Clinical Trials
Category Added in a WPeMatico Campaign
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Longitudinal Remodeling and Network Architecture of the Proximal Aorta in Children and Adolescents With Marfan Syndrome
CONCLUSIONS: The proximal aorta shows a multisegment architecture in which organization across patients is stronger than within-patient coordination of change. Network findings complement, but do not replace, serial measurement of individual aortic levels, and their prognostic value requires independent validation.
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Generative Artificial Intelligence Augmentation of a Clinical Trial of a Dermo-cosmetic Intervention for Acne Remission Maintenance
BACKGROUND: A practical application of artificial intelligence (AI) in healthcare is to generate artificial datasets that capture the characteristics of a real source dataset without exposing protected health information. This approach is particularly relevant to research settings where recruitment and long-term follow-up are barriers to generating robust clinical evidence.
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Co-Designed Text Messaging Intervention for Parents of Children With Early Childhood Caries: Randomized Controlled Trial
CONCLUSIONS: These findings suggest that co-designed SMS text messaging-based programs show promise and may represent a feasible strategy for oral health behavior change. However, larger-scale and longer-term studies are needed to confirm sustained effectiveness using clinical outcomes. Future research should also explore ways mobile health can be scaled and cost-effectively embedded into comprehensive, interdisciplinary primary…
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Prognostic value of Murray law-based quantitative flow ratio after percutaneous coronary intervention
CONCLUSIONS: Post-PCI μQFR distributions were similar between treatment groups, but lower values were associated with higher 5-year adverse event risk without significant treatment interaction. Its limited binary discrimination supports use as a continuous metric for post-PCI physiological risk stratification. (ClinicalTrials.gov: NCT03656848).
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Added Value of Preoperative Contrast Enhanced Mammography in Staging of Malignant Breast Lesions (PROCEM): A Randomized Controlled Trial
Background Contrast-enhanced mammography (CEM) is increasingly used in breast cancer diagnostics; however, randomized trials assessing the added value of CEM in preoperative staging of breast cancer beyond digital mammography, digital breast tomosynthesis, and US are lacking. Purpose To assess the added value of CEM for preoperative breast cancer staging in a randomized controlled trial. Materials…
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Full-Service Mobile Food Markets and Dietary Quality in Low-Income Housing Communities: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this study, satisfaction with the mobile market was high, but the mobile market did not improve diet quality or most outcomes examined. The mobile market was associated with a meaningful sodium reduction that could improve population-level health.
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Visual Perceptual Learning Based on Adaptive Contrast Detection Training Enhances Vision and Contrast Sensitivity in Diabetic Retinopathy
CONCLUSIONS: The results reveal significant plasticity in the visual system in DR and suggest that contrast detection training may extend to motion perception tasks. Our study provides additional support for VPL as a potential treatment for DR.
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Effects of Vitamin D 3 Supplementation on Glycaemic Parameters and Insulin Sensitivity in Pre-diabetic Adults: A Prospective Controlled Interventional Study
CONCLUSIONS: Vitamin D 3 supplementation significantly improved glycaemic control and insulin sensitivity in pre-diabetic adults, supporting its role as a safe, cost-effective adjunct to lifestyle modification in pre-diabetes management.
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Reminder recall is associated with higher mammogram uptake among overdue repeat screeners: an exploratory telephone survey within a randomized trial
CONCLUSIONS: MR recall was associated with higher mammogram uptake among overdue repeat screeners. Timely reminders, simplified scheduling, and close follow-up remain key to overcoming behavioural barriers to screening in high-access health systems.
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Five-year outcomes of the STOP-AD randomised controlled trial: Long-term effects of early emollient therapy in high-risk infants
CONCLUSIONS: Early, short-term emollient use initiated in the neonatal period was associated with lower AD prevalence and severity at 5 years in high-risk children. Although the effect estimate remained similar following multiple imputation, uncertainty due to attrition remained. These findings suggest that brief early-life barrier support may influence longer-term AD outcomes and support further investigation…