Clinical Trials
Category Added in a WPeMatico Campaign
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Collaborative model of care between orthopaedics and allied health professionals in knee osteoarthritis (CONNACT): process evaluation of an effectiveness-implementation hybrid randomized control trial
CONCLUSION: The themes have allowed a better understanding of the RCT primary and secondary outcomes and informed the next phase of implementation. CONNACT and similar interventions should identify and address reasons for refusing participation [Reach]; improve group classes with initial evaluations, equal attention paid to patients, tailored exercises, and acknowledge progress [Effectiveness, Implementation]; and adopt…
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Acute Effects of a Week of Stochastic-Random Whole-Body Vibration on Manual Ability Performance in Healthy Subjects: A Preliminary Pilot Study
Aim: The aim of the study is to evaluate whether stochastic whole-body vibration (WBV) can improve dexterity and manipulative capacity in healthy individuals using a conventional squat position over a short period (1 week). Introduction: Many pathologies specifically affect fine motor dexterity. Numerous therapies are aimed at improving upper extremity functionality. In this context, WBV…
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Hypotension prediction index smart alerts and trends to improve compliance with goal-directed hemodynamic therapy: a feasibility study
CONCLUSIONS: This study demonstrated the potential for HPI Smart Alerts to improve compliance with an intraoperative GDHT algorithm in adults undergoing moderate to high-risk non-cardiac surgery. A low burden of intra-operative hypotension was observed, suggesting potential decreases in other associated adverse outcomes. Larger-scale randomized studies are warranted.
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Effectiveness of pictorial educational intervention on foot care among individuals having type 2 diabetes at slums of Karachi, Pakistan: asingle blinded randomized control trial
CONCLUSION: Education had a crucial role in positively impacting patient behavior. Therefore, patients must be actively involved in their healthcare education awareness, focusing more on modifying their behavior.
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Outcome of silicone oil tamponade combined dexamethasone implantation in patients with proliferative diabetic retinopathy and retinal detachment undergoing vitrectomy: a prospective randomized controlled clinical trial
CONCLUSION: In patients with proliferative diabetes retinopathy complicated with retinal detachment, the combination of vitrectomy with silicone oil tamponade and dexamethasone implantation can reduce the incidence of preretinal proliferative membrane and macular epiretinal membrane and improve the visual outcome during 1 year follow-up.
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The effect of exercises done with virtual reality glasses on pain, daily life activities, and quality of life of individuals with lumbar disc hernia: a randomized controlled trial
CONCLUSION: Virtual reality -based exercises effectively reduced pain, improved daily activities and quality of life, and decreased fall risk in lumbar disc herniation patients, suggesting their potential as a complementary rehabilitation approach. Blinding was not applied due to the nature of the interventions, which may introduce a potential risk of bias.
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Comparison of three different puncture techniques for endobronchial ultrasound transbronchial needle aspiration: a single-center, prospective, randomized controlled study
CONCLUSIONS: All three EBUS-guided puncture techniques exhibited high diagnostic accuracy and low bleeding risk, with no statistically significant differences observed. These findings suggest that technique selection may depend on operator preference or the clinical context rather than superiority in diagnostic performance.
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Effect of percutaneous release versus steroid injection among adults with trigger fingers: a randomized clinical trial
CONCLUSION: Percutaneous release of A1 pulley illustrated greater improvement in functional mobility with a moderate effect size and pain with a large effect size compared to steroid injection in trigger fingers. A multicenter trial with a larger sample size and involving a diverse participant cohort may enhance the strength of the evidence.
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Efficacy of probiotic co-supplementation with omega-3 PUFAs on pancreatic beta-cell function in type 2 diabetes
The current understanding of the beneficial effects of probiotics in type 2 diabetes (T2D) relies on both animal and clinical data, which focus mainly on their impact on insulin resistance. The use of high-dose omega-3 polyunsaturated fatty acid (PUFA) therapy has been well tolerated in pilot trials and could have a positive effect on the…
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In vivo analysis of conservation of tooth structure using conventional method, loupes, and dental operating microscope — A randomized clinical trial
CONCLUSION: Magnification-assisted endodontics significantly improves the precision of access cavity preparation. While the DOM offers optimal dentin conservation and enhanced canal orifice detection, surgical loupes strike a balance between improved visualization and procedural efficiency. The integration of magnification tools in pediatric endodontics will surely enhance clinical outcomes, although practical considerations such as cost, training, and…