Clinical Trials
Category Added in a WPeMatico Campaign
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Continuous vs Intermittent Postoperative Vital Sign Monitoring: A Cluster Randomized Crossover Trial
CONCLUSIONS AND RELEVANCE: In this cluster randomized crossover trial of continuous compared with intermittent vital sign monitoring, continuous monitoring reduced the duration of desaturation in patients recovering from noncardiac surgery on general hospital wards. Reducing the duration of vital sign abnormalities may decrease the risk of more serious complications, and robust patient-centric outcomes trials seem…
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Phage therapy of purulent wounds: comparative clinical cytomorphological and microbiological analysis of effectiveness
CONCLUSION: The principles of purulent wounds treatment in our country are based on the method of active surgical treatment developed in the Department of Wounds and Wound Infections of the Vishnevsky Institute of Surgery (now the Vishnevsky National Research Medical Center of Surgery of the Ministry of Health of the Russian Federation). The results of…
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The Effect of Breast Cancer and Breast Self-Examination Health Education on Awareness, Beliefs, and Practices of Female Students at the Faculty of Health Sciences of a University in Somalia
CONCLUSION: HBM-based breast health education improved students’ knowledge, awareness, and BSE practice. Although BSE is not a screening tool, it is an essential awareness method in settings with limited access to diagnostic services.
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Enhancing presbyopia treatment: A comparative study of 1% Pilocarpine monotherapy versus combination with 0.09% Bromfenac
CONCLUSION: While both treatment regimens effectively improved near vision in patients with presbyopia, the combination of Pilocarpine and Bromfenac demonstrated superior outcomes in terms of accommodative function, safety profile, patient compliance, and a reduced need for glasses. These results suggest that this combination therapy may offer a more effective pharmacological approach to the management of…
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Comparison of the Effects of Glycopyrrolate and Atropine on Postoperative Delirium in Older Adult Patients Undergoing Laparoscopic Colorectal Surgery: A Randomized Controlled Trial
CONCLUSION: The combination of glycopyrrolate and neostigmine was associated with a lower incidence of POD than atropine in older adults undergoing laparoscopic colorectal surgery.
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Synbiotic supplementation reduces intestinal permeability and inflammation in overweight or obese kidney transplant recipients: a randomized controlled trial
Increased intestinal permeability resulting from gut dysbiosis, cardiovascular disease (CVD), and graft failure is common among kidney transplant (KT) recipients. This study was designed to investigate the effects of synbiotics on intestinal permeability, systemic and vascular inflammation markers, oxidative stress, and fibrosis in KT recipients. In this randomized controlled trial, 46 KT recipients were randomly…
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Certolizumab pegol, abatacept, tocilizumab or active conventional therapy in early rheumatoid arthritis: 48-week patient-reported outcomes from the NORD-STAR trial
BACKGROUND: Pain, fatigue, and impaired health-related quality of life are common manifestations of rheumatoid arthritis. The aim of this study was to compare the effects of active conventional treatment with three different biological disease-modifying antirheumatic drugs (DMARDs) on patient-reported outcomes after 48 weeks, in patients with early rheumatoid arthritis using data from the NORD-STAR trial.
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Determinants of the Uptake and Frequency of Use of a Web Portal Digital Health Intervention in Patients With Type 2 Diabetes and/or Coronary Heart Disease: Secondary Analysis of a Randomized Controlled Trial
CONCLUSIONS: This study is innovative in jointly examining determinants of the uptake and frequency of use of the same DHI within a single context and sample. By demonstrating that factors driving uptake do not necessarily increase the frequency of use, it advances existing research. The study contributes to a more differentiated understanding of DHI use…
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Comparison of sesame oil wafers and lozenges as saliva substitutes for dry mouth in head and neck cancer patients: A crossover randomized control trial
CONCLUSION: To conclude, FD-SOESS significantly improved objective dry mouth and dysphagia but not subjective dry mouth. It received a relatively high level of satisfaction. Therefore, this newly developed product has the potential to be an alternative product for dry mouth patients.
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Effects of the mHealth Supportive Care Program for Family Caregivers of Individuals With Dementia and Diabetes: Pilot Randomized Controlled Trial
CONCLUSIONS: This theoretically grounded mHealth supportive care program effectively reduced burden and improved outcomes for FCGs managing dementia-diabetes comorbidity. The integrated online-offline delivery model shows particular promise for male, younger, manual labor, and lower-income caregivers, suggesting mHealth’s potential to address health equity. These findings provide a feasible model for scalable caregiver support in resource-limited primary…