Clinical Trials
Category Added in a WPeMatico Campaign
-
Trust and Technology Acceptance: Comparing Traditional Search Engines and Artificial Intelligence for Colorectal Cancer Information Seeking
IntroductionThe integration of artificial intelligence (AI) into health information seeking is transforming health promotion. Understanding how users accept and trust these communication technologies is critical for health communication and cancer control. This study examined how the Technology Acceptance Model II (TAM II) applies to colorectal cancer information seeking, comparing link-based search (e.g., Google search) versus…
-
A Controlled Trial on the Effect of Self-Compassion Group Psychotherapy on Adolescents With Major Depressive Disorder
Major depressive disorder (MDD) is a prevalent mental disorder among adolescents, yet its clinical management remains challenging. This controlled trial aimed to evaluate the effectiveness of self-compassion group psychotherapy as an adjunctive treatment for adolescents with MDD. Sixty adolescents with MDD were recruited from the First Affiliated Hospital of Chongqing Medical University between March and…
-
Phase II randomised, placebo-controlled study to evaluate the efficacy and safety of an MK2 inhibitor in ankylosing spondylitis
CONCLUSIONS: Inhibition of MK2 by CC-99677 was insufficient to lead to significant clinical benefits in AS.
-
Effect of Integrated Internet-Based Acceptance and Commitment Therapy and Behavioral Activation Among Ethnic Minority Young Adults With Alcohol Use Disorder in Hong Kong: Pilot Randomized Controlled Trial
CONCLUSIONS: This study, unlike existing evidence, presents an innovative integration of ACT and BA delivered via an internet-based self-help format. The findings contribute to the field by providing preliminary evidence that this integrated intervention is feasible and promising for AUD. The main implication in the real world is to conduct a fully powered randomized controlled…
-
Echocardiographic Parameters for Predicting Atrial Fibrillation Following Ischemic Stroke: The PER DIEM Echocardiography Substudy
CONCLUSIONS: In patients with ischemic stroke, LAVI and LV GLS were significantly associated with subsequent AF detection. These findings may help risk stratify AF monitoring strategies for postischemic stroke management.
-
Factors associated with unplanned healthcare encounters in pediatric cancer patients
CONCLUSIONS: Unplanned healthcare utilization is common among newly diagnosed pediatric cancer patients. The association between unplanned healthcare utilization and standardized symptom screening and increasing physical full-time equivalents warrant further investigation. Key aspects to the implementation of routine symptom screening among pediatric patients with cancer will be resource allocation to prevent and manage common symptoms including…
-
Sustained on/off-treatment disease control with abrocitinib for moderate-to-severe atopic dermatitis
CONCLUSIONS: After 12 weeks of abrocitinib 200 mg, some patients achieved 40 weeks of sustained off-treatment disease control, with assessments demonstrating clear/mild AD, suggesting attainment of disease remission.
-
Absolute Eczema Area and Severity Index Responses with Lebrikizumab in Patients with Moderate-to-severe Atopic Dermatitis: A Secondary Analysis of Two Phase 3 Trials
The ADvocate trials (NCT04146363, NCT04178967) investigated adults/adolescents with moderate-to-severe atopic dermatitis (AD) receiving lebrikizumab (LEB) monotherapy, using percent improvement in the Eczema Area and Severity Index (EASI). In clinical trials, percent EASI improvement is used to compare study arms and measure treatment effect size/impact. In clinical practice, however, absolute EASI scores are used (especially in…
-
Amino Acid Profile and Composite Metabolic Markers in Postsurgical Oncology Patients Receiving Combined Nutritional Therapy
CONCLUSION: Cancer patients following abdominal surgery exhibit a pronounced amino acid imbalance that is partially correctable by combined nutritional support. The BCAA/AAA, UreaCycle, and arginine indices reflect the metabolic response and correlate with disease severity and nitrogen balance. The rate of correction of these disorders is comparable in both the group receiving Aminoven 10% and…
-
The effect of 5-hydroxytryptophan, a serotonin precursor, on adults with high levels of Attention Deficit Hyperactivity Disorder traits: A randomised, controlled trial
BACKGROUND: Although several effective therapies exist for Attention Deficit Hyperactivity Disorder (ADHD), current pharmaceutical treatment carries a high risk of misuse and high levels of discontinuation, evidencing a need for alternatives. One possible avenue is serotonergic intervention, particularly within the serotonin synthesis pathway, where there are several potential loci of dysfunction in ADHD. This study…