Clinical Trials
Category Added in a WPeMatico Campaign
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Changes in ectopic lipids, insulin sensitivity, and beta cell function after a low-fat vegan diet in adults with type 2 diabetes: a 16-week single-arm clinical trial
CONCLUSIONS: On an ad libitum low-fat plant-based (vegan) dietary intervention, the participants with type 2 diabetes experienced reductions in ectopic fat, particularly visceral and hepatocellular fat, improvements in insulin sensitivity, reductions in AGEs, and improvements in beta-cell function.
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Effect of amaranth flatbread on maternal anthropometry during pregnancy: Evidence from a cluster-randomized controlled trial in Southern Ethiopia
CONCLUSIONS: Daily consumption of amaranth grain flatbread significantly improved maternal anthropometric indicators, suggesting its potential as a sustainable nutritional intervention to enhance maternal nutritional status in resource-limited settings. These findings support integration of nutrient-rich traditional foods into maternal dietary programs.
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Microperimetry Sensitivity Changes at the Functional Transition Zone and at the EZ Margins in X-Linked Retinitis Pigmentosa Treated With Gene Therapy
CONCLUSIONS: High-dose AAV-RPGR gene therapy was associated with improved MP outcomes and greater ATE inside FTZ and intact EZ; however, loci with ≥7 dB improvement did not correlate with baseline EZ margin distance, highlighting challenges in prespecifying localized ≥7 dB changes.
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The Effect of Cerebellar tDCS On Inhibitory Control in Healthy Adults: Exploring Trait Moderation
Transcranial direct current stimulation (tDCS) research on inhibitory control (IC) has largely focused on prefrontal targets, with inconsistent results, while the cerebellum’s contribution to executive control networks remains underexplored. This study examines whether cerebellar anodal tDCS modulates IC in healthy adults, using both proactive (Go/No-Go) and reactive (Stop Signal) inhibition measures, and explores whether dispositional…
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Immunohistochemistry for c-MET, HLA class II, and CD68 does not show prognostic value in early-stage classic Hodgkin lymphoma patients in the EORTC-GELA H9 intergroup randomised trial
CONCLUSIONS: Using a rigorous statistical approach, we found that none of the three candidate biomarkers correlated with patient outcomes. While this lack of validation may be explained by trial-specific factors, such as risk-adapted treatment, the exclusion of advanced-stage patients, or challenges in scoring, these biomarkers provide insufficient prognostic value for implementation in clinical practice.
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Selecting optimized behavioral interventions from an optimization randomized controlled trial on increasing COVID-19 testing for African American/Black and Latino frontline essential workers not up-to-date on COVID-19 vaccination
CONCLUSIONS: The optimized intervention we identified based on empirical data from the NCAP optimization RCT shows potential to effectively increase the COVID-19 testing rate among AABL frontline essential workers who are not up to date on COVID-19 vaccination. Our demonstration of missing data strategies under the DAIVE framework offers meaningful practical guidance for behavioral medicine…
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Physical activity, weight, and cardiovascular risk factors after lifestyle behavioral weight loss treatment for binge-eating disorder
CONCLUSIONS: Lifestyle behavioral weight loss treatment for BED with obesity was associated with increased physical activity sustained through 12-month follow-up. Increased and moderate/active physical activity levels were associated with weight loss and improved eating-disorder psychopathology, but not cardiovascular disease risk factor outcomes/changes, which were associated with weight loss.
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Psychosocial mediators for the impact of personal genomic risk information on melanoma prevention and early detection behaviors
CONCLUSIONS AND RELEVANCE: The effectiveness of precision prevention and early detection interventions may be enhanced by targeting key psychosocial mediators through tailored communication of personal melanoma risk.
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Optogenetic Therapy for Restoring Aspects of Visual Function
CONCLUSIONS: Within the limits of this small study, intravitreal administration of a ChrimsonR-expressing AAV vector targeting retinal ganglion cells combined with use of light-stimulating goggles was safe. Additional research is needed to further assess safety and efficacy. (Funded by GenSight Biologics; PIONEER ClinicalTrials.gov number, NCT03326336.).
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The Role of Biofeedback in Improving Vertigo Management in Older Adults. A Controlled Clinical Study in Italy
CONCLUSION: Despite these promising results, future research should delve deeper into the underlying mechanisms of vertigo in older persons, examining psychological factors and exploring potential correlations with other common comorbidities in this population, such as cardiovascular issues and cognitive decline. Understanding these interconnections will be crucial for developing more comprehensive and effective treatment strategies for…