Clinical Trials
Category Added in a WPeMatico Campaign
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Impact of wearable-assisted walking on sarcopenia and body composition in older adults
CONCLUSIONS: Wearable devices, such as smartwatches and fitness trackers, provide real-time feedback and enable tailored exercise recommendations, offering a practical and personalized strategy for mitigating sarcopenia. This study confirms that wearable-assisted walking programs effectively improve muscle health and functional performance in older adults, reinforcing their potential for promoting healthy aging.
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Nicotine e-cigarettes for smoking cessation following discharge from smoke-free inpatient alcohol and other drug withdrawal services: a pragmatic two-arm, single-blinded, parallel-group, randomised controlled trial
BACKGROUND: Nicotine-containing electronic cigarettes (e-cigarettes) have been shown to be effective for smoking cessation among general populations, but there is little evidence in people with substance use disorders (SUDs). We aimed to assess the effectiveness of e-cigarettes for smoking abstinence in people with SUD following discharge from smoke-free inpatient withdrawal services.
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VIVALDI-CT shaping care home COVID-19 testing policy: A pragmatic cluster randomised controlled trial of asymptomatic testing compared to standard care in care home staff
CONCLUSION: This trial was not well-powered to evaluate the impact of the intervention on the primary outcome, and recorded uptake of staff testing was low. However, our pre-existing care home network underpinned by linked routinely collected data provides a model for more agile interventional studies in the care home setting.
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Geneva Homologous Recombination Deficiency Test Is Predictive of Survival Benefit From Olaparib and Bevacizumab Maintenance in Ovarian Cancer
CONCLUSION: The Geneva HRD test predicts PFS and OS benefit from olaparib + bevacizumab. The potential detrimental effect of olaparib + bevacizumab on OS in the HRD-negative population is hypothesis-generating and needs to be confirmed prospectively.
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Effect of the Otago Exercise Program on Activities of Daily Living in Older Adults With Sarcopenia
CONCLUSION: OEP significantly enhances activities of daily living, improves muscle strength, balance, and physical function in older adults, and is more effective than conventional rehabilitation exercise programs, making it suitable for extensive clinical application.
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Effectiveness of the WeChat-based mini-program («Sober Time ACT») on individuals with hazardous drinking in China: a randomized controlled trial
CONCLUSIONS: These findings provide preliminary prospective evidence that, despite the limitation of high dropout rate, the «Sober Time ACT» mini-program not only effectively reduces alcohol craving and consumption but also improves related psychological indicators to a certain extent, providing an innovative and effective intervention tool for addressing hazardous drinking in China.
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Psychoeducation for Caregivers of Individuals With Borderline Personality Disorder: A Randomized Controlled Trial of Multiple Family Group Therapy
Multiple family group (MFG) therapy is a psychoeducational intervention designed for caregivers of individuals with borderline personality disorder (BPD). This study is the first to compare MFG therapy with treatment as usual (TAU). The objectives were to assess MFG therapy’s impact on caregivers’ social functioning, perceived support from mental health professionals, coping and communication skills…
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Homologous recombination deficiency (HRD) tests for ovarian cancer: a multicenter French phase II study (HERO)
BACKGROUND: The identification of homologous recombination deficient (HRD) tumor is now a crucial step for the therapeutic management of ovarian cancer. The HRD tumors are both sensitive to olaparib maintenance treatment and to platinum-based chemotherapy. Despite the large amount of HRD tests currently available, only a few HRD tests were prospectively validated on a clinical…
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The study on delirium side-effects after ultra-brief pulse electroconvulsive therapy
CONCLUSION: Compared with BP ECT, UBP ECT may reduce the incidence of delirium post-treatment in SCZ without a significant difference in efficacy. The higher cholinesterase levels in the UBP group suggest that UBP ECT may reduce neuronal asynchronous depolarization, cholinergic disorder, and pro-inflammatory responses, thereby reducing the impact on delirium. These findings provide partial scientific…
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Evaluating the efficacy of rumination-focused cognitive-behavioral therapy in alleviating depression, negative affect, and rumination among patients with recurrent major depressive disorder: a randomized, multicenter clinical trial
CONCLUSIONS: Group-based Rumination-Focused Cognitive-Behavioral Therapy (g-RFCBT) demonstrated significant efficacy in reducing the severity of depressive symptoms, rumination, and negative affect among individuals with major depressive disorder (MDD). Moreover, these therapeutic benefits were maintained over a 6-month follow-up period, suggesting durable treatment effects.