Clinical Trials
Category Added in a WPeMatico Campaign
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Pentraxin-3 and Lipocalin-2 are decreased in patients with uveal effusion syndrome
CONCLUSION: Lipocalin-2 and Pentraxin-3 values, which are known to be induced by glucocorticoids, tend to be lower in patients with UES. The results suggest an impairment in the glucocorticoid receptor pathway and underline the hypothesis of a common pathophysiological pathway of CSCR and UES.
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Targeting Intolerance of Uncertainty During Pregnancy: A Randomized Controlled Trial to Prevent Postpartum Anxiety Disorders
Objective: Postpartum anxiety is common, often underrecognized, and associated with numerous negative outcomes for both the perinatal individual and their infant. Despite its high prevalence and burden, research focused on preventative strategies for postpartum anxiety remains very limited. This study investigated whether a 6-week cognitive behavioral therapy protocol targeting intolerance of uncertainty (CBT-IU) during pregnancy…
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Impact of Animal-Assisted Interactions on Quality of Life in Children With Relapsed/Refractory Cancer and Their Parents: A Randomized Controlled Pilot Study
BackgroundChildren with cancer are at increased risk for cognitive and physical suffering from side effects of treatment and disease sequelae. Animal-assisted interactions (AAIs) with canine therapy show strong promise to improve physical and psychosocial outcomes for children newly diagnosed with cancer. Few rigorous studies have focused on the role of AAI for children with relapsed/refractory…
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Randomized study evaluating the efficacy of sustained-release dexamethasone with or without prompt laser for branch retinal vein occlusion-related macular edema
CONCLUSION: Combination therapy of laser with intravitreal sustained-release DI leads to poorer visual outcomes and may indicate a negative impact of steroid therapy on healing.
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Efficacy and safety of combined lumbar plexus and quadratus lumborum block via Shamrock approach at L3 in total hip arthroplasty: a prospective randomized controlled trial
CONCLUSIONS: The combined technique may provide effective block with fewer technical challenges and hypotension risks compared to multi-level LPB, making it a feasible alternative for perioperative pain management in total hip arthroplasty. Trial registration ClinicalTrials.gov, NCT04266236. Registered on 10 February 2020.
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Communication About Sexuality (COSY) Encourages Physical Activity in COPD: A Randomised Trial
CONCLUSION: Communication about sexual wellbeing using the COSY instruments was well received by people with COPD and enable healthcare professionals to comfortably address an often-ignored topic. Recruitment challenges limited study power, but the findings offer strong justification for further research into this promising and needed holistic care approach.
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Effect of pharmacist-led medication reviews on appropriateness of prescribing in patients with dementia — results from the cluster randomized controlled «DemStepCare» study
CONCLUSION: Even a single comprehensive medication review significantly improved medication appropriateness in PwD. Based on the results, pharmacist-led medication reviews are strongly recommended for PwDs.
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Effectiveness of a digital game based study guide on head trauma assessment on knowledge and practical skills of nursing students: a quasi-experimental study
CONCLUSION: The study shows that a digital game-based study guide significantly enhances nursing students’ knowledge and skills in head trauma assessment.
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Net Water Uptake at CT Predicts the Treatment Effect of Thrombectomy for Low ASPECTS Stroke
Background Recent trials have demonstrated that supplementing best medical treatment (BMT) with endovascular thrombectomy (EVT) improves the functional outcomes of patients presenting with large ischemic lesions. Purpose To analyze whether net water uptake (NWU), quantified as infarct hypoattenuation at admission noncontrast CT, modifies the treatment effect of EVT and may aid in patient selection. Materials…
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Is the neighbourhood environment associated with indicators of health in children and adolescents? Developing and testing a new proof-of-concept Healthy Environments Index for Children in Taranaki, New Zealand
CONCLUSIONS: The theory-informed HEIC and its two subindices may be useful tools for policy and practice aiming at improving child health outcomes. However, they require validation in larger studies in other areas of New Zealand.