Clinical Trials
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Anabolic Effects of Salbutamol Are Lost Upon Immobilization
CONCLUSIONS: Salbutamol increases muscle mass and glucose uptake, although these effects are limited to active but not inactive muscles. This demonstrates that the mechanism of action and efficacy of β2-adrenoreceptor signalling are hampered upon immobilization, which offers potential for a combined treatment intervention of reintroducing muscle contraction and salbutamol administration to improve muscle mass and…
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Ethical issues in a cluster randomised controlled trial for evaluating effectiveness of screening for breast cancer by clinical breast examination in India
This article discusses issues of ethical concern in the conduct of a prospective, cluster randomised controlled trial for evaluating effectiveness of screening by clinical breast examination for downstaging of breast cancer, and in reducing mortality from the disease, in comparison to no screening. This trial was conducted in Mumbai, India, over 20 years, from May…
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A Randomized Controlled Trial Comparing Time for Tracheal and Pleural Ultrasonographic Confirmation of the Correct Placement of the Endotracheal Tube in Overweight and Obese Patients
CONCLUSION: Tracheal USG provides a faster confirmation of endotracheal intubation than pleural USG in overweight and obese patients. Pleural USG has the added advantage of diagnosing endobronchial intubation.
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Effect of low-concentration at-home bleaching gels on whitening and tooth sensitivity: a split mouth randomized clinical trial
CONCLUSIONS: Both products effectively whitened teeth while inducing mild tooth sensitivity, and both had a positive socio-psychological impact. The 3% HP gel provided a bleaching efficacy advantage, while the 8% CP gel demonstrated lower sensitivity and less enamel alteration.
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Virtual reality and hypnosis for symptom alleviation before bone marrow procedure
Bone marrow aspiration biopsy (BMAB) commonly causes anxiety in patients, negatively affecting their overall procedural experience. We aimed to evaluate the efficacy of hypnosis and virtual reality (VR) compared to standard-of-care in improving concerns of patients undergoing BMAB. In this exploratory open-label randomized-controlled trial, adult patients undergoing BMAB were randomly assigned to hypnosis, VR, or…
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Olaparib, durvalumab, and cyclophosphamide, and a prognostic blood signature in platinum-sensitive ovarian cancer: the randomized phase 2 SOLACE2 trial
SOLACE2 (ACTRN12618000686202) investigates whether 12-weeks of olaparib, or cyclophosphamide-olaparib priming, improves subsequent durvalumab-olaparib progression-free survival (PFS), and is superior to olaparib monotherapy without any priming, in platinum-sensitive recurrent ovarian cancer (n = 114). We also evaluate the utility of CUP-CC assay, an immune signature of C-C chemokine receptor type 4 up-regulation, chemokines, and cytokines. Priming…
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Safety of Using Risk Stratification Along With High-Sensitivity Cardiac Troponin in the Emergency Department: A Secondary Analysis
CONCLUSIONS: Risk stratification with high-sensitivity cardiac troponin reduced length of stay and increased discharge from the emergency department in both low- and intermediate-risk patients with suspected acute coronary syndrome. Patients discharged from the emergency department were at lower risk of subsequent myocardial infarction or cardiac death at 1 year. (High-Sensitivity Cardiac Troponin on Presentation to…
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Long-term safety and efficacy of upadacitinib in Japanese patients with rheumatoid arthritis and inadequate response to conventional synthetic disease-modifying antirheumatic drugs: 5-year results from the SELECT-SUNRISE randomised controlled trial
CONCLUSIONS: Upadacitinib showed sustained efficacy with no new safety signals identified through 5 years of treatment and is a long-term treatment option for Japanese patients with rheumatoid arthritis and csDMARDs-IR.
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Clinical trial of feasibility for mindfulness intervention for patients with newly diagnosed high grade glioma
CONCLUSIONS: Mindfulness intervention during active treatment for patients with high grade glioma is feasible. Given these results, a larger study has the potential to benefit patients with high grade glioma on active treatment.
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Does social media promotion influence citation counts? A long-term follow-up to a randomised trial in a general neurosurgical journal
Social media promotion has become mainstream for neurosurgical publications. Any effect of promotion on citation counts would significantly influence academia and is currently not well-studied. We previously reported that structured social media promotion of neurosurgical articles had no significant effect on citation counts, website visits, or PDF downloads at one- and two-years post promotion. In…