Clinical Trials
Category Added in a WPeMatico Campaign
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Azathioprine for the treatment of early Parkinson’s disease (AZA-PD): a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial
BACKGROUND: The immune system is implicated in Parkinson’s disease aetiology and prognosis. Although there are effective symptomatic treatments for Parkinson’s disease, there are currently no therapies that slow down disease progression. We aimed to investigate the clinical efficacy of the broadly acting peripheral immunosuppressant drug azathioprine for patients with early Parkinson’s disease.
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Getting to Implementation: applying data-driven implementation strategies to improve guideline concordant surveillance for hepatocellular carcinoma
CONCLUSIONS: GTI sustainably improved HCC surveillance, suggesting that applying data-driven implementation strategies within a manualized facilitation approach can improve care.
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Enhanced patient counselling and SMS reminder messages to improve access to community-based eye care services in Meru, Kenya: an embedded, pragmatic, individual-level, randomised, controlled, adaptive platform trial
BACKGROUND: In Meru county, Kenya, only 46% of people identified with an eye problem during screening go on to access eye care services at local clinics, with younger adults (aged 18-44 years) being the least likely to receive eye care. This study aimed to test whether provision of additional information was associated with better access…
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Monotherapy vs. combination paracetamol and tramadol for cancer-related pain in the emergency department: a comparative study
CONCLUSION: The co-administration of paracetamol and tramadol intravenously resulted in superior and sustained analgesia when compared with monotherapy, without an increase in adverse effects. These findings provide support for the utilization of this combination as a safe and effective multimodal strategy in the acute management of cancer-related pain in the emergency department.
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Efficacy of a bioflavonoid-enriched herbal versus 0.12% and 0.2% chlorhexidine mouthwashes in reducing peri-implant inflammation and subgingival Porphyromonas gingivalis carriage in patients with peri-implantitis
CONCLUSION: Prescription of a bioflavonoid-enriched herbal mouthwash following MD is more effective in reducing peri-implant inflammation and subgingival P. gingivalis compared with 0.12% and 0.2% CHX rinses.
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Assessing the Feasibility and Acceptability of a Colorectal Cancer Risk Prediction Tool in Primary Care to Increase Screening Uptake in Singapore: A Multi-Methods Pilot Study
CONCLUSION: Risk stratification of CRC using a RPT showed increased screening uptake. Future research is needed to understand which components of this complex intervention worked to bring about improved outcomes.
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Analysing concordance between MUAC, MUACZ, and WHZ in diagnosing acute malnutrition among children under five in Somalia
CONCLUSIONS: Poor concordance between MUAC and WHZ should prompt review of wasting measurement guidelines for this population. Stratified analyses and regression modelling showed increased MUAC with age among CU5. MUACZ or age-specific MUAC thresholds may identify more truly wasted children, improving coverage of treatment interventions. Policymakers should examine how adapting screening guidelines impacts health facilities…
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BC05 Efficacy and safety of 755-nm picosecond alexandrite laser with topical tranexamic acid vs. laser monotherapy for melasma and facial rejuvenation: a multicentre, randomized, double-blinded, split-face study
The aim of this study was to compare the efficacy and safety of 755-nm picosecond alexandrite laser and topical tranexamic acid (TTA) combination therapy vs. laser monotherapy, for the treatment of melasma and facial rejuvenation. This multicentre, randomized, double-blinded, split-face study enrolled 37 patients who presented with melasma and photoageing. Facial halves were randomized to…
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P072 Improvement across work productivity and quality of life with remibrutinib treatment in patients with chronic spontaneous urticaria in the REMIX-1/2 trials
Remibrutinib, an oral, highly selective Bruton tyrosine kinase inhibitor, has shown efficacy and favourable safety in the REMIX-1/2 studies in patients with chronic spontaneous urticaria (CSU). Herein, we report the impact of remibrutinib treatment on Work Productivity and Activity Impairment (WPAI) and Dermatology Life Quality Index (DLQI) outcomes. REMIX-1 and REMIX-2 were identical, phase III,…
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O12 Does frequency of bathing impact eczema symptoms? Results of the first Rapid Eczema Trials project randomized controlled trial
The aim of this study was to test whether a weekly bath or shower improves eczema symptoms compared with a daily bath or shower for people with eczema. This was an online, pragmatic, superiority randomized controlled trial, codesigned by people with eczema (citizen scientists), healthcare professionals and researchers. The Eczema Bathing Study is the first…