Clinical Trials
Category Added in a WPeMatico Campaign
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10-Year Randomized Outcomes of Transcatheter or Surgical Aortic Valve Replacement in Intermediate-Risk Aortic Stenosis
CONCLUSIONS: At the 10-year follow-up, TAVR in intermediate-risk patients with the SAPIEN XT prosthesis compared with surgery was associated with lower survival rates, with differences predominantly observed in the TA/TAo access cohort. TAVR with the XT valve was also associated with significantly higher rates of aortic valve reintervention. (PARTNER II Trial: Placement of AoRTic TraNscathetER…
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10-Year Outcomes of SAPIEN 3 Transcatheter Aortic Valve Replacement or Surgery in Intermediate-Risk Patients
CONCLUSIONS: At 10 years, TAVR with the SAPIEN 3 valve and surgery resulted in similar rates of mortality and aortic valve reintervention, and similar hemodynamics in intermediate-risk patients with symptomatic severe aortic stenosis. This analysis highlights challenges associated with extended long-term follow-up of clinical trials, including differential loss to follow-up and the competing risk of…
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Novel use of arm ergometry cardiopulmonary exercise testing for non-elective patients with chronic limb-threatening ischaemia: a feasibility trial
CONCLUSIONS: CPETarm is a feasible, safe and acceptable method for preoperative assessment in patients with CLTI who are unsuitable for conventional lower-limb CPET. Further research is required to establish modality-specific thresholds, evaluate prognostic value for postoperative outcomes and evaluate integration into perioperative care pathways.
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Effectiveness and cost-effectiveness of risk-based topical fluoride intervention on early childhood caries in Jiangnan District, Nanning City
CONCLUSIONS: The PSC-MCAT tool is effective and cost-effective for caries risk assessment and may serve as a practical framework for caries prevention.
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The time sensitivity of aspirational interventions: Evidence from a role-modeling RCT
This paper investigates the short-run effects of an aspiration-raising intervention delivered as part of a randomized controlled trial among postgraduate students at a UK university during the Covid-19 pandemic. We document suggestive evidence, that a video-based role-modeling intervention led to an immediate increase in aspirations and a delayed increase in self-reported effort. However, both effects…
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Community Optometrist-Led Monitoring of Quiescent Neovascular Age-Related Macular Degeneration: The FENETRE Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, community optometrist-led monitoring of quiescent nAMD was noninferior to hospital monitoring for detecting disease activity requiring treatment. These results provide evidence for its use in integrated clinical care models.
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Tumor-derived cell-free DNA detected in cerebrospinal fluid enables minimally invasive profiling of pediatric brain tumors
BACKGROUNDLiquid biopsy has emerged as a minimally invasive method for tumor diagnosis, monitoring, and therapeutic guidance. For CNS tumors, cerebrospinal fluid (CSF) provides a reliable and accessible source of tumor-derived cell-free DNA (ctDNA).METHODSThis study evaluates the clinical utility of CSF liquid biopsy in a real-world prospective setting. A total of 148 CSF samples from 120…
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Effectiveness of an online vaccine misinformation game for Arabic-speaking Australians: a randomized controlled trial
BACKGROUND: Vaccine misinformation can undermine vaccine confidence, institutional trust, and uptake. Arabic speakers in Australia are disproportionately susceptible to vaccine misinformation and have experienced adverse health outcomes. This randomized controlled trial tested the effectiveness of Cranky Uncle — Vaccine (Arabic), a gamified psychological inoculation intervention, in improving vaccine attitudes, misinformation discernment, and institutional trust among…
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Comparison of the Effects of Incubator and Radiant Environments on Physiological Criteria and Pain-Stress Levels during Heel Lance in Neonates in the Neonatal Intensive Care Unit: A Randomized Controlled Trial
CONCLUSION: Although body temperature increased significantly in the radiant heater environment compared with the incubator environment, this difference did not appear to play a vital role in affecting the physiological parameters of the newborn.
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Effect of a prior hypercapnia experience on recognition of hypercapnia in divers: a randomised controlled study
CONCLUSIONS: Although no significant training benefit was shown, becoming familiar with the sensations associated with hypercapnia under appropriate supervision could be useful to rebreather divers both recreationally and within occupational settings.