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Feasibility randomised controlled trial to assess the delivery of a novel isometric exercise intervention for people diagnosed with uncomplicated stage 1 hypertension in the National Health Service: key quantitative findings
CONCLUSIONS: We met our a priori recruitment criteria which allowed us to calculate a sample size (n=542) for a full RCT. The results demonstrate good acceptability and adherence rates to the treatment protocol. Our results show a signal towards a consistent sBP reduction in the IE group compared with baseline. →
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Effect of dapagliflozin on metabolic dysfunction-associated steatohepatitis: multicentre, double blind, randomised, placebo controlled trial
CONCLUSION: Treatment with dapagliflozin resulted in a higher proportion of participants with MASH improvement without worsening of fibrosis, as well as MASH resolution without worsening of fibrosis and fibrosis improvement without worsening of MASH, than with placebo. →
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Top Artificial Intelligence AI Books to Read in 2025
Top Artificial Intelligence (AI) Books to Read in 2025 Artificial Intelligence (AI) has made remarkable advancements in recent years, particularly with the rise of Large Language Models (LLMs). To stay informed on the latest trends and developments, reading about AI is essential. Below is a curated list of key AI books that business managers and… →
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NVIDIA AI Introduces ProRL: Extended Reinforcement Learning Training Unlocks New Reasoning Capabilities in Language Models
NVIDIA AI Introduces ProRL: Extended Reinforcement Learning Training Unlocks New Reasoning Capabilities in Language Models Recent advances in reasoning-focused language models have marked a significant change in AI by scaling test-time computation. Reinforcement learning (RL) plays a crucial role in developing reasoning capabilities and mitigating reward hacking pitfalls. However, a fundamental debate remains: whether RL… →
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H Company Releases Runner H Public Beta Alongside Holo-1 and Tester H for Developers
H Company Releases Runner H Public Beta Alongside Holo-1 and Tester H for Developers The concept behind Agentic AI is that multiple small, task-focused agents can collaborate to accomplish real work. H Company, based in Paris, aims to transform this concept into a practical reality. They have announced three significant advancements, starting with the public… →
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Three Essentials for Agentic AI Security
Matt Chinworth What if your productive new digital employee was also your greatest vulnerability? AI agents — powered by large language models (LLMs) — are no longer futuristic concepts. Agentic AI tools are working alongside humans, automating workflows, making decisions, and helping teams achieve strategic outcomes across businesses. But AI agents also introduce new risks… →
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Clinical Profile of Halobetasol Propionate 0.01%/ Tazarotene 0.045% Lotion in Patients With Hyperkeratotic Plaque Psoriasis
CONCLUSION: HP/TAZ was efficacious and well tolerated for treating hyperkeratotic plaques. →
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Rapid Onset of Itch Relief With Tapinarof in Two Phase 3 Trials in Atopic Dermatitis
CONCLUSION: Tapinarof demonstrated rapid and clinically meaningful pruritus relief in patients with AD, with improvements starting 24 hours after initial application and statistically significant improvements at day 2. →
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An Educational Video Game in Trauma Triage at Nontrauma Centers: A Secondary Analysis of a Randomized Clinical Trial
CONCLUSIONS: In this process evaluation of a randomized clinical trial, exposure to a theory-based video game was associated with liberalized thresholds for transfer and limited heterogeneity of the estimated treatment effect. →
