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Symptom Trajectories in Patients With Anxiety Disorders During Transdiagnostic Cognitive Behavioral Therapy
Growing research confirms the efficacy of transdiagnostic cognitive behavioral psychotherapy, that is treatments applicable across multiple diagnoses within a disorder class or spectrum, by examining group-level changes from pre- to posttreatment. However, less is known about interindividual differences and dynamic changes during therapy. Understanding different symptom trajectories and their associations with treatment outcome would allow… →
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Accurate Identification and Intervention System Construction of Treatable Traits in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Protocol for a Randomized Controlled Study
BACKGROUND: Considerable heterogeneity exists in patients experiencing acute exacerbation of chronic obstructive pulmonary disease (AECOPD) concerning etiology, clinical manifestations, phenotypic features, comorbidities, and treatment responsiveness. The concept of «treatable traits» is adapted to evaluate the clinical features of patients with chronic airway diseases from multiple dimensions and ultimately guiding precision treatment strategies. This prospective randomized… →
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Proof-of-concept randomised controlled trial of data-driven hearing rehabilitation versus standard care in older adults with hearing loss: the healthy hearing for healthy ageing protocol
INTRODUCTION: Hearing aids (HAs) can alleviate hearing loss; however, HA rehabilitation is frequently hampered by delayed diagnosis, suboptimal fitting and lack of systematic follow-up. Although the association between hearing loss and cognitive decline has been identified, evidence from randomised controlled trials remains limited. Addressing these gaps is essential for reducing hearing loss-related experiences and evaluating… →
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Creating Shared Prosperity With AI: Stanford Digital Economy Lab’s Erik Brynjolfsson
Erik Brynjolfsson has a challenge for anyone worried about artificial intelligence: Stop asking what AI will do to us, and start asking what we will do with AI. In this episode of Me, Myself, and AI, the Stanford University economist explains why technology isn’t the biggest barrier to progress — people, organizations, and institutions are.… →
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Toward Empowering Women in HIV Care: A Peer-Supported Patient-Initiated Viral Load Testing Cluster-Randomized Trial in Dar es Salaam, Tanzania
BackgroundRoutine viral load testing (VLT) is critical for monitoring HIV treatment effectiveness, yet adherence to annual testing and patient engagement remain suboptimal, particularly among women. We evaluated a peer educator-supported, patient-initiated VLT approach in Dar es Salaam, Tanzania.MethodsIn 2024, a two-arm cluster-randomized trial was conducted across six public HIV clinics. Intervention sites implemented a 4-6-month… →
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Integrated exposure-based therapy for co-occurring post-traumatic stress and substance use among young people: a randomized controlled trial
Background: Despite well-documented evidence demonstrating the efficacy and safety of integrated treatments for post-traumatic stress disorder (PTSD) and substance use disorder (SUD) in adults, few studies have been conducted among adolescents and young adults, developmental periods when these disorders typically have their onset.Objective: This randomized controlled trial compared the efficacy of an integrated exposure-based treatment… →
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Efficacy of Reticulocyte Haemoglobin Equivalent-Guided Versus Transferrin Saturation-Guided Iron Supplement Protocol in Haemodialysis Patients: A Multicenter Cluster Randomized Controlled Trial
CONCLUSION: RET-He-guided intravenous iron supplementation was non-inferior to TSAT-guided supplementation for reducing ERI over 6 months. Use of RET-He may offer a lower-cost and more accessible strategy for anaemia management in haemodialysis patients, particularly in resource-limited settings. →
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How Leaders Unlock Innovation on the Front Lines
PPaint/Ikon Images Balancing the daily grind of operations with the spark of innovation is one of the most persistent challenges managers face.1 Regulatory compliance, performance metrics, and the never-ending demands of customers can easily crowd out creative thinking. Work overload or mismanaged operations elevate employee stress, which directly constrains ideation capacity. This cognitive bottleneck triggers… →
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Digital Mental Health Treatment and Symptoms of Depression and Anxiety in Breast Cancer Survivors: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This randomized trial found that BCS can benefit from a DMHT program, particularly for reducing anxiety. Coaching may promote consistent engagement with a DMHT for those with difficulty engaging initially. →