Integr Cancer Ther. 2026 Jan-Dec;25:15347354251413222. doi: 10.1177/15347354251413222. Epub 2026 Mar 16.
ABSTRACT
This study compared Intraneural Facilitation (INF®) therapy and standard physical therapy (PT) in preventing chemotherapy-induced peripheral neuropathy (CIPN) in women with newly diagnosed breast and gynecologic cancer. Thirty-eight women undergoing platinum and/or taxane-based chemotherapy, without prior peripheral neuropathy, were randomized into INF® therapy (n = 20) and PT (n = 18). Treatments lasted 45 minutes, twice weekly, for 6 weeks. Neuropathy severity was evaluated using the Pain Quality Assessment Scale. Assessments were at baseline, 3 weeks, 6 weeks, and 3 months post-intervention. Acceptability, burden, and satisfaction were evaluated after 6 weeks. Among 38 patients, 12 (32%) experienced CIPN, with mean pain scores remaining mild (≤3) and no pharmacotherapy required until week 6. No adverse events were reported from the interventions. The INF® therapy arm showed significant changes in numbness (F = 6.030, P = .001, partial η2 = 0.262) after week 6, while the PT arm showed significant changes in numbness (Z = -2.39, P = .017), tingling (Z = -2.84, P = .004), cramping (Z = -2.120, P = .034), surface pain (Z = -2.75, P = .006), and deep pain (Z = -1.99, P = .046) between weeks 3 and 6. Nearly 80% of patients completed chemotherapy cycles with an average relative dose intensity of 90.4% (INF® therapy: 87.73% vs PT: 73.44%). Ninety-four percent of patients were satisfied with their care, accepted the treatments, and perceived them as a low burden. The results demonstrated that INF® therapy and PT are feasible options for CIPN, improving treatment adherence, outcomes, and quality of life for women with newly diagnosed breast and gynecological cancers.Trial Registration — The study was pre-registered on ClinicalTrials.gov (NCT03272919). August 8, 2017.
PMID:41840756 | DOI:10.1177/15347354251413222
