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Impact of standardized endoscopic imaging on early detection rate of upper gastrointestinal tract cancer: A quasi-experimental study
The outcomes of patients with upper gastrointestinal tract cancer are poor, and early detection is critical. This study investigated the impact of standardized endoscopic imaging on the early detection rate of upper gastrointestinal tract cancers. A quasi-experimental study was conducted between July 2022 and July 2023. Four tertiary hospitals were randomized to the control and… →
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T-cell receptor-like chimeric antigen receptor T cells targeting mesothelin: A first-in-human dose-escalation trial for platinum-resistant advanced ovarian cancer
CONCLUSIONS: This study highlights that KT127 has a manageable safety profile and shows preliminary biological activity in patients with advanced ovarian cancer, particularly those who have failed multiple lines of therapies. →
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The New Reality of Early-Stage GTM
First, announcing a new GTMfund Event: 100X Your Campaign Launches Using Claude Code [February 17th in San Francisco]. This is for vertical SaaS founders and operators. You can request to join here. Now, onto the edition. The barrier to entry for building enterprise-ready software has collapsed. AI has compressed the time between ideation and shipping… →
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Economic Evaluation of Tobacco Treatments From the Screen ASSIST Lung Cancer Screening Trial
CONCLUSIONS AND RELEVANCE: In this economic evaluation of smoking cessation treatment in LCS, 8-session counseling combined with 2 weeks of NRT was a cost-effective strategy, with a favorable ICQ relative to usual care and other treatment strategies evaluated. These findings are relevant for health systems considering integrating smoking cessation programs with LCS services. →
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Physiotherapy with kinesiotherapy and physical agents to reduce postpartum diastasis recti: a randomised trial
CONCLUSIONS: the combination of kinesiotherapy and physical agents is more effective in reducing inter-rectus distance and abdominal circumference than either approach alone in postpartum women with diastasis recti abdominis. →
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Factors influencing the decision to accept or decline aortic valve replacement for asymptomatic aortic stenosis: a nested longitudinal qualitative substudy of the EASY-AS randomised trial
CONCLUSIONS: Where evidence supports major intervention for an asymptomatic condition, patients are likely to accept the offer, although personal circumstances play an important role in decision-making. Where a condition is not well known to the public, such as AS, patients rely on clinicians and other resources to help decide. Liaison with patient groups in developing… →
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Why European retailers can’t afford to fear collaboration
In 2025, Carrefour ceased operations in Italy. This was, in part, due to transactional relationships with suppliers that undermined its competitiveness in the market. Vicente Foggia argues that retailers capture disproportionate value from collaboration, yet many continental European retailers remain reluctant to invest in partnership structures. In July 2025, Carrefour sold its Italian operations for €1 billion. Sales were… →
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AI Trends in 2026: Key Insights for Leaders
AI investment continues to fuel the U.S. economy, but many expect it to slow down dramatically in 2026. Agentic AI was the hot topic of 2025, but it remains an expensive early-stage experiment that’s not quite ready for mainstream use. What does this mean for leaders looking to guide their teams? In this video, MIT… →