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Early substrate-based catheter ablation vs. antiarrhythmic drug therapy for ventricular tachyarrhythmias among patients with prior myocardial infarction: the MANTRA-VT randomized trial
CONCLUSION: Early substrate-based RFCA was associated with reduced risk of ICD therapies, but with no meaningful difference in VT/VF burden, mortality, hospitalization, and adverse events. →
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The development, acceptability and preliminary efficacy of a sleep health intervention on frailty and quality of life in older adults
CONCLUSION: A sleep health intervention was favourable and effective in older adults and improved quality of life. →
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Long-acting intranasal insulin for the treatment of delirium-a randomised clinical trial
CONCLUSION AND RELEVANCE: This is the first study of intranasal insulin for delirium treatment. The reduced LOS combined with the observed age-related effects warrants further investigation into the clinical potential of intranasal insulin in managing delirium in older patients. →
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The influence of photodynamic therapy on the supragingival plaque accumulation and bacterial composition in orthodontic patients: a randomized controlled trial
CONCLUSION: The effects of PDT on oral health were mostly comparable to those produced by CHX and TCP-5% NaF varnish and significantly different from those observed in the control group. →
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Building a Context-Folding LLM Agent for Long-Horizon Reasoning with Memory Compression and Tool Use
«`html Understanding the Target Audience The target audience for building a Context-Folding LLM Agent primarily consists of AI researchers, data scientists, and business analysts who are interested in enhancing long-horizon reasoning capabilities in AI systems. This audience typically works in technology-driven environments, such as startups, research institutions, and large enterprises focused on AI innovation. Pain… →
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Evaluating the efficacy of opioid-sparing analgesic protocols in postoperative pain management for major trauma surgeries
This randomized, controlled trial evaluated the efficacy of opioid-sparing analgesic protocols in postoperative pain management for major trauma surgeries. A total of 120 patients were randomly assigned to either an opioid-sparing group or a conventional opioid-based group (n = 60 per group). Primary outcomes included pain severity, opioid use, and postoperative mobilization. The opioid-sparing group… →
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Anthropic Launches Claude Haiku 4.5: Small AI Model that Delivers Sonnet-4-Level Coding Performance at One-Third the Cost and more than Twice the Speed
Anthropic Launches Claude Haiku 4.5: Small AI Model that Delivers Sonnet-4-Level Coding Performance at One-Third the Cost and More than Twice the Speed Target Audience Analysis The primary audience for the Claude Haiku 4.5 launch includes software developers, data scientists, and business managers in technology-driven industries. These professionals are often looking for cost-effective solutions that… →
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Effects of a psychoeducational group intervention for adults diagnosed with ADHD: a pilot randomized controlled study
CONCLUSION: This psychoeducational group intervention significantly improved QoL and patient satisfaction but not symptom burden in adult patients with ADHD. Future studies should explore the long-term effects of psychoeducational group programs and examine ways to optimize treatment outcomes. →
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Meta AI’s ‘Early Experience’ Trains Language Agents without Rewards—and Outperforms Imitation Learning
Meta AI’s ‘Early Experience’ Trains Language Agents without Rewards—and Outperforms Imitation Learning Understanding the Target Audience The target audience for Meta AI’s ‘Early Experience’ research primarily includes AI researchers, business leaders in technology, and product managers focused on AI applications. Their pain points often revolve around the limitations of traditional training methods, such as imitation… →