Clinical Trials
Category Added in a WPeMatico Campaign
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Effects of combined diet and physical activity on glycemic control and body composition in male recreational athletes with type 2 diabetes mellitus
CONCLUSION: A combined therapeutic diet and physical activity program effectively improved body composition and biochemical parameters in recreational athletes with T2DM. This combined approach could be recommended as an integral strategy for diabetes management in physically active individuals.
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The role of compounded mouthwash with or without acyclovir in managing chemotherapy-induced oral mucositis in cancer patients: a randomized controlled trial
CONCLUSIONS: The incorporation of acyclovir into compounded mouthwash significantly reduced the incidence, severity, and duration of oral mucositis in patients undergoing chemotherapy, indicating its potential for expanded clinical application. Further large-scale studies are warranted to validate these findings and to standardize mouthwash formulations for institutional utilization.
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Efficacy of losartan plus modified FOLFIRINOX versus modified FOLFIRINOX in advanced pancreatic cancers: A randomized clinical trial (AFPAC Study)
CONCLUSIONS: The addition of losartan to mFOLFIRINOX in the AFPAC study did not provide an early signal of efficacy in improving progression-free survival in advanced PDAC. The trial will not proceed to full accrual of phase 3 design.
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Evaluating Group CBT for Depression in Newly Diagnosed Breast Cancer Patients in a Malaysian Public Hospital
CONCLUSION: G-CBT significantly reduced depressive symptoms in newly diagnosed breast cancer patients and the effect of intervention sustains until third month follow-up. These findings emphasize the value of incorporating G-CBT into standard care practices to provide targeted psychological support and improve mental health outcomes in this vulnerable population.
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Effects of scalable, wordless, short, animated storytelling videos on hope in China: a nationwide, single-blind, parallel-group, randomised controlled trial
CONCLUSIONS: While the short, single-exposure SAS videos did not significantly enhance overall hope levels among Chinese adults, the effectiveness of humour in certain subgroups highlights the cultural adaptability of health communication strategies. Given its scalability and accessibility, this approach warrants further research to refine narrative techniques, optimise engagement across diverse populations, and explore its broader…
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Cuff leak test and airway obstruction in mechanically ventilated ICU patients (COSMIC): a pilot feasibility randomized controlled trial protocol
INTRODUCTION: The cuff leak test (CLT) is hypothesised to help optimise extubation by assessing for laryngeal oedema which, if unrecognised and untreated, could lead to post-extubation stridor, post-extubation airway obstruction, and reintubation. However, the diagnostic accuracy of the CLT to detect post-extubation stridor (and hence potentially airway obstruction) remains uncertain. Given the equipoise that exists…
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Cost-Effectiveness of an Interdisciplinary, Internet-Based Transgender Health Care Program in Germany: Economic Evaluation Alongside a Randomized Controlled Trial
CONCLUSIONS: From a societal perspective, i²TransHealth was unlikely to be cost-effective, even at high WTP per additional QALY. However, the comparison of i²TransHealth with a waiting list could have led to a distortion of the results with regard to health care service usage. When considering additional reliable improvement on the BSI-18 GSI as health effect…
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First-in-human phase 1 study of KHK2455 monotherapy and in combination with mogamulizumab in patients with advanced solid tumors
CONCLUSIONS: KHK2455 + mogamulizumab was safe and well tolerated with manageable toxicities, and resulted in dose-dependent suppression of IDO1 activity; signals of antitumor activity were observed.
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An examination of imaging findings in patients with clinically diagnosed gluteal tendinopathy: a secondary analysis of a randomised clinical trial
CONCLUSION: In a clinical trial of people with GT, a substantial number of participants had multiple tendons affected, as well as concomitant tendon tears and calcification. MRI detected changes were not associated with levels of pain, function or disability.
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A Resilience-Disclosure Intervention for Managing Stigmatised North Korean Refugee Identity: A Quasi-Randomised Controlled Trial
North Korean refugee (NKR) undergraduate students in South Korean universities often conceal their NKR identity to mitigate discrimination, a strategy that can impede social connection and access to vital resources for college adjustment. This study evaluates the effectiveness of a resilience-disclosure intervention designed to encourage strategic identity management over complete concealment. In a quasi-randomised controlled…