CONCLUSIONS: GTI sustainably improved HCC surveillance, suggesting that applying data-driven implementation strategies within a manualized facilitation approach can improve care. →

BACKGROUND: In Meru county, Kenya, only 46% of people identified with an eye problem during screening go on to access eye care services at local clinics, with younger adults (aged 18-44 years) being the least likely to receive eye care. This study aimed to test whether provision of additional information was associated with better access… →

CONCLUSION: The co-administration of paracetamol and tramadol intravenously resulted in superior and sustained analgesia when compared with monotherapy, without an increase in adverse effects. These findings provide support for the utilization of this combination as a safe and effective multimodal strategy in the acute management of cancer-related pain in the emergency department. →

CONCLUSION: Prescription of a bioflavonoid-enriched herbal mouthwash following MD is more effective in reducing peri-implant inflammation and subgingival P. gingivalis compared with 0.12% and 0.2% CHX rinses. →

CONCLUSIONS: Poor concordance between MUAC and WHZ should prompt review of wasting measurement guidelines for this population. Stratified analyses and regression modelling showed increased MUAC with age among CU5. MUACZ or age-specific MUAC thresholds may identify more truly wasted children, improving coverage of treatment interventions. Policymakers should examine how adapting screening guidelines impacts health facilities… →

CONCLUSION: Risk stratification of CRC using a RPT showed increased screening uptake. Future research is needed to understand which components of this complex intervention worked to bring about improved outcomes. →

The aim of this study was to compare the efficacy and safety of 755-nm picosecond alexandrite laser and topical tranexamic acid (TTA) combination therapy vs. laser monotherapy, for the treatment of melasma and facial rejuvenation. This multicentre, randomized, double-blinded, split-face study enrolled 37 patients who presented with melasma and photoageing. Facial halves were randomized to… →

Remibrutinib, an oral, highly selective Bruton tyrosine kinase inhibitor, has shown efficacy and favourable safety in the REMIX-1/2 studies in patients with chronic spontaneous urticaria (CSU). Herein, we report the impact of remibrutinib treatment on Work Productivity and Activity Impairment (WPAI) and Dermatology Life Quality Index (DLQI) outcomes. REMIX-1 and REMIX-2 were identical, phase III,… →

Recruiting clinical trial participants to time and target can be challenging. Innovative recruitment strategies, such as facilitating participant self-referral, can be beneficial. The BEACON trial is a national multicentre phase IV assessor-blinded randomized controlled trial comparing the effectiveness, tolerability and cost-effectiveness of ciclosporin, methotrexate and dupilumab in adults with moderate-to-severe eczema. The aim of this… →

The aim of this study was to test whether a weekly bath or shower improves eczema symptoms compared with a daily bath or shower for people with eczema. This was an online, pragmatic, superiority randomized controlled trial, codesigned by people with eczema (citizen scientists), healthcare professionals and researchers. The Eczema Bathing Study is the first… →