Clinical Trials
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Effect of intrapulpal cryoanesthesia on intraoperative pain during root canal treatment in mandibular molars: a double blinded randomized control trial
To evaluate the impact of cooling the anesthetic solution prior to administering intra-pulpal anesthesia on the severity of intraoperative pain during root canal treatment in mandibular molars with symptomatic irreversible pulpitis and symptomatic apical periodontitis. Forty patients with mandibular molars diagnosed with symptomatic irreversible pulpitis and symptomatic apical periodontitis received root canal treatment by a…
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Evaluating the Efficacy of a Digital Therapeutic Intervention for Temporomandibular Disorders: Multicenter, Randomized, Sham-Controlled Trial
CONCLUSIONS: This randomized, sham-controlled trial demonstrated that a mobile-based DTx intervention led to significant improvement in pain at 6 weeks compared with sham control, with additional benefits in jaw function and oral behaviors, although no significant between-group difference was observed in psychological distress. These findings suggest that DTx interventions may serve as a promising and…
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Comparation of anterior maxilla and whole maxilla clockwise rotation to improve paranasal aesthetic defects of skeletal Class Ⅲ maxillofacial deformity
CONCLUSION: Compared with whole maxilla clockwise rotation, anterior maxilla clockwise rotation combined with segmental Le Fort Ⅰ osteotomy can increase the saggital displacement of the paranasal soft tissue, correct labial inclination of the upper incisors and the acute naso-labial angle and better improve the paranasal aesthetic defects in patients with Class Ⅲ maxillofacial deformity with…
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Effects of kinesiotaping combined with physical therapy in patients with migraine-associated neck pain: a randomized controlled study
CONCLUSION: The findings suggest that KT combined with PT and pharmacological treatment significantly improves clinical outcomes in migraineurs with neck pain. Specifically, the TG demonstrated greater reductions in intensity of headache and neck pain, along with increases in PPT and improvements in disability and QoL compared to both groups. These results can support the potential…
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Brexpiprazole for the Treatment of Co-occurring Schizophrenia and Substance Use Disorder: A Multisite, Randomized, Controlled Trial
Objective: This proof-of-concept study examined the effects of brexpiprazole treatment on substance use, psychiatric symptoms, and quality of life in patients with co-occurring schizophrenia and substance use disorder.
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Safety and efficacy of ranibizumab combined with dexamethasone intravitreal implant versus ranibizumab monotherapy for macular edema secondary to retinal vein occlusion: a 12-month prospective, randomized study
CONCLUSION: Combination therapy with ranibizumab and a dexamethasone implant provides superior visual outcomes and reduces the treatment burden compared to ranibizumab monotherapy for RVO-ME over 12 months. The safety profile was favorable, though monitoring for ocular hypertension is necessary. These benefits are particularly significant for patients with BRVO-ME.
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Oxycodone versus Sufentanil for Postoperative Recovery in Obese Patients Undergoing Laparoscopic Bariatric Surgery: A Randomized Controlled Trial
CONCLUSION: Oxycodone significantly enhanced postoperative recovery quality compared with sufentanil in obese patients undergoing laparoscopic bariatric surgery, providing superior analgesia and reducing opioid-related side effects.
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Effects of melatonin on advanced glycation end products, inflammation, and oxidative stress in peritoneal dialysis patients: a randomized controlled trial
Advanced glycation end products, systemic and vascular inflammation, and oxidative stress are risk factors for cardiovascular disease in peritoneal dialysis (PD) patients. No studies have examined the effects of melatonin on these risk factors in PD patients. This study was a randomized clinical trial. Forty-four PD patients were randomly assigned to either the melatonin or…
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Effect of orally administered L. crispatus M247 in favoring HR-HPV clearance and CST shift: results from a randomized, multi-center, placebo-controlled trial
Epidemiological evidence support the idea that CST I, L. crispatus-dominated vaginal microbiota, could protect women form cervical HPV infection also favoring the HPV clearance. Our prospective, multi-center, randomized, placebo-controlled trial on 62 women newly diagnosed of HPV infection without visible cervical lesions at colposcopy, was mainly aimed at evaluating the role exerted by the oral…
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Proactive Identification and Digital Mental Health Intervention for the Treatment of Depression Among Individuals With Likely Incurable Cancer: A Pilot Randomized Clinical Trial
CONCLUSIONS: A proactive ID + DMHI approach to identifying and treating depression among ILLIC is feasible, acceptable, and potentially efficacious. These promising data support conducting a large efficacy trial evaluating this approach.