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Digital Mahjong-Based Cognitive Engagement Intervention for Older Adults: Randomized Controlled Trial
CONCLUSIONS: This 6-month home-based digital mahjong intervention improved delayed recall and increased right insular ReHo. Integrating culturally familiar cognitive challenges with lifestyle engagement may be a feasible strategy associated with salience network-related functional changes and memory performance. Future large-scale trials should use active control conditions and factorial designs to rigorously isolate component-specific mechanisms. →
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How America out-deindustrialised Europe
Despite the prevailing narrative of Western deindustrialisation as one of a rigid Europe and a dynamic America, Richard Baldwin, Saul Estrin, and Bob Hancké argue that the comparison of the EU with the US turns this narrative on its head. While both have experienced deindustrialisation, it has been for different reasons and with the US’s running deeper. The familiar story of deindustrialisation says Europe is over-regulated, over-taxed and burdened by ageing factories, while the United States is… →
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Robots Are Coming — but Not Everywhere
Getty Images “The ChatGPT moment for robotics is coming,” declared Nvidia CEO Jensen Huang at the Consumer Electronics Show in January 2025. It’s a widespread expectation: that humanoid robots will follow the same explosive adoption curve as generative AI. Our research suggests the opposite. Humanoid robotics will be adopted unevenly, across diverging use cases and… →
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Impact of Responsibility Allocation Structures on Diagnostic Quality in AI-Assisted Diagnosis: Randomized Controlled Experiment
CONCLUSIONS: The dynamic responsibility structure may enable health care organizations to use AI more fully and appropriately without compromising clinicians’ diagnostic performance, thereby improving the safety and quality of AI-assisted diagnosis. →
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«My child before and now»: parental perceptions of changes in functioning following participation in the global integration method (Método de Integração Global) in children with autism spectrum disorder
CONCLUSION: Parents reported perceived changes in functioning following participation in MIG and described positive experiences related to the intervention process. →
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Digital Peer Support Intervention for Family Caregivers of Individuals With Neuromuscular Disease: Randomized Controlled Trial
CONCLUSIONS: Our 12-week digital peer support program had no effect on caregiver mastery or other caregiving or psychological outcomes among family caregivers of individuals with NMD. This might be partly due to moderate fidelity and variability in participant engagement. Unlike prior caregiver interventions that incorporated structured psychoeducation or self-management training, this intervention evaluated primarily peer… →
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The Effects of High- and Moderate-Intensity Exercise on Epithelial Integrity Markers and Inflammatory Responses in Healthy Young Men
The effects of exercise intensity on airway epithelial integrity markers and inflammatory responses remain unknown. Therefore, we investigated the effects of high- and moderate-intensity exercise on airway epithelial integrity markers (club cell protein 16 [CC16], surfactant protein D [SP-D], and the CC16/SP-D ratio), along with systemic inflammation assessed via high-sensitivity C-reactive protein [hs-CRP] in healthy… →
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Originalarbeiten / Original Articles. Evaluation of the Benefits of Experiential Play Therapy in Children with Conduct Disorder Using the Aberrant Behavior Checklist: A Prospective Clinical Trial / Evaluation der Wirksamkeit der erlebnisorientierten Spieltherapie bei Kindern mit Störung des Sozialverhaltens anhand der Aberrant Behavior Checklist: Eine prospektive klinische Studie
This study examined the efficacy of experiential play therapy in reducing behavioral problems among children with Conduct Disorder (CD). Between December 2022 and May 2024, a prospective clinical trial was conducted with 20 children aged 7-12 years (10 females, 10 males) diagnosed with CD according to DSM-5 criteria. The intervention involved eight weekly, 45-minute experiential… →
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Efficacy of a psychotherapeutic group intervention for patients with Post-COVID-19 condition: a randomized controlled trial (PsyLoCo study)
CONCLUSIONS: In this exploratory randomized controlled trial, the intervention did not show significant superiority over the control condition; findings should be interpreted cautiously given limited statistical power. Future psychotherapeutic group interventions for patients with PCS have to consider outcome measures beyond severity of persistent physical symptoms rather than evaluating global symptom scores. Group-based psychotherapeutic approaches… →
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Exploring brain-gut interaction mechanisms in Transcutaneous auricular Vagus Nerve stimulation for Major Depressive Disorder
CONCLUSION: taVNS effectively alleviates depressive symptoms in MDD patients via dual complementary pathways: directly modulating neural activity in the right SFG to regulate depression-related brain function, and indirectly maintaining gut microbiota homeostasis by enriching beneficial taxa such as Faecalibacterium prausnitzii. These findings provide novel mechanistic insights into the brain-gut interaction underlying the antidepressant effects of… →