Clinical Trials
Category Added in a WPeMatico Campaign
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Glycemic Status and Effect of Immediate Intensive Statin on Mild Ischemic Stroke: A Subgroup Analysis of the INSPIRES Trial
CONCLUSIONS: Patients without T2DM derived greater benefit in functional outcomes from immediate-intensive statin after ischemic stroke than those with T2DM.
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Treatment effect modifiers of virtual reality-based versus standard cognitive behavioral therapy for paranoia in schizophrenia spectrum disorders: an exploratory moderator analysis of clinical and demographic characteristics in the FaceYourFears trial
CONCLUSIONS: This exploratory study generates hypotheses for future research, including VR-CBTp’s potential to engage individuals with high avolition. Given the modest effects and largely nonsignificant findings, both CBTp and VR-CBTp appear suitable for a wide range of individuals with paranoia, highlighting the importance of considering patient preferences.
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High expression of low-risk hpv in nasal inverted papilloma and its response to interferon therapy
Objective:To investigate the expression of HPV 6/11 in NIP tissues and evaluate the adjuvant therapeutic effect of interferon-α gel on HPV-positive NIP patients. Methods:Forty-two newly diagnosed Nasal Inverted Papilloma（NIP） patients were included, and the expression of HPV6/11 in tissues was detected using fluorescence in situ hybridization with specific probes. Twenty-two HPV-positive patients were randomly divided…
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Neoadjuvant chemotherapy for soft-tissue sarcoma of the extremities: A post-hoc Sarculator-based risk analysis of the EORTC 62961-ESHO 95 randomized trial
CONCLUSIONS: This analysis of ESTS from a randomized trial confirmed the previously reported OS benefit by adding RHT to NAC. Although patients with higher predicted risk seemed to benefit more from the combined treatment, these findings do not suggest that treatment decisions should be based on risk estimates alone, supporting the use of RHT combined…
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Effect of a DBT-Informed Dyadic Intervention (Better Together) on Psychosocial Outcomes in Colorectal Cancer Patient-Spouse Dyads: A Randomized Controlled Trial
CONCLUSIONS: The BT program effectively improved both individual and dyadic outcomes, with patients benefiting immediately in psychological domains and caregivers exhibiting delayed improvements in relational outcomes during the follow-up period. These findings support implementing phased, role-sensitive dyadic interventions that address the distinct temporal needs of patients and caregivers in cancer care.
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Acceptability and efficacy of low-dose zinc with or without probiotics in acute watery diarrhoea-a prospective comparative study
Acute watery diarrhoea (AWD) has not been well-treated with 20 mg elemental zinc, primarily because of adverse symptoms like vomiting. In contrast to 20 mg of zinc, this study sought to determine whether a lower dose of zinc, with or without probiotics, is as beneficial as 20 mg of zinc, yet tolerated better. The aim…
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Learning to Unveil: Tackling Implicit Bias in Pain Recognition Through Education
CONCLUSIONS: This suggests that the intervention heightened students’ sensitivity to pain-related cues and encouraged a re-evaluation of clinical judgements. These results underscore the value of targeted educational initiatives in addressing disparities in pain recognition and treatment driven by facial cues, providing evidence that even brief interventions may contribute to mitigating implicit biases and support more…
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The stress reduction potential of Bhagavad Gita and Yoga for healthcare workers during the COVID-19 pandemic: A randomized controlled trial
BACKGROUND: Healthcare workers (HCWs) experienced elevated psychological distress during the COVID-19 pandemic. Culturally embedded, non-stigmatizing approaches may improve uptake of mental health support in this population. We aimed to evaluate the impact of Yoga, Bhagavad Gita learning, and their combination (Yoga+Gita) on psychological distress among HCWs.
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A secondary head-to-head comparison of low-intensity focused ultrasound and repetitive transcranial magnetic stimulation for motor recovery after stroke
CONCLUSION: LIFU and rTMS were associated with comparable short-term motor outcomes in subacute stroke. Differences observed in change-from-baseline motor improvements and exploratory neuroimaging measures suggest potential divergence in recovery dynamics and cortical modulation, warranting further investigation in larger, longitudinal studies.
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Positive Affect Treatment for Depression, Anxiety, and Low Positive Affect: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of 98 adults with severely low positive affect, depression, and anxiety, findings suggested that modulation of reward and threat processes was a central mechanism of therapeutic improvement, with a reward-focused intervention producing superior clinical outcomes.