Clinical Trials
Category Added in a WPeMatico Campaign
-
Patients’ perceptions on HIV testing and starting antiretroviral therapy during implementation of universal test and treat
CONCLUSIONS: The implementation of UTT in South Africa has provided a supportive framework for people to understand their diagnosis, accept it and adhere to ART in a caring space.
-
Effectiveness of virtual reality exposure therapy in improving body dissatisfaction and shape-related concerns in adolescent girls with anorexia nervosa: a controlled, randomized, superiority trial
BACKGROUND: Anorexia nervosa (AN) involves qualitative and quantitative dietary restrictions, leading to significant weight loss and changes in body shape. Patients with AN are often more concerned about their body image than the general population is. Body dissatisfaction and shape-related concerns (BD-SRC), which are risk factors for relapse, are some of the most difficult AN…
-
Effect of coffee bean chlorogenic acid on peripheral skin temperature and skin blood flow in healthy Japanese women with cold sensitivity: a placebo-controlled, randomized, double-blind, study
CONCLUSION: These results suggest that the ingestion of coffee bean CGA can suppress the decrease in SkT and SkBF in a cold environment.
-
Cost-Effectiveness of Remote Symptom Monitoring During Adjuvant Endocrine Therapy in Breast Cancer
CONCLUSIONS AND RELEVANCE: In this economic evaluation of RPM for women receiving AET, app-only RPM showed lower costs with similar QALY compared with EUC. Its simpler design may also be more readily scalable than the app plus feedback intervention, supporting its potential as a pragmatic, value-based supportive care strategy in oncology.
-
Role of magnesium as a protective agent in cisplatin-induced nephrotoxicity in head and neck cancer
CONCLUSIONS: Mg can serve as a protective agent against CIN, as it reduces renal injury biomarkers, including urinary KIM-1, urinary NGAL, serum sFasL, and serum MDA when incorporated into treatment regimens at different doses, compared to cisplatin alone. Moreover, Mg had a promising role in the improvement of quality of life in cases with HNC…
-
Spatial Acid-Associated Niches Inform Irinotecan-Based DEB-TACE in Colorectal Liver Metastases: A Multicentre Randomized Trial
CONCLUSIONS: Acid-associated spatial organization and drug-response predictions provide a rationale for local irinotecan delivery in CRLM. These findings support further evaluation of UniPearls-based DEB-TACE and prospective biomarker-stratified studies linking niche biology to clinical benefit.
-
A multi-center, single-arm, phase 2 trial of dasatinib in T follicular helper cell lymphomas
T follicular helper cell lymphomas (TFHL) harbor activating T cell receptor (TCR) signaling mutations and epigenetic alterations, such as TET2 mutations. Here, we conduct a multi-center, single-arm, phase 2 trial of the tyrosine kinase inhibitor dasatinib in patients with relapsed/refractory TFHLs (jRCT2031190079). The primary outcome is the overall response rate (ORR) according to CT-based Lugano…
-
Teacher-student-machine interaction autonomous learning: a structured LLM-integrated framework for developing independent clinical reasoning in residency training
CONCLUSIONS: The TSM-AL framework significantly enhanced clinical reasoning competencies that transferred to independent performance, demonstrating that structured LLM integration develops autonomous reasoning rather than fostering technological dependency.
-
Effects of Dual-Task Training With and Without Backward Walking on Balance, Functional Mobility, and Participation in Ambulatory Children With Spastic Diplegic Cerebral Palsy: A Randomized Controlled Trial
CONCLUSIONS: In ambulatory children with spastic diplegic CP (GMFCS Levels I-II), adding BW to DTT was associated with a small additional improvement in functional mobility over 4 weeks (approximately 1 s on the TUG) of uncertain clinical importance, whereas superiority for balance or participation was not demonstrated; the trial was not powered for these secondary…
-
Effect of Preoperative Intranasal Dexmedetomidine on Postoperative Myocardial Injury in Patients Undergoing Coronary Artery Bypass Grafting
CONCLUSION: In this single-center trial, two-dose preoperative intranasal dexmedetomidine was associated with lower postoperative hs-cTnT and CK-MB concentrations, better subjective preoperative sleep quality, and a lower observed incidence of postoperative delirium. These findings are preliminary and require confirmation in larger, adequately powered multicenter randomized trials to determine whether the biomarker reductions translate into clinically meaningful…