BACKGROUND AND OBJECTIVES: Antibiotics rapidly reduce intestinal bacterial diversity, leading to dysbiosis that persists for months to years. Although emerging evidence from retrospective and claims-based studies has linked dysbiosis to cognitive function, prospective data are lacking. We aim to examine the prospective association of antibiotics with cognitive aging among initially healthy older adults. →
CONCLUSION: This protocol did not meet its prespecified primary end point. Defactinib monotherapy had limited clinical activity in this cohort of previously treated patients with solid tumors exhibiting NF2 loss. →
CONCLUSIONS: Although preventive treatment with levofloxacin led to a lower incidence of tuberculosis than placebo among children with household exposure to MDR tuberculosis, the difference was not significant. (Supported by Unitaid and others; TB-CHAMP ISRCTN Registry number, ISRCTN92634082.). →
CONCLUSIONS: Although the incidence of tuberculosis was lower in the levofloxacin group than in the placebo group at 30 months, the difference was not significant. (Funded by the National Health and Medical Research Council of Australia; VQUIN MDR Australia New Zealand Clinical Trials Registry number, ACTRN12616000215426.). →
Software development presents numerous challenges, from debugging complex code to navigating legacy systems and adapting to rapidly evolving technologies. These obstacles can hamper productivity, increase error rates, and steepen the learning curve for developers. While AI tools offer promising solutions, high subscription costs, and limited accessibility have often excluded many, especially students and open-source contributors.… →
Artificial intelligence has made significant progress over the years, yet certain challenges remain, particularly in advanced reasoning. Many AI models struggle with generalization, often falling short in scenarios requiring logical deduction, multi-step decision-making, or nuanced understanding. These limitations are particularly evident in areas such as financial forecasting, medical diagnostics, and complex programming tasks. Developers and… →
Speech synthesis technology has made notable strides, yet challenges remain in delivering real-time, natural-sounding audio. Common obstacles include latency, pronunciation accuracy, and speaker consistency—issues that become critical in streaming applications where responsiveness is paramount. Additionally, handling complex linguistic inputs, such as tongue twisters or polyphonic words, often exceeds the capabilities of existing models. To address… →
One of the crucial factors in achieving high-quality outputs from these models lies in the design of prompts—carefully crafted input instructions that guide the model to produce the desired responses. Despite their importance, prompt creation is a labor-intensive process that often requires domain-specific knowledge and significant human effort. These limitations have spurred the development of… →
CONCLUSIONS: The iACT effectively decreased health care professionals’ psychological distress and burnout and improved their psychological flexibility. Our findings provide implications and guidance for the development and broad implementation of iACT in health care settings to improve the mental health of health care professionals. →
CONCLUSION: HIV self-testing is feasible for refugee youth in Uganda and can be supplemented with edutainment comics to advance HIV prevention efforts. →