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Bimekizumab treatment for sustained improvements in patient symptoms and health-related quality of life to 3 years in axial spondyloarthritis: results from the BE MOBILE studies and their open-label extension
CONCLUSIONS: Bimekizumab treatment led to rapid and sustained improvements in key patient symptoms and HRQoL to 3 years, emphasising its long-term value in controlling symptoms which profoundly affect patients’ experience and daily lives. →
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Regulatory B cell expansion and type 1 innate lymphoid cell suppression characterise immune modulation in paediatric lupus nephritis
CONCLUSIONS: BAFF inhibition in paediatric LN is associated with rebalancing of innate and adaptive immunity through enhancement of Breg function and suppression of ILC1-driven inflammation. →
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Prophylactic tranexamic acid for the prevention of postpartum haemorrhage in women with placenta praevia: multicentre, double blind, randomised, placebo controlled, phase 3 trial
CONCLUSIONS: In women with placenta praevia who underwent caesarean delivery and received prophylactic oxytocin, treatment with tranexamic acid resulted in a statistically significant yet modest reduction in the incidence of postpartum haemorrhage, with no signal of increased serious adverse events. →
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Exploring the Impact of Yoga on Autonomic Nervous System Function, Social Functioning, and Quality of Life in People with IBS
As per the Rome IV criteria, a disorder of gut-brain interaction such as irritable bowel syndrome (IBS) is characterized by recurrent abdominal pain occurring at least 1 day per week for the previous 3 months and associated changes in bowel movements (defecation, stool frequency, or stool form). These symptoms must have begun at least 6… →
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Resolve the Conflict Between Efficiency and Resilience
Ellice Weaver/Ikon Images Operational efficiency is critical for both financial success and customer satisfaction. Efficient systems, characterized by minimal buffers and idle time, tight schedules, and maximum asset utilization, allow organizations to do more with less, thereby boosting revenue and appealing to time-sensitive customers. However, such systems often lack resilience, increasing an organization’s vulnerability to… →
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Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts
CONCLUSIONS: Ensitrelvir administered to household contacts of a patient with Covid-19 within 72 hours after symptom onset in the index patient was effective in preventing Covid-19 in the contacts. (Funded by Shionogi; SCORPIO-PEP Japan Registry for Clinical Trials number, jRCT2031230124; ClinicalTrials.gov number, NCT05897541.). →
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VC: “Software Is Basically Worth Zero Now” | Tyler Hogge, Ex-Pelion
The GTM Podcast is available on any major directory, including: Apple Podcasts Spotify YouTube Tyler Hogge helped take Divvy from zero to a $2.5B acquisition by Bill.com. Now, as General Partner at Pelion Ventures, he argues that charging for software is dead, per-seat pricing is collapsing, and the next decade of venture-scale companies will be built… →
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Curcumin Supplementation Reduces Inflammation, Neutrophil-to-Lymphocyte Ratio (NLR), and Antioxidant Status in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and impaired insulin secretion, and curcumin-a polyphenolic compound derived from Curcuma longa-has shown potential anti-inflammatory and antioxidant effects. This randomized, double-blind, placebo-controlled trial evaluated the effects of 1500 mg/day curcumin supplementation for 12 months in 114 adults with T2DM, with assessments… →
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Anti-Nogo-A NG101 treatment induces changes in spinal cord micro- and macrostructure following spinal cord injury
NG101 is a recombinant antibody that neutralizes the nerve growth inhibitor Nogo-A, promoting neural repair and improving upper extremity motor function in spinal cord injury (SCI). This study evaluated spinal cord MRI biomarkers to detect treatment-related structural changes and enhance patient stratification using data from 106 participants with acute cervical SCI in the phase 2b… →
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Beyond Verification — What Responsible AI Really Demands of Human Experts
For the fifth year in a row, MIT Sloan Management Review and Boston Consulting Group (BCG) have assembled an international panel of AI experts that includes academics and practitioners to help us understand how responsible artificial intelligence is being implemented across organizations worldwide. In our first post this year, we explored how organizations should think… →