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Management of post-operative pain by metoclopramide in patients undergoing cesarean section: A double-blinded randomized clinical trial
CONCLUSION: Metoclopramide significantly reduced early post-operative pain and opioid requirements, with reductions exceeding minimal clinically important difference thresholds. While statistically robust, these benefits should be weighed against its transient antiemetic effects and the need for larger trials to confirm functional recovery benefits. →
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Can online peer influencers accelerate HIV testing among young adult males living in Nairobi, Kenya? A study protocol
CONCLUSION: Findings will provide rigorous evidence to inform HIV testing policies and scalable digital behavior change interventions targeting young men in Nairobi and similar urban settings. →
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Beware of What You Expect? A Partial Replication Study on the Behavioral and Psychophysiological Effects of Negative Expectations on Mechanical Hypersensitivity
Mechanical hypersensitivity of uninjured skin surrounding a cutaneous injury is a sign of plasticity of the nociceptive system and can be induced in healthy individuals using high-frequency electrical stimulation (HFS). However, despite a broad body of evidence for acute painful stimuli, mixed results have been reported concerning the role of negative expectations in the development… →
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A randomised, double-blind, placebo-controlled crossover trial on cannabinoid-based medication for behavioural disorders in old patients with severe dementia: the study results
CONCLUSIONS: In this real-life crossover study, THC/CBD oil did not show superiority over placebo in reducing agitation in severe dementia. However, it was safe and associated with a significant reduction in the use of as-needed psychotropic medications prescribed for behavioural and psychological symptoms of dementia. CBM may represent a possible adjunctive option in selected patients,… →
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Effectiveness of Lotrafilcon B and Balafilcon A bandage contact lenses on epithelial healing and visual symptoms after transepithelial photorefractive keratectomy in the hyperopic patients
CONCLUSIONS: Lotrafilcon B bandage contact lenses are more effective than Balafilcon A lenses in reducing ocular pain during the postoperative period of T-PRK. →
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What Gets Your Best Employees to Stay
Chris Gash/theispot.com A recent battle for AI talent illustrates how difficult it is for companies to retain key employees. In 2025, OpenAI’s stock-based compensation averaged roughly $1.5 million per employee — unprecedented for a pre-IPO company — yet OpenAI still experienced high-profile defections. Rivals such as Meta were reportedly extending offers in the hundreds of… →
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Prospective Comparison of Ultra-Low-Dose Versus Standard-Dose Computed Tomography for Esophageal Foreign Body Detection
The objective of this study was to verify the non-inferiority of ultra-low-dose computed tomography (ULD-CT) versus standard-dose CT (SD-CT) for esophageal foreign body (EFB) detection and to quantify dose-quality trade-offs. This prospective, randomized, blinded-reader study enrolled 180 patients (120 adults, 60 children) presenting with suspected EFB ingestion. Patients were randomized to ULD-CT (100 kV/50 mA,… →
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Gross motor function, functional level, physical performance, and muscle strength in preschool children newly diagnosed with cancer: Data from the RePlay trial
CONCLUSION: These results show that preschoolers newly diagnosed with cancer have gross motor function, functional level, and muscle strength impairments, underlining the importance of targeted physical rehabilitation. →