Clinical Trials
Category Added in a WPeMatico Campaign
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A prospective cluster randomized trial of an interventions bundle to reduce inappropriate antibiotic use for upper respiratory tract infections in the outpatient setting
CONCLUSION: A multi-component intervention can significantly reduce inappropriate antibiotic prescriptions for URTIs in the outpatient setting.
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Impact of the 5A nursing model on immune balance and lymph node metastasis in primary liver cancer patients post-CyberKnife treatment
CONCLUSION: The 5A nursing model significantly impacts immune balance and reduces lymph node metastasis in primary liver cancer patients following CyberKnife treatment. This model enhances CD8 + T cell and NK cell concentrations while reducing Tregs cells, thereby promoting a stronger anti-tumor immune response and ultimately decreasing the rate of lymph node metastasis.
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Effects of a flavonoid-enriched orange juice on antioxidant capacity, lipid profile, and inflammation in obese patients: A randomized placebo-controlled trial
Recent studies underscore the therapeutic potential of citrus polymethoxylated flavonoids-such as tangeretin, sinensetin, and nobiletin-in attenuating inflammation, mitigating oxidative stress, and enhancing metabolic health in individuals with obesity. This randomized, double-blind, placebo-controlled clinical trial assessed the effects of a functional orange juice enriched with flavonoids (200 mL/day) combined with a low-calorie diet over six weeks…
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Application of Multidisciplinary Diagnosis and Treatment (MDT) clinical teaching model in the clinical teaching of some undergraduates of breast diseases in surgery
CONCLUSION: This study pioneers the application of the MDT teaching method in breast cancer clinical education, comparing its efficacy against traditional teaching modes. Findings demonstrate that MDT-based breast cancer diagnosis and treatment education is more efficient and optimized, offering a transformative basis for clinical undergraduate education reform in China. The results advocate for the reconfiguration…
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Cognitive behavioural therapy in comparison to treatment as usual in young adults at high risk of developing bipolar disorder (Bipolar At Risk): a randomised controlled trial to investigate the efficacy of a treatment approach targeted at key appraisal change: Bipolar At Risk Trial II (BART II)
BACKGROUND: Research has demonstrated the ability to identify and treat individuals at high risk of developing psychosis. It is possible to use a similar strategy to identify people who have an emergent risk of bipolar disorder (BD). Interventions during the early phase may improve outcomes and reduce risk of transition. Criteria have been established to…
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Improving the time-efficiency of initial mental health assessment (triaging) using an online assessment tool followed by a clinical interview via phone: a randomised controlled trial
CONCLUSION: The use of online self-report clinical assessment by patients can save time to complete subsequent clinician assessment. Greater time-saving can be expected with better integration of this tool in workflow and increased clinician familiarity with using online self-reported data.
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A phase 1 safety and feasibility trial of a ketogenic diet plus standard of care for patients with recently diagnosed glioblastoma
Despite great interest, there is limited clinical evidence to support the use of a ketogenic diet (KD) for cancer patients. We conducted a single-arm phase 1 trial of a KD among patients with recently diagnosed glioblastoma (GBM) receiving standard-of-care (SOC) treatment. Adults with GBM within 3 months of diagnosis followed a supervised 16-week intervention of…
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Effects of WeChat-based telehealth on patients reported outcomes of hypertension: a randomized controlled trial
Patient-reported outcomes (PROs) are assessments based on patients’ self-perception. This study aimed to explore whether WeChat-based health education is more effective than traditional health education in terms of improving PROs for hypertensive patients during a 3-month period. This prospective, single-center, single-blind randomized controlled trial was conducted from April to August 2022 at the hypertension ward…
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Preoperative chlorhexidine mouthwash can reduce the risk of postoperative pulmonary complications in elderly patients undergoing general anesthesia with endotracheal intubation
To investigate whether preoperative chlorhexidine mouthwash can reduce the risk of postoperative pulmonary complications(PPCs) in elderly patients with tracheal intubation under general anesthesia. 78 elderly patients undergoing elective surgery under general anesthesia and endotracheal intubation were randomly divided into the chlorhexidine group (CH group, n = 39) and the normal saline group (NS group, n…
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Phase II study of transcatheter arterial chemoembolization (TACE) combined with apatinib for advanced perihilar cholangiocarcinoma
To confirm transcatheter arterial chemoembolization (TACE) combined with apatinib for advanced perihilar cholangiocarcinoma (PCC) is effective and safe. A comprehensive treatment plan involving TACE combined with targeted therapy was implemented for the patients with pathologically diagnosed advanced PCC, where TACE was performed every 4-6 weeks to deliver albumin paclitaxel and gemcitabine for a maximum of…