CONCLUSION: Denosumab, alendronate and zoledronic acid significantly and similarly reduced BTMs, increased BMD and TBS in men with osteoporosis, whether the gonadal function of patients was normal or decreased. Previous anti-bone resorption therapy may partially diminish the efficacy of denosumab. →

Insomnia and anxiety are highly prevalent and often comorbid in older adults. Although cognitive behavioural therapy is the first-line treatment for insomnia, few interventions simultaneously address both conditions. Furthermore, access remains limited by provider availability and high costs. To address these gaps, we developed an online CBT programme for insomnia and anxiety (eCBT+). This randomised… →

CONCLUSION: A DBCI promoting the adoption of AVOID behaviours among nonfrail, community-dwelling older people is effective in preventing frailty and improving QoL when implemented. Solving technical barriers and incorporating intelligent technologies could enhance impact. →

CONCLUSION: Both CAF alone and CAF combined with L-PRF yielded comparable clinical and volumetric outcomes in RT1 treatments. No statistically significant advantages were observed with the adjunctive use of L-PRF. →

CONCLUSIONS AND RELEVANCE: In this trial-based economic evaluation, START was a cost-effective approach for addressing opioid use disorder in the inpatient setting by increasing the initiation of medication for OUD and linkage to OUD-focused care after discharge. →

CONCLUSION: Culturally adapted PR was feasible and acceptable to adults with COPD in Sri Lanka. A fully powered trial is warranted for evaluating clinical and cost-effectiveness of culturally adapted PR. →

Preserving pulp vitality in deep carious lesions remains a clinical challenge. Indirect pulp capping with bioactive calcium silicate materials such as Biodentine has shown favorable biological outcomes, while diode laser irradiation has been proposed as an adjunct to enhance hemostasis, disinfection, and pulpal healing. However, evidence regarding their combined use is limited. This randomized controlled… →

CONCLUSION: It was determined that EFT reduces pain, alleviates symptoms, and enhances quality of life in women with dysmenorrhea symptoms. →

CONCLUSION: The findings demonstrate that Pilates-based tele-exercises significantly enhance the overall health and well-being of women with primary dysmenorrhea. This is achieved through improved menstrual symptoms and positive changes in attitudes toward menstruation. These results suggest that PBTE could be an effective non-pharmacological approach to managing primary dysmenorrhea. →