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Immunogenicity, safety, and efficacy of rurioctocog alfa pegol in previously untreated patients with severe hemophilia A
CONCLUSION: These data demonstrate a low incidence of FVIII inhibitors among previously untreated patients receiving rurioctocog alfa pegol for severe hemophilia A. Efficacy and safety results were similar to prior reports in previously treated patients. →
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Intraoperative Dexmedetomidine and Postoperative Delirium After Head and Neck Cancer Surgery with Free-Flap Reconstruction: A Secondary Analysis of a Randomized Placebo-Controlled Trial
CONCLUSION: In patients undergoing head and neck cancer surgery with free-flap reconstruction, intraoperative dexmedetomidine infusion was associated with a lower incidence of postoperative delirium during the first 5 postoperative days, without an apparent increase in perioperative adverse events. →
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Effect of a Computer-Aided Device on Endoscopists’ Biopsy Practice for Gastric Neoplasms: A Secondary Analysis of a Randomized Controlled Trial
CONCLUSIONS: Red-box classification was associated with more targeted biopsy sampling, while false-positive prompts were not associated with indiscriminate biopsies. →
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Randomised controlled trial of fluoxetine versus naltrexone in compulsive sexual behaviour disorder
CONCLUSIONS: Although no statistically significant between-group difference was observed at week 8, symptom trajectories and adverse effect profiles differed between groups. →
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#aware.hiv Europe study: protocol for a stepped-wedge cluster randomised trial of a multimodal hospital-based implementation strategy targeting HIV indicator-condition-guided testing in European hospitals
INTRODUCTION: Across Europe, many people with HIV are diagnosed late despite repeated contact with hospital services for HIV indicator conditions. These conditions flag a possible underlying HIV infection for which HIV testing is recommended. They provide an opportunity to identify people with HIV, yet implementation of indicator condition-based testing remains insufficient in hospital practice. The… →
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Effects of Virtual Reality on Pain, Anxiety, and Fear During Thyroid Fine-Needle Aspiration Biopsy: Open-Label Randomized Controlled Trial
CONCLUSIONS: The adjusted analysis suggested a small reduction in procedural pain with VR; however, the between-group difference was not statistically significant in the unadjusted analysis and reached statistical significance only after adjustment for baseline pain and 2 nonprespecified covariates selected on the basis of observed baseline imbalance. Moreover, the observed adjusted effect (f=0.207) was smaller… →
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The Real Reasons Why Digital Projects Fail
Danae Diaz/Ikon Images It’s a familiar scenario: An organization implements digital tools intended to improve a particular process but fails to obtain the desired result. Employees who are meant to use them complain that the tools don’t solve the problem or that they add inefficiencies. Managers who investigate problems with the tools chalk the failure… →
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Who Builds the Green Economy?
Scientists have been warning us about climate change for decades, telling us that if we don’t reduce our carbon emissions soon, life on Earth will become exceedingly difficult. And for a while, it seemed like people cared: governments passed policies, companies made net-zero pledges, people shopped with reusable bags. But, as it stands, global emissions… →
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Reliability of Childhood Autism Rating Scale, Second Edition, Assessments Using Telepsychiatry for Children With Neurodevelopmental Disorders and Their Caregivers: Randomized Feasibility Study
CONCLUSIONS: CARS2 total scores obtained through telepsychiatry showed moderate agreement with scores obtained through face-to-face assessment when the assessments were conducted by different evaluators in different settings. Higher point estimates were observed among older children and girls, although these subgroup findings should be interpreted cautiously. Telepsychiatry-based CARS2 assessment may be considered a complementary approach rather… →
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Microbiological surveillance after automated reprocessing of gastrointestinal endoscopes in routine clinical practice: A prospective randomized microbiological surveillance study
Microbiological surveillance is used to monitor the quality of gastrointestinal endoscope reprocessing, but prospective data comparing automated endoscope reprocessor systems under routine workflow conditions remain limited. We conducted an exploratory, single-center, prospective randomized surveillance study of 222 endoscope-use episodes involving patient-used forward-viewing upper and lower gastrointestinal endoscopes. Endoscope-use episodes were allocated 1:1:1 to strongly acidic… →
