Clinical Trials
Category Added in a WPeMatico Campaign
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Digital Intervention (MiVacunaLA 2.0) to Promote COVID-19 Vaccine Acceptance Among Hispanic Children: Community-Based Randomized Controlled Trial
CONCLUSIONS: MiVacunaLA demonstrates that a culturally tailored, community-based, mobile phone-delivered vaccine educational intervention can increase COVID-19 vaccine uptake among Hispanic children and improve caregivers’ trust in governmental vaccine processes. MiVacunaLA is innovative in its integration of community-informed design with a fully automated, mobile phone-centric format and builds on prior literature by prospectively evaluating a culturally…
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Efficacy and safety of efgartigimod in the treatment of impending myasthenic crisis
CONCLUSION: Efgartigimod demonstrated comparable efficacy to IVIg for IMC remission but with a significantly faster onset, supporting its role as a rapid and safe alternative.
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The effect of perioperative lidocaine during modified radical mastectomy on postoperative pain and immune response: A randomized clinical trial
CONCLUSION: Perioperative systemic lidocaine infusion in patients with breast cancer could modulate the production of IL-6, and through the reduction of this cytokine, patients experienced better pain control in the immediate postoperative period.
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Efficacy and Safety of Escitalopram in Alleviating Depression and Anxiety Symptoms in COPD Patients: A Randomized Double-Blind Placebo-Controlled Trial
CONCLUSION: Short-term treatment with low-dose escitalopram significantly alleviates depression and anxiety in COPD patients. Notably, this brief intervention initiated a sustained positive clinical trajectory over 12 months. Combined with a favorable safety profile, these findings support its potential integration into comprehensive COPD management protocols, pending multicenter validation.
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Remimazolam Reduces the Cough Reflexes in Elderly Patients Undergoing Fiberoptic Bronchoscopy Under Remifentanil/Cipepofol-Based Anaesthesia: A Randomized Clinical Trial
CONCLUSION: The combination of remimazolam reduced the incidence of cough reflexes and dosage of cipepofol and remifentanil in elderly patients undergoing FOB under remifentanil/cipepofol-based anaesthesia.
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Standardized Berry Extract Improves Selected Visual Function Outcomes in Presbyopia: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial with Exploratory Biomarker Analysis
CONCLUSIONS: Overall, short-term AKB supplementation was associated with modest, exploratory changes in selected functional and systemic biomarker outcomes, but larger and longer-term studies are needed to confirm clinical relevance and clarify underlying mechanisms.
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Implementation Lessons and Policy Implications of Same-Day Antiretroviral Therapy Initiation: Insights from the ART Same-Day Counselling and Initiation (ASCI) SOP in South Africa
Same-day antiretroviral therapy (ART) initiation (SDI) is globally recommended to improve ART uptake. However, retention in care and viral suppression in South Africa remain suboptimal. This study evaluated the experiences of healthcare providers, patients, and community stakeholders in implementing the ART Same-day Counselling and Initiation (ASCI) Standard Operating Procedure (SOP), focusing on facilitators, barriers, and…
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Minimally Cooked Potato Improved Glycemic Response Across Two Meals and Insulin Sensitivity of Rice-Potato Mixed Meals: A Randomized Controlled Acute Trial
Objectives: This study aimed to investigate the possible association among texture, oral processing and starch digestive characteristics of hard-cooked (HP) and soft-cooked (SP) potato samples, as well as their acute postprandial glycemic and insulinemic response, when co-ingested with rice in a meal. Methods: HP and SP replaced one-third of rice carbohydrates. Postprandial glycemic and insulinemic…
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Long-Term Outcomes of Concurrent Chemoradiotherapy With S-1 in Older Patients With Esophageal Cancer: A Secondary Analysis of a Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this secondary analysis of a randomized clinical trial, long-term results showed that CCRT with S-1 was associated with a sustained survival benefit compared with RT alone, without increased noncancer-related mortality. This finding supports CCRT with S-1 as the preferred regimen for patients aged 70 to 85 years with EC.
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Eptinezumab With Patient Education for Chronic Migraine and Medication-Overuse Headache: The Randomized, Placebo-Controlled RESOLUTION Trial
BACKGROUND AND OBJECTIVES: Medication-overuse headache (MOH) commonly co-occurs with and complicates chronic migraine (CM). This trial evaluated efficacy and safety of eptinezumab, an anti-calcitonin gene-related peptide monoclonal antibody for migraine prevention-combined with a standardized brief educational intervention (BEI)-in adults with CM and MOH. We report results from the 12-week placebo-controlled period, of which weeks 1-4…