Clinical Trials
Category Added in a WPeMatico Campaign
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Effect of vitamin D and E supplementation on pain relief and premenstrual symptoms in primary dysmenorrhea: a randomized controlled trial
CONCLUSION: Combined vitamin D and E supplementation significantly reduces pain and PMS in vitamin D-deficient women. Healthcare providers may consider this regimen for dysmenorrhea management, pending further optimization studies.
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A Randomized Clinical Trial Evaluating Plaque and Gingivitis Effects of an Entry-Tier Oscillating-Rotating Electric Toothbrush
Purpose The purpose of this study was to evaluate plaque and gingivitis reduction efficacy of an entry-tier oscillating-rotating (OR) electric toothbrush, used in two brushing modes (Daily Clean and Sensitive), as compared to a manual toothbrush.Methods This was a three-treatment, three-period crossover study, assessing plaque with the Rustogi Modification of the Navy Plaque Index after…
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Experimental partial-night sleep restriction increases pain sensitivity, but does not alter inflammatory plasma biomarkers
CONCLUSIONS: The present findings indicate that heat and cold pressor pain were rated higher following SR, whereas pain thresholds remained unchanged. We did not find an effect of SR on biomarkers of inflammation. The findings should be cautiously interpreted given the poor adherence to the SR condition.
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Efficacy and safety of vunakizumab in patients with moderate-to-severe plaque psoriasis across different regions of China: a post-hoc exploratory analysis of a phase III, randomized controlled trial
CONCLUSION: The efficacy and safety of vunakizumab are not affected by different regions of China in patients with moderate-to-severe plaque psoriasis.
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Effectiveness of oral glutathione in reducing nitric oxide and IL-1alpha concentrations for clinical improvement in mild to moderate acne vulgaris: a randomized controlled trial
CONCLUSIONS: Oral glutathione supplementation demonstrated a non-significant trend toward reducing oxidative and nitrosative stress markers and improving mild to moderate AV. Further studies are recommended to validate these findings.
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Coenrollment of critically ill patients in PROSPECT: characteristics and association with treatment efficacy and safety
CONCLUSION: In this international, blinded trial, one-fifth of patients enrolled were coenrolled in at least one other study, which had no influence on the effect of probiotics on the primary outcome. Coenrolled patients were more likely to have higher disease severity, and to be recruited from a center with a longer history of participation in…
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Effect of dexmedetomidine on perioperative blood glucose regulation in type 2 diabetic patients undergoing laparoscopic colorectal cancer radical resection: a randomised double-blinded controlled trial
CONCLUSION: Dexmedetomidine loading dose 1 μg/kg and a Maintenance dose 0.25 μg/kg/h can be used in type 2 diabetic patients for better glucose regulation without increasing the incidence of perioperative hyperglycemia, adverse effects, and extending extubation time.
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Lessons Learned from Sepsis Microlearning Intervention
Improving early recognition and treatment of sepsis is key to decreasing patient mortality. A large academic health system implemented several quality improvement initiatives, yet monthly compliance with sepsis best practices remained low.Develop and evaluate an electronic health record (EHR)-embedded microlearning intervention to address suboptimal adherence to sepsis care best practices.We conducted a randomized stepped-wedge trial…
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Efficacy and safety of ultrasonic bone scalpel in posterior cervical expansive open-door laminoplasty for cervical degenerative diseases: A prospective randomized controlled trial
BackgroundKey instruments used in posterior cervical expansive open-door laminoplasty (CEOL), such as the high-speed drill (HSD) and the ultrasonic bone scalpel (UBS), are selected based on surgeon preference. However, skepticism remains among some surgeons regarding the superiority of the HSD over the widely used UBS, necessitating a scientific evaluation of its practical utility.ObjectiveTo evaluate the…
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Vonoprazan-containing Dual and Triple Therapies are Non-inferior to Bismuth-quadruple Therapy for Helicobacter pylori Eradication: A Single-center, Prospective, Open-label, Real-World Study
CONCLUSIONS: Efficacy of the two Vo-containing regimens was comparable and non-inferior to the BQT in this region, and could serve as the first-line regimen for H. pylori eradication, and reduced use of one antibiotic per each patient treatment in real-world clinical application.