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  • Effect of prenatal genetic counseling on anxiety and test attitudes in pregnant women: a randomized trial

    28 сентября, 2026

    CONCLUSION: These findings support the potential role of nurse-led prenatal genetic counseling in reducing anxiety and improving attitudes toward prenatal testing. Larger multicenter studies with longer follow-up are required before educational or policy recommendations can be made. →

    Clinical Trials
  • Evaluation of a Mental Health Care App-Based Fatigue Management Program for Patients With Inflammatory Bowel Disease in Remission: Protocol for a Randomized Controlled Trial

    28 сентября, 2026

    CONCLUSIONS: This study may contribute valuable knowledge regarding participant engagement and the potential impact of a multicomponent mobile cognitive behavioral intervention package on fatigue in patients with IBD. The findings will support future refinement of the intervention and inform large-scale evaluations and implementation efforts. →

    Clinical Trials
  • Empagliflozin Promotes Natriuresis in Diabetic Patients with Cirrhotic Refractory Ascites: A Proof-of-Concept Study

    28 сентября, 2026

    CONCLUSIONS: In this open-label, proof-of-concept study, empagliflozin was associated with improved short-term natriuretic indices over 10 days in diabetic patients with decompensated cirrhosis and refractory ascites, without serious adverse events. Larger, blinded, longer-term trials are warranted to confirm these preliminary findings. →

    Clinical Trials
  • Impact of previous skin hydration on postsclerotherapy hyperpigmentation: a prospective, randomized, comparative study (SKINCARE Study)

    28 сентября, 2026

    CONCLUSIONS: In this randomized, double-arm, prospective, pilot study, the use of moisturizer 30 days before polidocanol 0.5% sclerotherapy did not reduce PSH. →

    Clinical Trials
  • High-Frequency Oscillatory Ventilation Combined With Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: A Single-Center Randomized Clinical Trial

    28 сентября, 2026

    CONCLUSIONS: In the observed per-protocol population, HFOV + iNO was associated with fewer deaths or ECMO events and faster improvement in oxygenation and right-ventricular echocardiographic measures than either comparator. Because 12 randomized infants were excluded and the overall comparison was not robust to the differential worst-case missing-outcome assumption, confidence in the apparent treatment effect is… →

    Clinical Trials
  • Continuous Versus Routine EEG in Critically Ill Patients Without Primary Neurologic Condition: Analysis of a Randomized Controlled Trial

    28 сентября, 2026

    CONCLUSION: In critically ill adults without a primary neurologic condition, cEEG was not associated with measurable benefits in survival, neurological recovery, or epileptiform activity detection compared with repeated rEEG, in a cohort without detected electrographic seizures or status epilepticus. Pending larger, ideally prospective comparative studies, repeated routine EEG may represent a reasonable alternative in resource-limited… →

    Clinical Trials
  • The Effect of Carbetocin on Cardiac Repolarization: A Randomized, Placebo- and Positive-Controlled QT/QTc Study in Healthy Adults

    28 сентября, 2026

    Carbetocin is an oxytocin receptor agonist used for postpartum hemorrhage prevention. While oxytocin is known to transiently prolong the QT/QTc interval, robust QTc data for carbetocin are limited. Carbetocin is known to elevate HR, which can impact QTc analyses; thus, a dose that did not overly elevate HR was important to select. This randomized, placebo-… →

    Clinical Trials
  • Comparison of Remimazolam and Propofol for Anesthesia Management in Liver Cancer Patients Undergoing Percutaneous Radiofrequency Ablation: A Randomized Controlled Trial

    27 сентября, 2026

    CONCLUSION: Remimazolam with remifentanil provided better hemodynamic stability and respiratory safety than propofol in PRFA for liver cancer (Child-Pugh A/B, without severe comorbidities). The shorter recovery time, though partly confounded by flumazenil, supports remimazolam as a promising alternative. Further studies in higher-risk patients are needed. →

    Clinical Trials
  • Effects of clear aligner-based expansion screw and nickel-titanium palatal expander on airway dimensions and sleep parameters in unilateral cleft lip and palate patients: a randomized clinical trial

    27 сентября, 2026

    CONCLUSION: Both CAE and NiTi palatal expanders significantly improved airway dimensions and sleep parameters in UCLP patients. Anterior transverse widening (intercanine and intermolar width) correlated positively with airway volume gains, whereas basal skeletal widening (J-J’ width, basal bone width) and molar inclination did not, suggesting that the overall expansion effect rather than its mechanistic subtype… →

    Clinical Trials
  • Acute and Chronic Effects of Green Tea Kombucha With and Without Grape Skin Extract on Immune and Oxidative Stress Markers in Beginner Runners: A Randomized Controlled Trial

    27 сентября, 2026

    Green tea kombucha is an antioxidant-rich beverage with promising health benefits. However, evidence regarding its effects in physically active individuals remains limited. This study investigated the acute and chronic effects of green tea kombucha, with or without grape skin extract, on immune and oxidative stress markers in beginner runners. This 12-week randomized clinical trial included… →

    Clinical Trials
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