chemotherapy-a randomized controlled trial
CONCLUSION: A targeted, multifactorial nursing intervention substantially reduced falls and fall-related complications among older adults with NHL receiving chemotherapy. Integration of fall prevention measures into routine oncologic care is strongly recommended to safeguard treatment continuity and patient well-being. Further multicenter and long-term studies are warranted to validate these findings and refine comprehensive fall prevention strategies. →
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Evaluation of the clinical efficacy of accelerated photoactivated chromophore for keratitis-CXL for early to mid-stage fungal keratitis: a prospective, multicenter randomized controlled trial
CONCLUSIONS: This first RCT demonstrates that adjuvant accelerated PACK‑CXL significantly hastens clinical recovery, reduces disease burden and corneal transplantation rate, and shortens healing time in mild-to-moderate fungal keratitis, with a favorable safety profile. →
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The 2026 Paid Playbook: Audience, Channels, and AI
AI made the production side of paid marketing nearly free. Copy, creative variants, landing pages, ad ops – all of it has collapsed in cost. And yet most B2B paid programs aren’t scaling any better than they were three years ago. That’s because the constraint moved. AI hasn’t produced a new social network or a… →
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Does Cognitive Bias Modification for Appraisals Change Symptom-Cognition Relations in PTSD? Preliminary Evidence from Network Analysis in a Randomized Controlled Trial
CONCLUSION: Given the small sample and moderate network stability, findings are preliminary but suggest that CBM-APP may influence the relational structure of PTSD symptoms and cognitions. →
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A phase III double-blind, placebo-controlled, randomized withdrawal trial of 5-aminolevulinic acid hydrochloride with sodium ferrous citrate for efficacy and safety in patients diagnosed as Leigh syndrome
CONCLUSION: These findings suggest that SPP-004 is safe and may provide therapeutic effect for LS patients who achieved an initial clinical response. →
