Clinical Trials
Category Added in a WPeMatico Campaign
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Raising the bar of efficacy in Atopic Dermatitis: deep response in week 16 responders treated with lebrikizumab over 2 years
BACKGROUND: Lebrikizumab, a high-affinity monoclonal antibody targeting interleukin-13, effectively treats moderate-to-severe atopic dermatitis (AD).
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Application of Mixed Reality for Ophthalmic Clinical Skills and Diagnosis: Prospective Study
CONCLUSIONS: EyelearnMR with traditional teaching was noninferior to traditional teaching alone. It provided a comparable experience and supported learning objectives equally. It is an effective supplementary teaching tool in ophthalmic education and may confer additional learning benefits beyond a traditional clinical posting.
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App-Based Training Module on Guiding Physicians’ Prescription for Antibiotic Treatment of Gonorrhea: Cluster Randomized Controlled Trial
CONCLUSIONS: In our study, the implementation of an app-based training tool did not improve adherence to treatment recommendations. Concern regarding the efficacy of generic ceftriaxone may be one of the intrinsic factors associated with nonadherence.
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Exploring the efficacy of an online guided self-treatment of post-traumatic stress disorder in wildfire evacuees
Objectives Disasters are increasing in frequency and intensity worldwide. Individuals exposed to them are at risk of developing post-traumatic stress disorder (PTSD), insomnia or depression. A stepped care approach, in which the first levels offer interventions that are less costly in terms of specialized resources, could help in meeting the mental health needs of disaster-affected…
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HPV, Cytology, and Cotest Cervical Cancer Screening and the Risk of Precancer
CONCLUSIONS AND RELEVANCE: In this cohort study of cervical cancer screen testing approaches and risk of cervical precancer, after a negative HPV test (regardless of cytology results) risk of precancer remained acceptably low throughout long-term follow-up. This suggests that cotesting yielded limited benefits, while increasing costs, relative to primary HPV testing.
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Validation of a synthetic lumbar spinal endoscopy simulator: skills transfer to real surgery
CONCLUSION: The simulator demonstrated strong transfer validity, significantly improving surgical performance. GOALS scores tripled among simulator-trained participants, and acceptance of the simulator for educational use was unanimous..
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Efficacy of 1.4% solution for infusion arginine sodium succinate in patients with obliterating atherosclerosis of lower limbs (international clinical study)
CONCLUSION: According to the results of the analysis, for all parameters of effectiveness, a statistically significant superiority was shown in patients with stage II obliterating atherosclerosis of the vessels of the lower extremities treated with arginine sodium succinate compared to pentoxifylline.
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Can a Targeted Pre-Exercise Education Intervention Enhance the Exercise-Induced Hypoalgesia (EIH) Response in Individuals With Knee Osteoarthritis (OA)?
CONCLUSION: Despite enhancing beliefs about exercise-induced pain relief, positive pre-exercise education did not enhance EIH compared to control education. These findings highlight the need for alternative strategies to optimize exercise-induced pain relief in OA.
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Multi-center investigation on the influence of clinical characteristics and molecular group A streptococci diagnostics on the management of tonsillopharyngitis in pediatric practices in Berlin-BASE study
CONCLUSION: A McIsaac score ≥ 3 and a positive streptococcal test result were strong drivers for antibiotic prescription. No difference in antibiotic prescription rates between study groups was observed. Antibiotic usage was high in our patient cohort and requires further efforts regarding diagnostic and antibiotic stewardship. Tonsillopharyngitis also utilized substantial resources during follow-up.
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Effectiveness of the Components of a Digital Multiple Health Behavior Intervention Among University Students (Buddy): Factorial Randomized Trial
CONCLUSIONS: We dismantled a complex digital multiple behavior intervention and examined it using a factorial design to provide novel insights into the effectiveness of the intervention’s different components. Both marginal and synergistic effects were observed across multiple behaviors, providing evidence regarding which components are most promising in complex interventions. These findings should be considered in…