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Effects of Training Modalities and Additional Pain Education on Exercise-Induced Hypoalgesia in People With Osteoarthritis of the Knee: A Randomised Controlled Feasibility Trial
CONCLUSION: Progression to a larger study is warranted. RTL, but also AET and RTU may induce EIH in people with knee OA. Pain education might have a useful supporting function, but its effect would need to be determined in a study design using a control group that receives training and no education. →
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Impact of mean arterial pressure on reproductive endocrine characteristics in infertile patients with polycystic ovary syndrome: a secondary analysis of a randomized clinical trial
CONCLUSION: Elevated MAP is associated with dysregulation of glucose and lipid metabolism and alterations in endocrine hormone levels. It may thus serve as a promising screening approach for IR-related conditions in patients with PCOS. →
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Microsoft Releases ‘Microsoft Agent Framework’: An Open-Source SDK and Runtime that Simplifies the Orchestration of Multi-Agent Systems
«`html Microsoft Releases ‘Microsoft Agent Framework’: An Open-Source SDK and Runtime that Simplifies the Orchestration of Multi-Agent Systems Target Audience Analysis The target audience for the Microsoft Agent Framework includes software developers, data scientists, and business managers involved in AI and multi-agent system development. Their pain points often revolve around the complexity of integrating various… →
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Evaluation of Patient-reported Outcome Measures during the Correction of Skeletal Class III Malocclusion with Maxillary Constriction in Early Adolescence
CONCLUSION: Treatment of class III malocclusion in growing patients by both appliances did not negatively affect PROMs. Moreover, the application of both appliances was associated with a gradual improvement in the levels of pain and functional impairments until they were almost nonexistent after 6 months. →
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Safety and efficacy of a dexamethasone-sparing regimen with daratumumab and lenalidomide in patients with frailty and newly diagnosed multiple myeloma (IFM2017-03): a phase 3, open-label, multicentre, randomised, controlled trial
BACKGROUND: Patients with frailty and newly diagnosed multiple myeloma have worse outcomes due to higher rates of adverse events (AEs) and treatment discontinuation. This study evaluated a dexamethasone-sparing regimen of daratumumab plus lenalidomide versus lenalidomide plus dexamethasone in frail patients with newly diagnosed multiple myeloma. →
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Neuphonic Open-Sources NeuTTS Air: A 748M-Parameter On-Device Speech Language Model with Instant Voice Cloning
Neuphonic Open-Sources NeuTTS Air: A 748M-Parameter On-Device Speech Language Model with Instant Voice Cloning Neuphonic Open-Sources NeuTTS Air: A 748M-Parameter On-Device Speech Language Model with Instant Voice Cloning Understanding the Target Audience The target audience for NeuTTS Air includes: AI Developers: Interested in implementing advanced speech synthesis in applications. Business Managers: Seeking innovative solutions for… →
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Thinking Machines Launches Tinker: A Low-Level Training API that Abstracts Distributed LLM Fine-Tuning without Hiding the Knobs
Thinking Machines Launches Tinker: A Low-Level Training API that Abstracts Distributed LLM Fine-Tuning without Hiding the Knobs Understanding the Target Audience The primary audience for Tinker includes AI researchers, machine learning engineers, and data scientists who are engaged in developing and fine-tuning large language models (LLMs). These professionals often work in academic institutions, research labs,… →
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How to Build an Advanced Voice AI Pipeline with WhisperX for Transcription, Alignment, Analysis, and Export?
«`html How to Build an Advanced Voice AI Pipeline with WhisperX for Transcription, Alignment, Analysis, and Export In this tutorial, we walk through an advanced implementation of WhisperX, focusing on transcription, alignment, and word-level timestamps in detail. This process includes setting up the environment, loading and preprocessing audio files, and executing the full pipeline, from… →
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Who really benefits from the online gig economy?
It’s estimated that over 160 million global workers are registered on online gig economy platforms but only a small fraction of them are working at any point in time. Dr Catherine Thomas writes that despite this, gig workers who are hired capture a significant share of market surplus. These findings challenge calls to reclassify freelancers… →
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Leaders at All Levels: How a Leader at Fidelity Supercharged Productivity
When a top performer confided that she was experiencing an intolerable level of burnout and was job hunting, it was a wake-up call about team leadership for Lauren Dreyer. The 20-year veteran of Fidelity Investments had had no idea that burnout was an issue for anyone on her team. And only later did Dreyer realize… →