Clinical Trials
Category Added in a WPeMatico Campaign
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Nebulized dexmedetomidine prior to flexible bronchoscopy in reducing procedural cough episodes a randomized double blind clinical trial. (NCT: CTRI/2022/07/044389, NICOBAR group of investigators)
CONCLUSION: This study demonstrated that Nebulized dexmedetomidine has insignificant topical action to reduce cough episodes as compared to normal saline in diagnostic FOB, but systemic effects remain to be investigated.
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Multiple micronutrient supplementation for maternal anemia prevention (MMS-MAP): an individually randomized trial of higher-dose iron (60 mg, 45 mg) compared to low-dose iron (30 mg) in multiple micronutrient supplements in pregnancy
BACKGROUND: Antenatal multiple micronutrient supplementation (MMS) has been shown to be more effective than iron-folic acid (IFA) alone in reducing adverse pregnancy and birth outcomes. However, there is a concern that MMS containing 30 mg of iron may be less effective in reducing maternal anemia compared to IFA supplements containing 60 mg of iron. This…
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Acceptability of health-only versus climate-and-health framings in lifestyle-related climate-sensitive health counselling: results of a randomised survey experiment in Germany
BACKGROUND: Climate-sensitive health counselling (CSHC) delivered by health professionals could promote individual patients and planetary health, particularly within lifestyle counselling. However, health professionals’ uncertainty about the acceptability of CSHC remains a barrier to implementation. This study aimed to establish the effects of different topics and framings on patients’ acceptability of lifestyle-related CSHC.
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Surgery versus corticosteroid injection for carpal tunnel syndrome (DISTRICTS): an open-label, multicentre, randomised controlled trial
BACKGROUND: Surgery and corticosteroid injections are established treatments for carpal tunnel syndrome, but the optimal treatment strategy remains unclear. This study aimed to compare starting treatment with surgery versus starting with a corticosteroid injection.
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Evaluating machine learning algorithms for prediction of treatment response for sleep disturbances in patients with schizophrenia: A post-hoc analysis from a randomized controlled trial
CONCLUSIONS: Machine learning models are an emerging trend in clinical research and should be translated into clinical practice. The logistic regression model predicted responders with 90% accuracy.
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Estimating pain visual analogue scale from health assessment questionnaire for rheumatoid arthritis with beta mixture models
To map from the health assessment questionnaire disability index (HAQ) to the pain visual analogue scale (VAS) for people with rheumatoid arthritis. The estimation sample comprised adults with rheumatoid arthritis and inadequate response to tumour necrosis factor-α inhibitors in a multicentre phase 4 randomised controlled trial. Beta mixture models were estimated with combinations of HAQ…
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Therapeutic effects of curcumin and piperine combination in critically ill patients with sepsis: a randomized double-blind controlled trial
CONCLUSION: Curcumin-piperine supplementation over a short period had beneficial effects on some inflammatory and laboratory indices in critically ill patients with sepsis.
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Interleukin-1β in circulating mononuclear cells predicts steatotic liver disease improvement after weight loss in subjects with obesity and prediabetes or type 2 diabetes
CONCLUSION: In patients with obesity with initial impairment of glucose metabolism successful weight loss is associated with a reduction of both IL-1β levels and MASLD degree. Of interest, basal levels of IL-1β predict the extent of MASLD improvement, regardless of the intervention. Our results may set the stage for ad-hoc studies investigating the usefulness of…
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Disease-Modifying, Neuroprotective Effect of N-Acetyl-l-Leucine in Adult and Pediatric Patients With Niemann-Pick Disease Type C
BACKGROUND AND OBJECTIVES: N-acetyl-l-leucine (NALL) has been established to improve the neurologic manifestations of Niemann-Pick disease type C (NPC) after 12 weeks in a placebo-controlled trial. In the open-label extension phase (EP) follow-up, data were obtained after 12 and 18 months to evaluate the long-term effects of NALL for NPC.
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The effects of multimodal cocktail analgesic local injection in postoperative pain control after laminoplasty: A study protocol of a prospective randomized controlled trial
BACKGROUND: Laminoplasty is the most widely used surgical technique for cervical spondylotic myelopathy. This surgery can cause severe postoperative pain; if not controlled, recovery or rehabilitation may be delayed. Therefore, effective control of postoperative pain is crucial. This randomized prospective study aims to evaluate the effects of a multimodal cocktail injection on postoperative pain and…