Clinical Trials
Category Added in a WPeMatico Campaign
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Real-Time Artificial Intelligence Diagnostic Copilot in Simulated Primary Care Consultations: Randomized Simulation Study
CONCLUSIONS: In this randomized, high-difficulty simulation study, real-time, voice-based AI assistance was associated with higher physician Top-3 diagnostic accuracy than an unassisted, resource-restricted comparator. Some sensitivity analyses were supportive, while others were directionally favorable but inconclusive, and the safety analysis suggested possible overreliance without statistically conclusive difference between conditions. These findings support further refinement and…
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A randomised, participant- and assessor-blinded, sham-controlled trial investigating acupuncture for disorders of gut-brain interaction in children (P-GAP)
BACKGROUND: Disorders of gut-brain interaction (DGBIs) affect approximately 25% of children worldwide and account for a substantial proportion of paediatric gastroenterology consultations. These conditions are associated with significant morbidity, including chronic pain, school absenteeism, anxiety and reduced quality of life. Current treatment options offer limited efficacy, particularly in paediatric populations. Acupuncture, a widely used complementary…
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A workbook- and audio-administered, telephone-guided, low-intensity cognitive behavioural therapy intervention (EJDeR) for parents of persons treated for cancer during childhood: protocol for the CHANGE-pilot randomised controlled trial
INTRODUCTION: Childhood cancer and its treatment place substantial demands on parents, causing significant disruptions in multiple areas of life. Parents report psychological, psychosocial, and economic consequences related to their child’s illness. In Sweden, psychosocial support is available to parents via paediatric oncology care during cancer treatment; however, only a minority of parents have access to…
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Duration-dependent acute effects of foam rolling on dominant-hand visual reaction time in male youth basketball players: A randomized controlled study
CONCLUSION: FR-A had consistently lower adjusted reaction time than FR-B across all scoring methods. However, the FR-A-control comparison depended on baseline reaction time and scoring method. Thus, the findings do not establish a scoring-independent benefit of the 30-second protocol over passive rest or support a firm practical recommendation.
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The Digital Diabetes Patient Reminder Tool for Adults With Type 2 Diabetes: Protocol for a Proof-of-Concept Randomized Controlled Trial
CONCLUSIONS: This study will provide insights into the potential added value of a digital reminder tool for T2DM management in a real-world setting as well as the usability and acceptability of this tool.
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A Theory of Planned Behavior-Based Cluster Randomized Trial to Improve Health Literacy Among Rural Adults in China
Rural populations often face structural barriers to accessing, interpreting, and using health information, contributing to persistent health literacy disparities. This cluster randomized controlled trial evaluated whether a theory of planned behavior-based intervention could improve health literacy acquisition behaviors and overall health literacy among rural residents in Changzhou, China. Twenty villages were randomized to a 12-month…
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Glabridin content and metabolic effects of liquorice confectionaries: A secondary analysis of a randomized crossover trial in young adults
CONCLUSION: Liquorice intake did not improve metabolic markers but attenuated hsCRP elevation. The potential metabolic benefits of glabridin are unlikely to outweigh the hypertensive effects when consumed as whole liquorice.
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Clinical performance of glass hybrid and short fiber-reinforced composite restorations in MIH-affected molars: A 60-month split-mouth randomized controlled trial
CONCLUSIONS: Both GH and SFRC-supported microhybrid composite restorations provided clinically acceptable long-term outcomes in MIH-affected molars after SCR. Although clinical performance per modified USPHS criteria was comparable, SFRC-supported microhybrid composite restorations demonstrated superior long-term survival.
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Clinical effectiveness of Er, Cr: YSGG laser compared with conventional rotary instrumentation for caries removal in primary teeth: a randomized split-mouth clinical trial
To compare the clinical efficacy of erbium, chromium-doped yttrium scandium gallium garnet (Er, Cr: YSGG) laser versus conventional air-rotor handpiece for caries removal in primary teeth and their effects on children’s anxiety and pain levels, to provide evidence for optimizing pediatric dental treatment. A total of 90 children (aged 6-10 years) with primary tooth caries…
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Effect of Chinese medicine compound on intestinal bifidobacteria recovery and CD4+ T-Cell activation in postoperative chemotherapy patients with breast cancer
CONCLUSION: The traditional Chinese medicine compound effectively maintained intestinal flora balance, promoted beneficial bacterial growth, reduced adverse reactions and offered better therapeutic prospects for breast cancer patients.