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The 2026 Paid Playbook: Audience, Channels, and AI
AI made the production side of paid marketing nearly free. Copy, creative variants, landing pages, ad ops – all of it has collapsed in cost. And yet most B2B paid programs aren’t scaling any better than they were three years ago. That’s because the constraint moved. AI hasn’t produced a new social network or a… →
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Does Cognitive Bias Modification for Appraisals Change Symptom-Cognition Relations in PTSD? Preliminary Evidence from Network Analysis in a Randomized Controlled Trial
CONCLUSION: Given the small sample and moderate network stability, findings are preliminary but suggest that CBM-APP may influence the relational structure of PTSD symptoms and cognitions. →
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A phase III double-blind, placebo-controlled, randomized withdrawal trial of 5-aminolevulinic acid hydrochloride with sodium ferrous citrate for efficacy and safety in patients diagnosed as Leigh syndrome
CONCLUSION: These findings suggest that SPP-004 is safe and may provide therapeutic effect for LS patients who achieved an initial clinical response. →
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Accuracy and safety of C-TST for tuberculosis infection: A clinical trial in Brazil
CONCLUSION: In BCG‑vaccinated adults, C-TST showed a trade-off of higher specificity and lower sensitivity than PPD RT-23 at the 5-mm cut-off; and a favourable safety profile. Adding erythema to readings did not improve accuracy, suggesting that C-TST may be a useful alternative for programmatic TBI screening in high-burden settings. →
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Comparison of Early Bracing Versus Splinting for the Initial Treatment of Acute Humeral Shaft Fractures (The COBRAS Trial)
CONCLUSIONS: Immediate Sarmiento bracing was associated with increased patient-reported pain (roughly 1 point on the 0-10 numeric rating scale) and higher skin complication rates during the initial 10-day period after injury compared with initial coaptation splinting for acute humeral shaft fractures, without demonstrable benefits in function, analgesic requirements, or patient satisfaction. These findings support the… →
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Effectiveness and acceptability of biometrics to evaluate intervention coverage and contamination in a cluster randomised trial of community-based sexual and reproductive health services for youth in Zimbabwe
CONCLUSION: Biometric identification is useful for assessment of CRT coverage and contamination. →
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What CEOs Need to Know About Sovereign AI
Carolyn Geason-Beissel/MIT SMR | Getty Images As multinational companies implement artificial intelligence workflows and look to adopt AI across their global operations, they are increasingly running up against country-specific regulations and policies that aim to govern AI and align its use with national priorities and local cultural norms. These regulations and policies — which fall… →
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Effects and User-Reported Experiences of a Self-Management Mobile Health App for Grieving Adolescents: Randomized Controlled Trial
CONCLUSIONS: Overall, the findings indicate that Alba may be beneficial in reducing mental health symptoms among bereaved adolescents and highlight its potential as a safe, acceptable, and scalable mHealth intervention. →
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Intranasal Oxytocin for Alcohol Use Disorder: A Randomized, Double-Blind, Placebo-Controlled Multisite Trial Assessing Efficacy and Safety
CONCLUSION: Intranasal oxytocin was well tolerated but did not significantly reduce drinking or AUD-related outcomes. Higher doses, longer treatment duration, or larger trials may be required to identify responsive subgroups and determine oxytocin’s efficacy in AUD. →
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Individually designed fall prevention strategies compared to generic strategies for mastering complex fall risk situations in people with multiple sclerosis: study protocol of a randomised controlled trial
INTRODUCTION: Of individuals with mild-to-moderate multiple sclerosis (MS), 56% report falling at least once during a 3-month period. Several fall risk factors have been identified, but the issue is complex, with interactions between triggering factors and preceding activities and events. There is a lack of studies explicitly evaluating fall prevention strategies given as counselling over… →
