Clinical Trials
Category Added in a WPeMatico Campaign
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Empagliflozin Promotes Natriuresis in Diabetic Patients with Cirrhotic Refractory Ascites: A Proof-of-Concept Study
CONCLUSIONS: In this open-label, proof-of-concept study, empagliflozin was associated with improved short-term natriuretic indices over 10 days in diabetic patients with decompensated cirrhosis and refractory ascites, without serious adverse events. Larger, blinded, longer-term trials are warranted to confirm these preliminary findings.
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High-Frequency Oscillatory Ventilation Combined With Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: A Single-Center Randomized Clinical Trial
CONCLUSIONS: In the observed per-protocol population, HFOV + iNO was associated with fewer deaths or ECMO events and faster improvement in oxygenation and right-ventricular echocardiographic measures than either comparator. Because 12 randomized infants were excluded and the overall comparison was not robust to the differential worst-case missing-outcome assumption, confidence in the apparent treatment effect is…
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Continuous Versus Routine EEG in Critically Ill Patients Without Primary Neurologic Condition: Analysis of a Randomized Controlled Trial
CONCLUSION: In critically ill adults without a primary neurologic condition, cEEG was not associated with measurable benefits in survival, neurological recovery, or epileptiform activity detection compared with repeated rEEG, in a cohort without detected electrographic seizures or status epilepticus. Pending larger, ideally prospective comparative studies, repeated routine EEG may represent a reasonable alternative in resource-limited…
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The Effect of Carbetocin on Cardiac Repolarization: A Randomized, Placebo- and Positive-Controlled QT/QTc Study in Healthy Adults
Carbetocin is an oxytocin receptor agonist used for postpartum hemorrhage prevention. While oxytocin is known to transiently prolong the QT/QTc interval, robust QTc data for carbetocin are limited. Carbetocin is known to elevate HR, which can impact QTc analyses; thus, a dose that did not overly elevate HR was important to select. This randomized, placebo-…
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Acute and Chronic Effects of Green Tea Kombucha With and Without Grape Skin Extract on Immune and Oxidative Stress Markers in Beginner Runners: A Randomized Controlled Trial
Green tea kombucha is an antioxidant-rich beverage with promising health benefits. However, evidence regarding its effects in physically active individuals remains limited. This study investigated the acute and chronic effects of green tea kombucha, with or without grape skin extract, on immune and oxidative stress markers in beginner runners. This 12-week randomized clinical trial included…
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Effects of clear aligner-based expansion screw and nickel-titanium palatal expander on airway dimensions and sleep parameters in unilateral cleft lip and palate patients: a randomized clinical trial
CONCLUSION: Both CAE and NiTi palatal expanders significantly improved airway dimensions and sleep parameters in UCLP patients. Anterior transverse widening (intercanine and intermolar width) correlated positively with airway volume gains, whereas basal skeletal widening (J-J’ width, basal bone width) and molar inclination did not, suggesting that the overall expansion effect rather than its mechanistic subtype…
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Comparison of Remimazolam and Propofol for Anesthesia Management in Liver Cancer Patients Undergoing Percutaneous Radiofrequency Ablation: A Randomized Controlled Trial
CONCLUSION: Remimazolam with remifentanil provided better hemodynamic stability and respiratory safety than propofol in PRFA for liver cancer (Child-Pugh A/B, without severe comorbidities). The shorter recovery time, though partly confounded by flumazenil, supports remimazolam as a promising alternative. Further studies in higher-risk patients are needed.
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Application of a chain management protocol in patients with chronic refractory wounds under the medical consortium model: a health-services intervention study
CONCLUSION: A medical consortium-based chain management protocol effectively optimizes health service organization, strengthens interdisciplinary and inter-institutional collaboration, and improves the continuity, standardization, and efficiency of chronic wound care. This model shortens healing time, enhances patient satisfaction, and provides an implementable and scalable strategy for chronic wound management in the health service system. It offers important…
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Omega-3 Supplementation Modulates Whole-Blood EPA and DHA Without Improving Patient-Reported Outcomes in Youth with Migraine: A Quasi-Randomized Pilot Trial
CONCLUSIONS: Omega-3 PUFA supplementation significantly altered lipid biomarker profiles in youth with migraine over 12 weeks, supporting a measurable whole-blood EPA + DHA response in this proof-of-concept trial. Future larger-scale trials with longer duration are needed to evaluate clinical effects.
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Dietary Behaviours Mediate Intervention Effects on Body Composition Outcomes in Children: Evidence from a Cluster-Randomised Controlled Trial
CONCLUSIONS: The DECIDE-Children intervention improved body composition by reducing adiposity and increasing fat-free and muscle mass percentage, effects primarily mediated by dietary behaviour. These findings highlight dietary behaviour as a key component in paediatric obesity intervention.