CONCLUSIONS: Spatial concordance between absolute scotomas and GA structural features is moderately high and slightly higher for choroidal hypertransmission than FAF-defined GA. This supports choroidal hypertransmission, a key cRORA feature, as an outcome measure in interventional trials. OCT provides more information to explain visual function than FAF alone. However, given some discordance for both structural… →
OpenAI’s Deep Research AI Agent offers a powerful research assistant at a premium price of $200 per month. However, the open-source community has stepped up to provide cost-effective and customizable alternatives. Here are four fully open-source AI research agents that can rival OpenAI’s offering: 1. Deep-Research Overview:Deep-Research is an iterative research agent that autonomously generates… →
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of infants with congenital heart disease, NO administered via the CPB oxygenator did not improve neurodevelopmental outcomes or HRQOL 12 months after open heart surgery. Further research should explore homogenous cohorts with higher surgical risk and higher-dose or alternative therapies. →
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of CPT-TAU vs WL-TAU, CPT was superior in reducing PTSD symptoms. These results strengthen the evidence for use of CPT in East Asian populations. →
CONCLUSION: Comprehensive assessment of MRI findings allows for avoiding invasive diagnostic procedures in decision-making on cerebrospinal fluid shunting surgery in some patients with idiopathic normal pressure hydrocephalus. →
Large Language Models (LLMs) have demonstrated notable reasoning capabilities in mathematical problem-solving, logical inference, and programming. However, their effectiveness is often contingent on two approaches: supervised fine-tuning (SFT) with human-annotated reasoning chains and inference-time search strategies guided by external verifiers. While supervised fine-tuning offers structured reasoning, it requires significant annotation effort and is constrained by… →
Reinforcement Learning RL trains agents to maximize rewards by interacting with an environment. Online RL alternates between taking actions, collecting observations and rewards, and updating policies using this experience. Model-free RL (MFRL) maps observations to actions but requires extensive data collection. Model-based RL (MBRL) mitigates this by learning a world model (WM) for planning in… →
CONCLUSIONS: Although the combined ABM and CBT intervention did not result in statistically significant reductions in relapse risk and cravings compared to CBT alone, the overall reduction in these outcomes in both groups highlights the effectiveness of CBT in treating AUD. Future studies should use naturalistic settings and tailor the intervention to individual cognitive profiles. →
CONCLUSION: The Vitagnus-soy combination was more effective in alleviating PMS psychological and total symptoms than using either Soy or Vitagnus alone, making it a recommended option for reducing PMS symptoms.Trial Registration Number: IRCT2022072005514N. →
CONCLUSIONS: Adjunctive D-cycloserine with iTBS is a promising strategy to reduce suicidal ideation and implicit suicide risk in depression. →