Clinical Trials
Category Added in a WPeMatico Campaign
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Patritumab deruxtecan (HER3-DXd) in patients with active brain metastases of non-small-cell lung cancer (TUXEDO-3): a multicentre, single-arm, phase 2 trial
BACKGROUND: Patritumab deruxtecan (HER3-DXd) is a novel antibody-drug conjugate targeting HER3, which is overexpressed in CNS metastases of advanced non-small-cell lung cancer (NSCLC). We aimed to evaluate the activity and safety of HER3-DXd in patients with advanced NSCLC and newly diagnosed brain metastases or brain metastases progressing after local therapy.
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The order of completing MDP and D12 does not affect the breathlessness responses: A randomised controlled trial
BackgroundBreathlessness is a common and distressing symptom across a wide range of medical conditions. Different aspects (dimensions) of breathlessness can be assessed using the Multidimensional Dyspnoea Profile (MDP) and Dyspnoea-12 (D12) questionnaires. We aimed to examine whether the order of completing MDP and D12 affects the breathlessness responses in people with cardiorespiratory disease.MethodsThis was a…
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Message-Based vs Video-Based Psychotherapy for Depression: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this sequential multiple assignment randomized clinical trial comparing MBP with VBP, there were no differences between groups on improvement in depression or social functioning. More participants in the VBP group disengaged from treatment, while VBP also had greater therapeutic alliance early in treatment among nonresponders. There were no differential effects from…
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Impact of astaxanthin on oxidative markers, uric acid, and clinical symptoms in heart failure: a randomized clinical trial
CONCLUSION: These findings suggest that ASX supplementation may be effective in improving oxidative stress biomarkers and clinical status in patients with HF.
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A Neuroaffirmative, Self-Determination Theory-Based Psychosocial Intervention for Adults With Attention-Deficit/Hyperactivity Disorder: Randomized Feasibility Study
CONCLUSIONS: This study suggests that a randomized controlled trial of an SDT-based psychosocial intervention with nondeficit-based outcomes for adults with ADHD is feasible and recommended.
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Multilevel and multicomponent intervention to promote colorectal cancer screening among Vietnamese Americans: a cluster randomized trial
CONCLUSIONS: This multicomponent intervention significantly improved CRC screening rates among Vietnamese Americans, highlighting the importance of community engagement and tailored health interventions that addresses individual and community level barriers.
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Safety, Efficacy, and Immunogenicity of a Salmonella Paratyphi A Vaccine
CONCLUSIONS: In healthy U.K. adults who were challenged with S. Paratyphi A in a controlled human infection model, a two-dose series of CVD 1902 led to protection against S. Paratyphi A infection without safety concerns. (Funded by the Medical Research Council; VASP ISRCTN Registry number, 15485902.).
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European Study of Prostate Cancer Screening — 23-Year Follow-up
CONCLUSIONS: Long-term follow-up confirms a sustained reduction in deaths from prostate cancer with PSA testing, alongside an improved harm-benefit ratio. Future screening strategies should adopt risk-based approaches to minimize overdiagnosis while maintaining clinical benefits. (Funded by the Dutch Cancer Society and others; ERSPC ISRCTN registry number, ISRCTN49127736.).
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Association between intraoperative hypotension during brain tumor resection and postoperative delirium: A secondary analysis of a randomized controlled trial
CONCLUSIONS: The current results could not indicate intraoperative hypotension of mean arterial pressure lower than 65 mmHg associated with delirium after frontotemporal brain tumor resection.
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Intended isocaloric time-restricted eating shifts circadian clocks but does not improve cardiometabolic health in women with overweight
Time-restricted eating (TRE) is a promising strategy to improve metabolic outcomes. However, it remains unclear whether TRE has cardiometabolic benefits in an isocaloric setting and whether its effects depend on the eating timing. We conducted a randomized crossover trial in 31 women with overweight or obesity to directly compare the effects of a 2-week early…