Clinical Trials
Category Added in a WPeMatico Campaign
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EQ-5D vision bolt-on in macular degeneration: associations with visual measures and effect on utility differences and cost-effectiveness of stereotactic radiotherapy
CONCLUSIONS: Resource use data from the trial and routine follow-up could be used for future economic models. The vision bolt-on captured quality of life differences between participants but may not be sufficiently responsive to visual acuity decline in trials where only one eye is treated.
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Effectiveness of acceptance and commitment therapy on sexual function in women infected with human papillomavirus: a randomized controlled trial
CONCLUSION: Group Acceptance and Commitment Therapy effectively enhances sexual function and overall quality of life in women with HPV, suggesting its integration into supportive healthcare interventions.
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Hydrocodone vs Oxycodone and Postoperative Pain and Opioid Use in Joint Arthroplasty
CONCLUSIONS AND RELEVANCE: In this cohort study of CYP2D6 NMs undergoing joint arthroplasty, within multimodal analgesia, hydrocodone provided comparable pain control to oxycodone with significantly lower opioid exposure, supporting its use as a viable and possibly preferable analgesic option.
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Differences in Posterior Ocular Morphology Following Red Light Therapy Versus 0.01% Atropine for Myopia Control: A Randomized Controlled Trial Analysis
CONCLUSIONS: Over 12 months, RLRL showed broader macular flattening and more region-specific MOSH changes compared with 0.01% atropine in this cohort. However, the underlying mechanisms and the independent contribution of myopic progression to these morphological differences require further study.
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Fractional Flow Reserve-Guided Renal Artery Stenting in Renovascular Hypertension: 1-Year Results of the FAIR Study
CONCLUSIONS: At the 1-year follow-up, FFR-guided renal artery stenting reduced stent use without loss of blood pressure control or renal safety compared with angiography guidance.
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Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow: A Randomized Double-Blind Placebo-Controlled Mechanistic Study
CONCLUSIONS: Sublingual NTG induced a significant decrease in left ventricular preload and afterload, resulting in a marked decrease in myocardial work. This was associated with a significant and adaptive decrease in absolute coronary blood flow.
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Investigation and treatment rates following minimal trauma fracture: results of a primary care physician survey
CONCLUSION: Rates of osteoporosis-directed investigations and treatment after minimal trauma fractures in primary care are below recommended levels. There remains a gap between observed management practices and established guidelines. A major barrier appears to be the reliance on DXA for confirmation of osteoporosis despite the presence of a minimal trauma fracture.
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Etomidate combined with TAPB in ovarian cancer surgery: A controlled study on hemodynamics and immune response
CONCLUSION: Etomidate combined with transversus abdominis plane block provides stable anesthesia and modulates perioperative inflammatory and immune responses while reducing postoperative biochemical pain mediator levels, thereby supporting a safer and more physiologically balanced recovery following ovarian cancer surgery.
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Comparison of the Efficacy of Different Doses of Glucocorticoid Nasal Spray Combined with Loratadine in the Treatment of Rhinitis in Children: A Randomized Clinical Trial
Pediatric rhinitis is a common recurrent disorder that may progress to asthma or sinusitis in severe cases. This study aimed to compare the efficacy of different doses of glucocorticoid nasal spray combined with loratadine for rhinitis in children, and provide evidence for optimizing clinical treatment. A total of 150 children with rhinitis admitted from June…
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Efficacy and safety of short- versus standard-course ceftriaxone therapy in children with pneumonia: A randomized trial
CONCLUSION: Short- and standard-course ceftriaxone sodium have similar overall efficacy. A short-course is suitable for mild cases with a prompt inflammatory response, while a standard-course is preferred for severe cases or delayed inflammation to prevent relapse.