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When the Fog Rolls In, Do Leaders Need a Map or a Compass?
Before Ernest Shackleton left on his Imperial Trans-Antarctic Expedition in 1914, he published a detailed map of the route he planned to take in becoming the first to cross the frozen continent. It didn’t go as planned. And when Shackleton and the crew of the Endurance were forced to abandon their icebound ship in October… →
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Inside the Company that Raised $30M at a $250M Valuation With 0 Employees | Ben Cera, Polsia
Listen on YouTube // Apple // Spotify A 14-month-old company hit $10M in run rate with no employees. Polsia closed $30M at a $250M valuation – and the AI ran most of the fundraise itself, live on Twitter, on a public dashboard. Ben Cera built it solo. He spent the prior decade building, including 4.5… →
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Japanese Encephalitis Vaccine Decision Aid for Travelers: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, the web-based JEVaDA was not associated with a further reduction in decisional conflict compared with an active comparator but was associated with higher vaccine uptake. These findings suggest that decision aids can support informed, values-congruent choices in complex, preference-sensitive health decisions such as travel vaccination and beyond. →
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Benefit-risk profile comparison between dupilumab and upadacitinib: a structured benefit-risk assessment of the Heads Up trial
CONCLUSIONS: This benefit-risk assessment using 24-week Heads Up trial data considered all key benefits and risks and demonstrated a higher benefit-risk score for dupilumab than upadacitinib. →
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Early choroidal thickness changes predict myopia control response to peripheral defocus spectacles in premyopic children
CONCLUSIONS: Peripheral defocus spectacles significantly controlled axial elongation and reduced myopia incidence in premyopic children with insufficient hyperopic reserve. Three-month choroidal thickness changes represent a valid early predictive biomarker for treatment response, enabling personalized intervention by 3 months rather than waiting 12 months for conventional outcomes. Early choroidal thickening identifies optimal responders, supporting choroidal perfusion… →
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Development and internal validation of a clinical prediction model for septic shock in pediatric respiratory syncytial virus bronchiolitis based on routine blood biomarkers and concomitant fungal infection
CONCLUSIONS: We developed and internally validated a prediction model incorporating fungal co-infection, admission glucose, antithrombin III, and interleukin-6 for early identification of septic shock risk in pediatric RSV bronchiolitis patients. The model demonstrated good discrimination (AUC 0.892) in this single-center cohort. However, given the modest sample size, external validation in larger, multicenter populations is essential… →
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Prehospital Use of Non-Invasive Ventilation for Acute Respiratory Failure due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease. A Randomised Trial
CONCLUSION: The clinical effect of prehospital non-invasive ventilation could not be determined due to early termination. This trial highlights important challenges relevant to future clinical trials in the prehospital setting, including patient selection, diagnostic requirements and implementation of complex interventions. →
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12-weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin-1 and inflammatory markers in men with obesity: a randomized controlled trial
CONCLUSION: Twelve weeks of concurrent interval resistance-aerobic training, especially when combined with fisetin, improved inflammatory resolution (↑Maresin‑1, ↓IL‑6, and ↓TNF‑α) and metabolic control (↓FBS, ↓insulin, and ↓HOMA‑IR) in obese men. The synergy between exercise‑induced adaptations and fisetin’s anti‑inflammatory properties offers a promising non‑pharmacological strategy for mitigating obesity‑related metabolic risk. →
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The Distribution Era
This article is a really important one to us at GTMfund. It’s the result of weeks of writing and years of compounding market perspective. It’s the belief that we founded GTMfund on, and it feels more important today than ever. Hope you enjoy reading it as much as we enjoyed writing it. The full thing… →
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A Personalised and Gamified Digital Decision Aid for Colorectal Cancer Screening: A Randomised Controlled Pilot Study
CONCLUSIONS: Preliminary findings suggest that a digital DA with personalised and gamified content may enhance CRC screening uptake and partially support informed choice. Larger, multisite studies are warranted to evaluate scalability, inclusivity, and long-term effectiveness in population-based cancer prevention. →
