Clinical Trials
Category Added in a WPeMatico Campaign
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Ruxolitinib Cream Versus Triamcinolone Cream in Adults With Mild to Moderate Atopic Dermatitis
Atopic dermatitis (AD), a chronic inflammatory skin disease, is typically treated with topical corticosteroids in patients with mild to moderate disease, creating an ongoing need for nonsteroidal therapies. As part of a phase 2, randomized, dose-ranging study of ruxolitinib (Janus kinase [JAK]1/JAK2 inhibitor) cream, twice-daily 1.5% ruxolitinib cream was compared with twice-daily 0.1% triamcinolone cream…
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A Novel Dermocosmetic Routine Containing Vitamin B3 and 2-Mercaptonicotinyl Glycine Significantly Improves Melasma After 3 Months of Daily Use
CONCLUSIONS: Both DC routine and KT significantly improved melasma after 3 months of use. DC further improved melasma when replacing KT for 3 further months, with similar results when used alone for 6 months.
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Role of Latissimus Dorsi-Thoracolumbar Fascia Complex Stretching on Pain and Pain-Related Parameters in Patients With Chronic Low Back Pain: A Randomised Clinical Trial
CONCLUSION: The results of this study suggest that stretching the LD-TLF complex may be a beneficial addition to the conventional physiotherapy approach for patients with CLBP. Specifically, LD-TLF complex stretching, when used in combination with conventional physiotherapy, appears to provide improved pain thresholds, decreased pain sensitivity and pain during activity, as well as reduced disability…
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Efficacy of direct adductor canal block in pain control and sparing opioid consumption after total knee arthroplasty: a randomized controlled trial
CONCLUSION: Intraoperative direct ACB demonstrated an opioid-sparing effect when combined with PAI. By performing ACB intraoperatively, no additional space, cost, or manpower was required, and patients did not need an additional catheter for pain control. Direct ACB is a simple and safe procedure that can facilitate recovery after TKA.
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The SUGAR handshake intervention to prevent hypoglycaemia in elderly people with type 2 diabetes: process evaluation within a pragmatic randomised controlled trial
CONCLUSIONS: This process evaluation highlights the SUGAR Handshake’s potential for broader implementation and scale-up. By addressing identified barriers, future educational interventions may enhance adherence, improve patient outcomes, and advance hypoglycaemia management in diabetes care.
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Evaluating the role of montelukast on doxorubicin-induced cardiotoxicity in breast cancer patients
CONCLUSION: The incorporation of ML into AC led to a substantial decrease in cardiac biomarkers confirming the feasibility of incorporating ML in individuals with breast cancer as an auxiliary treatment to prevent DOX-induced cardiotoxicity. Trial registration ClinicalTrials.gov: NCT05959889.
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Comparison of visual quality and optical zones after TransPRK, SMILE, and FS-LASIK myopia correction procedures
CONCLUSIONS: TransPRK has good postoperative visual quality, but its advantages may be mediated by its larger optical zone design. In terms of night vision performance, SMILE surgery can effectively preserve the biomechanical properties of the cornea, while FS-LASIK achieved comparable 6-month acuity; we did not assess time-to-recovery. Selection of surgical modality should be individualized based…
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Cholesterol desensitizes the response of endometrial cancer to progestin by attenuating progestin signaling
Progestin is the primary fertility-preserving treatment for patients with endometrial cancer (EC) and its precursor lesions, endometrial atypical hyperplasia (EAH); however, a subset of patients exhibits a poor response. In this study, through the analysis of serum lipid differences, we found that progestin-resistant patients with EC/EAH exhibited reduced serum apolipoprotein A-I concentrations and increased cholesterol…
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Multiuser Application for the Diagnosis and Treatment of Depression in Women’s Self-Help Groups: Pilot Randomized Controlled Trial
CONCLUSIONS: MITHRA is feasible and acceptable for use in women’s SHGs. Larger studies should examine the effectiveness of this approach in identifying and treating depression.
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Cost-Effectiveness of HPV Self-Testing Options for Cervical Cancer Screening
CONCLUSIONS AND RELEVANCE: In this economic analysis of a randomized clinical trial, directly mailing HPV kits to individuals who were screening adherent and overdue for screening was economically dominant over other strategies. Program costs declined rapidly over 4 years. Results support directly mailing HPV kits to eligible individuals as an effective, efficient, and affordable outreach…