Clinical Trials
Category Added in a WPeMatico Campaign
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Family Size and Longitudinal Outcomes of a Digital-Human Parenting Intervention in Chinese Preschool Families: Secondary Analysis
CONCLUSIONS: Family size might not always be associated with short-term intervention effectiveness but was associated with divergence in longer-term trajectories. These findings suggest that caregiving demands are relevant for the sustainability of intervention effects. By integrating baseline differences, short-term effects, and longitudinal trajectories within a single framework, this study highlights the importance of moving beyond…
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Early Nephrology Consultation and Acute Kidney Injury in Hospitalized Patients: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of structured ENC triggered by a machine-learning AKI risk score, there was no difference in ΔSCr. AKI consultation recommendations were not followed the majority of time; whether increasing adherence to recommendations could improve outcomes deserves further study.
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The Efficacy of Individualized Music Therapy in Patients With MCS: A Pilot Study on EEG
CONCLUSION: IMT is feasible and safe in medically fragile MCS patients and may induce right-hemisphere cortical activation. These pilot findings are hypothesis-generating and require confirmation in larger, adequately powered trials.
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Guided group reflection versus SNAPPS in enhancing clinical reasoning in final-year MBBS students at a public-sector teaching hospital in Pakistan: a quasi-experimental study
CONCLUSION: Both GGR and SNAPPS teaching methods effectively enhance CR skills among undergraduate medical students. However, GGR demonstrated greater effectiveness in CR domains requiring deeper analytical thinking and collaborative reflection, especially when managing complex cases. Incorporating GGR within undergraduate clinical clerkships may strengthen diagnostic reasoning, particularly in settings with limited faculty-student teaching opportunities.
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Effects of early continuous renal replacement therapy in critically ill patients requiring ECMO treatment: results of a randomised controlled trial
CONCLUSIONS: Early implementation of CRRT in patients with ECMO showed no evidence of a difference in 30-day mortality compared with conventional initiation. However, the trial was substantially underpowered and clinically important benefits or harms cannot be excluded.
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Validating a novel driving simulation-based MWT against the standard MWT in an OSA-cohort challenged by CPAP-withdrawal (DS-MWT2) — Protocol for a monocentric, controlled, randomized, crossover trial
BACKGROUND: Excessive daytime sleepiness (EDS) is a major yet under-recognized contributor to road traffic accidents. Traditional diagnostic tools, such as the Maintenance of Wakefulness Test (MWT), assess wakefulness under passive conditions but may not accurately reflect real-world driving risks. To address this gap, we have piloted a Driving Simulation-based MWT (DS-MWT), designed to evaluate sleepiness…
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Economic Costs and Benefits of the Digital OurRelationship Program for Distressed Couples
Relationship distress is a prevalent issue with significant economic and societal consequences, including increased mental and physical health problems, decreased workplace productivity, and increased absences. Although couple therapy has been shown to improve relationship and individual well-being, its high costs limit accessibility. Digital relationship interventions provide a cost-effective alternative. However, limited research has assessed the…
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Biomarker screen-guided care for preterm birth risk in nulliparous pregnancies: a subgroup analysis of the PRIME randomized controlled trial
CONCLUSIONS: In nulliparous PRIME trial participants, IGFBP4/SHBG screen-guided care reduced composite neonatal morbidity and NICU admissions compared to routine care. These findings support the clinical utility of biomarker-guided preventive strategies in first-time pregnancies lacking prior obstetric history.
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Primary Care Integrated Management of chronic obstructive pulmonary disease (PRIM-COPD): study protocol for a cluster-randomised controlled trial
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide, with China bearing a particularly high burden. Major gaps persist in early diagnosis, guideline-based treatment and long-term disease management, especially in primary care. This study aims to evaluate the efficacy and feasibility of the National Essential Public Health Services (NEPHS)…
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Development and Validation of a Computational Histology Artificial Intelligence-Powered Biomarker in Metastatic Hormone-Sensitive Prostate Cancer on Randomized Phase III Trials
CONCLUSION: We developed and validated an image-only AI-based biomarker associated with clinical outcomes and potential benefit from treatment escalation in mHSPC independent of conventional clinicopathologic risk factors.