Clinical Trials
Category Added in a WPeMatico Campaign
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MovingTogether: a randomised controlled trial of a mental-health-informed, digital health promotion intervention for older adults
CONCLUSION: The results suggest multicomponent digital health promotion interventions, combining lifestyle education, physical activity and social support, can improve the mental health of older adults. More research is needed to understand how to best utilise digital engagement strategies and improve retention in physical activity programmes for older adults.
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Remote monitoring of patients with NYHA functional class II-III chronic heart failure using the M-Cardio mobile application in residents of Kyrgyzstan
Aim Development and implementation of the M-Cardio mobile application for remote monitoring of patients with chronic heart failure (CHF) at the outpatient stage with an assessment of clinical effectiveness.Material and methods This study included 244 patients with NYHA functional class (FC) II-III CHF of ischemic etiology. During the inpatient phase, the patients were taught the…
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Effect of sumatriptan on ATP-sensitive potassium channel opening in migraine: A randomised controlled trial
ObjectiveTo investigate whether early administration of sumatriptan prevents migraine induced by ATP-sensitive potassium (K(ATP)) channel opener levcromakalim.MethodsThis single-centre, randomised, double-blind, placebo-controlled, two-way crossover study included adults with migraine without aura. Participants received a 20-minute intravenous infusion of levcromakalim on two separate occasions, followed immediately by a 10-minute intravenous infusion of either sumatriptan or placebo (isotonic…
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Comparison of intravenous nalbuphine and sufentanil on the median effective effect-site concentration of propofol to attenuate the response to cervical dilation during hysteroscopy: a double-blind, dose-response study
CONCLUSIONS: During hysteroscopic surgery, when compared with sufentanil, 0.2 mg·kg^(-1) nalbuphine significantly reduced the EC(50) for propofol to inhibit cervical dilation response and the propofol requirement, and did not delay the emergence from anesthesia. Whether 0.2 mg·kg^(-1) nalbuphine could improve perioperative prognosis is worthy of further studies.
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Design and protocol for the decompression-plus trial: a phase 1 clinical study of dorsal myelotomy and expansive duroplasty with or without autologous nerve grafting in acute traumatic spinal cord injury
CONCLUSION: DMED with or without ANGI represent novel interventions for managing acute tSCI. The results of this phase 1 trial will determine whether these interventions can be performed safely and feasibly in a consecutive cohort of patients to potentially enhance recovery and improve outcomes.
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Effectiveness of a standardised and interactive intervention to prevent preschooler unintentional injury in rural China: a cluster randomised controlled trial
CONCLUSION: The 9-month interactive intervention decreased unintentional injury incidence and substantially increased preschooler’s safety knowledge in rural China, offering an effective option for implementing or integrating in multifactorial interventions in resource-limited areas.
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Protective effect of celecoxib against capecitabine induced hand and foot syndrome in patients with colorectal Cancer
CONCLUSION: Celecoxib may represent a potential protective agent against capecitabine induced hand and foot syndrome in patients with colorectal cancer.
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Short- and Longer-Term Effects of Three Intensive Straw Phonation Interventions on the Voice of Female Speech-Language Pathology Students With Mild Dysphonia: A Randomized Controlled Trial
CONCLUSIONS: Positive effects were found for the three SP interventions. The most promising results were found for SP in 2 cm water, suggesting an optimal impedance match between the glottis and the vocal tract in this specific population of female SLP students with mild dysphonia.
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Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT
CONCLUSIONS: Five-year follow-up does not support the introduction of invasive urodynamics in reducing lower urinary tract symptoms or rates of prostate surgery, from a clinical or cost-effectiveness perspective.
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Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation
CONCLUSION: Participant-reported success in the urodynamics arm was not superior to the comprehensive clinical assessment only arm at 15-months follow-up. Urodynamics is not cost-effective at a threshold of £20,000 per quality-adjusted life-year gained. Longer-term follow-up is required to explore need for further interventions and treatments and their effect on the clinical and cost-effectiveness analyses.