CONCLUSIONS: PCI was effective across all ages in reducing angina frequency. Notably, there was limited improvement in treadmill exercise time in the elderly, challenging its role as a primary endpoint in many antianginal trials. These data should inform cardiovascular clinical trial design to ensure applicability across all ages. (Objective Randomized Blinded Investigation With Optimal Medical… →

CONCLUSION: Parents recognised the pressures on services to offer timely support; however, their well-being could be substantially improved by more clarity around wait times, as well as more effective signposting and support from services concerning the assessment process. This may help alleviate some of the stressors associated with their child’s assessment journey, such as feeling… →

INTRODUCTION: Depression is one of the most serious mental health disorders worldwide. Forest therapy has been shown to be an effective non-pharmacological intervention. This study examined the development and implementation of personalized forest therapy programs for patients with depression, particularly their effects on stress levels and obsessive-compulsive symptoms. →

CONCLUSIONS: DIT combined with antidepressant medication demonstrated superior efficacy compared to medication alone in alleviating insomnia, depressive symptoms, and anxiety, as well as in improving sleep quality among college students with depressive disorders. These results support the integration of DIT into standard clinical care to address co-occurring depression and insomnia in this vulnerable population. However,… →

CONCLUSIONS: The ketogenic diet was associated with the most pronounced long-term metabolic improvements, whereas 16:8 time-restricted eating yielded faster early responses and the most stable enhancement in Orexin-A levels. These findings indicate distinct metabolic and neuroendocrine adaptation profiles across dietary strategies. Given the small sample size, results should be interpreted cautiously, and larger trials are… →

Background and Objectives: Meniscus injuries, particularly Grade I and II, are common knee injuries that can affect pain, joint function and quality of life, but the effectiveness of non-invasive treatments like Kinesiology taping (KT) in this population remains limited. This pilot randomized controlled trial aimed to explore the short-term effects of KT on pain, fear… →

CONCLUSIONS: In this trial, melatonin did not significantly reduce the incidence of delirium. The lower-than-expected numbers of outcome events and resultant early termination for futility limited the study’s power. As a result, the study findings should be interpreted with caution, and further research is necessary before definitive recommendations can be made. →

CONCLUSIONS: Readily scalable in primary care and varied-resource settings, our WeChat mini-program-based intervention extends beyond weight loss to reduce hepatic steatosis and improve metabolic parameters, thereby addressing the critical gap in targeted MAFLD management in China with a low-cost model for high-burden populations. Nevertheless, larger future studies are needed to confirm these findings with greater… →