Clinical Trials
Category Added in a WPeMatico Campaign
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The Effect of Brief Group Psychoeducation on Cognitive Distortions, Automatic Thoughts and Functioning in Major Depressive Disorder: A Randomized Controlled Trial
Major depressive disorder (MDD) causes significant impairment and reduced functioning, yet it remains undertreated. This study examined the effectiveness of a structured, brief group psychoeducation programme for individuals diagnosed with MDD. The randomized controlled trial involved 52 adults diagnosed with MDD according to DSM-5 criteria. Participants were divided into two groups: an experimental group (n…
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Predictive Model for Sciatic Nerve Block Efficacy Based on Perfusion Index and Regional Blood Flow Changes
CONCLUSION: The Perfusion Index and regional blood flow changes in the lower extremities are reliable predictors of the success of sciatic nerve blocks. The predictive model developed in this study is accurate and clinically applicable, providing an objective tool for the early assessment of block efficacy.
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The development of a clinical prediction model for response to methotrexate, tofacitinib, and etanercept in patients with Psoriatic Arthritis
CONCLUSION: Our results support the use of baseline clinical data for prediction of response to different treatments. We intend to validate this prediction model and to assess the additional predictive value of imaging and multi-omics biomarkers in future analyses.
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Clinical outcome of Nd:YAG laser and bioactive glass combined use for dentin hypersensitivity after scaling and root planning: a short-term comparative study
CONCLUSIONS: The combined application of BAG and Nd:YAG laser therapy demonstrated a significant reduction in dentin hypersensitivity post-SRP, exhibiting superior and sustained efficacy compared to monotherapies. Furthermore, the sequential treatment involving BAG applied prior to Nd:YAG laser irradiation showed the most pronounced therapeutic effect in symptom alleviation.
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Improving physiotherapists’ ability to recognise the presence of a serious pathology with a digital educational training: a mixed methods feasibility study
CONCLUSIONS: Our findings suggest that a digital educational training aimed at improving physiotherapists’ ability to detect serious pathologies is feasible. Participants emphasized the importance of adaptable platforms and a variation in digital materials to enhance the training. Limitations included the need for additional complex vignettes and limited participation in face-to-face discussions. Future research should explore…
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The effect of a Web-Based BF education program for adolescent pregnant women in the third trimester on BF practices
CONCLUSIONS: It was concluded that the web-based breastfeeding education program effectively improved breastfeeding self-efficacy, breastfeeding success, exclusive breastfeeding rates, and intentions to breastfeed for up to two years.
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Impact of liberal versus restrictive fluid management on acute kidney injury after nephrectomy: a randomised controlled trial with cystatin C evaluation
CONCLUSIONS: A liberal intraoperative fluid strategy significantly reduced the incidence of AKI following nephrectomy. Serum cystatin C outperformed creatinine in the early detection of AKI, suggesting a liberal fluid strategy may be preferable to reduce AKI risk, and cystatin C may serve as a useful early AKI biomarker.
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Smaller infarct size with ticagrelor vs. clopidogrel in STEMI patients: Insights from cardiac magnetic resonance
CONCLUSION: In patients with STEMI under a pharmaco-invasive strategy, therapy with ticagrelor was associated with a smaller infarct size than clopidogrel.
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A Culturally and Linguistically Tailored Intervention to Improve Diabetes-Related Outcomes in Chinese Americans With Type 2 Diabetes: Pilot Randomized Controlled Trial
CONCLUSIONS: The culturally and linguistically tailored intervention showed promise in improving self-efficacy and diabetes self-care activities among Chinese Americans with T2D, warranting validation through a large-scale randomized controlled trial.
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A Randomized Controlled Trial of Stereotactic Body Radiation Therapy Versus Chemoradiation Following Induction Chemotherapy in Borderline Resectable and Locally Advanced Pancreatic Cancer
CONCLUSION: SBRT showed superior resectability, survival outcomes, and QoL compared to CRT in patients with BRPC and LAPC. However, due to the study’s small sample size and single-centre design, these findings are hypothesis-generating and warrant validation in larger multicentre trials.