Clinical Trials
Category Added in a WPeMatico Campaign
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Good Outcome Following Attempted Resuscitation Score and Clinical Frailty Scale for Estimating Long-Term Mortality: An Ancillary Study of the CLEAR Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this ancillary study of the CLEAR trial, the GO-FAR score and CFS effectively estimated long-term all-cause mortality, particularly when combined with the CCI. These tools may help clinical decision-making, resource allocation, and advanced care planning in aging, multimorbid patient populations.
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Health Care Professional Willingness to Treat Opioid Use Disorder vs Type 2 Diabetes in Primary Care
CONCLUSIONS AND RELEVANCE: These findings suggest that PCPs have positive attitudes toward treating OUD yet more willingness to treat type 2 diabetes in primary care. Future implementation studies are needed to support MOUD prescribing in primary care.
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Colorectal Cancer and Advanced Adenoma after Single CT Colonography or Biennial FIT Screening in the SAVE Randomized Controlled Trial
Background A 5-year screening interval for CT colonography (CTC) and a 2-year screening interval for fecal immunochemical tests (FITs) have been recommended on the basis of the natural history of colorectal cancer (CRC). Purpose To assess whether the recommended 5-year interval for screening CTC is appropriate and whether CTC is associated with earlier diagnosis relative…
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Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke
CONCLUSIONS AND RELEVANCE: In this cohort study of patients with AIS treated with intravenous thrombolysis, brain frailty markers-particularly white matter changes, cortical atrophy, and total brain frailty-were associated with worse outcomes. Consideration of these neuroimaging markers may better inform clinicians and patients about treatment expectations from thrombolytic therapy.
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Comparison of cheese with and without Propionibacterium freudenreichii subsp. shermanii LMGT 2951 on off-season muscle strength and VO(2) max development in Nordic skiers: a randomized clinical trial
CONCLUSION: Both Jarlsberg cheese, characterized by its unique Propionibacterium freudenreichii content, and Norvegia cheese, when combined with off-season training, led to increases in LBM, VO₂ max, and MS, with no significant differences observed between groups. However, there was a trend toward greater improvements in MS in the Jarlsberg group. Overall, increases in LBM through structured…
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Prevalence and predictors of nonceliac wheat sensitivity in refractory irritable bowel syndrome and functional dyspepsia: results from a randomized double-blind placebo-controlled study
CONCLUSION: Approximately one-fifth of the patients with refractory IBS/FD fulfill the NCWS criteria. Therefore, screening for NCWS in patients with refractory IBS or FD is extremely important to limit unnecessary pharmacotherapy and enhance patient outcomes.
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Neoadjuvant therapy with eribulin, doxorubicin and cyclophosphamide for patients with HER2-negative inflammatory breast cancer: a phase II study
CONCLUSIONS: Despite the low pCR rate, all patients were able to undergo curative surgery, and long-term outcomes were encouraging with 5-year EFS 85.6%. Decreases in tumor vascularization with treatment were detected by DCE-MRI parameters irrespective of initial chemotherapy received. Adipogenesis/fatty acid metabolism and cells associated with immunosuppression are potential mechanisms of resistance and targets for…
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Application of Meridian flow injection acupoint application combined with transcutaneous electrical acupoint stimulation in patients undergoing gastroenteroscopy
CONCLUSION: The combination of percutaneous acupoint electrical stimulation in gastroscopy patients has been demonstrated to be both highly safe and effective. The benefits of this approach include the promotion of postoperative gastrointestinal function, the reduction of stress response, the attainment of optimal results, and the enhancement of patient satisfaction.
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Effects of topical ozonated olive oil on lipid profile, quality of life, wound healing and glycemic control in patients with diabetic foot ulcers: a randomized controlled trial
CONCLUSION: Topical ozonated olive oil significantly enhances wound healing, quality of life, glycemic control, and reduces inflammation in DFU patients. Its affordability and efficacy make it a promising adjunctive therapy. Further studies should explore long-term effects and mechanisms. It offers a scalable solution for DFU management.
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Application of colonoscopic auxiliary devices in reducing the polyp miss rate: a prospective randomized controlled study
CONCLUSION: The use of auxiliary devices in colonoscopy significantly improves the PDR, espicialy no-adnoma or smaller polyp, and reduces treatment times compared to standard colonoscopy.