Clinical Trials
Category Added in a WPeMatico Campaign
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Enhancing Self Care Among Oral Cancer Survivors Using a Digital Approach: The Empowered Survivor Trial
CONCLUSIONS: The ES enhanced self-efficacy and increased self-care activities. Further examinations of survivorship preparedness and HRQoL in oral and oropharyngeal cancer are warranted.
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Impact of N-PEP-12 Supplementation on Attentional Performance and Mental Wellbeing in Healthy Adults with Subjective Cognitive Complaints: A Randomized, Placebo-Controlled Trial
Background: Subjective cognitive complaints (SCCs) are common in middle-aged and older adults and may reflect early cognitive changes, alongside alterations in stress, mood, sleep, and quality of life. N-PEP-12 is a peptide-based nutritional supplement with potential neuroprotective effects, but evidence of its benefits in healthy adults with SCCs remains limited. Objective: To evaluate the effects…
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The Effect of Using Hypotension Prediction Index to Reduce Intraoperative Hypotension in Elective Cesarean Sections: A Randomized Controlled Trial
Background and Objectives: The Hypotension Prediction Index (HPI) is a predictive algorithm that enables proactive management of intraoperative hypotension (IOH) and has been integrated into finger cuff devices for practical use in obstetric settings. This study aims to evaluate the effectiveness of HPI in reducing IOH during elective cesarean sections (CS). Materials and Methods: This…
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Comparison of Sensory-Adapted and Regular Dental Environments During Professional Oral Hygiene in Children with Mild Intellectual Disability and Moderate Dental Anxiety: A Randomized Clinical Trial
Background and Objectives: Children with mild intellectual disability (MID) frequently experience difficulties during dental treatment due to increased sensitivity to environmental stimuli and limited cooperation. Sensory-adapted dental environments (SADE) have been proposed as a strategy to improve the dental experience of patients with neurodevelopmental conditions; however, evidence regarding their effectiveness in children with MID remains…
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Effects of a Multi-Component Nutraceutical (NUT2) on the Lipid Profile in Adults with Low-to-Moderate Cardiovascular Risk: A Randomized Placebo-Controlled Trial
Background: Lifestyle intervention is recommended as first-line management for individuals with low-to-moderate cardiovascular (CV) risk and elevated low-density lipoprotein cholesterol (LDL-C), although dietary intervention alone often produces only modest lipid reductions. NUT2 is a proprietary multi-component nutraceutical formulated to target complementary pathways involved in lipid metabolism, oxidative stress and cardiometabolic risk. This study evaluated its…
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Pre-existing systemic immune state and dynamic myeloid remodeling shape response to neoadjuvant PD-L1 blockade
CONCLUSIONS: A single neoadjuvant dose of atezolizumab was feasible, safe, and elicited measurable systemic immune activation in patients with resectable head and neck squamous cell carcinoma. Direct analysis of fresh blood uncovered dynamic PMN-MDSC changes as a potential novel pharmacodynamic biomarker of treatment response, emphasizing the advantages of real-time, non-frozen immune cell profiling for complete…
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Efficacy and safety of rib-guided percutaneous thoracic sympathetic radiofrequency thermocoagulation at two different targets for primary palmar hyperhidrosis: a randomized controlled trial
CONCLUSIONS: Targeting the lateral margin of the fourth rib head for RFT achieved greater efficacy, better quality of life and higher patient satisfaction compared to the upper margin target.
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Recruitment Source and Participant Retention in a Digital HIV Prevention Intervention for Young Black and Latino Men and Transgender Women: Secondary Analysis of the HealthMpowerment 2.0 Randomized Controlled Trial
CONCLUSIONS: Recruitment source was associated with both participant characteristics and long-term retention in this digital HIV prevention intervention. Social media and prior research networks yielded higher retention, whereas partner-seeking apps reached populations at higher HIV risk but were associated with lower retention. Targeted retention strategies that account for both recruitment platform and participant characteristics (including…
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Effects of the LEARNS model-based self-management education on short-term treatment outcomes among newly diagnosed tuberculosis patients: a randomized controlled trial
CONCLUSIONS: The LEARNS model-based self-management program benefits inpatients with newly diagnosed pulmonary tuberculosis. It effectively improves patients’ self-management and tuberculosis prevention and control knowledge, and improves chest radiographic findings. However, this intervention yields no significant effects on anxiety, depression, social support, and sputum bacteriological conversion.
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Effect of Sour Taste on Swallowing Function of Patients With Dysphagia After Acute Ischemic Stroke: A Randomized Controlled Trial
CONCLUSIONS: Administration of a sour taste during the early period of acute ischemic stroke had a beneficial effect on swallowing function in patients with dysphagia. Sour taste stimulation may be considered a practical, feasible, and complementary sensory intervention in post-stroke dysphagia management.