Clinical Trials
Category Added in a WPeMatico Campaign
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Effectiveness of a Sodium Intake Monitoring Smartphone Application (NamakBan) on Clinical Outcomes of Patients Diagnosed With Hypertension: A Randomized Clinical Trial
CONCLUSIONS: In this RCT, the NamakBan application, used alongside usual care, was associated with modest but statistically significant improvements in systolic blood pressure, diastolic blood pressure and self-reported sodium intake over 2 months. However, the objective urinary sodium-to-potassium ratio did not differ between groups. The findings should therefore be interpreted with caution: dietary sodium was…
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Denecimig (Mim8) prophylaxis in children with hemophilia A with or without factor VIII inhibitors
CONCLUSION: Over 52 weeks, denecimig prophylaxis was well tolerated with no safety concerns and provided robust bleed protection, reduced treatment burden, and improved overall health-related quality of life in children with HA.
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NIHSS and Large Artery Atherosclerosis Affect Efficacy of Dual Antiplatelet Therapy Versus Alteplase for Minor Stroke
CONCLUSIONS: Neurological deficit and LAA may affect efficacy of DAPT versus alteplase in acute minor nondisabling stroke. In patients with NIHSS scores of 0 to 3 due to LAA, DAPT may be associated with numerically higher odds of 90-day functional outcomes compared to alteplase. Given the exploratory nature of this subgroup analysis and no formal…
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Subacute effects of ketamine on neural correlates of reward processing
Ketamine induces a sequence of temporally distinct effects on brain function, yet its impact on reward processing beyond the acute post-administration phase remains unclear. In this single-blind, placebo-controlled, crossover study, 28 healthy participants received 0.5 mg/kg racemic ketamine or placebo via a 40 min intravenous infusion. Functional magnetic resonance imaging was acquired approximately 5 h…
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Effects of rosehip (Rosa canina) supplementation on orthostatic intolerance symptoms in patients with type 2 diabetes: a randomized double-blind placebo-controlled clinical trial
CONCLUSION: Rosehip extract significantly reduced orthostatic symptom burden and the prevalence of OH in patients with T2DM. Benefits were primarily reflected in symptomatic scores and systolic blood pressure. While promising and well-tolerated, these preliminary results require confirmation in larger, multicenter trials incorporating long-term objective hemodynamic monitoring.
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Cost-Consequence Analysis of a Dementia Specialist Training Program for Home Care Workers: Results From a Stepped-Wedge Cluster-Randomised Controlled Trial
CONCLUSIONS: This health economic analysis should be interpreted separately from and alongside, the main PITCH trial findings on the primary outcome of home care workers’ competence. Within this secondary analysis, PITCH was associated with higher total costs during the intervention phase and no clear evidence of improvement in the selected secondary client and caregiver outcomes.
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Acute effects of volume-matched isometric exercise intensity on vascular function and autonomic regulation in men with elevated blood pressure
Isometric exercise (IE) has been introduced as an effective non-pharmacological strategy for blood pressure (BP) management; however, the influence of exercise intensity remains unclear during lower-limb IE. This study investigated the acute effects of volume-matched high-intensity (HIIE) and low-intensity IE (LIIE) on cardiovascular function in men with elevated BP. Seventeen men with prehypertension or stage…
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Acute Caffeine Intake Does Not Modulate Active or Reactive Inhibition in Non-Clinical Young Adults, and ADHD Symptoms Do Not Moderate Its Effects
CONCLUSIONS: Caffeine produced no acute benefit for either form of inhibition, and ADHD symptoms did not moderate its effects. Bayes factors supported the absence rather than the nondetection of these effects, arguing against an acute improvement of inhibitory control that scales with ADHD symptom severity in nonclinical young adults. Whether this also holds for chronic…
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A nationwide prospective randomized trial for diagnosing developmental disorders demonstrates genome sequencing outperforms standard of care
CONCLUSIONS: This nationwide study indicates GS outperforms SoC for the diagnosis of patients with DD in a decentralized hospital setting and well-characterized cohort. The results also highlight the importance of evaluating autosomal dominant inherited variants in genomics analyses for DD.
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RAGE mediates LPS-induced inflammatory pain in human skin — a double-blind, randomised, placebo-controlled full crossover study
Inflammatory pain is a major clinical challenge, yet appropriate human models mimicking local infection are lacking. We established a human pain model based on intradermal administration of lipopolysaccharide, a component of Gram-negative bacteria, and investigated the time course and underlying molecular mechanisms of inflammatory pain hypersensitivity. A placebo-controlled pilot study with 12 healthy subjects showed…