Clinical Trials
Category Added in a WPeMatico Campaign
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Early vs Late Initiation of Extracorporeal Membrane Oxygenation: Protocol for a Prospective, Randomized, Multicenter Study
CONCLUSIONS: The ELIEO trial will provide robust evidence regarding the optimal timing of vvECMO initiation in patients with severe ARDS. The findings may influence clinical decision-making, resource allocation, and organizational strategies for the management of ARDS in specialized intensive care settings.
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Identifying MicroRNA Biomarkers in Idiopathic Intracranial Hypertension: A Pilot Study
BACKGROUND AND OBJECTIVES: Idiopathic intracranial hypertension (IIH) is characterized by raised intracranial pressure (ICP). It predominantly affects women with obesity and can cause disabling headaches and permanent visual loss. IIH is misdiagnosed in up to 40% of cases. Diagnosis and monitoring often rely on frequent invasive lumbar puncture. This pilot study aimed to identify serum…
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Integrating Metronomic Therapy With Standard Chemotherapy in Advanced Unresectable Head and Neck Cancer: A Randomized Trial Addressing Global Cancer Care Equity (METRO PLUS)
CONCLUSION: In platinum-sensitive advanced HNSCC, the addition of triple OMCT to PC significantly improved OS and PFS with acceptable toxicity. PC + OMCT represents a feasible and cost-conscious first-line option in resource-constrained settings.
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CT Perfusion Blood Flow Provides an Early Response Marker for Progression-free Survival in a Prospective Randomized Clinical Trial of Metastatic Renal Cell Carcinoma
IntroductionThere is currently no biomarker for progression-free survival (PFS) for patients undergoing treatment for metastatic renal cell carcinoma (RCC). The aim of our study was to evaluate computed tomography perfusion (CTp) blood flow as an early marker of PFS in patients with mRCC treated with targeted agents.MethodsAssociations between CTp blood flow and PFS were evaluated…
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A randomized controlled trial of N-acetylcysteine in the treatment of early-onset preeclampsia: Study Protocol
BACKGROUND: Despite significant advancements in obstetric care, the incidence of preeclampsia remains a substantial public health challenge, and effective strategies to prevent the disease progression remain limited, particularly in low-resource settings. N-acetylcysteine (NAC), an antioxidant and glutathione precursor, has demonstrated anti-inflammatory and vasodilatory effects, making it a promising candidate for repurposing. However, robust evidence from…
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A Single Session of Slackline Training Induces Rapid, Task-Specific Balance Improvements and Elevated Resting-State Beta Band Power
Balance training underpins both sports performance and rehabilitation, while its efficacy depends on the amount of training and task difficulty. Here, we characterized neurophysiological changes accompanying the earliest phase of slackline-specific balance acquisition within a closely matched active-control design. For this purpose, 35 healthy, slackline-naïve adults were randomized to a slackline intervention or a time-matched…
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Fissios and postoperative complications (FPoC trial): a multicentre, randomised, controlled clinical trial
INTRODUCTION: Respiratory physiotherapy as a part of a perioperative physical training programme may reduce the risk of developing postoperative complications in patients diagnosed with non-small cell lung carcinoma (NSCLC) scheduled for surgery. However, there is heterogeneity in the design, implementation and evaluation of respiratory physiotherapy programmes.Fissios App contains a standardised respiratory physiotherapy programme. Analysing the…
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Diagnostic stewardship in emergency departments using the UNTIE framework: a stepped-wedge cluster randomised study protocol
INTRODUCTION: Pathology testing accounts for over half of non-labour costs in Australian Emergency Departments (EDs), yet up to one-fifth of tests are unnecessary. Despite national guidance from the Australasian College for Emergency Medicine (ACEM) and the Royal College of Pathologists of Australasia (RCPA), variation in test ordering persists across departments and across clinical presentations. The…
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Learning Gain and User Experience of AI Avatar-Based and Human-Presented Explainer Videos: Prospective Randomized Crossover Feasibility Study
CONCLUSIONS: This study shows that investigating AI-based explainer videos vs those using a human presenter in classroom settings is feasible and highlights methodological challenges, particularly those related to crossover designs involving content-identical materials. In this small exploratory sample, no significant differences in short-term learning gains were detected between different presentation formats. Nonetheless, participants clearly preferred…
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Cancer caregiver support system: A pilot study to assess the effect of improved caregiver support on postoperative recovery of oral cancer patients
CONCLUSION: The CCSS intervention demonstrated feasibility and acceptability, with early signals of benefit in reducing caregiver strain and postdischarge disruptions. This pilot study underscores the potential of context-sensitive, digitally enabled caregiver support in resource-constrained oncology settings. Further scale-up and integration with AI-driven personalization are planned.