Clinical Trials
Category Added in a WPeMatico Campaign
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A Randomized Controlled Trial of Stereotactic Body Radiation Therapy Versus Chemoradiation Following Induction Chemotherapy in Borderline Resectable and Locally Advanced Pancreatic Cancer
CONCLUSION: SBRT showed superior resectability, survival outcomes, and QoL compared to CRT in patients with BRPC and LAPC. However, due to the study’s small sample size and single-centre design, these findings are hypothesis-generating and warrant validation in larger multicentre trials.
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Long-term efficacy of three treatments for severe MGD: a comparative study in Chinese patients
CONCLUSION: MGX, IPL+MGX, and LipiFlow were all effective in improving signs and symptoms in severe MGD. IPL+MGX provide the most consistent long-term benefits in stabilizing tear film and alleviating symptoms.. These findings highlight the importance of individualized treatment strategies based on MGD severity and patient factors.
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On-treatment modified Glasgow Prognostic Score (mGPS) in hepatocellular carcinoma treated with atezolizumab and bevacizumab provides prognostic information
CONCLUSIONS: The on-treatment mGPS, as well as ACR and AIR, predicted outcomes in patients with HCC independent of and more accurately than radiological staging. Since, the mGPS is the most cost effective and widely validated score, we consider it best suited for clinical use. Prospective validation is needed to confirm these findings.
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Problem-solving training to improve caregiver burden and depressive symptoms among dementia caregivers: personal and clinical factors of responders vs. non-responders
CONCLUSION: Most caregivers demonstrated a clinically meaningful improvement in caregiver burden and/or depressive symptoms after receiving PST/DSJ. Notably, those who responded had higher symptoms of distress, including caregiver burden and overload and depressive symptoms and lower life satisfaction, and had care recipients with more severe dementia, indicating that those benefiting from the intervention were those…
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Traditional Chinese Medicine Combined Group Psychotherapy Experiences Among Colorectal Cancer Survivors: A Secondary Qualitative Analysis
CONCLUSION: During TCM combined online group psychotherapy interventions-including education, skill-building, TCM lifestyle coaching, and peer-exchange platforms-patients developed sustained self-health management practices, improving psychological resilience and physical symptoms. This holistic, tailored and culturally sensitive approach fostered long-term recovery and independence of CRC survivors.
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Effects of two comprehensive habituation training programs on alleviating motion sickness and visually induced motion sickness in college students
Objective: To examine the effects of two complete habituation training programs onsubjective and objective indicators in college students with motion sickness (MSD) and visually induced motion sickness (VIMSD). Methods: A randomized controlled trial was conducted. A total of 92 college students diagnosed with MSD/VIMSD, recruited from December 2023 to June 2024, were randomized into an…
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Short-term effects and influencing factors of short-term personalized vestibular rehabilitation on acute peripheral vestibular syndrome
Objective: To investigate the short-term effects and influencing factors of short-term personalized vestibular rehabilitation (ST-PVR) on acute peripheral vestibular syndrome (APVS). Methods: A randomized controlled study was conducted. APVS patients who visited the Department of Otolaryngology of Henan Provincial People’s Hospital from April 2024 to February 2025 were enrolled and divided into vestibular rehabilitation group…
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Cognitive Reappraisal as a Potential Mechanism of Unified Protocol for Emotional Disorders
This study aimed to investigate changes in cognitive reappraisal as a mechanism of the unified protocol (UP) for emotional disorders. Data were collected as part of a larger randomized clinical equivalence trial that assessed the efficacy of the UP, a transdiagnostic cognitive-behavioral therapy (CBT), relative to well-established single-disorder protocols and a wait-list control. The present…
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Anterior quadratus lumborum block at the lateral supra-arcuate ligament versus thoracic paravertebral block for postoperative analgesia after laparoscopic nephrectomy: a randomized non-inferiority trial
CONCLUSIONS: At 24-h postoperatively, QLB-LSAL had analgesic effects that were not inferior to those of TPVB for patients undergoing laparoscopic nephrectomy.
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Zanubrutinib, lenalidomide and rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone as initial treatment in non-germinal center B-cell diffuse large B-cell lymphoma: a multi-center phase 2 study by Jiangsu Cooperative Lymphoma Group (JCLG)
CONCLUSIONS: ZR2-CHOP demonstrated promising efficacy and manageable toxicity in newly diagnosed non-GCB DLBCL.