Clinical Trials
Category Added in a WPeMatico Campaign
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The Effect of Maternal Lullaby Singing, Affectionate Touch, and a Developmental Support Program on Comfort and Development in Premature Infants: A Randomized Controlled Trial
AIM: Premature infants require interventions supporting comfort in the NICU and development after discharge. Therefore, this study examined the effects of maternal affectionate touch and lullaby singing on early comfort and of a developmental support programme on subsequent development.
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Developing and evaluating a localized health education curriculum in Qinghai, China: a cluster randomized experimental study in high schools
CONCLUSION: The findings provide preliminary evidence that a localized health education curriculum may improve health literacy among high school students in Qinghai Province. However, because only four clusters were included, class-level variance could not be estimated reliably and cluster-level confounding cannot be ruled out. The findings should therefore be interpreted as preliminary rather than definitive…
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Randomised controlled trial to assess the safety and efficiency of a self-contained sampling device/disposable bronchoscope system versus usual sampling procedure (RASECAL)
CONCLUSIONS: Closed-system bronchoscopic sampling was safer (less spill and unplanned disconnections) and more efficient (setup, connectivity and loss prevention) than standard containers. Closed-system diagnostic sampling devices should be the standard during bronchoscopy.
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Vestibular rehabilitation in hereditary spastic paraplegia: a randomized pilot study
CONCLUSION: The use of VRi showed potential as a therapeutic adjunct in HSP rehabilitation, with improvements in balance and fall risk. However, larger studies are needed to corroborate these results.
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Determinants of procedural sedation requirements during endovascular treatment for acute anterior circulation ischaemic stroke: a post-hoc analysis of the INDIVIDUATE trial
CONCLUSION: Sedation requirements during EVT appeared to vary according to patient- and procedure-related factors, including sex, occlusion pattern, pre-stroke disability and procedural complexity. Sedation intensity was not associated with long-term clinical outcomes, supporting the use of adequate procedural sedation when clinically indicated.
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Effects of Cognitive Behavioral Couple Therapy With Integrated Mindfulness on Mindful Attention, Depressive Symptoms, and Dyadic Adjustment in Low-Income Couples: A Pilot Randomized Clinical Trial
Psychosocial distress can exacerbate marital conflict, maladjustment, and mental health vulnerability. This pilot randomized clinical trial examined cognitive-behavioral couple therapy (CBCT) integrated with mindfulness in low-income Brazilian couples (per-capita household income up to one minimum wage). Thirty-four participants (17 heterosexual couples) were randomized (independent computer-generated sequence) to an experimental (n = 16) or waitlist control…
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SPOT: An Early Detection Tool for Predicting Pain Trajectories Following Intra-Articular Injections
The purpose of this study was to identify 12-month postinjection knee osteoarthritis (KOA) pain trajectories and develop an early prediction model using patient-reported pain scores. Data were derived from a multi-site, single-blind randomized controlled trial of intra-articular injections for KOA. The primary analysis focused on participants assigned to autologous bone marrow aspirate concentrate, umbilical cord…
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Cardiovascular outcome of glucagon-like peptide-1 receptor agonists vs dipeptidyl peptidase-4 inhibitor on end-stage kidney disease patients with heart failure: an emulated target trial in patients with diabetes
Patients with end-stage kidney disease (ESKD) receiving maintenance dialysis have a high burden of heart failure (HF), with cardiovascular disease the leading cause of death, yet are largely excluded from randomized trials. Using the TriNetX federated electronic health record network, we emulate a target trial comparing initiation of glucagon-like peptide-1 receptor agonists (GLP-1RAs) versus dipeptidyl…
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Digital recruitment and prevalence of screen-detected atrial fibrillation in nationwide patch-based ECG screening: the NORSCREEN randomized clinical trial
CONCLUSION: The NORSCREEN trial demonstrates that fully digital, large-scale, site-less AF screening is feasible and effective in an at-risk population, identifying previously undiagnosed AF in 1.9% of screened individuals and showing high adherence to therapeutic recommendations.
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Population reach and participation rate in opportunistic vs. systematic atrial fibrillation screening: STROKESTOP III
CONCLUSION: Opportunistic screening increased participation among invited individuals and identified a higher-risk population, but its overall population reach was limited by incomplete eligibility assessment. Combining opportunistic and systematic strategies may optimize reach and participation in AF screening programmes.