Clinical Trials
Category Added in a WPeMatico Campaign
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Clinical Characteristics and Factors Associated with One-Year Smoking Cessation Among Smokers with COPD: A Subgroup Analysis of a Multicentre Randomised Trial
CONCLUSION: Immediate referral to a cessation clinic was the factor most strongly associated with one-year abstinence, together with absence of comorbidity and, tentatively, repeated hospitalisation; greater disease severity was associated with quitting only in unadjusted comparisons. These exploratory findings support structured cessation pathways in routine COPD care.
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Emotion-focused therapy in the treatment of prolonged grief disorder: study protocol for a randomized controlled trial
BACKGROUND: Prolonged grief disorder (PGD) impacts various dimensions of the bereaved person’s life, such as psychological, social, and/or health domains. Psychological interventions, particularly those beyond the cognitive-behavioral approach, are essential to address these difficulties. This is especially relevant given that not all interventions are effective for all bereaved individuals, leaving a subset of people without…
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Effectiveness of psychosocial counselling on treatment adherence among patients with a new tuberculosis diagnosis in primary care: a study protocol for a cluster-randomised controlled trial
INTRODUCTION: Newly diagnosed tuberculosis (TB) patients frequently experience psychological distress, stigma, and concerns regarding treatment duration, side effects and social consequences, which may negatively affect adherence. Psychosocial counselling has been proposed as a patient-centred strategy to address these challenges; however, evidence regarding its effectiveness among newly diagnosed TB patients in primary care settings remains limited.…
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The effects of therapeutic play on angiography procedures in children: a randomised controlled trial
CONCLUSIONS: Our study found that therapeutic play programmes can reduce pain, fear and anxiety in children. These findings demonstrate that negative experiences during invasive procedures affect children not only physiologically, but also psychologically and behaviourally. Therapeutic play can therefore be a powerful supportive intervention. Therefore, we recommend integrating therapeutic play into nursing clinical guidelines and…
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Implementing a medical opinion leader-led management model to promote timely treatment initiation among screen-positive patients with upper gastrointestinal cancer in rural China: a cluster randomised controlled trial protocol
INTRODUCTION: Upper gastrointestinal cancer (UGC), including oesophageal and gastric cancers, imposes a substantial health burden, particularly in China. Timely treatment after a positive screening result is critical, as treatment delays may contribute to disease progression and poorer outcomes. This study aims to evaluate the effectiveness of a management model led by medical opinion leaders (MOLs)…
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Intermittent fasting versus continuous calorie energy reduction in prostate cancer patients on active surveillance
CONCLUSIONS: Our study provides evidence for our interventions’ feasibility and preliminary efficacy signals for clinically meaningful weight loss in PCa patients on AS. Future studies examining weight loss’ impact on PCa progression and related biomarkers are needed.
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Clinical outcomes of hyaluronic acid-sorbitol injection in athletes with patellofemoral pain: Evaluation of the potential influence of body mass index
CONCLUSION: Athletes with PFP, including those with elevated BMI, showed consistent improvement in knee function and symptoms over 6 months following hyaluronic acid-sorbitol injection. These findings support intra-articular hyaluronic acid-sorbitol as a feasible, well-tolerated option for athletes with PFP, regardless of body weight. Controlled trials are needed to confirm the treatment’s contribution, given the single-arm…
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Skills Training in Affective Recovery Video and Text Programs for Recent Sexual Assault Survivors: A Pilot Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this preliminary randomized clinical study for recent SA survivors, the video program was associated with immediate reductions in acute stress and pain; the text program was associated with reductions in week 4 pain. These results suggest that the study’s video and text programs were easy-to-administer interventions that can be used in…
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Mediation Analysis of Urine Osmolality and Response to Tolvaptan in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Assessment
CONCLUSION: This study supported short-term change in Uosm as a predictive biomarker of longer-term kidney function in a non-Japanese cohort; the relationship was not significant in the smaller Japanese cohort. Tolvaptan exhibited a direct treatment effect on the growth of kidney volume in both cohorts of ADPKD patients.
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Quantification of Immediate Surgical Stress After Major and Minor Thoracic Surgeries Through HRV: A Secondary Post Hoc Analysis of a Randomized Controlled Trial
CONCLUSION: HRV parameters reflected surgery-induced autonomic alterations, with more pronounced and persistent changes observed in patients undergoing PR compared with PM surgery. No clear recovery toward baseline was detected during the 2-day postoperative follow-up, suggesting prolonged autonomic disturbances after thoracic surgery.