Clinical Trials
Category Added in a WPeMatico Campaign
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COMPARATIVE EFFICACY OF 200 UNITS VERSUS 155 UNITS OF ONABOTULINUMTOXIN A FOR CHRONIC MIGRAINE
CONCLUSIONS: The study concludes that administering 200 U of OnaBT-A, significantly decreases the frequency and duration of headaches when compared to 155 U. It recommends considering this dosage for patients who do not accomplish adequate relief with 155 U of OnaBT-A. The promising outcomes suggest a need for further studies into long-term effects and evaluation…
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Multidimensional efficacy characterization of xeligekimab in moderate-to-severe plaque psoriasis: regional responses, treatment targets, and patient-reported outcomes from a randomized controlled trial
CONCLUSION: Xeligekimab provides rapid symptom resolution across all clinical dimensions, high and sustained achievement of treatment targets, and comprehensive restoration of quality of life.
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Intensified return to work clinical aftercare for sick-listed employees with diagnosed mental disorders in Germany: effects of a multicentre randomized controlled trial
CONCLUSIONS: On average, RTW-PIA did not significantly improve SRTW or secondary outcomes. Employees without a recognized disability degree, with low social support at work, or with diagnosed recurrent depressive disorders might benefit from RTW-PIA. These hypotheses need to be tested in independent samples. Further research should also focus on the implementation of RTW-PIA.
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Clinical and Inflammatory Benefits of Nebulized Furosemide with Salbutamol-Ipratropium in COPD Exacerbations: A Randomized Controlled Trial
Exacerbations of chronic obstructive pulmonary disease (COPD) are a leading cause of morbidity, mortality, and healthcare burden. While standard bronchodilator therapy alleviates airway obstruction, its efficacy is often limited. This study evaluated nebulized furosemide, which has bronchodilatory and anti-inflammatory effects, as an adjunct to salbutamol-ipratropium in hospitalized COPD patients. Ninety‑two patients with exacerbated COPD were…
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Denecimig (Mim8) prophylaxis over 52 weeks in adolescents and adults with hemophilia A: FRONTIER2 extension study
CONCLUSIONS: Denecimig maintained low ABRs over 52 weeks, was well tolerated, and improved patient-reported outcomes in adolescents and adults with HA with or without inhibitors.
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Does baseline physical function modify the response to a physical activity intervention in adults with arthritis? A secondary analysis of a randomized trial
Responses to physical activity interventions vary among adults with arthritis, and baseline functional limitations may affect increases in walking. To determine whether baseline physical function moderated changes in accelerometer-measured steps/day after a telephone-delivered Walk With Ease (WWE-T) intervention. This secondary analysis included 267 adults from a randomized trial of WWE-T versus wait-list control. Baseline function…
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Wound dehiscence following biportal endoscopic versus microscopic spine surgery for single-level lumbar decompression: a post hoc analysis of two randomized controlled trials
CONCLUSIONS: BESS was associated with significantly lower wound dehiscence rates compared with MSS in patients undergoing single-level lumbar decompression or discectomy. Drainage volume ≥ 100 mL may serve as a clinical indicator for enhanced wound surveillance in MSS patients. These hypothesis-generating findings warrant validation in independent cohorts.
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A secondary analysis of the SODa-BIC randomized clinical trial using multiple hierarchical composite outcomes
CONCLUSION: In this post-hoc analysis of the SODa-BIC trial, the use of hierarchical composite outcomes did not alter the neutral overall interpretation of the original trial. However, this analysis provides additional insight into the relative contribution of individual components of the primary outcome.
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Clinical Characteristics and Factors Associated with One-Year Smoking Cessation Among Smokers with COPD: A Subgroup Analysis of a Multicentre Randomised Trial
CONCLUSION: Immediate referral to a cessation clinic was the factor most strongly associated with one-year abstinence, together with absence of comorbidity and, tentatively, repeated hospitalisation; greater disease severity was associated with quitting only in unadjusted comparisons. These exploratory findings support structured cessation pathways in routine COPD care.
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Emotion-focused therapy in the treatment of prolonged grief disorder: study protocol for a randomized controlled trial
BACKGROUND: Prolonged grief disorder (PGD) impacts various dimensions of the bereaved person’s life, such as psychological, social, and/or health domains. Psychological interventions, particularly those beyond the cognitive-behavioral approach, are essential to address these difficulties. This is especially relevant given that not all interventions are effective for all bereaved individuals, leaving a subset of people without…