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Effects of Remimazolam on Perioperative Inflammatory Response and Neurocognitive Disorders in Elderly Patients Undergoing Video-Assisted Thoracic Surgery: A Randomized Controlled Trial
CONCLUSION: Although remimazolam is less effective than propofol in suppressing the early postoperative inflammatory response in elderly patients undergoing VATS, it did not increase the risk of PND or infection. It has significant advantages in hemodynamic stability, facilitates faster recovery, and reduces injection pain, establishing it as a preferred anesthetic option for geriatric VATS, though… →
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Fluoxetine versus N-acetylcysteine in reducing craving in Indian men with alcohol dependence syndrome: a randomised controlled trial
CONCLUSION: Both fluoxetine and NAC were effective in reducing alcohol craving over 12 weeks, with greater reduction in the NAC group at each follow-up assessment. The NAC group also had a lower relapse rate and better adherence and tolerability. →
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Effects of Asparagus-Derived 20-Hydroxyecdysone Supplementation on Fat Oxidation and Insulin Sensitivity in Resistance-Trained Males
This study investigated the effects of 20-hydroxyecdysone (20E) derived from Asparagus officinalis extract on substrate utilization and metabolic health in young males undergoing resistance training (RT). Twenty healthy males were randomly assigned in a double-blind design to receive either a placebo (PLA; n=10) or 30 mg/d of 20E (n=10) for 12 wk, during which all… →
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A first-line regimen combining Bruton’s tyrosine kinase and programmed cell death protein-1 inhibitors with chemotherapy excluding methotrexate achieves high response rates in primary central nervous system lymphoma
CONCLUSIONS: Orelabrutinib combined with PD-1 blockade and fotemustine demonstrated high antitumor activity with manageable toxicity, supporting its potential as a frontline regimen for PCNSL. →
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Clinical trial of press needle therapy with low-dose atropine for mild myopia in children
CONCLUSION: Periocular acupuncture with low dose atropine solution (.01%) seems to be a safe and more effective method as compared with conventional treatment alone for controlling mild myopia in children. Large scale trials should be conducted for validating these findings. →
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Prognostic value of T-lymphocyte subsets, lymphocyte-to-high-density lipoprotein ratio, interleukin 6, C-reactive protein and procalcitonin in patients with septic shock and effects of vitamin C on patients with septic shock
CONCLUSION: The combination of LHR, IL-6, CRP, PCT and CD4+/CD8+ has prognostic value. Vitamin C adjunct therapy significantly enhances hemodynamic improvement, reduces inflammation, lowers SOFA scores and improves prognosis in septic shock patients. →
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Effectiveness and safety of alprostadil injection in the treatment of patients with type 2 diabetes complications
CONCLUSION: Alprostadil injection as an adjunctive therapy for T2DM-related DF or DPN exhibits significant efficacy and good safety. It not only enhances the overall therapeutic response but also effectively improves lipid metabolism disorders, with a low incidence of adverse events. →
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Ultra-Early Continuous ECG Monitoring for Silent Atrial Fibrillation Diagnosis in Cryptogenic Stroke: The CRIPTOFAST Randomized Controlled Trial
CONCLUSIONS: An ILR implanted early after CS improves the detection of PAF compared to standard care. Individuals with abnormal LA features may benefit the most from ILR. →
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Regional multi-center randomized trial of three vonoprazan-amoxicillin dosing regimens for Helicobacter pylori eradication in Sichuan Province, China
CONCLUSION: VPZ-AMO dual therapy achieved excellent eradication, safety, and patient compliance. All regimens were similarly effective, whereas the 0.5 g QID dosing strategy offered the most favorable balance of efficacy and tolerability, supporting its use as a first-line option in high-prevalence settings. →
