-
Hormonal mechanisms of women’s risk in the face of traumatic stress
Women are underrepresented in biomedical research, limiting understanding of their disproportionate rates of stress-related disorders. Although men experience more trauma, women are twice as likely to develop posttraumatic stress disorder (PTSD). We tested whether ovarian hormones contribute to this disparity via their influence on threat-related brain activity. In a randomized, double-blind crossover study of 110… →
-
Beat Burnout: 10 Essential MIT SMR Reads
Many employees feel stretched thin right now — facing excessive workloads, unclear expectations, and a lack of meaningful connection at work. This kind of burnout quietly erodes people’s motivation and sense of well-being. At the other end of the spectrum, the most fulfilled workers say that they are challenged and inspired in their roles and… →
-
Digital Cognitive Behavioral Treatment for Generalized Anxiety Disorder: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, DCBT provided significant and sustained benefits to adults with GAD. Given the limitations in access to empirically supported CBT, an efficacious DCBT program has clear potential for public health benefit. →
-
VC 2: How Cassie Young Picks Winners Before They Even Leave Their Jobs
Brought to you by: AngelList How did we build the GTMfund back office? Easy! We leveraged AngelList’s Rolling Fund product for Fund I, which was the perfect vehicle to scale up GTMfund in its first iteration. This structure allowed us to build our network, and add revenue leaders while we raised and deployed capital simultaneously,… →
-
Effectiveness and cost-effectiveness of a multimodal, physiotherapist-led, vocational intervention for people with rheumatoid arthritis or axial spondyloarthritis and a reduced work ability: a randomized, controlled trial
To evaluate the (cost-)effectiveness of a physiotherapist-led, multimodal vocational intervention compared to usual care in adults with rheumatoid arthritis (RA) or axial spondyloarthritis (axSpA) experiencing reduced work ability. (Self-)employed people with RA or axSpA and reduced work ability were randomized to a 12-month vocational intervention or usual care. Assessments were conducted at baseline, 3, 6,… →
-
Omni-Attribute: Open-Vocabulary Attribute Encoder for Visual Concept Personalization
Omni-Attribute introduces a new paradigm for fine-grained visual concept personalization, solving a long-standing problem in image generation: how to transfer only the desired attribute (identity, hairstyle, lighting, style, etc.) without leaking irrelevant visual details. Developed by researchers from Snap Inc., UC Merced, and CMU, this work proposes the first open-vocabulary image attribute encoder explicitly designed… →
-
Comparison of unilateral biportal and percutaneous endoscopic discectomy in treating far lateral lumbar disc herniation
CONCLUSION: Our study results suggest that UBE is a viable alternative to PELD for treating FLLDH, offering comparable clinical outcomes with reduced radiation exposure. →
-
Effect of self-acupressure on fatigue and sleep quality in patients with multiple sclerosis: A randomized controlled trial
CONCLUSION: Self-acupressure was proven to reduce fatigue levels and improve sleep quality in adults with multiple sclerosis. In conclusion, self-acupressure is an accessible, cost-effective, and efficacious technique for alleviating fatigue and enhancing sleep quality in patients with multiple sclerosis. →
-
Azathioprine for the treatment of early Parkinson’s disease (AZA-PD): a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial
BACKGROUND: The immune system is implicated in Parkinson’s disease aetiology and prognosis. Although there are effective symptomatic treatments for Parkinson’s disease, there are currently no therapies that slow down disease progression. We aimed to investigate the clinical efficacy of the broadly acting peripheral immunosuppressant drug azathioprine for patients with early Parkinson’s disease. →
