Clinical Trials
Category Added in a WPeMatico Campaign
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Does order matter? Evaluating the impact of binocular vision test sequence
CONCLUSIONS: The sequence of testing of associated and dissociated techniques did not influence outcomes. Additionally, when the testing sequence was kept consistent between the first and third study visits, there were no statistically significant differences in accommodative and vergence function measures obtained with investigated methods. The generally high variability of some measurements across sessions suggests…
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Effects of Self-Compassion and Mindfulness Interventions on Mental Health and Work-Related Outcomes Among Japanese Workers: Randomized Controlled Trial
CONCLUSIONS: This low-intensity, fully self-guided, smartphone-based meditation program demonstrated good feasibility, as reflected by high adherence and relatively low attrition. Between-group effects were limited; therefore, the findings should be interpreted as preliminary and do not support strong causal claims of intervention superiority. Clinical significance remains unclear in this nonclinical sample and should be evaluated in…
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Integrating Large Language Models Into Trauma Education for Medical Students: Randomized Controlled Pilot Trial
CONCLUSIONS: While students appreciated the inclusion of artificial intelligence (AI), unstructured LLM use did not improve performance and may have disrupted the group reasoning. The use of non-English prompting likely contributed to lower AI performance, underscoring the importance of language alignment in LLM applications. This pilot study highlights the need for structured AI integration and…
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Cold-Water Immersion Impairs Power Earlier than Strength Through Time-Dependent Reductions in Intramuscular Temperature in Human Dorsiflexor Muscles
CONCLUSIONS: These results highlight that peak power is more sensitive to reductions in intramuscular temperature than maximal isometric strength, reflecting a time- and temperature-dependent effect on skeletal muscle function.
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A Novel Approach of Intraneural Facilitation Versus Standard Physical Therapy for the Prevention of Chemotherapy-Induced Peripheral Neuropathy: A Randomized Controlled Trial
This study compared Intraneural Facilitation (INF^(®)) therapy and standard physical therapy (PT) in preventing chemotherapy-induced peripheral neuropathy (CIPN) in women with newly diagnosed breast and gynecologic cancer. Thirty-eight women undergoing platinum and/or taxane-based chemotherapy, without prior peripheral neuropathy, were randomized into INF^(®) therapy (n = 20) and PT (n = 18). Treatments lasted 45 minutes,…
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The breath and mind connection in young people with post-COVID syndrome: feasibility and acceptability of a pilot randomised co-designed intervention
Post-COVID syndrome is widely recognised in children and young people (CYP), where one or more persistent physical symptoms are present 12 weeks after the initial infection that cannot be explained by an alternative cause. We aimed to assess whether an intervention based on narrative therapy and breathing pattern retraining, co-designed with CYP with PCS (12-18…
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Cost-effectiveness of levonorgestrel intrauterine system versus hysteroscopic niche resection for caesarean scar-related spotting in China: an economic evaluation alongside a randomised controlled trial
CONCLUSIONS: LNG-IUS is highly cost-effective compared with HNR for the treatment of niche-related postmenstrual spotting at 6 months. These findings support LNG-IUS as first-line therapy for niche-related spotting in women with a residual myometrium ≥2.2 mm.
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Helping primary care providers recognize and respond to medication non-adherence and drug-drug interactions: A randomized-controlled clinical utility trial in a value-based care setting
CONCLUSION: Primary care providers with results from a definitive saliva-based test for MNA and DDI were significantly more likely to identify those common challenges and make appropriate updates to the patient’s treatment plan. This has important implications for improving quality and value, especially for the millions of patients with chronic conditions on multiple medications.
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Position-Guided Nasopharyngeal Irrigation for Post-Radiotherapy Ulcer Care in Nasopharyngeal Carcinoma
To describe and standardize a position-guided nasopharyngeal irrigation protocol for post-radiotherapy nasopharyngeal ulceration (RINU) in patients with nasopharyngeal carcinoma (NPC), a prospective comparative clinical setting was used among 184 patients diagnosed with RINU between January and March 2025. Participants were randomly assigned to receive either routine manual irrigation (n = 92) or irrigation using an…
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Does postoperative drainage influence early pain after total knee arthroplasty? A randomized comparative study
BackgroundThe routine use of postoperative drainage after total knee arthroplasty (TKA) remains controversial, particularly in the era of modern blood-saving strategies. While drains have traditionally been used to reduce hematoma formation, their effect on early postoperative pain has not been clearly established. This study aimed to evaluate whether postoperative drainage influences early pain outcomes following…