Clinical Trials
Category Added in a WPeMatico Campaign
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Effect of early integration of supportive care in addition to standard care in patients with breast cancer: A randomised controlled trial
CONCLUSIONS: Early supportive care integration significantly reduces symptom burden, enhances psychological well-being, and lowers financial stress, supporting its inclusion as standard adjunct cancer care in developing countries, providing actionable evidence for policymakers in LMICs.
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Leg compression for preventing hypotension after spinal anesthesia in elderly hip fracture patients
CONCLUSION: The application of medical compression stocking in elderly patients undergoing HF surgery demonstrated an ability to reduce the incidence of hypotension perioperatively and might prevent in-hospital hypotension-related complication.
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Minimally Invasive Sacroiliac Joint Fusion Using 3D Printed Implants and a Lateral Approach: Safety and Effectiveness Assessments of Fusion Performed by Interventional Physicians in a Prospective Multicenter Single-Arm Clinical Study (The FICS Study)
CONCLUSIONS: Laterally placed SIJ fusion titanium alloy implants are a safe and effective treatment for patients with refractory SIJ dysfunction, as evidenced by significant improvements in pain and function, high rates of radiological fusion, and a favorable safety profile.
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Impact of treatment interruption on the efficacy and safety of vunakizumab in patients with moderate-to-severe plaque psoriasis: a post-hoc analysis of a phase 3 trial
CONCLUSION: Interrupted vunakizumab treatment reduced the clinical response and quality of life in patients with moderate-to-severe plaque psoriasis.
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Efficacy of Intralesional Triamcinolone Acetonide Combined With Cryotherapy Compared to Intralesional Triamcinolone Acetonide Alone in Treating Limited Patchy Alopecia Areata of the Scalp and Face: A Prospective, Randomized, Within-Subject Controlled Trial
CONCLUSION: This study demonstrated that both combination therapy and triamcinolone injection are equally effective in treating alopecia. However, future research with a larger sample size, extended follow-up, and comparisons of trichoscopic findings is warranted.
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Protective effect of pituitrin combined with norepinephrine on cardiopulmonary injury in patients with septic shock diagnosed by critical care ultrasound evaluation
CONCLUSION: ADH combined with NE can effectively improve the inflammatory response, cardiac and pulmonary function indexes of septic patients, and exert significant cardiopulmonary protection effects. It is a viable and effective therapeutic strategy for septic patients.
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Could Primary Contact Physical Therapy Improve Emergency Department Care While Being Efficient? A 3-Month Cost-Utility Analysis
OBJECTIVE: To evaluate the cost utility of 2 emergency department (ED) care models: management by an emergency physician (EP; usual care), and management by a primary contact physical therapist (PT) and an EP (PT + EP; intervention). DESIGN: Cost-utility analysis based on data collected during a pilot pragmatic randomized clinical trial over a 3-month period…
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Interval cancer, sensitivity, and specificity comparing AI-supported mammography screening with standard double reading without AI in the MASAI study: a randomised, controlled, non-inferiority, single-blinded, population-based, screening-accuracy trial
BACKGROUND: Evidence indicates that artificial intelligence (AI) can improve mammography screening by increasing cancer detection and reducing screen reading workload, but its effect on interval cancers (primary breast cancers diagnosed between two screening rounds or within 2 years after the last scheduled screening that were not detected at screening) is unknown. We aimed to compare…
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Treatment of Youth Misophonia: A Randomized Controlled Trial Comparing Transdiagnostic Cognitive-Behavioral Therapy to Psychoeducation and Relaxation Training
Misophonia is a distinct clinical disorder that lacks official diagnostic classification. Despite growing evidence of the prevalence and impairment associated with this condition, little research has tested possible evidence-based interventions. The current study presents outcomes from a two-site randomized controlled trial (N = 43) comparing the efficacy of the Unified Protocols for Transdiagnostic Treatment of…
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Circulating Metabolites Treat Human TMJ-OA by Eliminating Senescent Chondrocytes via the C1QBP/C1q/p14ARF Axis
Temporomandibular joint osteoarthritis (TMJ-OA) is a progressive degenerative disorder, for which therapeutic interventions remain limited. The disruption of metabolic homeostasis plays a critical role in the pathogenesis and advancement of TMJ-OA. However, it remains unclear whether extracellular vesicles (EVs) as cellular metabolites are correlated with the pathogenesis, treatment and diagnosis of TMJ-OA. In this study,…