Clinical Trials
Category Added in a WPeMatico Campaign
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A study on Mahjong intervention to improve cognitive impairment in patients with schizophrenia: a pilot, single-blind, randomized, controlled trial
CONCLUSION: While this exploratory study suggests that Mahjong intervention may benefit certain cognitive functions and quality of life in patients with schizophrenia, these findings should be interpreted with caution. Further research with larger, more diverse samples and longer intervention is necessary to confirm and extend these findings.
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Motivational Framing Strategies in Health Care Information Security Training: Randomized Controlled Trial
CONCLUSIONS: This study underscores the importance of aligning SETA programs with the professional values of target groups, in addition to adapting these programs to specific contexts of professional action. In the investigated hospital setting, a motivational framing that resonates with health care professionals’ sense of responsibility for patient safety has proven to be effective in…
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Low-Molecular-Weight Heparin Plus Insulin in Hypertriglyceridemic Acute Pancreatitis: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, the combination of LMWH and insulin failed to demonstrate superior efficacy vs insulin alone in patients with hypertriglyceridemic acute pancreatitis. LMWH might not be necessary for early lipid-lowering in hypertriglyceridemic acute pancreatitis.
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Impact of anchoring bias in medical diagnostic decision-making: an experimental study
CONCLUSIONS: The findings highlight the importance of addressing cognitive biases -particularly anchoring bias- in medical training to improve diagnostic accuracy and reduce clinical errors.
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Dupilumab efficacy by disease severity in pediatric type 2 asthma
CONCLUSION: Long-term dupilumab treatment reduced exacerbation rates and improved lung function and asthma control in children with type 2 asthma irrespective of disease severity, with numerically greater improvements in children with severe asthma.
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Endolysin significantly improves symptoms with atopic dermatitis: bridging the gap from research to clinical practice
CONCLUSIONS: Topical endolysin gel is a well-tolerated, effective, and promising agent for the treatment and proactive maintenance of mild-to-moderate AD in adults.
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Comparative efficacy and safety of topical caspofungin 0.5% and voriconazole 1% for fungal keratitis: a pilot clinical trial
To compare the efficacy of topical caspofungin 0.5% with topical voriconazole 1% in patients with fungal keratitis. In this pilot clinical trial, thirty-four eyes from 34 patients diagnosed with fungal keratitis, confirmed by positive smear or culture results or in vivo confocal microscopy (IVCM), were included in the study. Patients were randomized to receive either…
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Testing two digital stress-management interventions in a randomized controlled trial of breast cancer patients
The digital stress-management intervention StressProffen has been shown to be associated with improved well-being and quality of life for cancer survivors. In the Coping After Breast Cancer (CABC) trial, effects of 6 months’ access to modified versions of StressProffen, delivered through a digital download-only model, were examined. Women with breast cancer were invited to participate…
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Impact of early FAST ultrasound on severe trauma outcomes: a randomized trial in a low-resource African emergency setting (The ALIFAST Trial)
CONCLUSION: Early use of FAST significantly reduced mortality, CT use, and surgical delays. These findings support guideline recommendations for integrating FAST into trauma triage protocols, particularly in LMICs.
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Randomized target engagement trial of a dissonance-based transdiagnostic eating disorder treatment versus transdiagnostic interpersonal psychotherapy
CONCLUSIONS: Results provide further evidence of target engagement for BPT and suggest that it is more effective than IPT in treating a range of eating disorders.