Clinical Trials
Category Added in a WPeMatico Campaign
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Brief Video Intervention to Increase Treatment-Seeking Intentions Among Young Adults With Psychiatric Symptoms: A Randomized Controlled Trial
Objective: Brief social contact-based video interventions are effective in decreasing self-stigma and increasing treatment-seeking intentions. The present study is the first to target essential workers with self-reported anxiety, depression, and posttraumatic stress disorder (PTSD) symptoms during the COVID-19 pandemic. We hypothesized that viewers of the intervention would show greater increases in treatment-seeking intentions than nonviewers…
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Multi-wave locked system laser therapy in chronic non-specific neck pain: a double-blind placebo randomized-controlled trial
CONCLUSIONS: Both MLS Laser and Sham Laser therapies resulted in statistically significant improvements in pain, disability, and movement velocity. However, these changes were not clinically meaningful. MLS Laser therapy provided more pronounced and sustained pain relief and improved range of motion in head movements.
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Cost-utility analysis of a polylactic acid matrix versus a collagen dressing for the closure of diabetic foot ulcers
CONCLUSION: PLA dermal matrices provide a cost-effective alternative to collagen dressings, promoting faster wound closure, improved quality of life, and reduced healthcare costs. These results support the adoption of PLA as a preferred treatment for DFUs.
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Investigation of the Relevance of CYP3A4 Inhibition on the Pharmacokinetics of the Novel P2X3 Antagonist Filapixant: Results of In Vitro Explorations and a Fixed-Sequence Clinical Trial with Itraconazole in Healthy Volunteers
Hypersensitized P2X3 receptor signaling has been described to play a role in several disorders, including chronic cough. The goal of our in vitro and in vivo studies was to investigate the biotransformation and the influence of CYP3A4 inhibition on the pharmacokinetics of the selective P2X3 antagonist filapixant. Metabolic turnover of filapixant in human liver microsomes…
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The establishment and application of an early warning scoring system for neonatal pneumonia based on information technology
CONCLUSION: The application of an early warning scoring system for neonatal pneumonia based on information technology can shorten the time to symptom resolution, improve respiratory status, normalize blood gas indices, and reduce the incidence of complications.
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Computational Modelling Suggests Bacteriostatic Saline Does Not Reverse Botulinum Toxin-Induced Brow Ptosis
Anecdotal reports have recently circulated suggesting that intramuscular injection of bacteriostatic saline (BS)-which contains benzyl alcohol (BnOH)-can reverse botulinum toxin type A (BoNTA)-induced brow ptosis. Given the well-established intracellular persistence of BoNTA’s light chain and its irreversible cleavage of SNAP-25, such rapid functional recovery challenges existing pharmacological understanding. This study employed high-resolution pharmacokinetic/pharmacodynamic (PK/PD) modelling…
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Effect of Valemetostat on the Pharmacokinetics of Midazolam and Digoxin: A Phase 1 Drug-Drug Interaction Study in Patients With Non-Hodgkin Lymphoma
Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH)2/1, under investigation in non-Hodgkin lymphomas (NHLs) and solid tumors. In vitro, it inhibits cytochrome P450 3A (CYP3A) and P-glycoprotein (P-gp) when combined with sensitive CYP3A or P-gp substrates. This drug-drug interaction (DDI) sub-study is part of the phase 1 trial…
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Cost-effectiveness of office-based, magnetic resonance imaging-guided transperineal versus transrectal prostate biopsy: An economic analysis of the PREVENT trial
CONCLUSIONS: In this model, TP biopsy was more cost-effective than TR from a health care payer perspective. In the setting of increasing concerns about the risk of infection from traditional TR biopsy, these findings suggest that office-based TP biopsy is a more cost-effective population-level alternative.
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Cardiac Effects of Dapagliflozin in People with Chronic Kidney Disease
CONCLUSIONS: In a heterogeneous population of patients with chronic kidney disease, dapagliflozin significantly reduced left ventricular mass index compared with placebo. These findings provide mechanistic insights into the early treatment benefits of SGLT2 inhibitors seen previously in chronic kidney disease. Further research is needed to replicate and further define these early treatment benefits. (Funded by…
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Cost-Effectiveness of Single Versus Multiple Sessions of Physical Therapy for Adults With Spinal Disorders: An Economic Evaluation From a Pragmatic Randomized Controlled Trial
OBJECTIVE: To evaluate the cost-utility of a single session compared with multiple sessions of physical therapy care for adults with spinal disorders. DESIGN: Economic evaluation based on a pragmatic randomized controlled trial. METHODS: Patients with spinal disorders who were referred for a spinal surgery consultation and triaged as nonsurgical cases by an advanced practice physical…