Daru. 2026 Oct 5;34(2):90. doi: 10.1007/s40199-026-00657-3.
ABSTRACT
BACKGROUND: Orthostatic hypotension (OH) and related symptoms are common complications in individuals with type 2 diabetes mellitus (T2DM). Antioxidant compounds, such as those found in rosehip fruit, may have the potential to alleviate orthostatic symptom burden. This study evaluated the effects of rosehip fruit extract on orthostatic symptoms in adults with T2DM.
METHODS: This randomized, double-blind, placebo-controlled, parallel-group clinical trial was conducted over four weeks among 60 adults with T2DM and OH referred to the Yazd Center for Diabetes. Participants were randomly assigned to receive either rosehip fruit extract (two capsules daily, each containing 500 mg) or placebo. Orthostatic symptoms were assessed using the Orthostatic Intolerance Questionnaire (OIQ). Clinical relevance was evaluated using predefined minimal clinically important difference thresholds.
RESULTS: Of the 60 randomized participants, 57 completed the 4-week intervention. At the end of the study, a greater proportion of participants in the rosehip group no longer met diagnostic criteria for orthostatic hypotension compared with the placebo group (prevalence ratio = 2.57, 95% CI: 1.18-5.62). The rosehip group experienced significantly greater reductions in OIQ scores compared with placebo, and these differences remained statistically significant after adjustment for baseline values and age (P = 0.001). The magnitude of symptom improvement in the rosehip group exceeded the predefined thresholds for clinical relevance.
CONCLUSION: Rosehip extract significantly reduced orthostatic symptom burden and the prevalence of OH in patients with T2DM. Benefits were primarily reflected in symptomatic scores and systolic blood pressure. While promising and well-tolerated, these preliminary results require confirmation in larger, multicenter trials incorporating long-term objective hemodynamic monitoring.
PMID:42831964 | DOI:10.1007/s40199-026-00657-3
