Clinical Trials
Category Added in a WPeMatico Campaign
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In vivo assessment of the Optipen optical reflectometer for detecting enamel surface changes following an erosive challenge
CONCLUSIONS: The Optipen optical reflectometer detected immediate changes in enamel surface reflectance in vivo following a single erosive challenge.
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Facilitated Transitions to Postpartum Primary Care and Mental Health Care Services: Secondary Analysis of a Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This study found that supported transitions to postpartum primary care may improve receipt of primary care-provided mental health care services. This relatively low-cost intervention may be one strategy to facilitate ongoing access to mental health care supports and treatments beyond the immediate postpartum period.
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Effect of Sexocorporel-based sexual counseling on sexual health literacy and sexual quality of life among married deaf women of reproductive age: a randomized controlled trial
CONCLUSION: Sexocorporel-based sexual counseling may represent an effective and communication-sensitive approach for improving sexual health literacy and sexual quality of life among married deaf women. Integrating disability-inclusive and visually accessible counseling approaches into sexual healthcare programs may contribute to more equitable sexual healthcare services for women with hearing disabilities.
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Manual, digital, and AI tumour-infiltrating lymphocyte scoring: a secondary analysis of the APHINITY randomised trial
BACKGROUND: Stromal tumour-infiltrating lymphocytes (sTILs) are prognostic in early-stage HER2-positive breast cancer, but their role in the context of dual HER2 blockade remains undefined. We evaluated manual, digital, and artificial intelligence (AI)-based sTIL quantification, together with AI-derived spatial metrics, for prognostic and treatment-benefit stratification using tumour samples from the phase 3 APHINITY trial.
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A 12-Month Trial-Based Economic Evaluation Comparing Positive Parenting Program (Triple P) and Circle of Security Parenting Program (COSP) Versus Treatment as Usual for Families With Young Children (2-6 Years)
CONCLUSIONS: The trial results suggest that compared to TAU, Triple P and COSP represent efficient use of public resources.
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Efficacy and safety of recombinant von Willebrand factor in on-demand treatment of children with von Willebrand disease: up to 4 years of phase 3/3b follow-up
CONCLUSION: rVWF, without or with rFVIII, was efficacious for treating nonsurgical BEs in pediatric patients with severe VWD, with efficacy maintained for up to 4 years and no new safety findings.
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Clinical efficacy study of LED red and infrared light therapy for chronic non-specific low back pain
To evaluate the efficacy and safety of an LED red and infrared light therapy for the treatment of chronic nonspecific low back pain. From September to December 2022, 176 patients diagnosed with chronic non-specific low back pain were enrolled and randomly assigned to two groups: the experimental group (n = 89) and the control group…
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Reducing pain during exercise with offset analgesia in young healthy adults
CONCLUSIONS: OffA can be translated into exercise prescription to reduce pain and improve feelings during isometric exercise in young healthy adults. [Marquette University Institutional Review Board (#4434)].
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Impact of organic selenium supplementation on glycaemic control and quality of life in patients with diabetic neuropathy: a randomized placebo-controlled trial
CONCLUSION: Eight weeks of organic selenium supplementation significantly improved glycemic indices and insulin sensitivity in patients with T2DM and DPN, without notable adverse effects. These findings suggest that selenium supplementation may serve as a potentially useful adjunctive intervention for improving short-term metabolic control in patients with T2DM and DPN. The approximately 1.2% reduction in HbA1c…
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Clinical and biochemical effects of cryotherapy protocols on mandibular premolars with symptomatic apical periodontitis: a randomized clinical trial
CONCLUSION: Different Cryotherapy techniques effectively reduce (POP) and modulate SP expression. Irrigation with cold hypochlorite throughout chemo mechanical process was most effective for pain reduction while final flush with cold saline achieved the greatest decrease in SP.