BACKGROUNDLipogenesis contributes substantially to the pathological accumulation of intrahepatic triacylglycerol (IHTG) in metabolic dysfunction-associated steatotic liver disease (MASLD). Since hepatic lipogenesis is highly sensitive to energy intake, we hypothesized that mechanisms of MASLD regression induced by weight loss would be driven by a marked reduction in the lipogenic pathway.METHODSOverweight adults with high liver fat (HighLF;… →

CONCLUSION: Independent risk factors for developing SAP include CRP(48), Ca^(2+), and PNI(48). CTSI, BISAP, and the combination of PNI(48) and the Ranson score can act as reliable predictors of SAP. →

Total knee arthroplasty (TKA) is crucial for alleviating pain and improving the quality of life in patients with end-stage knee arthritis. Postoperative sleep disturbances are common and can persist for months following the surgery, potentially hindering the overall rehabilitation process and the quality of life. Robotic-assisted TKA (RATKA) offers greater precision and less invasiveness than… →

INTRODUCTION: While recent research suggests that acupuncture may offer benefits to individuals with diarrhoea-predominant irritable bowel syndrome (IBS-D), high-quality studies are scarce in this area. We intend to investigate the efficacy and safety of individualised sensitised acupuncture in IBS-D. →

BACKGROUND: In patients with acute myeloid leukaemia treated with curative intent, the detection of measurable residual disease (MRD) generally confers a poor prognosis. This study aimed to identify whether altering treatment based on MRD results can improve survival. →

CONCLUSIONS: The results indicate that feedback after web-based depression screening is not associated with negative effects such as misdiagnosis, mistreatment, and deterioration in depression severity or in emotional response to symptoms. However, it cannot be ruled out that nontailored feedback may increase the risk of deterioration in suicidal ideation. Robust prospective research on negative effects… →

CONCLUSIONS: We underline the need for intertrigo screening in patients with obesity, especially in those with risk factors, such as female, older, and higher BMI. The use of a novel MWF effectively alleviates symptoms within a short treatment period and should be considered as an optional intertrigo treatment. →

Background: The TrialNet Oral Insulin (OI) prevention trial showed no overall treatment effect, using the diagnosis of type 1 diabetes as an endpoint. A significant delay in onset was only found in a high-risk stratum (termed secondary stratum 1) of participants with low first-phase insulin release (FPIR). Methods: Since trials with an endpoint of type… →

ABSTRACTBackground: Ample studies have demonstrated the effectiveness of psychotherapy for posttraumatic stress disorder (PTSD). However, large individual variation in treatment outcome remains unsolved and treatment options for complex posttraumatic stress disorder (CPTSD) are debated. There is a need for exploring methods for matching patients with treatment they will most likely benefit from.Objective: To develop a… →