Clinical Trials
Category Added in a WPeMatico Campaign
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Exploring the feedback effects of incentive methods on HIV rapid self-testing among men who have sex with men in Chongqing, China
CONCLUSION: Our results show no significant differences in feedback rates across groups at follow-up time points. Significant differences in feedback rate trends among the three groups were observed, with the extra lottery incentive providing more sustained motivation for feedback. And privacy concerns are crucial for expanding HIVST among MSM via social apps.
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Percutaneous Coronary Intervention in Multivessel Disease and Infarct-Related Cardiogenic Shock: A DanGer Shock Substudy
CONCLUSIONS: Immediate multivessel PCI was associated with 60% lower odds of all-cause mortality compared with culprit-only PCI.
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Efficacy of In-office Bleaching Gel One Week After Mixing: A Randomized Clinical Trial
CONCLUSION: In-office dental bleaching with Opalescence Boost PF 40% remained effective, without differences in risk and intensity of TS and GI, even 1 week after mixing.
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Clinical Interchangeability of PD-L1 Immunohistochemistry Assays in First-Line Non-Small Cell Lung Cancer Management With Cemiplimab
CONCLUSION: Similar efficacy (OS and PFS) was observed with the 22C3+ and SP263+ populations, demonstrating the interchangeability of these PD-L1 IHC assays for selecting patients with PD-L1 ≥50% for first-line cemiplimab monotherapy for advanced NSCLC.
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A randomised controlled trial to assess the feasibility and acceptability of remote psychosocial and exercise interventions for people with lupus: The ADAPT feasibility trial
Limited psychosocial support is available for people with lupus despite the highly reduced quality of life. This study assessed the acceptability, feasibility, and effectiveness estimations, of three (two psychosocial, one exercise) interventions. Lupus patients (N = 124) were randomised to a control arm or one of three interventions delivered remotely over 8-12 weeks: (1) listening…
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Multimodal prognostic modeling of individual cognitive trajectories to enhance trial efficiency in preclinical Alzheimer’s disease
INTRODUCTION: Cognitive decline in asymptomatic preclinical Alzheimer’s disease (AD) is slow and variable, limiting detection of treatment effects. This study developed models to forecast trajectories and improve trial efficiency.
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Eribulin plus Pyrotinib in Trastuzumab-Resistant, HER2-Positive Advanced Breast Cancer: A Single-Arm, Multicenter Phase II Trial (EPIC Trial)
CONCLUSION: The combination of Eribulin and Pyrotinib emerges as a viable treatment option for HER2-positive advanced breast cancer patients who have exhibited resistance to trastuzumab. Despite advancements in anti-HER2 therapies, further research is required to address remaining challenges in this specific clinical scenario.
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Culturally adapted hypocaloric diet improves hepatic steatosis, inflammatory and oxidative biomarkers in Egyptian MASLD patients: a single-arm interventional study
CONCLUSION: A culturally tailored hypocaloric diet effectively improved hepatic steatosis, inflammatory status, and antioxidant capacity in Egyptian MASLD patients. These improvements were partially weight-independent and partially mediated by anti-inflammatory responses. These findings support hypocaloric dietary strategies as a potentially scalable therapeutic option for MASLD management in resource-limited settings, though the absence of a control group…
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Validating the Efficacy of a Mobile Digital Therapeutic for Insomnia (WELT-I): Randomized Controlled Decentralized Clinical Trial
CONCLUSIONS: WELT-I showed significant therapeutic efficacy and safety in improving sleep efficiency and sleep-related dysfunctional attitudes in cases of insomnia. In addition, this study demonstrated the feasibility of DCTs, and the findings of rapid recruitment, high compliance and retention rates, and strong participant satisfaction suggest that DCTs have sufficient potential to be expanded to clinical…
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A New Progressive Motor-Control-Based Exercise Approach for Women with Diastasis Recti Abdominis: The Denizoglu Method
CONCLUSIONS: The Denizoglu Method emerges as a promising approach for managing DRA in clinical practice. It can be effectively implemented as a supervised home-based exercise program or integrated in women’s health care centers during the 1 to 3 years postpartum period.