-
When a Rebrand Meets Backlash
When Cracker Barrel unveiled its new logo as part of a larger rebranding initiative this summer, the company hoped it would symbolize a new era for the company. The sleek, simplified branding was linked to the restaurant’s newly modernized interiors and menu, an attempt to revitalize the struggling roadside chain for a younger generation. But… →
-
Measurement-Based Care to Enhance Antidepressant Treatment Outcomes in Major Depressive Disorder: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This trial of adults with MDD found that MBC led to faster time to response and time to remission than standard care in low-resource settings. Future studies need to confirm the clinical effectiveness of MBC and assess its cost-effectiveness in LMICs. →
-
Behavioral Economic Framing for Enrollment and Retention of Patients in Remote Blood Pressure Monitoring: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, the behavioral economic approach of opt-out framing vs opt-in framing did not improve enrollment and retention of patients in a remote BP monitoring program. The findings suggest additional approaches are needed to boost participation. →
-
Jueling Mingmu decoction combined with ranibizumab for retinal vein occlusion induced macular edema: A randomized controlled clinical trial
CONCLUSION: The combination of Jueling Mingmu Decoction and ranibizumab appears to be a potentially effective treatment for improving visual and anatomical outcomes in RVO-related ME, especially in BRVO patients. However, it does not significantly reduce the number of required intravitreal injections compared to monotherapy. Further studies are needed to confirm these findings and explore the… →
-
High-power Ho:YAG lithotripsy increases subclinical renal stress: a prospective randomized KIM-1 study
This study aimed to compare the safety profile of high-power (HPL) and low-power (LPL) Holmium:YAG lasers in retrograde intrarenal surgery (RIRS), using urinary Kidney Injury Molecule-1 (KIM-1) as an early biomarker for acute kidney injury (AKI). Sixty patients with renal stones (1.5-2.5 cm) were prospectively randomized into HPL and LPL groups. Urinary KIM-1 and KIM-1/creatinine… →
-
Effect of cotton roll biting on pain perception during orthodontic bracket debonding using Weingart pliers: A randomized controlled trial
ObjectiveThis study aimed to evaluate the effectiveness of biting on a cotton roll in reducing pain during metal bracket removal using a Weingart plier compared with the conventional method.MethodsThis two-arm, parallel-group, randomized controlled trial included 36 patients (11 males and 25 females) with a mean age of 20.5 ± 3.08 years (range: 16-25 years). The… →
-
High-intensity Interval Training and Mindfulness Breathing Induce Hormonal, Metabolic, and Anticarcinogenic Effects in Obese Postmenopausal Women: A Randomized Controlled Trial
ObjectiveTo find out the effect of high-intensity interval training (HIIT) and mindfulness breathing on the levels of sex hormones, insulin resistance, lipid profiles, and tumor biomarkers in postmenopausal obese women.DesignSeventy obese postmenopausal women (aged 55-65 years, with a body mass index (BMI) ranging from 35-44.9 kg/m²) were allocated into two groups for this prospective, randomized,… →
-
The effects of communicating illness diagnostic and treatment information and C-reactive protein test results on people’s antibiotic expectations
CONCLUSIONS: Simple, evidence-based communication strategies-particularly when combined with diagnostic test results-can reduce antibiotic expectations, offering practical tools for clinicians to support appropriate prescribing. →
-
Health Services and Economic Impacts of the Limit of Detection in Emergency Department (LEGEND) Rule-Out Strategy in Australian Emergency Departments: A Stepped-Wedge Cluster Randomised Trial
CONCLUSIONS: The LEGEND strategy demonstrated reduced resource utilisation and costs compared to guideline-based ACS assessment, particularly for low-risk patients. Widespread adoption could improve the efficiency and cost-effectiveness of ACS assessment in the healthcare system. →
-
Google AI Introduces Stax: A Practical AI Tool for Evaluating Large Language Models LLMs
Google AI Introduces Stax: A Practical AI Tool for Evaluating Large Language Models (LLMs) Evaluating large language models (LLMs) presents unique challenges. Unlike traditional software testing, LLMs operate as probabilistic systems, generating varied responses to identical prompts. This variability complicates efforts to ensure consistency and reproducibility in testing. Google AI has responded to this challenge… →