Microbial-based therapeutics in clinical practice are of considerable interest, and a recent study demonstrated fecal microbial transplantation (FMT) followed by dietary fiber supplements improved glucose homeostasis. Previous evidence suggests that donor and recipient compatibility and FMT protocol are key determinants, but little is known about the involvement of specific recipient factors. Using data from our… →
CONCLUSION: The findings suggest the combination of PD-1-inhibitor and mFOLFOX6 showed efficacy and acceptable toxicity for locally advanced GC. Extended follow-up is required to determine the duration of the response. This study lays essential groundwork for developing precise neoadjuvant regimens. →
Multimodal large language models (MLLMs) integrate text and visual data processing to enhance how artificial intelligence understands and interacts with the world. This area of research focuses on creating systems that can comprehend and respond to a combination of visual cues and linguistic information, mimicking human-like interactions more closely. The challenge often lies in the… →
Initially designed for continuous control tasks, Proximal Policy Optimization (PPO) has become widely used in reinforcement learning (RL) applications, including fine-tuning generative models. However, PPO’s effectiveness relies on multiple heuristics for stable convergence, such as value networks and clipping, making its implementation sensitive and complex. Despite this, RL demonstrates remarkable versatility, transitioning from tasks like… →
CONCLUSION: The innovative desensitizing paste featuring 8% L-arginine, calcium carbonate, and potassium nitrate effectively occluded dentinal tubules and reduced dentin permeability. It mitigated immediate and prolonged dentin hypersensitivity to various stimuli, supporting its potential role in managing dentin hypersensitivity. →
Artificial intelligence (AI) is transforming healthcare, bringing sophisticated computational techniques to bear on challenges ranging from diagnostics to treatment planning. In this dynamic field, large language models (LLMs) are emerging as powerful tools capable of parsing and understanding complex medical data, thus promising to revolutionize patient care and research. A key issue confronting the healthcare… →
Boston Dynamics has been at the forefront of robotics innovation for decades, and its latest offering—the fully electric Atlas robot—marks a significant milestone in the field. As it announces the retirement of its hydraulic Atlas, a new era begins with an electric version poised to transform real-world applications across various industries. Image Source A Decade… →
CONCLUSIONS: On average, methenamine hippurate was less costly and more effective than antibiotic prophylaxis but these results are subject to uncertainty. Methenamine hippurate is more likely to be considered cost-effective when the benefits of reduced antibiotic use were included in the analysis. →
INTRODUCTION: Low vitamin D status is prevalent among women with polycystic ovary syndrome (PCOS). The objective of the study is to assess the effect of vitamin D supplementation on (1) the ovulation rate to letrozole and (2) other reproductive, endocrine and metabolic outcomes after 1 year of supplementation in women with PCOS. →