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  • To assess the impact of individualized strategy and continuous glucose monitoring on glycemic control and mental health in pregnant women with diabetes

    3 июля, 2025

    CONCLUSION: The individualized strategy encompasses an insulin titration protocol guided by CGM, coupled with structured lifestyle modifications that address dietary patterns, physical activity and more, combined with short-term glucose monitoring can exert a positive effect on glycemic improvement in the short term and meet the requirements of glycemic control in pregnancy, which has important clinical… →

    Clinical Trials
  • Differential effects of dual antiplatelet and dual antithrombotic therapy on hemostasis in chronic coronary syndrome patients: the DEFINE CCS study

    3 июля, 2025

    Optimal long term antithrombotic treatment in high-risk chronic coronary syndrome (CCS) patients remains uncertain. Both ticagrelor (60 mg BID) and low-dose rivaroxaban (2.5 mg BID) in addition to low-dose aspirin resulted in significant reductions in major cardiovascular events in high-risk patients at the expense of increased bleeding risk. We aimed to compare the effects of… →

    Clinical Trials
  • Comparison of Postoperative Pain Using Endo-Activator Vs. Conventional Irrigation in Symptomatic Periapical Periodontitis: A Randomised Controlled Trial

    3 июля, 2025

    CONCLUSION: The intensity and severity of postoperative pain occurring in patients presenting with symptomatic periapical periodontitis was significantly reduced by the use of endo-activator when used with 2.5% NaOCl seven days after single-visit endodontic treatment. →

    Clinical Trials
  • Effectiveness of three manual toothbrushes with different bristle designs in terms of plaque removal and gingival inflammation: A randomized controlled trial

    3 июля, 2025

    CONCLUSION: This study showed that the three different toothbrushes were equally effective in plaque removal and reduction of gingival inflammation. The Zigzag toothbrush showed maximum reduction in plaque and gingival inflammation; however, the difference was not significant. →

    Clinical Trials
  • Efficacy of methylprednisolone sodium succinate combined with acoustic resonance therapy on inflammatory response indicators and cerebral microcirculation in patients with sudden sensorineural hearing loss

    3 июля, 2025

    CONCLUSION: The findings suggest that the synergistic application of MPSS and acoustic resonance therapy effectively reduces inflammation and improves cerebral blood flow, leading to better auditory outcomes in patients with SSNHL. This research underscores the potential of integrated treatment approaches in managing SSNHL. →

    Clinical Trials
  • Effectiveness of an online sexual and reproductive health educational program on knowledge, attitudes, and behaviours among senior primary school students: a cluster randomized controlled trial

    3 июля, 2025

    CONCLUSIONS: The online sexual and reproductive health educational program significantly improved knowledge, attitudes, and behaviours among senior primary students, providing valuable guidance for school health nurses in designing and implementing sexual and reproductive health education programs. →

    Clinical Trials
  • Effect of different administration methods of dexamethasone on postoperative pain and swelling following implant flap surgery: A randomized controlled trial of patient-centered outcomes

    3 июля, 2025

    CONCLUSIONS: Intraoperative submucosal dexamethasone was associated with earlier swelling reduction compared to oral administration, though both methods showed comparable pain control. These findings suggest a potential clinical advantage for the intraoperative route that warrants further investigation. →

    Clinical Trials
  • Levels of peripheral CD4 + and CD8 + T cells and glycaemic control level in patients with both type 2 mellitus diabetes and stage III-IV periodontitis: a randomized controlled trial in Chinese population

    3 июля, 2025

    CONCLUSION: Participants under hyperglycemia (HbA1c ≥ 7.5%) and stage III-IV periodontitis exhibited higher sensitivity of HbA1c level to SRP treatment. When HbA1c ≥ 7.5%, The peripheral CD4+/CD8 + ratio showed a slight increase in the intervention group while only reduction was found in other groups. And the peripheral CD4+/CD8 + ratio of SRP + OHI… →

    Clinical Trials
  • Influences of social support following hip-fracture surgery for older adults with cognitive impairment and their family caregivers

    3 июля, 2025

    CONCLUSIONS: Good perceived social support positively influenced recovery trajectories for older adults with cognitive impairment and improved HRQoL for both care receivers and caregivers, highlighting the importance of developing targeted interventions to enhance social support during post-surgical recovery for this vulnerable population. →

    Clinical Trials
  • Efficacy of combined topical nepafenac 0.3% with suprachoroidal injection of triamcinolone acetonide using a modified custom needle in pseudopkakic cystoid macular edema

    3 июля, 2025

    CONCLUSION: Combined SCTA using this modified custom needle with topical nepafenac 0.3% resulted in better anatomical and functional results in PCME patients compared to topical nepafenac 0.3% alone. The study was prospectively registered with clinical trial.gov ID (NCT04690608) in 27-12-2020. →

    Clinical Trials
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