Clinical Trials
Category Added in a WPeMatico Campaign
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Comparative analysis of postoperative pain following bioceramic sealer application with three obturation methods: A randomized controlled trial
CONCLUSIONS: The sealer-based and hot modified methods significantly reduced postoperative pain compared to traditional techniques. These findings support the clinical adoption of innovative bioceramic sealer techniques to optimize pain management and patient satisfaction.
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Novel application for the JAK inhibitor baricitinib in the treatment of Vogt-Koyanagi-Harada disease: a prospective cohort study
CONCLUSION: This study demonstrates that baricitinib is a promising therapeutic option for both early- and late-stage VKH disease. It effectively controls choroidal inflammation, improves visual function, and allows for a substantial reduction in corticosteroid burden with a favorable safety profile.
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Sex Differences in Statin Intolerance: Insights From the CLEAR Outcomes Trial
CONCLUSIONS: This is the only cardiovascular outcomes trial to date that exclusively enrolled patients with statin intolerance, and the largest contemporary study of lipid lowering therapy in females, a group historically underrepresented in clinical trials. Bempedoic acid was equally tolerated by both sexes and represents a viable alternative to statins to reduce cardiovascular risk.
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Vonoprazan Versus Tegoprazan-Amoxicillin Dual Therapy for Treatment-Naïve Patients With Helicobacter pylori Infection: A Prospective, Multicenter, Open-Label, Randomized Controlled Study
CONCLUSION: Vonoprazan/amoxicillin dual therapy achieved satisfactory H. pylori eradication rates with a favorable safety profile in treatment-naïve patients. Tegoprazan/amoxicillin dual therapy was associated with fewer gastrointestinal adverse event incidences, while optimizing tegoprazan dosing frequency may be necessary to improve the eradication.
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The effect of inhaled dry salt on pulmonary mucociliary clearance in obstructive lung disease: A randomised, placebo-controlled, crossover study
CONCLUSIONS: Inhalation of 40 mg dry NaCl was well tolerated without acute adverse effects in COPD patients. However, early termination left the study underpowered, increasing the risk of type II error. Non-significant findings should not be interpreted as evidence of no effect. Larger, adequately powered trials are needed to clarify the impact of dry NaCl…
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Psychologically informed reminder messages for promoting BRCA1/2 carrier screening: evidence from a large-scale population-based study
Psychologically Informed Reminder Messages (PIRMs) may promote health-behavior change, but their impact on preventive genetic screening is unclear. Due to low adherence to a screening program, Clalit Health Services initiated an intervention to encourage BRCA1/2 carrier screening in July 2022. This observational study assesses the effectiveness of the intervention in encouraging screening and its spillover…
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Correlates and Predictors of Criminal Legal Involvement in People With First-Episode Psychosis
Objective: Because limited research has evaluated criminal legal involvement (CLI) during a first episode of psychosis (FEP), we explored rates, correlates, and predictors of CLI among people with FEP.
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Comparative effects of caffeine and paraxanthine on rowing performance and sleep quality: a randomized crossover study
CONCLUSION: These results indicate that the combined ingestion of caffeine and paraxanthine elicited the most pronounced performance benefits, while paraxanthine alone did not demonstrate clear standalone ergogenic efficacy at the administered dose. However, paraxanthine was associated with better subjective sleep outcomes compared to caffeine, suggesting that its potential value may be related more to tolerability…
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Efficacy and cost analysis of two fluoride varnishes in community-based interventions for early childhood caries
CONCLUSIONS: I-ReHealth^(®) is non-inferior to Duraphat® in caries-preventive efficacy but superior in cost-effectiveness in reducing patient expenses.
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Effectiveness of virtual reality technology combined with conventional pelvic floor rehabilitation training in postpartum myofascial pelvic pain syndrome: A randomized controlled trial
CONCLUSION: The integration of virtual reality technology with conventional pelvic floor rehabilitation therapy has the potential to improve the relaxation capacity of fast-twitch muscle fibers within the pelvic floor muscles. However, it does not seem to offer any benefits in increasing pelvic floor muscle thickness or in alleviating myofascial pelvic pain.