Clinical Trials
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The effects of multimodal cocktail analgesic local injection in postoperative pain control after laminoplasty: A study protocol of a prospective randomized controlled trial
BACKGROUND: Laminoplasty is the most widely used surgical technique for cervical spondylotic myelopathy. This surgery can cause severe postoperative pain; if not controlled, recovery or rehabilitation may be delayed. Therefore, effective control of postoperative pain is crucial. This randomized prospective study aims to evaluate the effects of a multimodal cocktail injection on postoperative pain and…
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Efficacy and Safety of Hormone Replacement Combined With Escitalopram in the Treatment of Chronic Insomnia in Perimenopausal Women: A Randomized Controlled Trial
CONCLUSION: Femoston plus escitalopram improves chronic insomnia in perimenopausal women. Serum levels of 5-HT, E2, FSH, and LH may objectively indicate the clinical severity of chronic insomnia in this population.
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Efficacy of Power Training on Sarcopenic Obesity in Community-Dwelling Older Women: A 32-Week Randomized Clinical Trial
Background/Objectives: Exercise is a key nonpharmacological strategy for the management of sarcopenic obesity (SO), characterized by low muscle mass and excess fat. However, long-term interventions and specific modalities, such as power training (PT), remain unexplored in this population. Methods: In this 32-week randomized controlled trial, 40 community-dwelling women (mean age: 77.0 ± 6.8 years) with…
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Implementation of a Quality Improvement and Clinical Decision Support Tool for Cancer Diagnosis in Primary Care: Process Evaluation
CONCLUSIONS: While some components of the intervention, such as the CDS tool, were considered to be acceptable and useful, this process evaluation highlighted barriers such as time and resources, practice differences, and considerations around the optimal amount of support needed when delivering the intervention. Addressing these in future studies may optimize the implementation process. Further…
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Pegylated liposomal doxorubicin + cyclophosphamide followed by taxane as adjuvant therapy for early-stage breast cancer: a randomized controlled trial
CONCLUSION: The PLD-based regimen for early-stage BC showed significantly lower rates of elevated hs-cTnT and grade 3-4 AEs with comparable efficacy to the doxorubicin-based regimen. (ClinicalTrials.gov Identifier: NCT03949634; IRB Approved: Ethics committee institutional review board of Shanghai Cancer Hospital, Fudan University’s (No. 1706173-19-1904B) and other center).
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Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity Profiles of a Single-Dose JYB1904 in Healthy Chinese Participants: A Phase Ia, Randomized, Double-Blind, Placebo-Controlled Study
Allergic asthma, characterized by airborne allergen sensitivity and Th2 immune responses, is a common and increasing global health concern. Omalizumab, while effective, has limitations such as weight- and IgE-dependent dosing regimens. JYB1904, a recombinant anti-IgE humanized monoclonal antibody (IgG1 subtype), showed superior preclinical properties. We performed a single-center, randomized, double-blind, placebo-controlled, single ascending-dose phase Ia…
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Netarsudil v/s Ripasudil: The battle of supremacy between two ROCKS-I (rho kinase inhibitors)
CONCLUSION: Topical netarsudil 0.02% once daily was well tolerated with fewer side effects and in reducing IOP than topical ripasudil 0.4% twice daily dosing in POAG patients. Netarsudil 0.02% once daily may be considered an important option for the IOP control in POAG.
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Central-boost Ablative Radiation Therapy for Solid Tumors: Study Protocol of a Single-arm, Phase II Trial (CBART)
BackgroundThough stereotactic body radiation therapy (SBRT) has been widely used in advanced tumors, ablative doses may not be appropriate in the case of large tumors or those abutting to the gastrointestinal tracts, resulting in unfavorable outcomes. Therefore, partial irradiation with high doses to tumors have been investigated. In order to achieve a larger high dose…
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Systematic evaluation of the effectiveness of Xuesaitong combined with nutraceutical drugs in the treatment of diabetic peripheral neuropathy
This study aims to evaluate the effectiveness of combining Xuesaitong with nutraceutical drugs, including alpha-lipoic acid, B vitamins, and coenzyme Q10, in the treatment of diabetic peripheral neuropathy (DPN). A 12-week randomized controlled trial was conducted with 140 clinically diagnosed DPN patients, who were randomly assigned into two groups. The intervention group received Xuesaitong along…
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An auxiliary role of deep neural network ophthalmic disease identification models in choosing medication treatment strategy
To evaluated a Deep Neural Network (DNN)-based ophthalmic disease diagnosis framework in facilitating personalized medication treatment plans using a prospective, single-center, randomized controlled clinical trial design. 500 patients were randomly assigned to either a DNN-aided experimental group or a control group receiving standard physician-based treatment plans. The primary outcomes were medication selection accuracy, clinical efficacy…