Clinical Trials
Category Added in a WPeMatico Campaign
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Does the use of benzodiazepine influence the effectiveness of lifestyle intervention? Secondary analysis from the Sarcopenia and Physical fRailty iN older people strategies (SPRINTT) trial
CONCLUSION: In frail older adults, benzodiazepine use significantly blunts the effectiveness of lifestyle interventions for preventing mobility disability. These findings support a prudent approach to benzodiazepine use in frail older patients.
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Self-Monitoring of Weight Loss Over Time: Secondary Data Analysis of a Randomized Controlled Trial
CONCLUSIONS: The study demonstrates that the effect of self-monitoring on weight loss is time-dependent. While a higher frequency of self-monitoring is associated with greater weight loss early in the intervention, its influence decreases as time progresses. These findings emphasize the importance of sustained engagement with self-monitoring rather than focusing solely on frequency, suggesting that interventions…
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Feasibility and Methodological Reflections From the Co-Creation of a Randomized Controlled Trial (The Kid’s Trial): Decentralized, Child-Led Citizen-Science Study
CONCLUSIONS: The Kid’s Trial demonstrates the feasibility of a decentralized, child-led RCT cocreated through participatory citizen-science methods. Children can meaningfully contribute to trial design and conduct, and experiential participation may support engagement with trial concepts. Future studies should enhance engagement through community partnerships, shorter intervals between steps, and embedded learning assessments to improve inclusivity and…
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Evaluation of a cornea-specialized large language model for diagnostic and management accuracy in complex corneal cases
CONCLUSIONS: A cornea-specialized LLM enhanced with RAG improved diagnostic accuracy in complex corneal cases, particularly among clinicians with lower baseline performance. Effects on management accuracy were inconsistent. Future studies should explore the use of open-ended management tasks and examine whether smaller, curated retrieval corpora yield better model performance.
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Angiography-Based Index of Microcirculatory Resistance in Assessing the MVO and Infarct Size in STEMI Patients
CONCLUSIONS: In STEMI patients, a single bolus of r-SAK before PCI was associated with numeric reductions in post-PCI angio-IMR, MVO, MVO extent and IS. Additionally, angio-IMR exhibited a significantly positive correlation with both MVO extent and IS, demonstrating the diagnostic value of this wire-free method for assessing microvascular injury.
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Combined hyperbaric oxygen and repetitive transcranial magnetic stimulation for vascular cognitive impairment: a randomized controlled trail
CONCLUSION: Combined HBOT and rTMS therapy demonstrates superior efficacy in improving cognitive function which may be mediated by the primary somatosensory cortex and primary motor cortex of the brain. However, the combined regimen did not yield greater improvement in daily function or mood. Combined HBOT + rTMS is a promising cognitive rehabilitation strategy in the…
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Serplulimab combined with bevacizumab and chemotherapy as first-line treatment for recurrent or metastatic cervical cancer (ASTRUM-CC01): a phase II trial
CONCLUSION: First-line treatment with serplulimab in combination with bevacizumab and chemotherapy demonstrated promising antitumor activity and acceptable safety in R/M cervical cancer. These findings support further evaluation in phase III trials.
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Impact of leuprolide and goserelin on androgen suppression and adverse events in patients with prostate cancer
CONCLUSION: ADT effectively achieves hormonal suppression in prostate cancer; however, differences between LHRH agonists influence clinical and metabolic outcomes. Leuprolide 22.5 mg showed superior PSA reduction but higher rates of vasomotor symptoms and weight gain, while goserelin 10.8 mg was associated with hormonal instability and cardiovascular risk. Genetic findings suggest that BRCA2 variants may affect…
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Effect of a person-centered care intervention on return and sustained reengagement after treatment interruptions from HIV care in Zambia: A post-hoc analysis of a stepped-wedged cluster randomized trial
CONCLUSIONS: The PCC intervention likely improved rates of return to care after TIs, sustained reengagement after return, and overall retention among individuals with TIs. Strategies targeting caring aspects of HCW behavior and client experience may help lower barriers to and address persistent challenges with reengagement in care.
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Internet-Delivered Cognitive Behavioral Therapy for Fathers With Postnatal Depression: Randomized Controlled Trial of DadBooster
CONCLUSIONS: This randomized controlled trial demonstrates the efficacy of DadBooster, the first online treatment targeting clinically diagnosed postnatal depression in fathers, addressing a critical gap in the treatment of postnatal depression, an area that has until recently been primarily focused on mothers. By providing evidence for an intervention specifically designed for fathers with potential for…