Diffuse interstitial fibrosis is associated with adverse outcomes in hypertensive heart disease and may be reversible. Sacubitril/valsartan could offer greater anti-fibrotic effects than valsartan alone. In the REVERSE-LVH phase 2 open-labelled trial (clinicaltrials.gov NCT: 03553810; funded by the National Medical Research Council of Singapore), 78 patients with essential hypertension and left ventricular hypertrophy (LVH) were… →

CONCLUSION: RME and AT significantly improved sleep-related respiratory parameters in patients with POSA. RME demonstrated comparable efficacy to AT in reducing AHI and improving LAST, MSAT, and REM sleep time. However, AT provided significantly better improvement in clinical symptoms and quality of life. →

CONCLUSION: The clinical effect of subscleral trabecular surgery combined with intravitreal injection of ranibizumab in the treatment of NVG patients is positive, which can more effectively correct the visual acuity and intraocular pressure of patients. →

CONCLUSIONS: In this study, we evaluated if the ACoE could reliably phenotype cognitive symptoms relative to the assessments of established standard paper-based cognitive assessments. We found that the ACoE reliably phenotypes patient cognition, which can be used to screen patients. In the future, these cognitive phenotypes may be used to diagnose specific etiologies. →

CONCLUSION: The combination of TOR and rehabilitation utilization resulted in short-term improvements in physical function after traumatic orthopaedic injury. Participants who received TOR experienced clinically meaningful short-term improvements in pain, pain catastrophizing, and pain anxiety. These data may support the inclusion of screening for psychological response to injury within routine clinical practice. For patients with… →