Clinical Trials
Category Added in a WPeMatico Campaign
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More than Hormones? Metabolic Effects of Twelve-Week Probiotic Supplementation in Women with Polycystic Ovary Syndrome: A Secondary Analysis of a Randomized Double-Blind Placebo-Controlled Study
Background: Polycystic ovary syndrome (PCOS) is frequently associated with insulin resistance and dyslipidemia. Evidence regarding the metabolic effects of probiotics in PCOS remains inconsistent. This secondary analysis evaluated whether multispecies probiotic supplementation influenced glucose homeostasis, insulin resistance, and the lipid profile in women with PCOS. Methods: Data were derived from a 12-week randomized, double-blind, placebo-controlled…
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Effects of Two Different Multicomponent Cognitive-Motor Training Protocols on EEG Spectral Activity, Cognitive-Motor Interference, and Gait Performance in Individuals with Chronic Stroke: A Randomized Controlled Trial
Background and Objectives: This trial examined whether two task-complexity gait training protocols differentially affect EEG spectral activity, cognitive-motor interference, and gait performance in chronic stroke. Materials and Methods: Forty-four participants were randomly allocated to Progressive Task-Complexity Gait Training (PTCGT; n = 22) or Constant Task-Complexity Gait Training (CTCGT; n = 22). Both groups trained for…
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Combined Antegrade-Retrograde Cardioplegia for Myocardial Protection During Coronary Artery Bypass Grafting in Patients with Left Main Coronary Artery Disease: The CARDIOPROTECT-LMCAD Randomised Trial
Background and Objectives: Myocardial protection during on-pump coronary artery bypass grafting (CABG) limits ischaemic injury, particularly in patients with left main coronary artery disease (LMCAD), in whom severe proximal stenosis may compromise antegrade cardioplegia delivery. We investigated whether combined antegrade-retrograde blood cardioplegia reduces postoperative high-sensitivity cardiac troponin I (hs-cTnI) concentrations, a marker of perioperative myocardial…
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Biomarker Detection of Lung Cancers Before Clinical Symptoms or the Use of Traditional Imaging Methods in the ITALUNG Trial
The ITALUNG trial (Italian Lung Cancer Screening Trial) is a randomised controlled trial that evaluated the efficacy of Low-Dose Computed Tomography (LDCT) for lung cancer screening of over 3100 high-risk individuals, smokers and ex-smokers, aged 55-69. ITALUNG was coordinated by the Institute for Cancer Prevention Research in Florence and carried out across Tuscany in three…
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External validation of the NADIR model for early prostate-specific antigen response prediction in enzalutamide-treated metastatic hormone-sensitive prostate cancer: An analysis of the ARCHES trial
CONCLUSIONS: The NADIR model demonstrates robust and reproducible discrimination, calibration, and prognostic stratification in a distinct ARPI-treated mHSPC cohort, supporting its potential utility for early response risk stratification and trial enrichment pending prospective validation of model-guided treatment adaptation.
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Can we do better in identifying child developmental conditions early? Sensitivity and specificity of the Watch Me Grow Integrated (WMG-I) digital developmental screening and surveillance tool in Australia
CONCLUSIONS: Universal digital surveillance programmes such as WMG-I can enhance time and service efficiency to accurately identify developmental needs. Leveraging routine primary care contact such as immunisation visits to administer WMG-I digital offers a scalable solution for increasing the uptake of developmental surveillance at a population level internationally.
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Asthma Intervention with Residential Ventilation and Air Cleaner (AIRVAC) Study: A 4-arm parallel-group randomized controlled trial protocol
BACKGROUND: Evidence linking exposure to airborne particulate and gaseous pollutants, as well as mold spores, with asthma control and severity is well established. A growing body of literature has demonstrated that ventilation and air filtration can improve indoor air quality (IAQ); however, clinical evidence on their comparative health impacts remains limited. Therefore, this trial aims…
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Making Interventions More Effective: Changes in Theoretical Constructs During Delivery of a Peer-Led Physical Activity Program for Breast Cancer Survivors
CONCLUSIONS: Participants’ self-efficacy, specifically, for scheduling PA, positive affect and social support for PA adoption and intervention engagement merit future examination.
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Application of an AI-enabled personalized medical education model for improving clinical thinking among cardiovascular surgery trainees
CONCLUSION: The AI-enabled personalized teaching model may represent a feasible and effective approach for cardiovascular surgery education. It was associated with higher theoretical examination scores, better critical thinking disposition, higher scores in several dimensions of simulated clinical interview performance, and high learner satisfaction. Further studies are needed to confirm its broader applicability and long-term educational…
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Pain-Specific Benefits of Higher-Dose Neubotulinum Toxin Type A in Cervical Dystonia: A Multicenter Randomized Double-Blind Crossover Trial
Pain is a major contributor to disability in cervical dystonia (CD) and may persist despite improvement in abnormal head posture after botulinum toxin treatment. Whether increasing the dose of Neubotulinum toxin type A (Neu-BoNT-A) provides additional analgesic benefit without compromising safety remains uncertain. In this prospective, multicenter, randomized, double-blind, two-period crossover trial, 50 adults with…