Objective: To explore the efficacy and safety of toripalimab combined with platinum-based chemoradiotherapy in the treatment of locally advanced cervical cancer. Methods: A total of 82 patients diagnosed as locally advanced cervical cancer who received toripalimab combined with platinum-based concurrent chemoradiotherapy at Tianjin Medical University Cancer Institute and Hospital from May 24^(th) 2019 to August… →
Long-context LLMs enable advanced applications such as repository-level code analysis, long-document question-answering, and many-shot in-context learning by supporting extended context windows ranging from 128K to 10M tokens. However, these capabilities come with computational efficiency and memory usage challenges during inference. Optimizations that leverage the Key-Value (KV) cache have emerged to address these issues, focusing on… →
Recently, AI agents have demonstrated very promising developments in automating mathematical theorem proving and code correctness verification using tools like Lean. Such tools pair code with specifications and proofs to ensure it meets its intended requirements, offering very strong safeguards in safety-critical applications. Artificial Intelligence has demonstrated that it can enable the fundamental steps of… →
Creating a strong resume is key for making a great first impression. For computer vision engineers, it’s not just about listing qualifications—it’s about showcasing your unique skills and practical experience in a way that grabs attention. Here, we’ll explore practical tips to craft a resume that highlights your technical expertise and real-world achievements. Quantify Achievements… →
CONCLUSIONS: Health behaviour interventions in community settings are a cost-effective approach to manage type 2 diabetes, offering good value for money. However, more studies focused on long-term follow-up across diverse setting of LMICs should be warranted to assess the maximum impact of such interventions. →
The randomized phase 3 CHART trial (NCT03520478) revealed that rezvilutamide (REZ) plus androgen deprivation therapy (ADT) in high-volume, metastatic, hormone-sensitive prostate cancer (mHSPC) significantly enhanced radiographic progression-free and overall survival than bicalutamide (BIC)-ADT. Accordingly, we examined patient-reported outcomes (PROs) results, which were exploratory endpoints in the CHART trial. The patients were randomly allocated to receive… →
Generating all-atom protein structures is a significant challenge in de novo protein design. Current generative models have improved significantly for backbone generation but remain difficult to solve for atomic precision because discrete amino acid identities are embedded within continuous placements of the atoms in 3D space. This issue is especially significant in designing functional proteins,… →
Enzymes are indispensable molecular catalysts that facilitate the biochemical processes vital to life. They play crucial roles across metabolism, industry, and biotechnology. Despite their importance, there are significant gaps in our knowledge of these catalysts. Out of the approximately 190 million protein sequences cataloged in databases like UniProt, fewer than 0.3% are curated by experts,… →