Clinical Trials
Category Added in a WPeMatico Campaign
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Impact of clinical pharmacy services on medication adherence and quality of life in pre-dialysis patients with CKDu: a randomized controlled trial from Sri Lanka
CONCLUSIONS: Intervention significantly enhanced medication adherence and QOL among pre-dialysis patients with CKDu, demonstrating the positive impact of added clinical pharmacy services to existing healthcare team in managing CKD patients.
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Combined therapy with contralateral controlled functional electrical stimulation and transcranial direct current stimulation for early post-stroke hand dysfunction
CONCLUSIONS: Contralateral controlled functional electrical stimulation combined with tDCS substantially improves hand function in patients with early stage stroke, with better outcomes than tDCS therapy alone.
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An enhanced educational intervention for improving confidence in the eye health benefits of appropriate care for age-related macular degeneration: a randomized controlled trial
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss worldwide. Appropriate care is available for patients, reducing the risk of AMD progression. Unfortunately, patients do not always receive appropriate eye care. Our study aimed to develop and evaluate an enhanced educational intervention focused on the health benefits expected from receiving appropriate eye…
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The effect of qigong on frailty in older cancer survivors: a randomised controlled trial
CONCLUSION: Qigong was not superior to an active control in its effect on improving frailty in older cancer survivors. Researchers should include routine care as control and examine the underlying mechanisms driving the change in frailty.
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Clinicians’ perspectives on a primary healthcare intervention to reduce antibiotic prescription for acute lower respiratory tract infections in Barcelona (Spain): a qualitative study
CONCLUSIONS: CPR testing and promoting communication skills can be useful tools to support clinical decisions for ALRTIs. Structural barriers (e.g., healthcare pressures) and social inequities amongst service users were acknowledged as the main barriers for the implementation of ALRTIs interventions.
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Evaluating a brief imagery-based intervention for adolescent depression: study protocol for a Phase IIB randomised control trial (INDIGO) in secondary schools
BACKGROUND: There is an urgent need for psychological interventions that can target depression in late adolescence and prevent it from having lifelong implications. Schools have been identified as a promising setting to enhance access to interventions and offer support earlier. We have co-developed a novel intervention, IMAGINE, that targets key cognitive mechanisms implicated in depression…
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Graded motor imagery as an adjunct to comprehensive physiotherapy in chronic rotator cuff-related pain: a single blind randomized controlled trial
CONCLUSION: This study highlights that both groups showed significant improvements in pain, range of motion, functionality, and pain-related fear. However, adding GMI therapy led to faster pain relief, better mechanical sensitivity, improved motor imagery skills, and greater treatment satisfaction, warranting further research with larger samples and extended follow-ups to confirm its broader applicability.
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Consumer-Focused Osteoarthritis e-Learning to Complement Physiotherapy Care in People With Knee Osteoarthritis: Protocol for the PEEKO Randomised Controlled Trial
CONCLUSION: This RCT evaluates whether supplementing physiotherapy care with consumer-focused e-learning improves outcomes for people with knee OA.
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Early Neurodevelopment of Extremely Preterm Infants Administered Autologous Cord Blood Cell Therapy: Secondary Analysis of a Nonrandomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This phase 1 nonrandomized clinical trial assessing the safety and feasibility of autologous UCBCs in extremely preterm infants did not find significant differences in brain imaging parameters and early neurodevelopmental outcomes between the cell therapy and contemporaneous untreated groups. It was encouraging to note no infants who received UCBCs were assessed as…
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Balancing Efficiency and Accuracy in Hepatitis C Rapid Antibody Testing: Insights From a Cluster Randomised Crossover Trial
Hepatitis C remains a significant global health problem, particularly among people who inject drugs. To achieve Australia’s 2030 elimination targets, efficient testing strategies are needed. The OraQuick rapid antibody test provides results in 20 min, but many non-viraemic individuals with resolved infections test positive, potentially leading to unnecessary confirmatory RNA testing. Reducing the read time…