Clinical Trials
Category Added in a WPeMatico Campaign
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THE EFFICACY OF RANIBIZUMAB COMBINED WITH SUBSCLERAL TRABECULAR SURGERY IN THE TREATMENT OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
CONCLUSION: The clinical effect of subscleral trabecular surgery combined with intravitreal injection of ranibizumab in the treatment of NVG patients is positive, which can more effectively correct the visual acuity and intraocular pressure of patients.
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Psychosocial Intervention and Rehabilitation Utilization Together Improve Pain and Function After Traumatic Orthopaedic Injuries: A Secondary Analysis of a Randomized Controlled Trial
CONCLUSION: The combination of TOR and rehabilitation utilization resulted in short-term improvements in physical function after traumatic orthopaedic injury. Participants who received TOR experienced clinically meaningful short-term improvements in pain, pain catastrophizing, and pain anxiety. These data may support the inclusion of screening for psychological response to injury within routine clinical practice. For patients with…
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Machine Learning-Based Cognitive Assessment With The Autonomous Cognitive Examination: Randomized Controlled Trial
CONCLUSIONS: In this study, we evaluated if the ACoE could reliably phenotype cognitive symptoms relative to the assessments of established standard paper-based cognitive assessments. We found that the ACoE reliably phenotypes patient cognition, which can be used to screen patients. In the future, these cognitive phenotypes may be used to diagnose specific etiologies.
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High-definition transcranial direct current stimulation modulation of brain network connectivity in patients with mild cognitive impairment
CONCLUSION: HD-tDCS selectively modulates key nodes of cognitive and motor networks in MCI, as demonstrated by targeted DC alterations. Despite the absence of MMSE/MoCA improvements, this network-specific neuromodulation indicates HD-tDCS engages disease-relevant functional circuits. Longer interventions and sensitive cognitive metrics may clarify clinical relevance.
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Factors influencing the response to periodontal therapy in patients with diabetes: post hoc analysis of a randomized clinical trial using machine learning
CONCLUSION: The combination of nine baseline periodontal, metabolic, and demographic factors from patients with periodontitis and type 2 DM may indicate the response to periodontal therapy. Lower levels of full mouth PD, CAL, plaque index, and HbA1c at baseline increased the chances of achieving the endpoint for treatment at 6-month follow-up. However, all nine features…
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The COMFORT Trial: A Randomised Control Trial Comparing Group-Based COMpassion-FOcused Therapy Techniques and Breathing Pattern ReTraining With Treatment as Usual on the Psychological Functioning of Patients Diagnosed With Cancer Recurrence
CONCLUSIONS: COMFORT demonstrates that an online intervention met its primary outcome of distress reduction. Further multisite trials are required.
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Is Intralesional Methotrexate an Effective Alternative to Intralesional Triamcinolone in Alopecia Areata? Findings From a Randomized Controlled Trial
BACKGROUND: Alopecia areata (AA) is an autoimmune condition resulting in hair loss, sometimes just in small patches but occasionally across larger areas like the entire scalp. For localized AA, treatments often involve injecting corticosteroids, such as triamcinolone acetonide (TrA), directly into the affected areas. Methotrexate (MTX), a drug known for its ability to suppress immune…
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Clinical Observation of a Novel Moisturizing Cream for Reducing Neurovascular Hyper-Reactivity in Sensitive Skin
CONCLUSION: The new cream has good safety and can effectively reduce neurovascular hyper-reactivity, alleviating symptoms in individuals with sensitive skin.
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A randomized open-label study to evaluate the effectiveness and safety of once-daily rimegepant 75 mg orally disintegrating tablet for the short-term preventive treatment of fasting-triggered headache in individuals with migraine
AimTo evaluate rimegepant, a calcitonin gene-related peptide receptor antagonist, for short-term prevention of fasting-triggered headache during Ramadan.MethodsParticipants, aged 18-65 years and diagnosed with migraine or headache attributed to fasting, were randomized to open-label once-daily (QD) rimegepant 75 mg orally disintegrating tablet (ODT) from weeks 1-4 of the fast (Immediate Start arm; n = 52) or…
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Clinical Efficacy of Canrenone in Restoring Sinus Rhythm in Patients With Atrial Fibrillation-A Pilot, Randomized, Double-Blind Study
Background and aimsRenin-angiotensin-aldosterone system (RAAS) inhibition is an upstream therapy for managing atrial fibrillation (AF). Of all RAAS-inhibiting agents, only canrenone in the form of potassium canrenoate, a specific inhibitor of mineralocorticoid receptors, is administered intravenously. We evaluated the clinical efficacy of intravenous potassium canrenoate in restoring sinus rhythm in patients with paroxysmal AF episodes.MethodsThis…