Clinical Trials
Category Added in a WPeMatico Campaign
-
Ivarmacitinib in patients with moderate to severe atopic dermatitis stratified by baseline characteristics: a post-hoc analysis of a phase 3 clinical trial
CONCLUSION: Ivarmacitinib demonstrated efficacy and good tolerability in treating moderate to severe AD with diverse patient characteristics.
-
From awareness to action: Health Belief Model-based educational intervention to improve breast self-examination practice among college teachers in Pakistan (CRCT)
CONCLUSION: HBM-based intervention effectively enhanced BSE knowledge, beliefs, and practices while reducing barriers. Findings emphasize the value of structured educational interventions in promoting preventive health behaviors among female educators.
-
Intensive blood pressure control and risks of cognitive outcomes in patients with new-onset orthostatic hypotension
CONCLUSIONS: The occurrence of OH requires close monitoring, with caution for potential cognitive adverse effects during ongoing intensive BP-lowering treatment. Validation of current findings in studies with justified methodological designs is warranted.
-
Effectiveness and implementation of a multi-faceted intervention to facilitate adoption of asthma self-management practices in Peruvian children and adolescents: a hybrid type 2 individually randomized controlled trial
BACKGROUND: Peru has one of the highest burdens of asthma in the world, as well as large gaps in access to evidence-based treatments. Studies often overlook the ways in which the research context and data collection activities interact and influence the experience of a research participant, their perception of an intervention, and, by extension, study…
-
Low-Intensity Blood Flow-Restricted Multi-Joint Exercise Improves Muscle Function in Patients With Patellofemoral Pain Syndrome: A Randomized Trial
BACKGROUND Patellofemoral pain syndrome (PFPS) limits physical activity and quality of life, especially during weight-bearing tasks. Although high-load resistance exercises are recommended for rehabilitation, they may worsen symptoms in pain-sensitive individuals. Low-intensity blood flow restriction (BFR) training has emerged as a potential alternative. However, its effects on functional performance and mechanical properties remain unclear. MATERIAL…
-
Evaluating the effect of cryotherapy and low-level laser therapy on postoperative pain and quality of life in patients with symptomatic apical periodontitis- a randomized controlled clinical study
The aim of this randomized controlled clinical study is to compare the effect of intracanal cryotherapy and intraoral Low-Level LASER Therapy (LLLT) applications on postoperative pain and quality of life in patients following endodontic treatment for symptomatic apical periodontitis. After ethical clearance and registering the trial at clinical trial registry of India, a randomized, parallel-controlled…
-
Association Between Age and PCI Effectiveness in Stable CAD: Secondary Analysis of ORBITA-2
CONCLUSIONS: PCI was effective across all ages in reducing angina frequency. Notably, there was limited improvement in treadmill exercise time in the elderly, challenging its role as a primary endpoint in many antianginal trials. These data should inform cardiovascular clinical trial design to ensure applicability across all ages. (Objective Randomized Blinded Investigation With Optimal Medical…
-
‘Until You Get the Diagnosis You’re Forever in Limbo’-Parents’ Experiences of Waiting for an Attention-Deficit/Hyperactivity Disorder Assessment With Child and Adolescent Mental Health Services
CONCLUSION: Parents recognised the pressures on services to offer timely support; however, their well-being could be substantially improved by more clarity around wait times, as well as more effective signposting and support from services concerning the assessment process. This may help alleviate some of the stressors associated with their child’s assessment journey, such as feeling…
-
Dynamic interpersonal therapy combined with antidepressant medication for college students with depression and insomnia: A randomized controlled trial
CONCLUSIONS: DIT combined with antidepressant medication demonstrated superior efficacy compared to medication alone in alleviating insomnia, depressive symptoms, and anxiety, as well as in improving sleep quality among college students with depressive disorders. These results support the integration of DIT into standard clinical care to address co-occurring depression and insomnia in this vulnerable population. However,…
-
The effect of personalized forest therapy programs on stress and obsessive-compulsive symptoms in patients with depression
INTRODUCTION: Depression is one of the most serious mental health disorders worldwide. Forest therapy has been shown to be an effective non-pharmacological intervention. This study examined the development and implementation of personalized forest therapy programs for patients with depression, particularly their effects on stress levels and obsessive-compulsive symptoms.