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Phase 1 dose-escalation study of IBI324, a VEGF-A/Ang-2 bispecific antibody, for the treatment of diabetic macular oedema
CONCLUSION: IBI324 was well tolerated with evidence of functional and anatomical improvement in patients with DME. →
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Singing for lung health following completion of pulmonary rehabilitation: feasibility of a randomised controlled trial
CONCLUSIONS: A definitive randomised controlled trial of SLH post-PR appears feasible, with acceptable uptake and completion rates. →
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Topical Efinaconazole 10% for Onychomycosis: Pooled Phase 3 Analysis in White, Black, and Asian Participants
CONCLUSIONS: Topical efinaconazole 10% showed favorable efficacy/safety in White, Asian, and Black participants with mild-to-moderate onychomycosis. Results were generally consistent with the overall phase 3 populations and position efinaconazole as an efficacious treatment for patients, regardless of race.  . →
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Evaluation of an Advanced, Multimodal Skin Tone Correcting Serum in Participants With Mild-to-Severe Dyschromia and Hyperpigmentation
CONCLUSIONS: A new multimodal skin tone correcting serum demonstrated significant improvements in MASI scores and in the appearance of skin texture and dullness. Significant improvements were also achieved in participants using both the skin tone correcting serum and double-conjugated retinoid/AHA cream. Participants reported high levels of satisfaction over 12 weeks.  . →
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Clinical Evaluation of a Thiamidol-Based Regimen With SPF Compared With SPF Alone for Facial Hyperpigmentation
CONCLUSION: These data support the integration of Thiamidol-containing formulations into existing skin regimens for individuals with facial hyperpigmentation.  . →
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A Randomized, Controlled, Split-Face, Double-Blind Study Comparing Topical Malassezin to Hydroquinone 4% for Melasma
CONCLUSION: These findings suggest that malassezin shows comparable efficacy to the gold standard, hydroquinone. Our results further support malassezin as a promising new treatment for patients with melasma.  . →
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Efficacy and safety of a topical nitric oxide-releasing solution (NORS) as a noninvasive treatment for plantar warts (verrucae plantaris)
CONCLUSION: NORS demonstrated favorable safety and early clinical activity, warranting larger, longer-term efficacy trials. →
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Five Trends in AI and Data Science for 2026
Carolyn Geason-Beissel/MIT SMR | Getty Images Organizations tend to change much more slowly than AI technology does these days. This means that forecasting enterprise adoption of AI is a bit easier than predicting technology change in this, our third year of making AI predictions. Neither of us is a computer or cognitive scientist, so we… →
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Clinical efficacy of 12 o’clock peripheral iridectomy in aphakic eyes undergoing pars plana vitrectomy with heavy silicone oil tamponade
Objective: To investigate the clinical effect of performing a 12 o’clock peripheral iridectomy during vitrectomy with heavy silicone oil tamponade in aphakic eyes. Methods: This was a prospective controlled study. Patients diagnosed with tractional retinal detachment secondary to proliferative diabetic retinopathy and scheduled to undergo combined lens extraction and pars plana vitrectomy with heavy silicone… →
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Cluster-randomized evaluation of neonatal intensive care unit quality improvement interventions in extremely preterm infants: secondary analysis of the INTACT trial
CONCLUSIONS: This secondary analysis of a cluster-randomized controlled trial demonstrated that the intervention group receiving a NICU-specific QI program had reduced acute-phase morbidities, particularly among infants born between 22 and 27 weeks of gestation. Our findings highlight the potential for widespread clinical implementation of QI programs based on participatory learning and action in neonatal intensive… →
