Clinical Trials
Category Added in a WPeMatico Campaign
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Effect of probiotics derivatives (postbiotics and metabiotics) on glycemic control in individuals with type 2 diabetes: a randomized clinical trial (DELI_Diab study)
CONCLUSIONS: Three-month supplementation with L. rhamnosus DV lysate significantly improves glycemic control (HbA1c) and reduces waist circumference compared to placebo in T2D patients. While positive trends in insulin sensitivity and anthropometrics were observed, further large-scale studies are required to confirm these metabolic benefits and assess long-term sustainability.
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Clinical efficacy of Fufang Zaofan Pills and their immunomodulatory effects on peripheral blood dendritic cells in individuals with lower-risk myelodysplastic syndrome
The aim of this study is to evaluate the clinical efficacy of Fufang Zaofan Pills in individuals diagnosed with lower-risk myelodysplastic syndrome (MDS) and to assess associated changes in peripheral blood dendritic cell (DC) levels. A cohort of 60 individuals with newly diagnosed lower-risk MDS were enrolled at the Department of Hematology, Jiading Central Hospital,…
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Efficacy and Tolerability of a Triple Acid-Containing Serum Combined With 0.1% Adapalene in Mild-to-Moderate Acne Vulgaris: A Randomized, Open-Label Controlled Trial
CONCLUSION: TAS in combination with AG was shown to improve mild-to-moderate acne with good tolerability and may effectively reduce the recurrence rate when applied as a maintenance treatment post-AG.
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Effect of strict oral hygiene on self-rated halitosis and quality of life in patients with periodontitis: a secondary randomized controlled trial analysis
This single-blind, randomized clinical trial evaluated the impact of a strict oral hygiene (OH) phase on self-reported halitosis and quality of life (QoL) in patients with periodontitis. This study reports a secondary analysis of a single-blind randomized controlled trial (parallel, 1:1), registered at RBR-5jmx32v. The study included 24 individuals diagnosed with periodontitis who were randomly…
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Nutritional intervention with a partially hydrolyzed formula during the first 6 months of life may reduce the risk of food allergy and atopic dermatitis up to the age of 5 years
CONCLUSION: In non-exclusively breastfed infants at high-risk for allergy, mixed-feeding with a specific whey-based pHF during the first 6 months of life may reduce the risk of atopic dermatitis and food allergy from birth up to the age of 5 years. However, further A.R.T. follow-ups and other longitudinal studies with larger sample size are needed…
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Randomized Controlled Trial on the Effects of Metacognitive Training (MCT) in a Sample of Patients With Recent Onset Psychosis: Study of the Impact on the Severity and Dimensions of Delusions, Self-Esteem and Depression
CONCLUSIONS: In recent-onset psychosis patients, MCT demonstrated the expected benefits in conviction, as ‘sowing seeds of doubt’ is the core MCT mechanism of change. Despite functioning differently, both interventions improved patients’ self-esteem. No superiority of MCT was discovered in self-esteem or depression in the short-term follow-up studied.
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Probiotics for chronic constipation: A randomized, prospective, placebo-controlled study
CONCLUSION: GutBio Plus is a safe and effective treatment for chronic constipation, offering significant symptom relief and an improved quality of life. The sustained benefits highlight its potential as a reliable alternative to conventional laxatives.
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Feasibility, acceptability and efficacy of a nurse-led palliative care health coaching intervention (Educate, Nurture, Advise before Life Ends) for patients with heart failure and their caregivers in Singapore: a randomised wait-list controlled pilot study of health coaching in Asian heart failure
CONCLUSIONS: Proportion of participants who completed health coaching was high, though proportion of approached participants who consented was lower than expected. Our acceptability and efficacy targets were met. Further phase III testing is planned.
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Effects of music-based occupational therapy activities on attention executive functions in children with attention deficit and hyperactivity disorder
CONCLUSION: Overall, music-based occupational therapy activities demonstrated positive effects on attention levels, executive functions, and caregiver burden in children with ADHD. Future studies are encouraged to incorporate a broader range of musical instruments into occupational therapy intervention plans, aligned with specific therapeutic goals. It is considered important for therapists to develop strategies that tailor the…
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Effect of Subanesthetic Doses of Esketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy: A Randomized Clinical Trial
CONCLUSION: Perioperative subanesthetic esketamine may provide modest improvement in early postoperative pain sensitivity, and may serve as a useful adjunct in multimodal postoperative analgesia for emergency laparoscopic salpingectomy.