Clinical Trials
Category Added in a WPeMatico Campaign
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Cost-effectiveness of an integrated falls prevention programme in primary healthcare for older people in rural China: an economic evaluation alongside the FAMILY trial
CONCLUSIONS: A primary healthcare-integrated, falls prevention programme in rural China can improve health outcomes in older adults whilst reducing costs, providing a scalable solution for resource-constrained settings.
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Effects of Low-Dose Acetylsalicylic Acid on Spontaneous Pain, Pain Sensitivity, and Central Pain Modulation in Response to a Sleep Restriction Challenge in Healthy Individuals
CONCLUSIONS: Pre-emptive low-dose ASA attenuated pain responses to sleep restriction, particularly widespread pain and impaired central pain inhibition, consistent with modulation of nociplastic-like pain mechanisms. Elucidating the mechanisms underlying this effect of ASA could help inform the development of targeted strategies for individuals who experience recurrent short or disrupted sleep and may be at increased…
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A randomized controlled trial of mobile-based contingency management to promote self-monitoring among individuals with chronic pain
CONCLUSIONS: This study is the first to test an app-based escalating variable-ratio CM schedule for promoting sustained daily pain self-monitoring. Findings indicate a large-scale RCT may be warranted. Establishing a valid method for improving self-monitoring adherence has broad research implications. Future studies will explore other target behaviors and examine relationships between pain symptom severity and…
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Epley maneuver versus 360 maneuver for treatment of posterior canal benign paroxysmal positional vertigo in a mechanical rotation chair: a randomized controlled trial
CONCLUSION: Epley- and 360° maneuvers with an MRC demonstrated similar treatment efficacy across objective and patient-reported outcomes, suggesting flexibility in the maneuver choice. Further research should investigate optimization of treatment protocols and long-term follow-up regarding recurrence patterns.
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Effects of acceptance and commitment therapy on fear of progression in young and middle-aged patients with breast cancer receiving particle therapy: a randomized controlled trial
CONCLUSION: Acceptance and commitment therapy reduced FoP and psychological distress in this population, with a delayed effect on psychological flexibility. These findings support integrating structured, group-based ACT into routine care during particle therapy. Multicenter trials with longer follow-up are needed.
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Effectiveness evaluation of heat-sensitive moxibustion self-management in community patients with essential hypertension: a randomized controlled trial
CONCLUSIONS: Heat-sensitive moxibustion self-management can reduce systolic blood pressure, improve antihypertensive effective rate, and alleviate hypertension-related symptoms and quality of life in community patients with essential hypertension, with favorable safety and compliance. These findings suggest that heat-sensitive moxibustion can be promoted as an adjunctive management strategy for essential hypertension in community settings.
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TACE combined with apatinib versus TACE alone for unresectable hepatocellular carcinoma in China: a cost-effectiveness and budget impact analysis
CONCLUSIONS: The TACE-apatinib regimen provides clear clinical benefit for uHCC in China, but its cost-effectiveness and budget feasibility are contingent on drug price. Successful national centralised procurement is the key policy lever to enable value-based access, as demonstrated by this integrated evidence framework.
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Low Prevalence of Exploratory Biochemical Patterns Compatible with Osteomalacia in a Large Cohort of Participants with Low Serum 25-Hydroxyvitamin D Levels
The threshold for vitamin D deficiency is mainly based on osteomalacia prevention. Osteomalacia is diagnosed by bone biopsy, but may potentially also be identified biochemically. Our objective was to examine the prevalence of exploratory biochemical patterns compatible with osteomalacia in a population with low vitamin D status, as well as the effect of vitamin D…
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Prophylactic vs Therapeutic Anticoagulation in Hospitalized Patients With COVID-19: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In patients hospitalized with COVID-19, in-hospital therapeutic anticoagulation with LMWH followed by edoxaban to day 42 did not statistically significantly reduce death and/or thromboembolic events compared with prophylactic anticoagulation followed by placebo.
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Short-Term Clinical Comparison of Scapular Stabilization With and Without Added Kinetic-Chain Exercises on Pain, Scapular Kinematics, and Upper-Extremity Function in Overhead Athletes With Subacromial Pain Syndrome: A Randomized Controlled Trial
CONCLUSION: Both rehabilitation programs were associated with short-term improvements in patient-reported outcomes. However, adding kinetic-chain exercises did not result in a clear additional short-term benefit compared with scapular stabilization alone. Because the kinetic-chain group also completed more exercises overall, the specific contribution of the kinetic-chain component cannot be determined. Given the small sample size and…