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1% Colloidal Oatmeal Cream/Baby Wash Regimen Improved Atopic Dermatitis in Pediatric Patients From First Use
CONCLUSIONS: The study regimen was effective and well-tolerated in this pediatric population with AD. Improvements occurred as early as day 1, with a rapid reduction in pruritus and increased well-being. →
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Ruxolitinib Cream Versus Triamcinolone Cream in Adults With Mild to Moderate Atopic Dermatitis
Atopic dermatitis (AD), a chronic inflammatory skin disease, is typically treated with topical corticosteroids in patients with mild to moderate disease, creating an ongoing need for nonsteroidal therapies. As part of a phase 2, randomized, dose-ranging study of ruxolitinib (Janus kinase [JAK]1/JAK2 inhibitor) cream, twice-daily 1.5% ruxolitinib cream was compared with twice-daily 0.1% triamcinolone cream… →
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10 GTM Campaign Plays Startups Are Using to Build Pipeline in 2025
Building pipeline is one of the toughest challenges for early-stage startups. What works for one company rarely works the same for another. Yet across dozens of Seed to Series A teams, we’ve noticed a handful of repeatable campaign plays that consistently generate conversations and conversions. Here are 10 of the campaign strategies that are proving… →
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IBM Released new Granite 4.0 Models with a Novel Hybrid Mamba-2/Transformer Architecture: Drastically Reducing Memory Use without Sacrificing Performance
IBM Releases Granite 4.0 Models with Novel Hybrid Mamba-2/Transformer Architecture IBM has introduced Granite 4.0, an open-source family of large language models (LLMs) that utilizes a hybrid Mamba-2/Transformer architecture. This innovative design significantly reduces memory usage while maintaining performance quality. The models include: Granite-4.0-H-Small: 32B total, ~9B active (hybrid MoE) Granite-4.0-H-Tiny: 7B total, ~1B active… →
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A Novel Dermocosmetic Routine Containing Vitamin B3 and 2-Mercaptonicotinyl Glycine Significantly Improves Melasma After 3 Months of Daily Use
CONCLUSIONS: Both DC routine and KT significantly improved melasma after 3 months of use. DC further improved melasma when replacing KT for 3 further months, with similar results when used alone for 6 months. →
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Role of Latissimus Dorsi-Thoracolumbar Fascia Complex Stretching on Pain and Pain-Related Parameters in Patients With Chronic Low Back Pain: A Randomised Clinical Trial
CONCLUSION: The results of this study suggest that stretching the LD-TLF complex may be a beneficial addition to the conventional physiotherapy approach for patients with CLBP. Specifically, LD-TLF complex stretching, when used in combination with conventional physiotherapy, appears to provide improved pain thresholds, decreased pain sensitivity and pain during activity, as well as reduced disability… →
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Efficacy of direct adductor canal block in pain control and sparing opioid consumption after total knee arthroplasty: a randomized controlled trial
CONCLUSION: Intraoperative direct ACB demonstrated an opioid-sparing effect when combined with PAI. By performing ACB intraoperatively, no additional space, cost, or manpower was required, and patients did not need an additional catheter for pain control. Direct ACB is a simple and safe procedure that can facilitate recovery after TKA. →
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The SUGAR handshake intervention to prevent hypoglycaemia in elderly people with type 2 diabetes: process evaluation within a pragmatic randomised controlled trial
CONCLUSIONS: This process evaluation highlights the SUGAR Handshake’s potential for broader implementation and scale-up. By addressing identified barriers, future educational interventions may enhance adherence, improve patient outcomes, and advance hypoglycaemia management in diabetes care. →
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Comparison of visual quality and optical zones after TransPRK, SMILE, and FS-LASIK myopia correction procedures
CONCLUSIONS: TransPRK has good postoperative visual quality, but its advantages may be mediated by its larger optical zone design. In terms of night vision performance, SMILE surgery can effectively preserve the biomechanical properties of the cornea, while FS-LASIK achieved comparable 6-month acuity; we did not assess time-to-recovery. Selection of surgical modality should be individualized based… →
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Evaluating the role of montelukast on doxorubicin-induced cardiotoxicity in breast cancer patients
CONCLUSION: The incorporation of ML into AC led to a substantial decrease in cardiac biomarkers confirming the feasibility of incorporating ML in individuals with breast cancer as an auxiliary treatment to prevent DOX-induced cardiotoxicity. Trial registration ClinicalTrials.gov: NCT05959889. →
