Clinical Trials
Category Added in a WPeMatico Campaign
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Amikacin liposome inhalation suspension in newly diagnosed Mycobacterium avium complex lung disease (ARISE): a 6-month double-blind, active comparator trial
CONCLUSIONS: More patients with newly diagnosed MACLD receiving 6 months of ALIS alongside a macrolide-based regimen achieved culture conversion by month 6 and month 7 numerically more rapidly versus comparator. No new safety signals were identified.Clinical trial registered with www.clinicaltrials.gov (NCT04677543).
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Two-Year Outcomes of Less Invasive Surfactant Administration Among Preterm Neonates: A Secondary Analysis of a Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this secondary analysis of a randomized clinical trial of preterm infants supported with CPAP, early caffeine administration plus LISA did not reduce the incidence of death or moderate to severe NDI noted on the BSID. Infants who received LISA were more likely to have a fine motor domain score in the…
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Significant Incidental Findings in the National Lung Screening Trial and Diagnosis of Extrapulmonary Cancer
CONCLUSIONS AND RELEVANCE: This cohort study found that cancer SIFs were associated with an increased risk of an extrapulmonary cancer diagnosis in the year following an LDCT lung cancer screening examination. These findings suggest that certain SIFs should be evaluated as potential indicators of undiagnosed cancers.
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Comparison of Post-Cementation Sensitivity Between Resin Modified Glass Ionomer Cement and Conventional Glass Ionomer Cement as a Luting Material-A Randomized Clinical Trial
CONCLUSION: RMGIC demonstrated significantly lower post-cementation sensitivity compared to conventional GIC.
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Catheter Ablation for Frequent Premature Ventricular Contractions or Paroxysmal Supraventricular Tachycardia With Vagal Bradycardia: A New Clinical Application of Superior Vena Cava-Aorta Ganglionated Plexus Modification
CONCLUSION: The simplified right atrial Ao-SVC GP ablation effectively treats vagal bradycardia. Additionally, combining it with radiofrequency ablation for concurrent tachyarrhythmia offers a safe and innovative therapy.
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The Impact of Different Oral Antidiabetic Drugs on Insulin Pump Intensive Therapy in Type 2 Diabetes Patients: A Clinical Study
CONCLUSION: These findings suggest that compared with metformin, dapagliflozin combined with intensive insulin pump therapy holds greater promise for optimizing glycaemic control in patients with T2DM, thus providing a more promising option for clinical practice.
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Effect of Intraoperative Low-Dose Esketamine on Postoperative High-Sensitivity Troponin T in Elderly Patients Undergoing Ivor Lewis Esophagectomy
CONCLUSION: Intraoperative low-dose esketamine effectively reduced hs-cTnT concentrations within 2 days postoperatively in elderly patients undergoing Ivor Lewis esophagectomy, demonstrating a potential beneficial effect in preventing myocardial injury and cardiovascular adverse events.
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The Investigation of the Effects of Group Exercise Treatment on Psychological Status, Muscle Strength, Respiratory Performance, and Balance Parameters in Hospitalized Patients in Psychiatry Departments: A Randomized Clinical Study
CONCLUSION: Group-based breathing, posture, and stretching exercises had greater effects on psychological symptoms than on physical performance parameters in psychiatric inpatients. These findings suggest that structured exercise interventions may serve as a valuable adjunct to medical treatment in this population.
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Influence of Device and Format: A Randomized Controlled Trial of an Electronic Health Record-Integrated Symptom Screening Questionnaire for Pediatric Patients With Cancer
CONCLUSION: Completing SSPedi on a computer or phone, each of which presented SSPedi differently, did not affect ease of use or bias results. Although the phone was more commonly preferred, availability of SSPedi via both phone and computer will be important for implementation of routine symptom screening in pediatric patients with cancer to provide patients…
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Virtual Reality Versus In-Person Simulation of Sepsis for Medical Students: Randomized Comparative Pilot Study
CONCLUSIONS: This study demonstrates the feasibility of the proposed trial method and provides insight into likely effect sizes for the design of further studies. The measured learning outcomes were similar across the groups, regardless of which simulation modalities were used prior to assessment. Our study found no statistically significant differences for VR simulation versus IP…