Clinical Trials
Category Added in a WPeMatico Campaign
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Impact of Patient-Controlled Bag Squeeze on Pain and Anxiety in Male Patients Undergoing Flexible Cystoscopy: A Double-Blind Randomized Control Study
CONCLUSIONS: Patient-controlled bag squeeze appears to be a safe and effective analgesia method comparable to caregiver-assisted methods, and demonstrates favorable patient preference.
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Comparison of cognitive workload between very short answer questions and multiple-choice questions: an eye-tracking experiment
Very short answer questions (VSAQs) have gained attention for their superior psychometric properties compared to multiple-choice questions (MCQs). While VSAQs require knowledge recall, MCQs primarily involve knowledge recognition. This difference in cognitive processes may lead to varying cognitive workloads, defined as the amount of mental processing in working memory. Previous studies have not demonstrated consistent…
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Oral diclofenac potassium and intramuscular hyoscine-n-butyl bromide versus oral diclofenac potassium alone for pain relief during hysterosalpingography: a double blind randomized controlled trial
Hysterosalpingography (HSG) is an important diagnostic tool in infertility, often associated with pain and tubal spasms, potentially resulting in false proximal tubal occlusions. This randomised controlled trial compared oral diclofenac potassium plus intramuscular hyoscine-N-butyl bromide (HBB) with oral diclofenac alone in 138 women undergoing HSG at Central Hospital, Warri. Pain perception, the primary outcome, was…
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RTMS Versus Fluvoxamine in the Treatment of OCD: A Randomized Open-label Pilot Study
Background: Obsessive‒compulsive disorder is a chronic, disabling mental disorder. While repetitive transcranial magnetic stimulation has emerged as a promising neuromodulation intervention for psychiatric disorders, its efficacy in treatment-naïve obsessive‒compulsive disorder patients remains understudied. Objective: This study aimed to test the preliminary efficacy of low-frequency repetitive transcranial magnetic stimulation in treatment-naïve obsessive‒compulsive disorder patients. Methods:…
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Efficacy and safety of SMET12 in combination with toripalimab and chemotherapy in advanced non-small-cell lung cancer patients tested positive for EGFR protein who are treatment-naive or harbor acquired resistance to standard therapy: a phase 2, multi-cohort clinical trial
CONCLUSIONS: Triple therapy consisting of SMET12, toripalimab, and chemotherapy exhibited manageable safety in patients with advanced non-small cell lung cancer (NSCLC) expressing EGFR protein, while demonstrating promising efficacy in EGFR-mutant patients with acquired resistance to EGFR-TKIs. The functional phenotype and differentiation pattern of peripheral blood T lymphocytes exert a critical impact on the therapeutic response…
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Randomized, Double-Blind, Placebo-Controlled Trial of ID-CBT5101, a Tyndallized Clostridium butyricum Postbiotic, in Adults with Mild-to-Moderate Knee Osteoarthritis
Osteoarthritis (OA) is a common cause of chronic pain and functional impairment in older adults. Evidence suggests a gut-joint axis, where gut dysbiosis and systemic low-grade inflammation may contribute to OA pathogenesis. Postbiotics, which are non-viable microbial products such as heat-killed bacteria, have been proposed as safe and stable alternatives to live probiotics. ID-CBT5101, a…
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Impact of standardized endoscopic imaging on early detection rate of upper gastrointestinal tract cancer: A quasi-experimental study
The outcomes of patients with upper gastrointestinal tract cancer are poor, and early detection is critical. This study investigated the impact of standardized endoscopic imaging on the early detection rate of upper gastrointestinal tract cancers. A quasi-experimental study was conducted between July 2022 and July 2023. Four tertiary hospitals were randomized to the control and…
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Diagnostic Performance of Linked Color Imaging Compared to White Light Imaging During Secondary Endoscopic Evaluation in Patients with Gastric Neoplasia Referred for Endoscopic Resection: A Randomized Comparative Study
CONCLUSION: Linked color imaging may improve lesion detection performance and efficiency during the endoscopic evaluation of GSNs. Cite this article as: Lee JG, Yoo IK, Lee SP, et al. Diagnostic performance of linked color imaging compared to white light imaging during secondary endoscopic evaluation in patients with gastric neoplasia referred for endoscopic resection: A randomized…
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T-cell receptor-like chimeric antigen receptor T cells targeting mesothelin: A first-in-human dose-escalation trial for platinum-resistant advanced ovarian cancer
CONCLUSIONS: This study highlights that KT127 has a manageable safety profile and shows preliminary biological activity in patients with advanced ovarian cancer, particularly those who have failed multiple lines of therapies.
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Physiotherapy with kinesiotherapy and physical agents to reduce postpartum diastasis recti: a randomised trial
CONCLUSIONS: the combination of kinesiotherapy and physical agents is more effective in reducing inter-rectus distance and abdominal circumference than either approach alone in postpartum women with diastasis recti abdominis.