Clinical Trials
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Application and efficacy analysis of empowerment theory-based Pharmacological intervention in the rehabilitation of children with autism
To explore the application and efficacy of a combined pharmacological and behavioral intervention in the rehabilitation of children with autism, emphasizing individualized treatment approaches. Ninety-six hospitalized children diagnosed with autism, aged 3-8 years, were randomly assigned to an experimental group or a control group. The control group received conventional interventions, including systematic language training, behavioral…
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Herbal fumigation combined with vessels acupoint improves the prognosis and reduces inflammation in patients with dry eye disease: A retrospective study
Dry eye disease (DED) is a prevalent condition often associated with inflammation and tear film dysfunction. Complementary treatments such as herbal fumigation and acupoint applications have shown promise in handling EDE. This study evaluates the combined efficacy of herbal fumigation and vessels acupoint in treating DED. A total of 123 DED patients were randomly assigned…
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A large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing
Considering the complexity of serotonergic influence on emotions, we conducted a comprehensive investigation of the interplay between emotion processing and the serotonergic system using simultaneous functional and molecular neuroimaging during pharmacological challenge while disentangling the effects of serotonin transporter (SERT) binding, genotype, and diagnosis of major depressive disorder (MDD). Herein, 153 subjects (44 with MDD)…
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Validity and usability for digital cognitive assessment tools to screen for mild cognitive impairment: a randomized crossover trial
CONCLUSIONS: Digital cognitive tests are valid and feasible in PHC settings but face implementation challenges, especially in usability and adaptability among individuals with lower education levels.
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Awareness of baseline functioning and sensitivity to improvement in older people with and without mild cognitive impairment receiving a computerized functional skills training program
CONCLUSIONS: Participants with MCI underestimated their performance deficits at baseline. Self-reports of changes in everyday functioning do not track the substantial objective changes. Previous studies have reported a lack of sensitivity to training gains in several different conditions. Strategies to increase awareness of training gains may be required to sustain treatment benefits.
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Systemic indocyanine green administration to detect bile leakage after liver surgery: a prospective clinical trial, using historical controls
CONCLUSIONS: Intraoperative ICG administration and assessment effectively lower bilirubin levels in drainage fluid during hepatectomy, potentially reducing the incidence of BL.
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Development and validation of a nomogram for predicting the clearance of jaundice in children with biliary Atresia after Kasai portoenterostomy
CONCLUSION: This study developed and validated a nomogram incorporating four indictors, including Age at KPE, postoperative AST level at two weeks, CR of DB at two weeks post-KPE and F-score at KPE, may be useful for predicting CJ at 3 months after KPE in children with BA.
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Efficacy of Action of Low-Temperature Plasma Radiofrequency Ablation in the Treatment of Early Glottic Carcinoma
CONCLUSION: Our findings demonstrate the successful application of low-temperature plasma radiofrequency ablation in the management of early glottic carcinoma. This innovative technique offers several potential advantages, including reduced intraoperative bleeding, shorter surgical duration, and hospital stay. Additionally, it promotes enhanced postoperative voice restoration and mucosal healing, while minimizing the occurrence of postoperative complications. These compelling…
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Effects of Music and Aromatherapy on Blood Pressure and Heart Rate Among Endodontic Patients: A Randomized Clinical Trial
CONCLUSIONS: Music and aromatherapy did not produce statistically significant reductions in blood pressure and heart rate among endodontic patients. Alternative methods should be explored to manage patient anxiety better.
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Impact of molar incisor hypomineralization on oral health-related quality of life, dental fear and anxiety in Swedish children
CONCLUSIONS: Restorative treatment and extraction of FPMs affected by MIH lead to similar impact on DFA and OHRQoL at 11 years of age.