Clinical Trials
Category Added in a WPeMatico Campaign
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Optimizing treatment for depressed parents of children with emotional and behavioral disorders: A multi-site feasibility trial
CONCLUSION: Given that a priori progression criteria were met and we found preliminary indication of efficacy, we conclude that an RCT of ADAPT to determine efficacy is warranted.
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Subliminal Priming Effects on Motor and Cognitive Performance: Pilot Evidence With Implications for Neurorehabilitation
CONCLUSIONS: Subliminal priming produced modest gender-dependent effects on maximal walking speed and reaction time. These preliminary findings indicate selective sensitivity of high-demand motor tasks to subliminal cues, warranting further investigation using larger sample sizes and clinical populations.
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Efficacy and safety of reduced-dose daratumumab plus bortezomib and dexamethasone (DVd-lite) in newly diagnosed MGRS patients
CONCLUSIONS: These findings demonstrated that the DVd-lite regimen is an effective and well-tolerated first-line treatment option for newly diagnosed MGRS patients.
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Hospital-Based Psychosocial Case Management and Suicide Prevention in South Korea: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this RCT of outpatients with MDD and high suicide risk, ACM significantly reduced C-SSRS total scores and psychological distress compared with usual care. These findings provide a critical, high-level evidence base for the national implementation of standardized, hospital-centered psychosocial interventions as a scalable public health strategy for suicide prevention.
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Short-term OCT-based evaluation of corneal epithelial remodeling with two silicone hydrogel bandage contact lenses after t-PRK
CONCLUSIONS: Both bandage contact lens materials demonstrated broadly comparable short-term postoperative epithelial remodeling patterns and refractive outcomes after t-PRK. Minor early regional differences observed on OCT should be interpreted cautiously.
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Cost-effectiveness of immediate septoplasty versus medical management with the option for delayed septoplasty for nasal airways obstruction: a multicentre, open-label, randomised controlled trial
CONCLUSIONS: Over a 24-month time horizon, immediate septoplasty would be cost-effective in the management of deviated nasal septum.
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At-Home Transvaginal Pelvic Ultrasonography and Image Quality in Premenopausal Women: A Nonrandomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This nonrandomized clinical trial of at-home pelvic ultrasonography in premenopausal women demonstrated that broad use of at-home gynecologic ultrasonography technology is feasible, safe, and preferred by participants and sonographers compared with in-clinic ultrasonography. At-home ultrasonographic imaging presented an innovative and clinically acceptable alternative to in-clinic care, providing opportunities for improved access to…
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Evaluating the Safety and Efficacy of Sirolimus Topical Gel 0.2% to Treat Acanthosis Nigricans
CONCLUSION: Sirolimus gel 0.2% was safe and effective for AN, producing early improvements in pigmentation, texture, and patient-reported outcomes. Larger randomized controlled trials are warranted to validate these findings.  .
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Efficacy and Tolerability of a Topical Pigment-Correcting Serum in Melasma and Postinflammatory Hyperpigmentation
CONCLUSIONS: The LTN serum is an effective treatment for improving melasma and PIH, particularly among participants with FST IV–VI.  .
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Stapokibart provides significant improvements in signs and symptoms of atopic dermatitis irrespective of prior systemic treatment: a post-hoc analysis of a phase 3 trial
CONCLUSIONS: Stapokibart demonstrated significant clinical efficacy and manageable safety in AD patients irrespective of prior systemic treatment.