CONCLUSIONS: Providing participants with feedback on their previous pain score did not meaningfully influence within-person pain variability or retention during 60 weeks of weekly monitoring. These findings aid the interpretation of repeated longitudinal pain assessments by showing that the observed variability was robust to this specific study design. →

CONCLUSIONS: Condensed SE guidelines improved adherence to selected emergency interventions compared with both full NCS guidelines and no guideline support. Guideline usability may represent a modifiable target for improving time-critical neurological emergencies. →

CONCLUSIONS: Therapist-guided I-BA reduced depressive symptoms at lower cost than TAU, but clinical importance and robustness are uncertain. Self-guided I-BA showed no clear superiority but was cost-efficient. →

CONCLUSIONS: This trial aims to address critical gaps in accessible, personalized, and gender-sensitive mental health care. If effective, the 3D Program may serve as a scalable, cost-efficient adjunct to routine care for women with depressive symptoms in public health systems, while biomarker findings may lay the groundwork for future trials examining predictors of response. →

CONCLUSIONS: The research shows that the use of VR prior to LP significantly reduces level of pain and fear compared to standard care. These results support VR as a non-pharmacological intervention for fear and pain to improve patient experience during invasive procedures. In contrast, the control group experienced no improvement.Trial Registration: The IRCT code for… →

CONCLUSION: Online psychoeducational videos and assessment were safe, feasible, and acceptable to participants with newly diagnosed BPD. Psychoeducation with personalized feedback appears to be more effective than either BPD or general psychoeducation alone in improving deficits in self-functioning, which may relate to an increased capacity to be alone with fewer symptoms. →

To evaluate whether an integrated classification combining the CHAARTED and LATITUDE criteria improves prognostic stratification and to explore treatment effects across risk groups, including further stratification by metastasis timing, in metastatic castration-sensitive prostate cancer (mCSPC). This post hoc analysis included 1,052 patients from the TITAN trial (NCT02489318) randomized to receive apalutamide plus androgen deprivation therapy… →

CONCLUSION: This study demonstrates comparable and in some key indicators higher clinical and economic efficiency of domestic enteral nutrition products in perioperative period for cancer patients with nutritional disorders. This may be explained by minor biologically active substances in domestic nutrition improving not only protein absorption in the body, but also metabolic and detoxification processes. →

CONCLUSIONS: Preoperative administration of 4 mg tizanidine and 25 mg baclofen showed comparable efficacy in post-operative pain management. As this study lacked a placebo control, it cannot confirm the absolute analgesic efficacy of either drug over no treatment. Although tizanidine demonstrated a trend toward lower pain scores at certain intervals, these differences were not statistically… →