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Effects of finerenone on arterial stiffness and cardiorenal biomarkers in patients with type 2 diabetes and chronic kidney disease: a randomised placebo-controlled mechanistic trial (FIVE-STAR)
CONCLUSIONS: Finerenone did not affect changes in vascular stiffness but led to a significant and sustained reduction in albuminuria in patients with T2D and CKD. The clinical benefits of finerenone may result from lowering intraglomerular pressure rather than from its effect on vascular stiffness. →
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3 Tips for Ethical Decision-Making
In any organization, leaders are responsible for making decisions. Some decisions, like where to open a new location or whether to change prices, can largely be decided based on research, rational discussion, and clear lanes of decision-making authority. But other decisions boil down to value-based judgements, bringing out strong opinions and offering no easy answers.… →
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Lessons from Snowflake’s CRO
Hello and welcome to The GTMnow Newsletter by GTMnow – a weekly publication by VC firm, GTMfund. Build, scale and invest with the best minds in tech. This is Part III in our series on lessons from some of the top 1% leaders in B2B SaaS. In case you missed them: Part I: Canva’s CCO… →
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Cost-effectiveness of a single-layer high compression bandage versus Unna’s boot for venous leg ulcer treatment: the VENOS trial
CONCLUSION: In this study, SLHCB was cost-effective when compared with UB. These findings may prompt decision-makers to weigh the prospect of allocating an additional R$1.07 (I$0.42) for each percentage point reduction in VLU area or R$1739.13 (I$687.40) per QALY gained. This financial consideration holds significant implications for guiding resource allocation. →
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Efficacy of the Combination Therapy of Intense Pulsed Light and Microneedling With a Postbiotic Formulation for Melasma
CONCLUSION: The combination therapy of IPL and microneedling with a postbiotic formulation exhibits a multidimensional synergistic effect, presenting a promising new direction for melasma therapy. →
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The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial
CONCLUSION: A facial mask based on Bentonite and A. sulphurea extract effectively reduces acne severity and enhances patient satisfaction. These findings suggest its potential as a natural alternative or adjunct to conventional acne treatments. →
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Cost-effectiveness of a self-management maintenance programme following pulmonary rehabilitation: a UK randomised controlled trial for patients with chronic obstructive pulmonary disease
INTRODUCTION: Pulmonary rehabilitation (PR) is an effective intervention for patients with chronic obstructive pulmonary disease (COPD) but impact typically only lasts 6-12 months. This paper presents results of an economic evaluation of a PR maintenance programme (Self-management Programme of Activity, Coping and Education (SPACE)) undertaken within a prospective assessor-blind randomised controlled trial. →
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The Effectiveness of Digital Cognitive Behavioral Therapy to Treat Insomnia Disorder in US Adults: Nationwide Decentralized Randomized Controlled Trial
CONCLUSIONS: The results of this trial demonstrate the effectiveness of digital CBT-I (SleepioRx) for treating insomnia, with gains sustained at 6 months, and support the FDA authorization of SleepioRx for the treatment of insomnia disorder. These findings underscore the potential of a new class of FDA-authorized, fully automated digital treatments to provide first-line, guideline-recommended CBT… →
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How AI can make foreign language films more immersive
Foreign-language films offer audiences the opportunity to engage in cross-cultural experiences, however traditional localisation methods risk disrupting immersion. Yangting Li explores her recent research paper showing how artificial intelligence (AI)-driven technology is providing ground-breaking solutions. The Champion is Polish-language film that tells the true story of Tadeusz Pietrzykowski, a Polish boxer who became famous for… →
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The Top 10 MIT SMR Articles of 2025
Carolyn Geason-Beissel/MIT SMR | Getty Images “You may feel that this is a time of radical uncertainty, when past patterns no longer reliably predict the future. Uncertainty inherently leads us to a place of emotional discomfort because it signals both potential opportunity and adversity.” — David Tuckett, “Five Traits of Leaders Who Excel at Decision-Making”… →