CONCLUSION: Compared with BP ECT, UBP ECT may reduce the incidence of delirium post-treatment in SCZ without a significant difference in efficacy. The higher cholinesterase levels in the UBP group suggest that UBP ECT may reduce neuronal asynchronous depolarization, cholinergic disorder, and pro-inflammatory responses, thereby reducing the impact on delirium. These findings provide partial scientific… →

BACKGROUND: The identification of homologous recombination deficient (HRD) tumor is now a crucial step for the therapeutic management of ovarian cancer. The HRD tumors are both sensitive to olaparib maintenance treatment and to platinum-based chemotherapy. Despite the large amount of HRD tests currently available, only a few HRD tests were prospectively validated on a clinical… →

CONCLUSIONS: Group-based Rumination-Focused Cognitive-Behavioral Therapy (g-RFCBT) demonstrated significant efficacy in reducing the severity of depressive symptoms, rumination, and negative affect among individuals with major depressive disorder (MDD). Moreover, these therapeutic benefits were maintained over a 6-month follow-up period, suggesting durable treatment effects. →

CONCLUSION: The 5A nursing model significantly impacts immune balance and reduces lymph node metastasis in primary liver cancer patients following CyberKnife treatment. This model enhances CD8 + T cell and NK cell concentrations while reducing Tregs cells, thereby promoting a stronger anti-tumor immune response and ultimately decreasing the rate of lymph node metastasis. →

CONCLUSION: A multi-component intervention can significantly reduce inappropriate antibiotic prescriptions for URTIs in the outpatient setting. →

Recent studies underscore the therapeutic potential of citrus polymethoxylated flavonoids-such as tangeretin, sinensetin, and nobiletin-in attenuating inflammation, mitigating oxidative stress, and enhancing metabolic health in individuals with obesity. This randomized, double-blind, placebo-controlled clinical trial assessed the effects of a functional orange juice enriched with flavonoids (200 mL/day) combined with a low-calorie diet over six weeks… →

CONCLUSION: This study pioneers the application of the MDT teaching method in breast cancer clinical education, comparing its efficacy against traditional teaching modes. Findings demonstrate that MDT-based breast cancer diagnosis and treatment education is more efficient and optimized, offering a transformative basis for clinical undergraduate education reform in China. The results advocate for the reconfiguration… →

BACKGROUND: Research has demonstrated the ability to identify and treat individuals at high risk of developing psychosis. It is possible to use a similar strategy to identify people who have an emergent risk of bipolar disorder (BD). Interventions during the early phase may improve outcomes and reduce risk of transition. Criteria have been established to… →

CONCLUSION: The use of online self-report clinical assessment by patients can save time to complete subsequent clinician assessment. Greater time-saving can be expected with better integration of this tool in workflow and increased clinician familiarity with using online self-reported data. →

Patient-reported outcomes (PROs) are assessments based on patients’ self-perception. This study aimed to explore whether WeChat-based health education is more effective than traditional health education in terms of improving PROs for hypertensive patients during a 3-month period. This prospective, single-center, single-blind randomized controlled trial was conducted from April to August 2022 at the hypertension ward… →