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Effectiveness of Closed Blood-Sampling Devices in Critically Ill Adults: A Feasibility Trial
CONCLUSIONS: A full-scale RCT evaluating CBSDs in ICU patients is feasible with protocol modifications, including broader site participation and improved device integration with advanced monitoring systems. Preliminary data suggest that CBSDs may reduce transfusion requirements and blood loss in critically ill patients. →
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A phase III, randomised, double-blind, multi-dose, placebo- and naproxen-controlled study to evaluate the efficacy and safety of fasinumab in patients with pain due to osteoarthritis of the knee or hip
CONCLUSION: In a difficult-to-treat population with OA, fasinumab 1 mg Q4W achieved clinically meaningful improvements by week 16 versus placebo and naproxen. The safety profile was similar to that previously observed for fasinumab. →
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An Internet-Delivered Intervention to Reduce LGBTQ+ Prejudice Among Romanian Teachers: Randomized Controlled Trial
CONCLUSIONS: The intervention offers initial evidence for the effectiveness of a cost-effective and portable online resource for educators and high school counselors, particularly in regions where negative attitudes toward the LGBTQ+ community are prominent. The results show that integrating blended cognitive (information), affective (indirect contact and perspective taking), and behavioral (self-efficacy and empowerment) approaches is… →
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Can a New GPT Accelerate Human–AI Collaboration in Science?
Generative AI is getting exceptionally good at automating tasks and processing information. And that’s making life easier for professionals across the board, from business managers to university professors. But for researchers like Erzhuo Shao, a PhD student at the Kellogg Center for Science of Science and Innovation (CSSI), most of the current AI models are… →
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Berberine and Adiposity in Diabetes-Free Individuals With Obesity and MASLD: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of diabetes-free individuals with obesity and MASLD, a 6-month berberine treatment at a daily dose of 1 g had an excellent safety profile but did not reduce VAT area or liver fat content. →
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Brain Amyloid Plaque Levels Affect Clinical Progression in Alzheimer Disease: Assessment of Amyloid PET and Change in CDR-SB Utilizing Semi-Mechanistic Model
Lecanemab is a humanized IgG1 monoclonal antibody binding with high affinity to protofibrils of amyloid-beta (Aβ) protein. In clinical studies, lecanemab has been shown to reduce amyloid markers in early symptomatic Alzheimer’s disease and slow decline on clinical endpoints of cognition and function. Nonlinear mixed-effects modeling assessed the correlation between amyloid PET and change in… →
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Does Past Myopia Progression Predict Future Progression?
CONCLUSIONS: Changes in SER and AL of children in the prior 12 months were poor predictors of future myopia progression, limiting their usefulness for clinical decision-making or selecting participants for clinical trials. →
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Privacy Fact Sheets for Mitigating Disease-Related Privacy Concerns and Facilitating Equal Access to the Electronic Health Record: Randomized Controlled Trial
CONCLUSIONS: Our results demonstrate that PFSs may help to increase EHR uploads in people interacting with a realistic EHR click dummy, by mitigating privacy concerns in scenarios involving stigmatized diseases. Results further indicate that a PFS is mainly relevant and effective for people with increased privacy risk perceptions, whereas they neither benefit nor hurt others.… →
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The benefits of neurodiversity in business
Neurodivergent individuals often bring unique strengths to business, such as creativity and the ability to handle varied tasks; however, they still face significant barriers. Dr Dorottya Sallai highlights case of auticon, an IT consulting firm, that is transforming lives and perceptions by seeing success in employing exclusively autistic adults. By 2030, the demand for skilled… →