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Intravenous Immunoglobulin Alone for Coronary Artery Lesion Treatment of Kawasaki Disease: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This randomized clinical trial demonstrated the noninferiority of IVIG alone compared with IVIG plus aspirin, with a noninferiority margin set at 10%. The findings suggest that addition of high-dose aspirin during initial IVIG treatment is not clinically meaningful for CAL reduction in children with KD. Future studies on IVIG treatment alone for… →
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Phase IIa randomized placebocontrolled clinical trial to evaluate the efficacy of bromhexine in combination with standard therapy in the early treatment of COVID-19 in primary care patients
CONCLUSIONS: Since coughing is one of the primary forms of transmission for SARS-CoV-2, the observed reduction of coughing might be highly beneficial, particularly for patients living in crowded, poorly ventilated, or confined environments. →
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The effect of patient-centered empowerment program through telenursing on self-management in people with multiple sclerosis: a double-blinded randomized clinical trial
CONCLUSION: Empowering PwMS, focusing on their unique needs and delivering it through telenursing, can be an effective method in enhancing their self-management capabilities. Therefore, it is recommended that healthcare providers in chronic diseases prioritize patient empowerment based on individual needs. →
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A 3-week pause versus continued Bruton tyrosine kinase inhibitor use during COVID-19 vaccination in individuals with chronic lymphocytic leukaemia (IMPROVE trial): a randomised, open-label, superiority trial
BACKGROUND: Chronic lymphocytic leukaemia is the commonest leukaemia and is associated with profound immunosuppression. Bruton tyrosine kinase inhibitors (BTKi) have revolutionised chronic lymphocytic leukaemia management; however, therapy impairs vaccine-induced immunity. We evaluated whether a 3-week pause of BTKi treatment improved spike protein receptor binding domain (RBD) immunity to SARS-CoV-2 booster vaccination while maintaining disease control. →
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Evaluation of an Online-Based Self-Help Program for Patients With Panic Disorder: Randomized Controlled Trial
CONCLUSIONS: The presented online intervention can help reduce the core symptomatology of panic disorder and agoraphobia, as well as anxiety symptoms and associated depression. No effects were found for well-being and secondary outcomes. This may be due to higher illness burden in the intervention group and possibly the COVID pandemic, which caused unique challenges to… →
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Impact of a Symptom Checker App on Patient-Physician Interaction Among Self-Referred Walk-In Patients in the Emergency Department: Multicenter, Parallel-Group, Randomized, Controlled Trial
CONCLUSIONS: We found no evidence that the SCA improved satisfaction with the patient-physician interaction or care in an acute care setting. By contrast, both patients and their treating physicians predominantly described the SCA’s impact as beneficial. Our study did not identify negative effects of SCA use commonly reported in the literature, such as increased anxiety… →
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Introduction to MCP: The Ultimate Guide to Model Context Protocol for AI Assistants
Introduction to MCP: The Ultimate Guide to Model Context Protocol for AI Assistants The that defines a unified way to connect AI assistants (LLMs) with external data sources and tools. Think of MCP as a USB-C port for AI applications – a universal interface that allows any AI assistant to plug into any compatible data… →
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This AI Paper Unveils a Reverse-Engineered Simulator Model for Modern NVIDIA GPUs: Enhancing Microarchitecture Accuracy and Perf…
This AI Paper Unveils a Reverse-Engineered Simulator Model for Modern NVIDIA GPUs: Enhancing Microarchitecture Accuracy and Performance Prediction GPUs are widely recognized for their efficiency in handling high-performance computing workloads, such as those found in artificial intelligence and scientific simulations. These processors are designed to execute thousands of threads simultaneously, with hardware support for features… →
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MCP – A Beginner’s Guide
Imagine you’re using an AI writing assistant to draft an email. It’s excellent at creating clear and concise text, but you need the email to reference specific updates from a recent team meeting and attach a relevant report. While the assistant is impressive in crafting polished content, it falters when accessing real-time context, like your… →