Clinical Trials
Category Added in a WPeMatico Campaign
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To assess the Ginkgo biloba extracts and vestibular rehabilitation training for improving prognosis in vestibular neuritis
The purpose of this research was to assess the impact of supplemental Ginkgo biloba extracts when administered in conjunction with vestibular rehabilitation training (VRT) to enhance patient outcomes in patients with vestibular neuritis (VN). A randomized controlled trial was conducted with 80 participants divided into two groups: Group A (Ginkgo biloba extracts+ VRT) and Group…
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The effect of bladder training with mobile application on quality of life and sexual satisfaction in women with overactive bladder: randomized controlled study
CONCLUSION: The mobile application-based bladder training program significantly improved quality of life and sexual satisfaction among women with OAB. High usability and engagement levels support the potential of mHealth interventions as viable, scalable, non-pharmacological management options for OAB.
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The effect of low-dose aspirin on reversing frailty status in older prefrail and frail adults: a secondary analysis of the ASPREE randomised clinical trial
CONCLUSION: Low-dose aspirin has no effect in reversing frailty among prefrail and frail individuals. The findings highlight the need to explore alternative anti-inflammatory medications for frailty management.
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Clinical efficacy and safety of repetitive transcranial magnetic stimulation (RTMS) in combination with antipsychotic medications in patients with schizophrenia
The global prevalence of schizophrenia is about 0.40% and in some parts of my country it is 0.54%-0.94%. Its treatment faces many difficulties. Antipsychotic drugs are commonly used treatments, but they have many side effects; repetitive transcranial magnetic stimulation (rTMS), as a non-invasive physical therapy, has a certain effect in improving mental and living abilities.…
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Pilocarpine 1.25% efficacy for management of uncorrected presbyopia (PILE-UP study)
CONCLUSION: Pilocarpine 1.25% eye drops demonstrated statistically significant improvements in DCNVA, near add, AoA, and DoF after one month of treatment. Pilocarpine 1.25% eye drops shown increase in the AoA and DoF; without any significant change in ocular biometry parameters. The use of pilocarpine 1.25% eye drops can be an alternative intervention for enhancing near…
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Early response to vunakizumab and its baseline predictors in patients with moderate-to-severe plaque psoriasis: a post hoc analysis of a phase-III trial
CONCLUSION: Early response rate to vunakizumab was 54.0% in patients with moderate-to-severe plaque psoriasis, where female gender and naïve status to local therapy predicted early response.
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The efficacy of combined povidone-iodine 1% and dexamethasone 0.08% prepared eye drops in treating post-viral corneal subepithelial infiltrates
CONCLUSION: Combined povidone-iodine 1% and dexamethasone 0.08% eye drops offer superior improvement in SEIs, BCVA, and symptom relief, with lower recurrence compared to individual treatments. These findings suggest a potential synergistic effect of combined treatment in managing SEIs.
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Ultrasound-guided nerve block anesthesia improves perioperative pain in patients undergoing free flap reconstruction for head-and-neck tumor: a randomized, controlled trial
CONCLUSION: Ultrasound-guided iliac fascia combined with trigeminus block anesthesia is an effective method for pain management in patients who underwent head-and-neck tumor surgery in conjunction with the simultaneous repair using the vascularized anterolateral femoral free flap.
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Effect of Motivational Interviewing on Exclusive Breastfeeding in Working Mothers: A Randomized Controlled Trial
CONCLUSIONS: The present study revealed that single-session MI telephone-based intervention helped boost maternal motivation for EBF, especially for those with inadequate BSE. Public health interventions that help nurture breastfeeding friendly culture in the workplace and community should be coupled with individualized interventions to dampen early cessation of breastfeeding.
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Poziotinib for EGFR exon 20-insertion NSCLC: Clinical efficacy of the phase 2 ZENITH trial and differential impact of EGFR exon 20 insertion location on sensitivity
EGFRex20 insertions (EGFRex20ins) can be classified as near- and far-loop based on the insertion location, however, the impact of location on responses to various EGFR tyrosine kinase inhibitors (TKIs) is poorly understood. In vitro studies show that afatinib, poziotinib, and zipalertinib more potently inhibited near-loop than far-loop insertions, whereas mobocertinib has similar IC(50) in both…