Clinical Trials
Category Added in a WPeMatico Campaign
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The Effect of Counseling Based on Watson’s Human Caring Theory (HCT) on Reproductive Concerns in Women Diagnosed With Cancer: A Randomized Controlled Trial
CONCLUSIONS: In this single-centre trial, counseling based on Watson’s Human Caring Theory was associated with lower reproductive concerns in women diagnosed with cancer. Although satisfaction scores in the intervention group were uniformly high, this outcome should be interpreted with caution given the ceiling effect and the limited discriminative capacity of the measure. These preliminary findings…
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Impact of rapid pathogen detection in ICU patients with suspected pneumonia on antimicrobial therapy: randomized, controlled open-label feasibility trial (IRISPAT-1)
CONCLUSION: Rapid mPCR with high adherence to antibiotic algorithms shortened time to appropriate antibiotics compared to standard care in mechanically ventilated patients with suspected pneumonia.
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Home Blood Pressure-Guided Lifestyle Intervention for Elevated Blood Pressure Detected at Workplace Health Checkups: A Randomized Pilot Trial
CONCLUSIONS: Home BP-guided lifestyle counseling may improve management of elevated BP detected at workplace health checkups.
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Clinical efficacy of warm acupuncture on wind-cold-dampness rheumatoid arthritis
CONCLUSION: Warm acupuncture, when used as an adjunct therapy, effectively ameliorates symptoms, alleviates pain, mitigates inflammatory responses, enhances quality of life, and exhibits a high safety profile in the treatment of RA.
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Eight-week omega-3 polyunsaturated fatty acid supplementation alters but does not attenuate exercise-induced muscle damage in older adults: a randomised controlled trial
CONCLUSION: n-3 PUFA supplementation did not improve functional recovery, but different molecular response patterns were observed. Habitual physical activity and sex may be determinants of post-exercise response; this exploratory finding warrants confirmation in larger studies.
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Effects of intradermal lymphocyte therapy in patients with recurrent pregnancy loss: secondary analysis of a randomized controlled trial investigating purinergic signaling, inflammation, and cellular energy status
CONCLUSION: Low-dose ILT may be associated with improved successful pregnancy and live birth rates in RPL patients. These clinical outcomes coincided with changes in purinergic signaling, inflammatory cytokines, and cellular energy status; however, formal mediation cannot be inferred from the present analysis.
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LEgal Guidance for Cancer Patients and CAREgivers (LEGACY CARE): A Pilot Clinical Trial
CONCLUSIONS: Proactive legal care for recently diagnosed patient-caregiver dyads was feasible and acceptable, and identified and addressed HHLNs. However, caregiver-inclusive medical-legal partnership models may require caregiver-specific intake, longitudinal follow-up, and clearer distinction between patient, caregiver, and shared needs.
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In-the-Bag Stability of a New Hydrophilic Acrylic Toric Intraocular Lens
CONCLUSIONS: Although mean absolute tilt and decentration values were low, in some cases, a pronounced tilt and posterior axial hyperopic shift occurred. Excessive anterior fibrosis development was responsible for these changes.
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Therapeutic plasma exchange improves survival in alcohol-related acute-on-chronic liver failure: a randomized controlled trial
CONCLUSION: PLEX improves short-term survival and disease severity in A-ACLF and may be a valuable therapeutic option where transplantation is limited.
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Establishment of reference ranges for disturbance coefficient (DC) and edema coefficient (EC) in neonates: a non-invasive cerebral edema monitoring study
CONCLUSIONS: In neonates over 36 weeks, DC significantly increased from 0-1 day to 1-2 and 2-3 days after birth, while EC decreased. DC showed a positive correlation with head circumference, weight, and body length, while EC exhibited a negative correlation. DC and EC were not affected by sex, mode of delivery, and gestational age.